EA201100160A1 - Терапевтическое применение специфического лиганда при заболеваниях, связанных с msrv - Google Patents
Терапевтическое применение специфического лиганда при заболеваниях, связанных с msrvInfo
- Publication number
- EA201100160A1 EA201100160A1 EA201100160A EA201100160A EA201100160A1 EA 201100160 A1 EA201100160 A1 EA 201100160A1 EA 201100160 A EA201100160 A EA 201100160A EA 201100160 A EA201100160 A EA 201100160A EA 201100160 A1 EA201100160 A1 EA 201100160A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- seq
- msrv
- disorders associated
- therapeutic application
- specific ligand
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 241000813323 Maize streak Reunion virus Species 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 3
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 2
- 101100495352 Candida albicans CDR4 gene Proteins 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Настоящее изобретение относится к лиганду, содержащему каждый из участков, определяющих комплементарность (CDR), представленных SEQ ID No. 1, SEQ ID No. 2, SEQ ID No. 3 SEQ ID No. 4, SEQ ID No. 5 и SEQ ID No. 6, или последовательность, имеющую либо указанное далее число замещенных аминокислот в пределах этих последовательностей: от 0 до 3 в CDR1 (SEQ ID No. 1), от 0 до 2 в CDR2 (SEQ ID No. 2), от 0 до 2 в CDR3 (SEQ ID No. 3), от 0 до 1 в CDR4 (SEQ ID No. 4), от 0 до 4 в CDR5 (SEQ ID No. 5), от 0 до 2 в CDR6 (SEQ ID No. 6), либо аминокислоты, замещенные другими аминокислотами, обладающими эквивалентными химическими функциями и свойствами, в пределах указанных последовательностей SEQ ID No. 1 - SEQ ID No. 6.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12961308P | 2008-07-08 | 2008-07-08 | |
| US20258109P | 2009-03-13 | 2009-03-13 | |
| US21318909P | 2009-05-15 | 2009-05-15 | |
| PCT/EP2009/058663 WO2010003977A1 (en) | 2008-07-08 | 2009-07-08 | Therapeutic use of specific ligand in msrv associated diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201100160A1 true EA201100160A1 (ru) | 2011-08-30 |
| EA024655B1 EA024655B1 (ru) | 2016-10-31 |
Family
ID=41165692
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201100160A EA024655B1 (ru) | 2008-07-08 | 2009-07-08 | ЛИГАНД, СВЯЗЫВАЮЩИЙСЯ С MSRV-ENV (ВАРИАНТЫ), ScFV И Fab ФРАГМЕНТЫ, АНТИТЕЛО, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, НУКЛЕИНОВЫЕ КИСЛОТЫ, ВЕКТОР, КЛЕТКА-ХОЗЯИН, СПОСОБ ЛЕЧЕНИЯ, АНТИЛИГАНД И СПОСОБ ЕГО ОПРЕДЕЛЕНИЯ, НАБОР И ЕГО ПРИМЕНЕНИЕ |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US8715656B2 (ru) |
| EP (2) | EP2315777B1 (ru) |
| JP (3) | JP6058264B2 (ru) |
| KR (1) | KR101682040B1 (ru) |
| CN (1) | CN102143975B (ru) |
| AU (1) | AU2009268025B2 (ru) |
| BR (1) | BRPI0915667B8 (ru) |
| CA (1) | CA2729869C (ru) |
| CY (2) | CY1119185T1 (ru) |
| DK (1) | DK3211005T3 (ru) |
| EA (1) | EA024655B1 (ru) |
| ES (2) | ES2875762T3 (ru) |
| HK (2) | HK1158232A1 (ru) |
| HR (2) | HRP20171067T1 (ru) |
| HU (2) | HUE033803T2 (ru) |
| IL (1) | IL210204A (ru) |
| LT (2) | LT2315777T (ru) |
| MX (1) | MX2010014319A (ru) |
| NZ (1) | NZ590515A (ru) |
| PL (2) | PL2315777T3 (ru) |
| PT (2) | PT3211005T (ru) |
| SI (2) | SI3211005T1 (ru) |
| WO (1) | WO2010003977A1 (ru) |
| ZA (1) | ZA201100446B (ru) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2064325B1 (en) | 2006-09-01 | 2011-12-07 | Therapeutic Human Polyclonals, Inc. | Enhanced expression of human or humanized immunoglobulin in non-human transgenic animals |
