JOP20210298A1 - طرق وتركيبات للوقاية من مرض السكري من النوع الأول - Google Patents

طرق وتركيبات للوقاية من مرض السكري من النوع الأول

Info

Publication number
JOP20210298A1
JOP20210298A1 JOP/2021/0298A JOP20210298A JOP20210298A1 JO P20210298 A1 JOP20210298 A1 JO P20210298A1 JO P20210298 A JOP20210298 A JO P20210298A JO P20210298 A1 JOP20210298 A1 JO P20210298A1
Authority
JO
Jordan
Prior art keywords
diabetes
compositions
methods
preventing type
diabetic subject
Prior art date
Application number
JOP/2021/0298A
Other languages
English (en)
Inventor
Jay S Skyler
Francisco Leon
Kevan C Herold
Original Assignee
Provention Bio Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Provention Bio Inc filed Critical Provention Bio Inc
Publication of JOP20210298A1 publication Critical patent/JOP20210298A1/ar

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

Abstract

غير متوفر
JOP/2021/0298A 2019-05-14 2020-05-14 طرق وتركيبات للوقاية من مرض السكري من النوع الأول JOP20210298A1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962847466P 2019-05-14 2019-05-14
PCT/US2020/032891 WO2020232247A1 (en) 2019-05-14 2020-05-14 Methods and compositions for preventing type 1 diabetes
US15/931,685 US11434291B2 (en) 2019-05-14 2020-05-14 Methods and compositions for preventing type 1 diabetes

Publications (1)

Publication Number Publication Date
JOP20210298A1 true JOP20210298A1 (ar) 2023-01-30

Family

ID=73289320

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2021/0298A JOP20210298A1 (ar) 2019-05-14 2020-05-14 طرق وتركيبات للوقاية من مرض السكري من النوع الأول

Country Status (7)

Country Link
US (2) US11434291B2 (ar)
JP (2) JP7137696B2 (ar)
KR (2) KR102503349B1 (ar)
BR (1) BR112021022682A2 (ar)
IL (1) IL288024A (ar)
JO (1) JOP20210298A1 (ar)
WO (1) WO2020232247A1 (ar)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102503349B1 (ko) * 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
KR20240023522A (ko) * 2021-05-24 2024-02-22 프로벤션 바이오, 인코포레이티드 감염 후 자가면역성 당뇨병을 치료하는 방법
WO2022251253A1 (en) * 2021-05-24 2022-12-01 Provention Bio, Inc. Methods for treating type 1 diabetes
CA3229864A1 (en) * 2021-09-13 2023-03-16 Provention Bio, Inc. Methods and compositions comprising anti-cd3 antibodies and dyrk1a inhibitors for treating diabetes

Family Cites Families (509)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6303121B1 (en) 1992-07-30 2001-10-16 Advanced Research And Technology Method of using human receptor protein 4-1BB
US6491916B1 (en) 1994-06-01 2002-12-10 Tolerance Therapeutics, Inc. Methods and materials for modulation of the immunosuppresive activity and toxicity of monoclonal antibodies
US20030108548A1 (en) 1993-06-01 2003-06-12 Bluestone Jeffrey A. Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7041289B1 (en) 1997-12-05 2006-05-09 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for treating established spontaneous auto-immune diseases in mammals
PA8474101A1 (es) 1998-06-19 2000-09-29 Pfizer Prod Inc Compuestos de pirrolo [2,3-d] pirimidina
US6723538B2 (en) 1999-03-11 2004-04-20 Micromet Ag Bispecific antibody and chemokine receptor constructs
RU2312860C2 (ru) 1999-04-15 2007-12-20 Бристол-Маерс Сквибб Компани Циклические ингибиторы протеинтирозинкиназ
US7125875B2 (en) 1999-04-15 2006-10-24 Bristol-Myers Squibb Company Cyclic protein tyrosine kinase inhibitors
US7527787B2 (en) 2005-10-19 2009-05-05 Ibc Pharmaceuticals, Inc. Multivalent immunoglobulin-based bioactive assemblies
US7534866B2 (en) 2005-10-19 2009-05-19 Ibc Pharmaceuticals, Inc. Methods and compositions for generating bioactive assemblies of increased complexity and uses
AUPQ431299A0 (en) 1999-11-26 1999-12-23 Unisearch Limited Method of inducing immune tolerance
DK1235830T3 (da) 1999-12-10 2004-03-29 Pfizer Prod Inc Pyrrolo[2,3-d]pyrimidin-forbindelser som proteinkinaseinhibitorer
US20020006403A1 (en) 1999-12-14 2002-01-17 Xue-Zhong Yu CD28-specific antibody compositions for use in methods of immunosuppression
DE10001372A1 (de) 2000-01-14 2001-08-02 Deutsches Krebsforsch Anti-CD3-Einzelketten-Antikörper mit humanem Cmu3- und Cmu4- Domänen
AU3108001A (en) 2000-01-20 2001-12-24 Coley Pharmaceutical Group, Inc. Immunostimulatory nucleic acids for inducing a th2 immune response
US7094874B2 (en) 2000-05-26 2006-08-22 Bristol-Myers Squibb Co. Soluble CTLA4 mutant molecules
