CY1123752T1 - Πρωτεϊνες δεσμευσης ιντερλευκινης-13 - Google Patents

Πρωτεϊνες δεσμευσης ιντερλευκινης-13

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Publication number
CY1123752T1
CY1123752T1 CY20201100972T CY201100972T CY1123752T1 CY 1123752 T1 CY1123752 T1 CY 1123752T1 CY 20201100972 T CY20201100972 T CY 20201100972T CY 201100972 T CY201100972 T CY 201100972T CY 1123752 T1 CY1123752 T1 CY 1123752T1
Authority
CY
Cyprus
Prior art keywords
hll
antibodies
activity
binding proteins
interleukin
Prior art date
Application number
CY20201100972T
Other languages
English (en)
Inventor
Richard W. Dixon
Jonathan P. Belk
Hua Ying
Maria A. Argiriadi
Carolyn A. Cuff
Paul R. Hinton
Shankar Kumar
Terry L. Melim
Yan Chen
Chengbin Wu
Original Assignee
Abbvie Bahamas Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bahamas Ltd. filed Critical Abbvie Bahamas Ltd.
Publication of CY1123752T1 publication Critical patent/CY1123752T1/el

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    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A01H1/02—Methods or apparatus for hybridisation; Artificial pollination ; Fertility
    • A—HUMAN NECESSITIES
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    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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Abstract

Η παρούσα εφεύρεση περιλαμβάνει πρωτεΐνες σύνδεσης IL-13. Συγκεκριμένα, η εφεύρεση αναφέρεται σε αντισώματα που είναι χιμαιρικά, εμβολιασμένα με CDR και εξανθρωπισμένα αντισώματα. Τα προτιμώμενα αντισώματα έχουν υψηλή συγγένεια με την hlL-13 και εξουδετερώνουν τη δραστικότητα της hlL-13 in vitro και in vivo. Ένα αντίσωμα της εφεύρεσης μπορεί να είναι ένα πλήρους μήκους αντίσωμα ή ένα τμήμα σύνδεσης αντιγόνου αυτού. Παρέχονται επίσης μέθοδος παρασκευής και μέθοδος χρήσης των αντισωμάτων της εφεύρεσης. Τα αντισώματα, ή τμήματα αντισωμάτων, της εφεύρεσης είναι χρήσιμα για την ανίχνευση της hlL-13 και για την αναστολή της δράσης της hlL-13, π.χ., σε ένα άτομο που πάσχει από μια διαταραχή στην οποία η δραστηριότητα της hlL-13 είναι επιβλαβής.
CY20201100972T 2006-09-08 2020-10-14 Πρωτεϊνες δεσμευσης ιντερλευκινης-13 CY1123752T1 (el)

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PCT/US2007/019660 WO2008127271A2 (en) 2006-09-08 2007-09-07 Interleukin -13 binding proteins
EP07873427.4A EP2064336B1 (en) 2006-09-08 2007-09-07 Interleukin -13 binding proteins

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