| PT3211005T (pt) * | 2008-07-08 | 2021-06-15 | Geneuro Sa | Utilização terapêutica de ligandos específicos nas doenças associadas a msrv |
| FR2945538B1 (fr) * | 2009-05-12 | 2014-12-26 | Sanofi Aventis | Anticorps humanises specifiques de la forme protofibrillaire du peptide beta-amyloide. |
| UA119032C2 (uk) * | 2012-10-02 | 2019-04-25 | Женеро Са | Фармацевтична композиція для лікування блокади ремієлінізації при захворюваннях, які пов'язані з експресією білка оболонки herv-w |
| EP2949342A1 (en) * | 2014-05-28 | 2015-12-02 | Geneuro SA | Antiretroviral drug targeting human endogenous retrovirus |
| CN113862300A (zh) * | 2015-10-29 | 2021-12-31 | 豪夫迈·罗氏有限公司 | 具有共同轻链的转基因兔 |
| JP2018028538A (ja) * | 2016-08-12 | 2018-02-22 | 公立大学法人名古屋市立大学 | 統合失調症とその関連疾患の診断用マーカー及びその使用 |
| WO2019201908A1 (en) | 2018-04-17 | 2019-10-24 | Geneuro Sa | Method for the detection of the soluble hydrophilic oligomeric form of herv-w envelope protein |
| EP3916015A1 (en) * | 2020-05-28 | 2021-12-01 | Geneuro SA | Anti-herv-w envelope protein antibody for use in the treatment of psychotic diseases |
| CN113940993B (zh) * | 2021-12-20 | 2022-02-22 | 深圳万可森生物科技有限公司 | 一种鲈鱼弹状病毒g2-2m亚单位疫苗及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| DE69031711T2 (de) | 1989-08-09 | 1998-04-09 | Dekalb Genetics Corp | Methoden und zusammensetzungen für die herstellung von stabil transformierten, fruchtbaren mais pflanzen und zellen dafür |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US7473423B2 (en) * | 1994-04-29 | 2009-01-06 | Mayo Foundation For Medical Education And Research | Human IgM antibodies, and diagnostic and therapeutic uses thereof particularly in the central nervous system |
| FR2734842B1 (fr) | 1995-06-02 | 1998-02-27 | Rhone Poulenc Agrochimie | Sequence adn d'un gene de l'hydroxy-phenyl pyruvate dioxygenase et obtention de plantes contenant un gene de l'hydroxy-phenyl pyruvate dioxygenase, tolerantes a certains herbicides |
| FR2736926B1 (fr) | 1995-07-19 | 1997-08-22 | Rhone Poulenc Agrochimie | 5-enol pyruvylshikimate-3-phosphate synthase mutee, gene codant pour cette proteine et plantes transformees contenant ce gene |
| JP2003512844A (ja) | 1999-10-28 | 2003-04-08 | ユニヴェルシテ・ドゥ・ジュネーブ | 多発性硬化症関連スーパー抗原 |
| JP5010281B2 (ja) * | 2003-05-31 | 2012-08-29 | マイクロメット アクツィエン ゲゼルシャフト | Ｅｐｃａｍに対する二重特異性抗体を含む薬学的組成物 |
| FR2865403B1 (fr) | 2004-01-23 | 2009-06-12 | Biomerieux Sa | Composition pour le traitement d'une pathologie associee a la msrv/herv-w |
| NZ579543A (en) | 2004-07-09 | 2011-07-29 | Chugai Pharmaceutical Co Ltd | Anti-glypican 3 antibody |
| EP2145954A1 (en) | 2004-09-06 | 2010-01-20 | Kyowa Hakko Kirin Co., Ltd. | Anti-A33 antibody |
| JPWO2006067847A1 (ja) * | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
| US8475798B2 (en) | 2005-06-16 | 2013-07-02 | Inhibitex, Inc. | Monoclonal antibodies recognizing a coagulase-negative staphylococcal protein |
| US7741448B2 (en) | 2005-06-21 | 2010-06-22 | Medical & Biological Laboratories Co., Ltd. | Antibody having inhibitory effect on amyloid fibril formation |
| FR2912314B1 (fr) | 2007-02-09 | 2012-08-03 | Geneuro Sa | Composition pharmaceutique comprenant des anticorps diriges contre l'enveloppe de herv-w. |
| PT3211005T (pt) * | 2008-07-08 | 2021-06-15 | Geneuro Sa | Utilização terapêutica de ligandos específicos nas doenças associadas a msrv |
