CY1120413T1 - Ειδικα εξανθρωπισμενα αντισωματα στην πρωτοϊνιδιακη μορφη του βητα-αμυλοειδους πεπτιδιου - Google Patents
Ειδικα εξανθρωπισμενα αντισωματα στην πρωτοϊνιδιακη μορφη του βητα-αμυλοειδους πεπτιδιουInfo
- Publication number
- CY1120413T1 CY1120413T1 CY20181100343T CY181100343T CY1120413T1 CY 1120413 T1 CY1120413 T1 CY 1120413T1 CY 20181100343 T CY20181100343 T CY 20181100343T CY 181100343 T CY181100343 T CY 181100343T CY 1120413 T1 CY1120413 T1 CY 1120413T1
- Authority
- CY
- Cyprus
- Prior art keywords
- beta
- humanized antibodies
- proteinological
- specially
- amyloid peptide
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- C12N2015/8518—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic expressing industrially exogenous proteins, e.g. for pharmaceutical use, human insulin, blood factors, immunoglobulins, pseudoparticles
Abstract
Η παρούσα αίτηση σχετίζεται με ειδικά εξανθρωπισμένα αντισώματα στην πρωτοϊνιδιακή μορφή του βήτα-αμυλοειδούς πεπτιδίου, καθώς και με την χρήση αυτών των αντισωμάτων στο πεδίο της νόσου Alzheimer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0953133A FR2945538B1 (fr) | 2009-05-12 | 2009-05-12 | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
EP10728743.5A EP2430049B1 (fr) | 2009-05-12 | 2010-05-11 | Anticorps humanises spécifiques de la forme protofibrillaire du peptide béta-amyloide |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1120413T1 true CY1120413T1 (el) | 2019-07-10 |
Family
ID=41591699
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100622T CY1116842T1 (el) | 2009-05-12 | 2015-07-14 | Ειδικα εξανθρωπισμενα αντισωματα στην πρωτοϊνιδιακη μορφη του βητα-αμυλοειδους πεπτιδιου |
CY20181100343T CY1120413T1 (el) | 2009-05-12 | 2018-03-27 | Ειδικα εξανθρωπισμενα αντισωματα στην πρωτοϊνιδιακη μορφη του βητα-αμυλοειδους πεπτιδιου |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20151100622T CY1116842T1 (el) | 2009-05-12 | 2015-07-14 | Ειδικα εξανθρωπισμενα αντισωματα στην πρωτοϊνιδιακη μορφη του βητα-αμυλοειδους πεπτιδιου |
Country Status (42)
Families Citing this family (38)
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EP2207568B1 (en) | 2007-11-16 | 2017-05-31 | The Rockefeller University | Antibodies specific for the protofibril form of beta-amyloid protein |
AR085302A1 (es) * | 2011-02-24 | 2013-09-18 | Sanofi Sa | Metodo de produccion de anticuerpos sialilados |
JP2013159596A (ja) * | 2012-02-08 | 2013-08-19 | Nihon Univ | β−アミロイド前駆体タンパク質のマイクロ凝集体に特異的なモノクローナル抗体 |
KR102218494B1 (ko) * | 2013-03-15 | 2021-02-19 | 인트린식 라이프사이언시스, 엘엘씨 | 항-헵시딘 항체 및 그의 용도 |
EP3177322A4 (en) | 2014-08-08 | 2018-07-18 | Alector LLC | Anti-trem2 antibodies and methods of use thereof |
US10323088B2 (en) | 2014-09-22 | 2019-06-18 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
PL3280441T3 (pl) | 2015-04-07 | 2022-02-21 | Alector Llc | Przeciwciała przeciwko sortilinie i sposoby ich stosowania |
EP3307779A2 (en) | 2015-06-12 | 2018-04-18 | Alector LLC | Anti-cd33 antibodies and methods of use thereof |
SG10201912085WA (en) | 2015-06-12 | 2020-02-27 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
US11327080B2 (en) | 2015-07-21 | 2022-05-10 | BioArctic Neruoscience AB | Method for treatment of traumatic brain injury targeting aggregated peptides |
CN108137702B (zh) | 2015-08-28 | 2023-01-06 | 艾利妥 | 抗siglec-7抗体及其使用方法 |
AU2016334051B2 (en) | 2015-10-06 | 2023-10-26 | Alector Llc | Anti-TREM2 antibodies and methods of use thereof |
CN116003596A (zh) | 2015-10-29 | 2023-04-25 | 艾利妥 | 抗siglec-9抗体及其使用方法 |
JP7023853B2 (ja) | 2016-03-04 | 2022-02-22 | アレクトル エルエルシー | 抗trem1抗体及びその使用方法 |
