BRPI0915667B8 - ligante, fragmentos scfv e fab, anticorpo, composição farmacêutica, ácido nucleico, molécula de ácido nucleico, vetor, célula hospedeira, método para produção do ligante, ligante, composição farmacêutica, método de detecção do antiligante em uma amostra biológica e kit de imunoensaio para detecção do antiligante em uma amostra biológica - Google Patents
ligante, fragmentos scfv e fab, anticorpo, composição farmacêutica, ácido nucleico, molécula de ácido nucleico, vetor, célula hospedeira, método para produção do ligante, ligante, composição farmacêutica, método de detecção do antiligante em uma amostra biológica e kit de imunoensaio para detecção do antiligante em uma amostra biológicaInfo
- Publication number
- BRPI0915667B8 BRPI0915667B8 BRPI0915667A BRPI0915667A BRPI0915667B8 BR PI0915667 B8 BRPI0915667 B8 BR PI0915667B8 BR PI0915667 A BRPI0915667 A BR PI0915667A BR PI0915667 A BRPI0915667 A BR PI0915667A BR PI0915667 B8 BRPI0915667 B8 BR PI0915667B8
- Authority
- BR
- Brazil
- Prior art keywords
- ligand
- seq
- nucleic acid
- pharmaceutical composition
- biological sample
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 10
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 239000012472 biological sample Substances 0.000 title abstract 3
- 238000003018 immunoassay Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 3
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 title abstract 2
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Communicable Diseases (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
ligante, fragmentos scfv e fab, anticorpo, composição farmacêutica, ácido nucleico, molécula de ácido nucleico, vetor, célula hospedeira, método para produção do ligante, método de tratamento, antiligante, método de detecção do antiligante em uma amostra biológica, kit de imunoensaio para detecção do antiligante, uso do kit de imunoensaio. a presente invenção se refere a um ligante que compreende cada uma das regiões determinantes de complementaridade (cdrs) estabelecidas na seq id n° 1, seq id n° 2, seq id n° 3, seq id n° 4, seq id n° 5 e seq id n° 6, ou em sequência quer com número de aminoácidos substituídos nas sequências mencionadas, conforme indicado a seguir, de 0 a 3 em cdr1(seq id n° 1), fde 0 a 2 em cdr2 (seq id n° 2), de 0 a 2 em cdr3 (seq id n° 3), de 0 a 1 em cdr4 (seq id n° 4), de 0 a 4 em cdr5 (seq id n° 5), de 0 a 2 em cdr6 (seq id n° 6), quer com aminoácidos substituídos por outros aminoácidos com funções e propriedades químicas equivalentes, nas referidas sequências seq id n° 1 a seq id n°6.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12961308P | 2008-07-08 | 2008-07-08 | |
| US61/129613 | 2008-07-08 | ||
| US20258109P | 2009-03-13 | 2009-03-13 | |
| US61/202581 | 2009-03-13 | ||
| US21318909P | 2009-05-15 | 2009-05-15 | |
| US61/213189 | 2009-05-15 | ||
| PCT/EP2009/058663 WO2010003977A1 (en) | 2008-07-08 | 2009-07-08 | Therapeutic use of specific ligand in msrv associated diseases |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BRPI0915667A2 BRPI0915667A2 (pt) | 2017-01-17 |
| BRPI0915667B1 BRPI0915667B1 (pt) | 2020-10-13 |
| BRPI0915667B8 true BRPI0915667B8 (pt) | 2021-05-25 |
Family
ID=41165692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0915667A BRPI0915667B8 (pt) | 2008-07-08 | 2009-07-08 | ligante, fragmentos scfv e fab, anticorpo, composição farmacêutica, ácido nucleico, molécula de ácido nucleico, vetor, célula hospedeira, método para produção do ligante, ligante, composição farmacêutica, método de detecção do antiligante em uma amostra biológica e kit de imunoensaio para detecção do antiligante em uma amostra biológica |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US8715656B2 (pt) |