US7395158B2 (en) 2000-05-30 2008-07-01 Sensys Medical, Inc. Method of screening for disorders of glucose metabolism
ES2586206T3 (es) 2000-06-19 2016-10-13 Beth Israel Deaconess Medical Center Composiciones y métodos de anticuerpos monoclonales y policlonales específicos para subpoblaciones de linfocitos T
EE200200711A (et) 2000-06-26 2004-06-15 Pfizer Products Inc. Pürrolo[2,3-d]pürimidiinühendid kui immunosupressiivsed vahendid
WO2002016414A2 (en) 2000-08-22 2002-02-28 Micromet Ag Composition for the elimination of autoreactive b-cells
KR20080014934A (ko) 2000-11-07 2008-02-14 노파르티스 아게 단백질 키나제 c 억제제로서의 인돌릴말레이미드 유도체
AU2002305716B2 (en) 2001-05-23 2007-10-25 Bristol-Myers Squibb Company Methods for protecting allogeneic islet transplant using soluble CTLA4 mutant molecules
CN1195779C (zh) 2001-05-24 2005-04-06 中国科学院遗传与发育生物学研究所 抗人卵巢癌抗人cd3双特异性抗体
US7595378B2 (en) 2001-06-13 2009-09-29 Genmab A/S Human monoclonal antibodies to epidermal growth factor receptor (EGFR)
GT200200234A (es) 2001-12-06 2003-06-27 Compuestos cristalinos novedosos
AU2003208839A1 (en) 2002-02-13 2003-09-04 Micromet Ag De-immunized (poly)peptide constructs
US20030216551A1 (en) 2002-03-08 2003-11-20 Diabetogen Biosciences Inc. Fully human anti-CD3 monoclonal antibodies
KR100517056B1 (ko) 2002-04-15 2005-09-27 재단법인 목암생명공학연구소 하이드록실 페닐 유도체, 그의 제조방법 및 그를 포함하는약학적 조성물
DE60329724D1 (de) 2002-06-07 2009-11-26 Waratah Pharmaceuticals Inc Methoden und Kompositionen um Diabetes zu behandeln
EP1837031B1 (en) 2002-06-07 2009-10-14 Waratah Pharmaceuticals, Inc. Compositions and methods for treating diabetes
WO2003105897A1 (en) 2002-06-14 2003-12-24 Novo Nordisk A/S Combined use of a modulator of cd3 and a glp-1 compound
US20040037826A1 (en) 2002-06-14 2004-02-26 Michelsen Birgitte Koch Combined use of a modulator of CD3 and a GLP-1 compound
US20030235583A1 (en) 2002-06-14 2003-12-25 Jeppe Sturis Combined use of a modulator of CD3 and a beta cell resting compound
ES2559763T3 (es) 2002-09-10 2016-02-15 Affimed Gmbh Anticuerpo humano específico de CD3 con propiedades inmunosupresoras
US7820166B2 (en) 2002-10-11 2010-10-26 Micromet Ag Potent T cell modulating molecules
AU2003283004A1 (en) 2002-10-22 2004-05-13 Waratah Pharmaceuticals, Inc. Treatment of diabetes
AU2003295471B2 (en) 2002-11-15 2011-08-25 Genmab A/S Human monoclonal antibodies against CD25
ES2729974T3 (es) 2003-01-23 2019-11-07 Ono Pharmaceutical Co Anticuerpo específico de PD-1 y CD3 humanas
US20060235201A1 (en) 2003-02-06 2006-10-19 Roman Kischel Enduring T cell response
US7196093B2 (en) 2003-04-09 2007-03-27 General Atomics Reversible inhibitors of SAH hydrolase and uses thereof
US20050043233A1 (en) 2003-04-29 2005-02-24 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation, migration or apoptosis of myeloma cells or angiogenesis
US7635472B2 (en) 2003-05-31 2009-12-22 Micromet Ag Pharmaceutical compositions comprising bispecific anti-cd3, anti-cd19 antibody constructs for the treatment of b-cell related disorders
NZ543202A (en) 2003-05-31 2008-04-30 Micromet Ag Pharmaceutical composition comprising a bispecific antibody for epcam
CN1822857A (zh) 2003-06-02 2006-08-23 阿莱克申药物公司 去免疫原性抗cd3抗体
EP1644370A4 (en) 2003-07-11 2008-06-04 Bristol Myers Squibb Co TETRAHYDROCHINOLINE DERIVATIVES AS CANNABINOID RECEPTOR MODULATORS
US7902338B2 (en) 2003-07-31 2011-03-08 Immunomedics, Inc. Anti-CD19 antibodies
US7326706B2 (en) 2003-08-15 2008-02-05 Bristol-Myers Squibb Company Pyrazine modulators of cannabinoid receptors
WO2005037199A2 (en) 2003-10-10 2005-04-28 Bristol-Myers Squibb Company Pyrazole derivatives as cannabinoid receptor modulators
US20050176028A1 (en) 2003-10-16 2005-08-11 Robert Hofmeister Deimmunized binding molecules to CD3
KR101229731B1 (ko) 2003-10-16 2013-03-07 암젠 리서치 (뮌헨) 게엠베하 다중특이적 탈면역화된 cd3-바인더
US20070053954A1 (en) 2003-10-24 2007-03-08 Rowe Stephen C Macromer-melt formulations
WO2005040163A1 (en) 2003-10-28 2005-05-06 Dr. Reddy's Laboratories Ltd Heterocyclic compounds that block the effects of advanced glycation end products (age)
EP1687066B1 (en) 2003-11-14 2012-08-29 Brigham and Women's Hospital, Inc. Methods of modulating immunity
US20050147581A1 (en) 2003-11-19 2005-07-07 The Board Of Trustees Of The University Of Illinois Macromolecular drug complexes having improved stability and therapeutic use of the same
DK1691833T3 (da) 2003-11-28 2010-05-03 Micromet Ag Præparater der omfatter polypeptider