JP2020500020A (ja) | 2016-11-14 | 2020-01-09 | ノバルティス アーゲー | 融合誘導性タンパク質minionに関連する組成物、方法、および治療上の使用 |
EP3354278A1 (en) * | 2017-01-31 | 2018-08-01 | Sanofi | Neuronal cell protective effect of antibodies specific for the protofibrillar form of the beta-amyloid peptide |
US11359014B2 (en) | 2017-05-16 | 2022-06-14 | Alector Llc | Anti-siglec-5 antibodies and methods of use thereof |
CR20190486A (es) | 2017-08-03 | 2020-02-10 | Alector Llc | Anti-cd33 antibodies and methods of use thereof |
SI3601358T1 (sl) | 2017-08-03 | 2023-10-30 | Alector Llc | Protitelesa ANTI-TREM2 in načini njihove uporabe |
US11319373B2 (en) | 2018-05-25 | 2022-05-03 | Alector Llc | Anti-SIRPA antibodies and methods of use thereof |
UY38247A (es) | 2018-05-30 | 2019-12-31 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
BR112020024919A2 (pt) | 2018-06-08 | 2021-03-09 | Alector Llc | Anticorpos, ácido nucleico, vetor, célula hospedeira, métodos de produção de um anticorpo e de prevenção, redução do risco ou tratamento de câncer e composição farmacêutica |
WO2020014617A1 (en) | 2018-07-13 | 2020-01-16 | Alector Llc | Anti-sortilin antibodies and methods of use thereof |
EP3830123A1 (en) | 2018-07-27 | 2021-06-09 | Alector LLC | Anti-siglec-5 antibodies and methods of use thereof |
TW202016307A (zh) | 2018-08-31 | 2020-05-01 | 美商阿列克特有限責任公司 | 抗cd33 抗體及其使用方法 |
UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
TW202110878A (zh) | 2019-05-16 | 2021-03-16 | 法商賽諾菲公司 | 在神經系統中表現抗原結合蛋白 |
CN114245807A (zh) | 2019-06-25 | 2022-03-25 | 吉利德科学公司 | Flt3l-fc融合蛋白和使用方法 |
US20220356233A1 (en) * | 2019-08-20 | 2022-11-10 | The Curators Of The University Of Missouri | Amyloid-beta antibodies |
JP2022548881A (ja) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法 |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
EP4073119A1 (en) | 2019-12-12 | 2022-10-19 | Alector LLC | Methods of use of anti-cd33 antibodies |
PE20231105A1 (es) | 2020-08-25 | 2023-07-19 | Gilead Sciences Inc | Moleculas de union a antigeno multi-especificas contra el vih y metodos de uso |
TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
TW202300517A (zh) | 2021-03-12 | 2023-01-01 | 美商美國禮來大藥廠 | 抗類澱粉β抗體及其用途 |
TW202313094A (zh) | 2021-05-18 | 2023-04-01 | 美商基利科學股份有限公司 | 使用FLT3L—Fc融合蛋白之方法 |
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WO2023081898A1 (en) | 2021-11-08 | 2023-05-11 | Alector Llc | Soluble cd33 as a biomarker for anti-cd33 efficacy |
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SI2436696T1 (sl) * | 2007-01-05 | 2017-10-30 | University Of Zurich | Anti-beta-amiloidno protitelo in načini njegove uporabe |
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EP2207568B1 (en) * | 2007-11-16 | 2017-05-31 | The Rockefeller University | Antibodies specific for the protofibril form of beta-amyloid protein |
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2009
- 2009-05-12 FR FR0953133A patent/FR2945538B1/fr not_active Expired - Fee Related
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2010
- 2010-05-11 HU HUE15160538A patent/HUE036737T2/hu unknown
- 2010-05-11 LT LTEP15160538.3T patent/LT2977385T/lt unknown
- 2010-05-11 EP EP16155574.3A patent/EP3050898B1/fr not_active Expired - Fee Related
- 2010-05-11 DK DK15160538.3T patent/DK2977385T3/en active
- 2010-05-11 AR ARP100101602A patent/AR076670A1/es active IP Right Grant
- 2010-05-11 PT PT151605383T patent/PT2977385T/pt unknown
- 2010-05-11 SI SI201030968T patent/SI2430049T1/sl unknown
- 2010-05-11 UA UAA201114656A patent/UA107574C2/ru unknown
- 2010-05-11 PE PE2011001949A patent/PE20120906A1/es active IP Right Grant