| EP (2) | EP2315777B1 (pt) |
| JP (3) | JP6058264B2 (pt) |
| KR (1) | KR101682040B1 (pt) |
| CN (1) | CN102143975B (pt) |
| AU (1) | AU2009268025B2 (pt) |
| BR (1) | BRPI0915667B8 (pt) |
| CA (1) | CA2729869C (pt) |
| CY (2) | CY1119185T1 (pt) |
| DK (1) | DK3211005T3 (pt) |
| EA (1) | EA024655B1 (pt) |
| ES (2) | ES2633965T3 (pt) |
| HK (2) | HK1158232A1 (pt) |
| HR (2) | HRP20171067T1 (pt) |
| HU (2) | HUE033803T2 (pt) |
| IL (1) | IL210204A (pt) |
| LT (2) | LT2315777T (pt) |
| MX (1) | MX2010014319A (pt) |
| NZ (1) | NZ590515A (pt) |
| PL (2) | PL2315777T3 (pt) |
| PT (2) | PT2315777T (pt) |
| SI (2) | SI3211005T1 (pt) |
| WO (1) | WO2010003977A1 (pt) |
| ZA (1) | ZA201100446B (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5087625B2 (ja) | 2006-09-01 | 2012-12-05 | セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド | 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化 |
| NZ590515A (en) * | 2008-07-08 | 2013-01-25 | Geneuro Sa | Therapeutic use of specific ligand in msrv associated diseases |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| UA119032C2 (uk) * | 2012-10-02 | 2019-04-25 | Женеро Са | Фармацевтична композиція для лікування блокади ремієлінізації при захворюваннях, які пов'язані з експресією білка оболонки herv-w |
| EP2949342A1 (en) * | 2014-05-28 | 2015-12-02 | Geneuro SA | Antiretroviral drug targeting human endogenous retrovirus |
| WO2017072208A1 (en) * | 2015-10-29 | 2017-05-04 | F. Hoffmann-La Roche Ag | Transgenic rabbit with common light chain |
| JP2018028538A (ja) * | 2016-08-12 | 2018-02-22 | 公立大学法人名古屋市立大学 | 統合失調症とその関連疾患の診断用マーカー及びその使用 |
| WO2019201908A1 (en) | 2018-04-17 | 2019-10-24 | Geneuro Sa | Method for the detection of the soluble hydrophilic oligomeric form of herv-w envelope protein |
| EP3916015A1 (en) * | 2020-05-28 | 2021-12-01 | Geneuro SA | Anti-herv-w envelope protein antibody for use in the treatment of psychotic diseases |
| CN113940993B (zh) * | 2021-12-20 | 2022-02-22 | 深圳万可森生物科技有限公司 | 一种鲈鱼弹状病毒g2-2m亚单位疫苗及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| JPH05501352A (ja) | 1989-08-09 | 1993-03-18 | ディカルブ ジェネティクス コーポレイション | 安定な形質転換稔性単子葉植物およびそれらの細胞を製造するための方法および組成物 |
| US7473423B2 (en) * | 1994-04-29 | 2009-01-06 | Mayo Foundation For Medical Education And Research | Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
| FR2734842B1 (fr) | 1995-06-02 | 1998-02-27 | Rhone Poulenc Agrochimie | Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides |
| FR2736926B1 (fr) | 1995-07-19 | 1997-08-22 | Rhone Poulenc Agrochimie | 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene |
| JP2003512844A (ja) * | 1999-10-28 | 2003-04-08 | ユニヴェルシテ・ドゥ・ジュネーブ | 多発性硬化症関連スーパー抗原 |
| RU2005137325A (ru) * | 2003-05-31 | 2006-09-10 | Микромет Аг (De) | Фармацевтическая композиция, содержащая конструкт, специфичный к ерсам |
| FR2865403B1 (fr) | 2004-01-23 | 2009-06-12 | Biomerieux Sa | Composition pour le traitement d'une pathologie associee a la msrv/herv-w |
| CN111925445A (zh) | 2004-07-09 | 2020-11-13 | 中外制药株式会社 | 抗-磷脂酰肌醇蛋白聚糖3抗体 |
| JP4088655B2 (ja) | 2004-09-06 | 2008-05-21 | キリンファーマ株式会社 | 抗ａ３３抗体 |
| WO2006067847A1 (ja) * | 2004-12-22 | 2006-06-29 | Chugai Seiyaku Kabushiki Kaisha | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
| US8475798B2 (en) | 2005-06-16 | 2013-07-02 | Inhibitex, Inc. | Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein |
| WO2006137354A1 (ja) | 2005-06-21 | 2006-12-28 | Medical & Biological Laboratories Co., Ltd. | アミロイド線維形成に対する阻害活性を有する抗体 |
| FR2912314B1 (fr) * | 2007-02-09 | 2012-08-03 | Geneuro Sa | Composition pharmaceutique comprenant des anticorps diriges contre l'enveloppe de herv-w. |
| NZ590515A (en) * | 2008-07-08 | 2013-01-25 | Geneuro Sa | Therapeutic use of specific ligand in msrv associated diseases |
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2009
- 2009-07-08 NZ NZ590515A patent/NZ590515A/xx unknown
- 2009-07-08 DK DK17159699.2T patent/DK3211005T3/da active
- 2009-07-08 PL PL09780311T patent/PL2315777T3/pl unknown
- 2009-07-08 BR BRPI0915667A patent/BRPI0915667B8/pt active IP Right Grant
- 2009-07-08 PT PT97803118T patent/PT2315777T/pt unknown
- 2009-07-08 LT LTEP09780311.8T patent/LT2315777T/lt unknown
- 2009-07-08 AU AU2009268025A patent/AU2009268025B2/en active Active
- 2009-07-08 CA CA2729869A patent/CA2729869C/en active Active
- 2009-07-08 ES ES09780311.8T patent/ES2633965T3/es active Active
- 2009-07-08 US US12/997,486 patent/US8715656B2/en active Active
- 2009-07-08 WO PCT/EP2009/058663 patent/WO2010003977A1/en active Application Filing
- 2009-07-08 EA EA201100160A patent/EA024655B1/ru unknown
- 2009-07-08 PL PL17159699T patent/PL3211005T3/pl unknown
- 2009-07-08 JP JP2011517153A patent/JP6058264B2/ja active Active
- 2009-07-08 LT LTEP17159699.2T patent/LT3211005T/lt unknown
- 2009-07-08 EP EP09780311.8A patent/EP2315777B1/en active Active
- 2009-07-08 HU HUE09780311A patent/HUE033803T2/en unknown
- 2009-07-08 KR KR1020117002937A patent/KR101682040B1/ko active IP Right Grant
- 2009-07-08 SI SI200932120T patent/SI3211005T1/sl unknown
- 2009-07-08 ES ES17159699T patent/ES2875762T3/es active Active
- 2009-07-08 CN CN200980134828.3A patent/CN102143975B/zh active Active
- 2009-07-08 EP EP17159699.2A patent/EP3211005B1/en active Active
- 2009-07-08 SI SI200931698T patent/SI2315777T1/sl unknown
- 2009-07-08 MX MX2010014319A patent/MX2010014319A/es active IP Right Grant
- 2009-07-08 PT PT171596992T patent/PT3211005T/pt unknown
- 2009-07-08 HU HUE17159699A patent/HUE054712T2/hu unknown
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2010
- 2010-12-23 IL IL210204A patent/IL210204A/en active IP Right Grant
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2011
- 2011-01-17 ZA ZA2011/00446A patent/ZA201100446B/en unknown
- 2011-11-25 HK HK11112831.5A patent/HK1158232A1/xx unknown
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2014
- 2014-03-21 US US14/221,963 patent/US9550824B2/en active Active
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2015
- 2015-03-11 JP JP2015048795A patent/JP6109869B2/ja active Active
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2016
- 2016-12-02 US US15/367,864 patent/US9815888B2/en active Active
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2017
- 2017-03-08 JP JP2017043877A patent/JP6495361B2/ja not_active Expired - Fee Related
- 2017-07-12 HR HRP20171067TT patent/HRP20171067T1/hr unknown
- 2017-07-20 CY CY20171100776T patent/CY1119185T1/el unknown
- 2017-10-26 US US15/794,541 patent/US10059758B2/en active Active
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2018
- 2018-02-28 HK HK18102934.5A patent/HK1243436A1/zh unknown
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2021
- 2021-06-02 CY CY20211100481T patent/CY1124281T1/el unknown
- 2021-06-04 HR HRP20210892TT patent/HRP20210892T1/hr unknown
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