BRPI0417820A (pt) 2003-12-19 2007-03-27 Bristol Myers Squibb Co heterociclos azabicìclicos como moduladores de receptor canabinóide
RU2006126122A (ru) 2003-12-19 2008-01-27 Бристол-Маерс Сквибб Компани (Us) Азабициклические гетероциклы как модуляторы каннабиоидного рецептора
US7235641B2 (en) 2003-12-22 2007-06-26 Micromet Ag Bispecific antibodies
AU2005213449A1 (en) 2004-02-04 2005-08-25 The La Jolla Institute For Allergy And Immunology Anti-CD3 and antigen-specific immunotherapy to treat autoimmunity
SI1716178T1 (sl) 2004-02-16 2010-11-30 Micromet Ag Manj imunogene vezne molekule
WO2005079840A2 (en) 2004-02-20 2005-09-01 Develogen Aktiengesellschaft Use of secreted protein products for preventing and treating pancreatic diseases and/or obesity and/or metabolic syndrome
US20050250691A1 (en) 2004-05-10 2005-11-10 Diamyd Therapeutics Ab Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
EP1755631A2 (en) 2004-03-03 2007-02-28 Diamyd Medical AB Immunomodulation by a therapeutic medication intended for treatment of diabetes and prevention of autoimmune diabetes
JP5848861B2 (ja) 2004-04-20 2016-01-27 ジェンマブ エー/エスGenmab A/S Cd20に対するヒトモノクローナル抗体
US20060194725A1 (en) 2004-05-07 2006-08-31 James Rasmussen Methods of treating disease with random copolymers
US7592313B2 (en) 2004-05-17 2009-09-22 Board Of Trustees Of The University Of Illinois Method of stimulating proliferation of regulatory T cells in a diabetic mammal
US7728114B2 (en) 2004-06-03 2010-06-01 Novimmune S.A. Anti-CD3 antibodies and methods of use thereof
WO2006002532A1 (en) 2004-07-01 2006-01-12 Waratah Pharmaceuticals, Inc. Methods and compositions using cd3 agonists
US20060058311A1 (en) 2004-08-14 2006-03-16 Boehringer Ingelheim International Gmbh Combinations for the treatment of diseases involving cell proliferation
MX2007002188A (es) 2004-08-30 2007-10-16 Schering Ag Tratamiento de infecciones por vih mediante modulacion de celulas t.
EP1799840A4 (en) 2004-09-03 2009-02-18 Univ Columbia ILT3-POLYPEPTIDES AND USES THEREOF
US20070264229A1 (en) 2004-09-13 2007-11-15 Strominger Jack L Peptides for Treatment of Autoimmune Disease
US7563443B2 (en) 2004-09-17 2009-07-21 Domantis Limited Monovalent anti-CD40L antibody polypeptides and compositions thereof
EP1815865A4 (en) 2004-11-08 2010-08-25 Ono Pharmaceutical Co THERAPEUTIC AGENT AGAINST DIABETES WITH A PROTEASE-INHIBITING COMPOUND
CA2589374C (en) 2004-11-30 2016-05-03 Curagen Corporation Antibodies directed to gpnmb and uses thereof
CA2596332A1 (en) 2005-02-04 2006-08-10 Dow Agrosciences, Llc Anti-t cell and autoantigen treatment of autoimmune disease
JP2008531730A (ja) 2005-03-04 2008-08-14 キュアーディーエム、インク. I型真性糖尿病及び他の症状を治療するための方法及び薬学的組成物
US20090142338A1 (en) 2005-03-04 2009-06-04 Curedm, Inc. Methods and Compositions for Treating Type 1 and Type 2 Diabetes Mellitus and Related Conditions
US20130039861A1 (en) 2005-04-06 2013-02-14 Immunomedics, Inc. Dye Conjugated Peptides for Fluorescent Imaging
KR101235484B1 (ko) 2005-04-06 2013-02-22 브리스톨-마이어스 스큅 컴퍼니 가용성 ctla4 돌연변이체 분자를 이용하여 이식편이식과 연관된 면역 장애를 치료하는 방법
US7968535B2 (en) 2005-05-04 2011-06-28 Develogen Atkiengesellschaft Use of azapaullones for preventing and treating pancreatic autoimmune disorders
US20080207594A1 (en) 2005-05-04 2008-08-28 Davelogen Aktiengesellschaft Use of Gsk-3 Inhibitors for Preventing and Treating Pancreatic Autoimmune Disorders
US7393919B2 (en) 2005-05-25 2008-07-01 Cure Dm, Inc. Peptides, derivatives and analogs thereof, and methods of using same
EP2497496A3 (en) 2005-07-11 2013-02-20 Macrogenics, Inc. Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity
US7612181B2 (en) 2005-08-19 2009-11-03 Abbott Laboratories Dual variable domain immunoglobulin and uses thereof
WO2007033230A2 (en) 2005-09-12 2007-03-22 Novimmune S.A. Anti-cd3 antibody formulations
US20070190052A1 (en) 2005-09-14 2007-08-16 The Trustees Of Columbia University In The City Of New York Regulatory CD8cells induced with anti-CD3 antibody
WO2007038687A2 (en) 2005-09-27 2007-04-05 Aciont, Inc. Ocular administration of immunosuppressive agents
CA2631598C (en) 2005-11-29 2017-06-27 Actogenix Nv Induction of mucosal tolerance to antigens
US8466263B2 (en) 2005-12-02 2013-06-18 Dana-Farber Cancer Institute, Inc. Carbonic anhydrase IX (G250) anitbodies
MX2008007287A (es) 2005-12-08 2008-10-27 Univ Louisville Res Found Metodos y composiciones para expandir celulas reguladoras t.