- 2010-05-11 DK DK10728743.5T patent/DK2430049T3/en active
- 2010-05-11 EP EP10728743.5A patent/EP2430049B1/fr active Active
- 2010-05-11 SI SI201031662T patent/SI2977385T1/en unknown
- 2010-05-11 MA MA34434A patent/MA33350B1/fr unknown
- 2010-05-11 EA EA201171388A patent/EA028357B1/ru not_active IP Right Cessation
- 2010-05-11 JP JP2012510343A patent/JP2012526541A/ja active Pending
- 2010-05-11 US US13/319,710 patent/US8614299B2/en active Active
- 2010-05-11 NZ NZ596540A patent/NZ596540A/xx not_active IP Right Cessation
- 2010-05-11 WO PCT/FR2010/050915 patent/WO2010130946A1/fr active Application Filing
- 2010-05-11 MX MX2011012060A patent/MX2011012060A/es active IP Right Grant
- 2010-05-11 AU AU2010247215A patent/AU2010247215B2/en not_active Ceased
- 2010-05-11 KR KR1020117029577A patent/KR101783058B1/ko active IP Right Grant
- 2010-05-11 RS RS20150459A patent/RS54122B1/en unknown
- 2010-05-11 TW TW105112498A patent/TWI583791B/zh not_active IP Right Cessation
- 2010-05-11 ES ES10728743.5T patent/ES2542757T3/es active Active
- 2010-05-11 MY MYPI2011005458A patent/MY159398A/en unknown
- 2010-05-11 ES ES15160538.3T patent/ES2664409T3/es active Active
- 2010-05-11 PT PT107287435T patent/PT2430049E/pt unknown
- 2010-05-11 EP EP15160538.3A patent/EP2977385B1/fr active Active
- 2010-05-11 PL PL15160538T patent/PL2977385T3/pl unknown
- 2010-05-11 TW TW099115013A patent/TWI542360B/zh not_active IP Right Cessation
- 2010-05-11 SG SG2011085255A patent/SG176155A1/en unknown
- 2010-05-11 CA CA2761665A patent/CA2761665A1/fr not_active Abandoned
- 2010-05-11 PL PL10728743T patent/PL2430049T3/pl unknown
- 2010-05-11 BR BRPI1012853-0A patent/BRPI1012853B1/pt not_active IP Right Cessation
- 2010-05-11 CN CN201080030434.6A patent/CN102459336B/zh not_active Expired - Fee Related
- 2010-05-12 UY UY0001032633A patent/UY32633A/es active IP Right Grant
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2011
- 2011-11-08 GT GT201100283A patent/GT201100283A/es unknown
- 2011-11-08 CR CR20110585A patent/CR20110585A/es unknown
- 2011-11-09 IL IL216237A patent/IL216237B/en active IP Right Grant
- 2011-11-10 TN TNP2011000571A patent/TN2011000571A1/fr unknown
- 2011-11-11 CO CO11153627A patent/CO6460745A2/es active IP Right Grant
- 2011-11-11 CL CL2011002831A patent/CL2011002831A1/es unknown
- 2011-11-11 ZA ZA2011/08301A patent/ZA201108301B/en unknown
- 2011-11-11 EC EC2011011452A patent/ECSP11011452A/es unknown
- 2011-11-11 NI NI201100195A patent/NI201100195A/es unknown
- 2011-11-11 SV SV2011004058A patent/SV2011004058A/es active IP Right Grant
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2012
- 2012-08-13 HK HK12107898.4A patent/HK1167152A1/xx not_active IP Right Cessation
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2013
- 2013-10-01 US US14/042,942 patent/US9382312B2/en active Active
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2015
- 2015-07-14 HR HRP20150776TT patent/HRP20150776T1/hr unknown
- 2015-07-14 CY CY20151100622T patent/CY1116842T1/el unknown
- 2015-10-01 JP JP2015195617A patent/JP6310895B2/ja not_active Expired - Fee Related
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2016
- 2016-06-02 US US15/171,708 patent/US10112991B2/en not_active Expired - Fee Related
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2018
- 2018-03-27 HR HRP20180516TT patent/HRP20180516T1/hr unknown
- 2018-03-27 CY CY20181100343T patent/CY1120413T1/el unknown
- 2018-09-26 US US16/142,666 patent/US20190119365A1/en not_active Abandoned
- 2018-11-27 HR HRP20181985TT patent/HRP20181985T1/hr unknown
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