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2009
- 2009-07-08 PT PT171596992T patent/PT3211005T/pt unknown
- 2009-07-08 EP EP09780311.8A patent/EP2315777B1/en active Active
- 2009-07-08 HU HUE09780311A patent/HUE033803T2/en unknown
- 2009-07-08 LT LTEP09780311.8T patent/LT2315777T/lt unknown
- 2009-07-08 EP EP17159699.2A patent/EP3211005B1/en active Active
- 2009-07-08 BR BRPI0915667A patent/BRPI0915667B8/pt active IP Right Grant
- 2009-07-08 AU AU2009268025A patent/AU2009268025B2/en active Active
- 2009-07-08 SI SI200932120T patent/SI3211005T1/sl unknown
- 2009-07-08 DK DK17159699.2T patent/DK3211005T3/da active
- 2009-07-08 EA EA201100160A patent/EA024655B1/ru unknown
- 2009-07-08 ES ES17159699T patent/ES2875762T3/es active Active
- 2009-07-08 CA CA2729869A patent/CA2729869C/en active Active
- 2009-07-08 PL PL09780311T patent/PL2315777T3/pl unknown
- 2009-07-08 ES ES09780311.8T patent/ES2633965T3/es active Active
- 2009-07-08 JP JP2011517153A patent/JP6058264B2/ja active Active
- 2009-07-08 PT PT97803118T patent/PT2315777T/pt unknown
- 2009-07-08 PL PL17159699T patent/PL3211005T3/pl unknown
- 2009-07-08 SI SI200931698T patent/SI2315777T1/sl unknown
- 2009-07-08 HU HUE17159699A patent/HUE054712T2/hu unknown
- 2009-07-08 KR KR1020117002937A patent/KR101682040B1/ko active IP Right Grant
- 2009-07-08 NZ NZ590515A patent/NZ590515A/xx unknown
- 2009-07-08 WO PCT/EP2009/058663 patent/WO2010003977A1/en active Application Filing
- 2009-07-08 MX MX2010014319A patent/MX2010014319A/es active IP Right Grant
- 2009-07-08 LT LTEP17159699.2T patent/LT3211005T/lt unknown
- 2009-07-08 US US12/997,486 patent/US8715656B2/en active Active
- 2009-07-08 CN CN200980134828.3A patent/CN102143975B/zh active Active
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2010
- 2010-12-23 IL IL210204A patent/IL210204A/en active IP Right Grant
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2011
- 2011-01-17 ZA ZA2011/00446A patent/ZA201100446B/en unknown
- 2011-11-25 HK HK11112831.5A patent/HK1158232A1/xx unknown
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2014
- 2014-03-21 US US14/221,963 patent/US9550824B2/en active Active
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2015
- 2015-03-11 JP JP2015048795A patent/JP6109869B2/ja active Active
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2016
- 2016-12-02 US US15/367,864 patent/US9815888B2/en active Active
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2017
- 2017-03-08 JP JP2017043877A patent/JP6495361B2/ja not_active Expired - Fee Related
- 2017-07-12 HR HRP20171067TT patent/HRP20171067T1/hr unknown
- 2017-07-20 CY CY20171100776T patent/CY1119185T1/el unknown
- 2017-10-26 US US15/794,541 patent/US10059758B2/en active Active
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2018
- 2018-02-28 HK HK18102934.5A patent/HK1243436A1/zh unknown
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2021
- 2021-06-02 CY CY20211100481T patent/CY1124281T1/el unknown
- 2021-06-04 HR HRP20210892TT patent/HRP20210892T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
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| PZ1A | Registration of pledge of rights to a eurasian application | ||
| PZ1A | Registration of pledge of rights to a eurasian application | ||
| HK9A | Amendment to the eapo bulletin concerning published eurasian application |