US20070264687A1 (en) 2005-12-15 2007-11-15 Min-Yuan Chou Recombinant triplex scaffold-based polypeptides
DK1976886T3 (en) 2005-12-16 2015-03-02 Amgen Res Munich Gmbh Means and methods for the treatment of tumor diseases
EP1981532A4 (en) 2005-12-21 2010-06-30 Medimmune Llc EPHA2 MOLECULES AND USES THEREOF
DK1976880T3 (en) 2005-12-21 2016-09-26 Amgen Res (Munich) Gmbh Pharmaceutical compositions with resistance to soluble cea
WO2007084775A2 (en) 2006-01-20 2007-07-26 The Trustees Of The University Of Pennsylvania Compositions and methods for modulation of suppressor t cell activation
GB0605702D0 (en) 2006-03-21 2006-05-03 Biotransformations Ltd Materials and methods for immune cell stimulation
TWI398252B (zh) 2006-05-26 2013-06-11 Novartis Ag 吡咯并嘧啶化合物及其用途
WO2007145941A2 (en) 2006-06-06 2007-12-21 Tolerrx, Inc. Administration of anti-cd3 antibodies in the treatment of autoimmune diseases
SG177907A1 (en) * 2006-06-14 2012-02-28 Macrogenics Inc Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity
EP1880729A1 (en) 2006-07-20 2008-01-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of soluble CD160 to suppress immunity
US20080026378A1 (en) 2006-07-28 2008-01-31 Gian Franco Bottazzo Prediction and prophylactic treatment of type 1 diabetes
ES2902063T3 (es) 2006-09-08 2022-03-24 Abbvie Bahamas Ltd Proteínas de unión a interleucina-13
EP2066174B1 (en) 2006-09-12 2017-11-08 Beth Israel Deaconess Medical Center, Inc. Compositions containing alpha-1-antitrypsin and methods for use
CN101164538B (zh) 2006-10-16 2011-12-14 中国医学科学院基础医学研究所 羧胺三唑类化合物及其盐在制备治疗疼痛性疾病和/或炎症性疾病的药物中的应用
WO2008064306A2 (en) 2006-11-22 2008-05-29 Curedm, Inc. Methods and compositions relating to islet cell neogenesis
EP2815750A1 (en) 2006-12-21 2014-12-24 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
US20100015142A1 (en) 2006-12-21 2010-01-21 Macrogenics Inc. Methods for the treatment of lada and other adult- onset autoimmune using immunosuppressive monoclonal antibodies with reduced toxicity
US8398956B2 (en) 2007-01-11 2013-03-19 Immunomedics, Inc. In vivo copper-free click chemistry for delivery of therapeutic and/or diagnostic agents
EP2125895B1 (en) 2007-02-02 2015-04-08 Vegenics Pty Ltd Vegf receptor antagonists for treating organ transplant alloimmunity and arteriosclerosis
US20100129361A1 (en) 2007-05-01 2010-05-27 The Brigham And Women's Hospital Immunosuppression with antibody against itm2a
WO2008138017A2 (en) 2007-05-08 2008-11-13 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for modifying t cell immune responses and inflammation
US20110300142A1 (en) 2007-05-25 2011-12-08 Salford Leif G Use of zeburaline for the treatment of autoimmune diseases or immune rejection of transplants
WO2009023566A2 (en) 2007-08-09 2009-02-19 Genzyme Corporation Method of treating autoimmune disease with mesenchymal stem cells
NZ599756A (en) 2007-08-30 2013-09-27 Curedm Group Holdings Llc Compositions and methods of using proislet peptides and analogs thereof
JP5490714B2 (ja) 2007-11-28 2014-05-14 メディミューン,エルエルシー タンパク質製剤
CA2707483A1 (en) 2007-11-30 2009-06-11 Wolfgang Fraunhofer Protein formulations and methods of making same
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
US9309313B2 (en) 2008-01-09 2016-04-12 The Schepens Eye Research Institute, Inc. Therapeutic compositions for treatment of ocular inflammatory disorders
PL2993186T3 (pl) 2008-03-14 2020-02-28 Biocon Limited Przeciwciało monoklonalne i sposób jego otrzymywania
WO2009132058A2 (en) 2008-04-25 2009-10-29 Zymogenetics, Inc. Levels of bcma protein expression on b cells and use in diagnostic methods
