UA115964C2 - Інтерлейкін-13-зв'язувальний білок - Google Patents
Інтерлейкін-13-зв'язувальний білокInfo
- Publication number
- UA115964C2 UA115964C2 UAA201302560A UAA201302560A UA115964C2 UA 115964 C2 UA115964 C2 UA 115964C2 UA A201302560 A UAA201302560 A UA A201302560A UA A201302560 A UAA201302560 A UA A201302560A UA 115964 C2 UA115964 C2 UA 115964C2
- Authority
- UA
- Ukraine
- Prior art keywords
- interlaykin
- binding protein
- binding
- owner
- antigen
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000003816 Interleukin-13 Human genes 0.000 abstract 2
- 108090000176 Interleukin-13 Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 abstract 1
- 102100020791 Interleukin-13 receptor subunit alpha-1 Human genes 0.000 abstract 1
- 101710112663 Interleukin-13 receptor subunit alpha-1 Proteins 0.000 abstract 1
- 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 abstract 1
- 101710112634 Interleukin-13 receptor subunit alpha-2 Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 102000019207 human interleukin-13 Human genes 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
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Abstract
Винахід належить до рекомбінантного антитіла або його антигензв’язувального фрагмента, які зв’язують IL-13 людини, блокує зв’язування IL-13 з IL-13Rα1 і з IL-13Rα2, виділеної нуклеїнової кислоти, що кодує вказане антитіло, вектора, клітини-хазяїна, способу одержання, фармацевтичної композиції та способу лікування суб’єкта від розладу, при якому активність IL-13 є шкідливою.
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