BR112013009083A8 - anticorpos humanos de oncostatin m e métodos de uso - Google Patents

anticorpos humanos de oncostatin m e métodos de uso

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Publication number
BR112013009083A8
BR112013009083A8 BR112013009083A BR112013009083A BR112013009083A8 BR 112013009083 A8 BR112013009083 A8 BR 112013009083A8 BR 112013009083 A BR112013009083 A BR 112013009083A BR 112013009083 A BR112013009083 A BR 112013009083A BR 112013009083 A8 BR112013009083 A8 BR 112013009083A8
Authority
BR
Brazil
Prior art keywords
antibodies
methods
oncostatin
human oncostatin
human
Prior art date
Application number
BR112013009083A
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English (en)
Other versions
BR112013009083A2 (pt
BR112013009083B1 (pt
Inventor
Fransson Johan
Pardinas Jose
Carlos Almagro Juan
Dubell William
Original Assignee
Janssen Biotech Inc
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Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of BR112013009083A2 publication Critical patent/BR112013009083A2/pt
Publication of BR112013009083A8 publication Critical patent/BR112013009083A8/pt
Publication of BR112013009083B1 publication Critical patent/BR112013009083B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
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    • C12P21/00—Preparation of peptides or proteins
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    • C07—ORGANIC CHEMISTRY
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    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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Abstract

anticorpos humanos de oncostatin m e métodos de uso. a presente invenção refere-se a anticorpose composições capazes de neutralizar funções biológicas de oncostatin m que são úteis no tratamento de doenças e distúrbios associados com oncostatin m, como osteoartrite e fibrose pulmonar idiopática.
BR112013009083-9A 2010-10-13 2011-10-10 Anticorpos humanos para oncostatina m, seu processo de fabricação, fragmento de ligação a antígeno, composição farmacêutica, polinucleotídeo isolado, célula hospedeira recombinante estavelmente transformada ou transfectada BR112013009083B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US39268310P 2010-10-13 2010-10-13
US61/392,683 2010-10-13
PCT/US2011/055606 WO2012051111A2 (en) 2010-10-13 2011-10-10 Human oncostatin m antibodies and methods of use

Publications (3)

Publication Number Publication Date
BR112013009083A2 BR112013009083A2 (pt) 2016-09-13
BR112013009083A8 true BR112013009083A8 (pt) 2018-01-02
BR112013009083B1 BR112013009083B1 (pt) 2021-08-10

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BR112013009083-9A BR112013009083B1 (pt) 2010-10-13 2011-10-10 Anticorpos humanos para oncostatina m, seu processo de fabricação, fragmento de ligação a antígeno, composição farmacêutica, polinucleotídeo isolado, célula hospedeira recombinante estavelmente transformada ou transfectada

Country Status (20)

Country Link
US (5) US20120093833A1 (pt)
EP (1) EP2627356B1 (pt)
JP (3) JP6216917B2 (pt)
KR (1) KR101920250B1 (pt)
CN (1) CN103261223B (pt)
AR (2) AR083418A1 (pt)
AU (1) AU2011313847B2 (pt)
BR (1) BR112013009083B1 (pt)
CA (1) CA2814652C (pt)
EA (1) EA031044B1 (pt)
IL (1) IL225573B (pt)
JO (1) JO3496B1 (pt)
MX (1) MX354095B (pt)
RU (1) RU2600444C2 (pt)
SG (2) SG10201600263QA (pt)
TW (1) TWI548749B (pt)
UA (1) UA118646C2 (pt)
UY (1) UY33670A (pt)
WO (1) WO2012051111A2 (pt)
ZA (1) ZA201303429B (pt)

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WO2016046738A1 (en) * 2014-09-24 2016-03-31 Università Degli Studi Di Padova Composition to induce bone marrow stem cell mobilization
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US10822406B2 (en) 2015-01-29 2020-11-03 Oxford University Innovation Limited Method for treating chronic intestinal inflammation and inflammatory bowel disease by administering antagonists of Oncostatin-M (OSM) and/or antagonists of OSM receptor-beta (OSMR)
WO2017106684A2 (en) * 2015-12-17 2017-06-22 Janssen Biotech, Inc. Antibodies specifically binding hla-dr and their uses
GB201614627D0 (en) * 2016-08-30 2016-10-12 Glaxosmithkline Ip Dev Ltd Antigen binding proteins
WO2019084307A1 (en) * 2017-10-26 2019-05-02 Celldex Therapeutics, Inc. ANTI-MERTK ANTIBODIES AND METHODS OF USE
FR3090637A1 (fr) * 2018-12-21 2020-06-26 Universite De Poitiers Protéine de liaison spécifique capable de se lier spécifiquement à l’oncostatine M humaine (hOSM) et ses utilisations.
CN109884320A (zh) * 2019-03-29 2019-06-14 重庆医科大学 抑瘤素m作为生物标志物在制备脓毒症诊断试剂中的应用
US11633457B2 (en) 2019-04-11 2023-04-25 Boise State University Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use
CN113678044A (zh) 2019-04-12 2021-11-19 住友电气工业株式会社 光纤带芯线、模具及光纤带芯线的制造方法

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