SG190572A1 (en) 2008-04-29 2013-06-28 Abbott Lab Dual variable domain immunoglobulins and uses thereof
US20100260668A1 (en) 2008-04-29 2010-10-14 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
DE102008023820A1 (de) 2008-05-08 2009-11-12 Aicuris Gmbh & Co. Kg Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen
SG172754A1 (en) 2008-10-10 2011-08-29 Trubion Pharmaceuticals Inc Tcr complex immunotherapeutics
PT3330293T (pt) 2008-11-07 2019-10-18 Amgen Res Munich Gmbh Tratamento da leucemia linfoblástica aguda pediátrica com anticorpos biespecíficos contra cd3xcd19
KR101695327B1 (ko) 2008-11-07 2017-01-11 암젠 리서치 (뮌헨) 게엠베하 급성 림프구성 백혈병의 치료방법
US9452227B2 (en) 2008-11-25 2016-09-27 Alderbio Holdings Llc Methods of treating or diagnosing conditions associated with elevated IL-6 using anti-IL-6 antibodies or fragments
US8323649B2 (en) 2008-11-25 2012-12-04 Alderbio Holdings Llc Antibodies to IL-6 and use thereof
WO2010065491A2 (en) 2008-12-01 2010-06-10 Carolus Therapeutics, Inc. Methods of treating inflammatory disorders
WO2010088522A2 (en) 2009-01-30 2010-08-05 Ab Biosciences, Inc. Novel lowered affinity antibodies and uses therefor
WO2010106542A2 (en) 2009-03-19 2010-09-23 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. USE OF NKp46 FOR PREVENTING DIABETES
RU2011148913A (ru) 2009-05-01 2013-06-10 Эбботт Лэборетриз Иммуноглобулин с двумя вариабельными доменами и его применение
WO2011011706A2 (en) 2009-07-24 2011-01-27 The Johns Hopkins University Methods and compositions for treating or preventing autoimmune diseases using immunomodulatory agents
KR20120060877A (ko) 2009-09-01 2012-06-12 아보트 러보러터리즈 이원 가변 도메인 면역글로불린 및 이의 용도
US8398966B2 (en) 2009-10-15 2013-03-19 Abbvie Inc. IL-1 binding proteins
EP2490719A4 (en) 2009-10-20 2013-11-06 Glaxo Group Ltd METHOD FOR THE USE OF ANTIBODIES TO CD3 FOR PREVENTING WEIGHT INCREASE
JP2013508392A (ja) 2009-10-20 2013-03-07 グラクソ グループ リミテッド 自己免疫疾患における抗cd3抗体の投薬
CN107227335A (zh) 2009-10-27 2017-10-03 安进研发(慕尼黑)股份有限公司 用于施用CD19xCD3双特异性抗体的给药方案
US20110165161A1 (en) 2009-12-23 2011-07-07 Shih-Yao Lin Anti-epcam antibodies that induce apoptosis of cancer cells and methods using same
SI2519543T1 (sl) 2009-12-29 2016-08-31 Emergent Product Development Seattle, Llc Beljakovine, ki se vežejo s heterodimeri in njihova uporaba
US20130129723A1 (en) 2009-12-29 2013-05-23 Emergent Product Development Seattle, Llc Heterodimer Binding Proteins and Uses Thereof
WO2011120135A1 (en) 2010-03-29 2011-10-06 Zymeworks, Inc. Antibodies with enhanced or suppressed effector function
US8557961B2 (en) 2010-04-02 2013-10-15 Amunix Operating Inc. Alpha 1-antitrypsin compositions and methods of making and using same
JP2013523153A (ja) 2010-04-07 2013-06-17 アッヴィ・インコーポレイテッド TNF−α結合タンパク質
US20130115207A1 (en) 2010-04-09 2013-05-09 The General Hospital Corporation Methods for the treatment of autoimmune diseases
AU2011246893A1 (en) 2010-04-29 2012-11-08 Hadasit Medical Research Service And Development Co. Ltd. Methods and compositions for treating hepatitis with anti-CD3 immune molecule therapy
SI2571532T1 (sl) 2010-05-14 2017-10-30 Abbvie Inc. Proteini, ki vežejo IL-1
WO2011156740A2 (en) 2010-06-10 2011-12-15 Myra Lipes Diagnosis of myocardial autoimmunity in heart disease
NZ603581A (en) 2010-06-19 2015-05-29 Sloan Kettering Inst Cancer Anti-gd2 antibodies
WO2011163566A2 (en) 2010-06-25 2011-12-29 Tolerx, Inc. Methods of treating patients with immune-related diseases
UY33492A (es) 2010-07-09 2012-01-31 Abbott Lab Inmunoglobulinas con dominio variable dual y usos de las mismas
KR102173938B1 (ko) 2010-08-18 2020-11-04 테레사 데이셔 림프양 조직에 줄기 세포와 조상 세포 결합을 저해하고, 그리고 림프 조직에서 배 중심을 재생하기 위한 조성물과 방법
US20120088678A1 (en) 2010-09-08 2012-04-12 Sanford-Burnham Medical Research Institute Method for prediction of response to rheumatoid arthritis therapeutics
US20130225427A1 (en) 2010-09-08 2013-08-29 Sanford-Burnham Medical Research Institute Method for prediction of response to immune mediated disease therapeutics
CN107050456B (zh) 2010-09-28 2022-08-12 加利福尼亚大学董事会 治疗代谢综合征相关疾病的gaba激动剂和治疗或预防i型糖尿病的gaba组合
DK2632954T4 (da) 2010-10-27 2021-08-09 Amgen Res Munich Gmbh Midler og fremgangsmåder til behandling af dlbcl
US20120263722A1 (en) 2010-11-04 2012-10-18 Abbott Laboratories Dual Variable Domain Immunoglobulins and Uses Thereof
CN103533943B (zh) 2010-11-10 2018-02-13 安进研发(慕尼黑)股份有限公司 由cd3特异性结合结构域导致的不良作用的预防
AR083847A1 (es) 2010-11-15 2013-03-27 Novartis Ag Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40
AR084210A1 (es) 2010-12-08 2013-05-02 Abbott Lab PROTEINAS DE UNION AL TNF-a
UY33827A (es) 2010-12-22 2012-07-31 Abbott Lab Proteínas de unión a media-inmunoglobulina y sus usos
UY33826A (es) 2010-12-22 2012-07-31 Abbott Lab Proteínas de unión con dominios trivariables y sus usos
CN103596591B (zh) 2011-02-08 2016-08-24 Abbvie公司 骨关节炎和疼痛的治疗
WO2012118863A1 (en) 2011-02-28 2012-09-07 The Schepens Eye Research Institute, Inc. Therapies that target autoimmunity for treating glaucoma and optic neuropathy
PT2683406T (pt) 2011-03-11 2019-07-08 Beth Israel Deaconess Medical Ct Inc Anticorpos anti-cd40 e utilização dos mesmos
EP2691515A2 (en) 2011-03-31 2014-02-05 President and Fellows of Harvard College A unique population of regulatory t cells that regulate tissue regeneration and wound healing
US10239952B2 (en) 2011-04-01 2019-03-26 Memorial Sloan Kettering Cancer Center Anti-WT1/HLA bi-specific antibody
EP3753572A1 (en) 2011-04-28 2020-12-23 Amgen Research (Munich) GmbH Dosage regimen for administering a cd19xcd3 bispecific antibody to patients at risk for potential adverse effects
SG195072A1 (en) 2011-05-21 2013-12-30 Macrogenics Inc Cd3-binding molecules capable of binding to human and non-human cd3
WO2012173819A2 (en) 2011-06-14 2012-12-20 Mayo Foundation For Medical Education And Research Anti-cd3 therapies
WO2012178160A2 (en) 2011-06-23 2012-12-27 University Of Florida Research Foundation, Inc. Materials and methods for modulating immune responses
WO2013012414A1 (en) 2011-07-18 2013-01-24 Medimmune, Llc Dosing regimens for treatment of cea-expressing cancers
CN102898527B (zh) 2011-07-25 2016-12-21 三星电子株式会社 融合蛋白、药物组合物及预防或治疗癌症的方法
ES2893855T3 (es) 2011-08-11 2022-02-10 Ono Pharmaceutical Co Agente terapéutico para enfermedades autoinmunes que comprende agonista de PD-1
US8932586B2 (en) 2011-09-06 2015-01-13 Intrexon Corporation Modified forms of Pseudomonas exotoxin A
UY34317A (es) 2011-09-12 2013-02-28 Genzyme Corp Anticuerpo antireceptor de célula T (alfa)/ß
CN103906514A (zh) 2011-09-13 2014-07-02 拜奥迈德瓦利探索有限公司 用于治疗代谢障碍的组合物和方法
CN104023721A (zh) 2011-09-21 2014-09-03 干细胞医药有限公司 用于治疗糖尿病的β-内酰胺化合物
JP2014530009A (ja) 2011-09-29 2014-11-17 エーピーオー‐ティー ビー.ヴイ. 異常細胞を標的とする多重特異性結合分子
EP2764362B1 (en) 2011-10-03 2018-09-05 Immunomedics, Inc. Dye conjugated peptides for fluorescent imaging
WO2013063702A1 (en) 2011-11-04 2013-05-10 Zymeworks Inc. Stable heterodimeric antibody design with mutations in the fc domain
US20140212425A1 (en) 2011-12-05 2014-07-31 Immunomedics, Inc. Therapeutic use of anti-cd22 antibodies for inducing trogocytosis
EP2793923B1 (en) 2011-12-22 2018-05-16 Medizinische Universität Wien Cyclotides as immunosuppressive agents
US20150017140A1 (en) 2011-12-23 2015-01-15 Anthrogenesis Corporation Organoids comprising decellularized and repopulated placental vascular scaffold
KR20200040893A (ko) 2012-01-13 2020-04-20 율리우스-막시밀리안스 우니버지태트 뷔르츠부르크 이중 항원-유도된 이분 기능 상보성
WO2013120497A1 (en) 2012-02-15 2013-08-22 Curevac Gmbh Nucleic acid comprising or coding for a histone stem-loop and a poly(a) sequence or a polyadenylation signal for increasing the expression of an encoded therapeutic protein
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
CN103382223B (zh) 2012-04-01 2015-06-10 上海益杰生物技术有限公司 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽
CN103372214B (zh) 2012-04-13 2017-09-29 北京艾棣维欣生物技术有限公司 治疗和/或预防ⅰ型糖尿病的药物组合物及其应用
JP6348484B2 (ja) 2012-04-18 2018-06-27 ノグラ ファーマ リミテッド 糖尿病を処置する方法および/または移植後の膵島の生存を促進する方法
ES2672974T3 (es) 2012-06-01 2018-06-19 Ibc Pharmaceuticals, Inc. Complejos multiméricos con estabilidad in vivo, farmacocinética y eficacia mejoradas
CA2915412A1 (en) 2012-06-14 2013-12-19 Therapix Biosciences Ltd. Humanized antibodies to cluster of differentiation 3 (cd3)
EP2895203A4 (en) 2012-06-15 2016-09-28 Imaginab Inc ANTIGEN BINDING CONSTRUCTIONS FOR CD3
KR20150033703A (ko) * 2012-06-27 2015-04-01 오르반 바이오테크 엘엘씨 당뇨병 치료를 위한 ctla4 융합 단백질
US20150231241A1 (en) 2012-08-14 2015-08-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
US9382329B2 (en) 2012-08-14 2016-07-05 Ibc Pharmaceuticals, Inc. Disease therapy by inducing immune response to Trop-2 expressing cells
US9315567B2 (en) 2012-08-14 2016-04-19 Ibc Pharmaceuticals, Inc. T-cell redirecting bispecific antibodies for treatment of disease
US9682143B2 (en) 2012-08-14 2017-06-20 Ibc Pharmaceuticals, Inc. Combination therapy for inducing immune response to disease
JOP20200236A1 (ar) 2012-09-21 2017-06-16 Regeneron Pharma الأجسام المضادة لمضاد cd3 وجزيئات ربط الأنتيجين ثنائية التحديد التي تربط cd3 وcd20 واستخداماتها
US8808689B1 (en) 2012-09-27 2014-08-19 Perle Bioscience, Inc. Insulin independence among patients with diabetes utilizing a PPI in combination with an immune tolerance agent
US9511110B2 (en) 2012-09-27 2016-12-06 Perle Bioscience, Inc. Generation of new pancreatic beta cells
WO2014075788A1 (en) 2012-11-13 2014-05-22 Biontech Ag Agents for treatment of claudin expressing cancer diseases
US9562110B2 (en) 2012-11-21 2017-02-07 Wuhan Yzy Biopharma Co., Ltd. Bispecific antibody
WO2014085154A1 (en) 2012-11-27 2014-06-05 Beth Israel Deaconess Medical Center, Inc. Methods for treating renal disease
US10329350B2 (en) 2012-12-26 2019-06-25 Industrial Technology Research Institute Method for producing a multivalent fab fragment with collagen-like peptide
JP6605957B2 (ja) 2013-01-04 2019-11-13 シトムクス セラピューティクス,インコーポレイティド 生体系におけるプロテアーゼ活性を検出するための組成物及び方法
EP2948475A2 (en) 2013-01-23 2015-12-02 AbbVie Inc. Methods and compositions for modulating an immune response
JO3529B1 (ar) 2013-02-08 2020-07-05 Amgen Res Munich Gmbh مضاد التصاق خلايا الدم البيض من أجل التخفيف من الاثار السلبية الممكنة الناتجة عن مجالات ارتباط cd3- المحدد
US20140234405A1 (en) 2013-02-15 2014-08-21 Claresa Levetan Insulin independence among patients with diabetes utilizing a ppi in combination with an immune tolerance agent
US20140235552A1 (en) 2013-02-15 2014-08-21 Claresa Levetan Insulin independence among patients with diabetes utilizing a ppi in combination with an immune tolerance agent
WO2014152795A2 (en) 2013-03-14 2014-09-25 Schentag Jerome J Cholestosome vesicles for incorporation of molecules into chylomicrons
US9732150B2 (en) 2013-03-14 2017-08-15 Alderbio Holdings Llc Therapeutic use of antibodies to HGF
AR095596A1 (es) 2013-03-15 2015-10-28 Amgen Res (Munich) Gmbh Moléculas de unión de cadena única comprendiendo n-terminal abp
JP6480907B2 (ja) 2013-03-15 2019-03-13 メモリアル スローン ケタリング キャンサー センター 多量体化技術
BR112015023267B1 (pt) 2013-03-15 2023-01-31 Epigen Biosciences, Inc Composto, e medicamento para tratar um indivíduo com doença ou condição lisofosfatídica dependente de ácido
KR102207859B1 (ko) 2013-03-15 2021-01-27 메모리얼 슬로안 케터링 캔서 센터 고 친화도 항-gd2 항체
GB201305714D0 (en) 2013-03-28 2013-05-15 Ucl Business Plc Method
CA2812016A1 (en) * 2013-04-05 2014-10-05 Boehringer Ingelheim International Gmbh Pharmaceutical composition, methods for treating and uses thereof
CA3205855A1 (en) 2013-04-16 2014-10-23 Orbsen Therapeutics Limited Medical use of syndecan-2
PL3030232T3 (pl) 2013-04-29 2022-11-07 Medregen, Llc Gojenie ran poprzez autologiczną mobilizację komórek macierzystych
WO2015172800A1 (en) 2014-05-12 2015-11-19 Numab Ag Novel multispecific molecules and novel treatment methods based on such multispecific molecules
SG11201509361TA (en) 2013-05-28 2015-12-30 Numab Ag Novel antibodies
ES2687094T3 (es) 2013-07-23 2018-10-23 Novaliq Gmbh Composiciones estabilizadas de anticuerpos
HRP20220553T1 (hr) 2013-07-25 2022-06-10 Cytomx Therapeutics Inc. Polispecifična protutijela, polispecifična protutijela koja se mogu aktivirati i postupci uporabe navedenih protutijela
CN104342453A (zh) 2013-08-06 2015-02-11 深圳先进技术研究院 含基因工程抗体基因表达盒的微环dna重组母质粒、含该表达盒的微环dna及应用
JP6623353B2 (ja) 2013-09-13 2019-12-25 ベイジーン スウィッツァーランド ゲーエムベーハー 抗pd−1抗体並びにその治療及び診断のための使用
ES2773306T3 (es) 2013-09-16 2020-07-10 Helmholtz Zentrum Muenchen Deutsches Forschungszentrum Gesundheit & Umwelt Gmbh Polipéptidos bi o multiespecíficos de unión a antígenos de superficie de células efectoras inmunitarias y antígenos de VHB para tratar infecciones por VHB y estados asociados
GB201317928D0 (en) 2013-10-10 2013-11-27 Ucl Business Plc Molecule
PE20160724A1 (es) 2013-11-04 2016-08-04 Glenmark Pharmaceuticals Sa Produccion de inmunoglobulinas heterodimericas de redireccionamiento de celulas t
EP3068891A1 (en) 2013-11-13 2016-09-21 Aequus Biopharma Inc. Engineered glycoproteins and uses thereof
WO2015073833A1 (en) 2013-11-15 2015-05-21 Pharmacyclics, Inc. Methods for delaying or preventing the onset of type 1 diabetes
US20160287622A1 (en) 2013-11-18 2016-10-06 Massachusetts Institute Of Technology Compositions and methods for treating immune and viral disorders and modulating protein-rna interaction
EP2878308B1 (en) 2013-12-02 2018-10-31 Thomas Harder Agents and methods for the suppression of T cell activation
SI3318565T1 (sl) 2013-12-05 2021-07-30 Pfizer Inc. Pirolo(2,3-D)pirimidinil, pirolo(2,3-B)pirazinil in pirolo(2,3-D)piridinil akrilamidi
DK3083689T3 (da) 2013-12-17 2020-08-03 Genentech Inc Anti-CD3-antistoffer og fremgangsmåder til anvendelse
CN106103476B (zh) 2013-12-24 2020-11-27 阿尔金克斯有限公司 FcRn拮抗剂及使用方法
JP6706578B2 (ja) 2013-12-30 2020-06-10 エピムアブ バイオセラピューティクス インコーポレイテッド タンデム型Fab免疫グロブリン及びその使用
WO2015103319A1 (en) 2013-12-31 2015-07-09 Heron Therapeutics, Inc. Polymer-based compositions for extended release of proteins
WO2015112534A2 (en) 2014-01-21 2015-07-30 Medimmune, Llc Compositions and methods for modulating and redirecting immune responses
DK3105252T3 (da) 2014-02-12 2019-10-14 Michael Uhlin Bispecifikke antistoffer til anvendelse ved stamcelletransplantation
US9321812B2 (en) 2014-03-28 2016-04-26 Perle Bioscience Insulin independence among patients with diabetes utilizing an optimized hamster REG3 gamma peptide
CN106459971B (zh) 2014-04-08 2019-08-16 弗劳恩霍夫应用研究促进协会 用于治疗自身免疫性疾病的联合疗法
KR101628872B1 (ko) 2014-05-28 2016-06-09 주식회사 레고켐 바이오사이언스 자가-희생 기를 포함하는 화합물
CN113549153A (zh) 2014-05-29 2021-10-26 宏观基因有限公司 三特异性结合分子和其使用方法
EP2955196A1 (en) 2014-06-10 2015-12-16 Effimune Antibodies directed against CD127
US20170218091A1 (en) 2014-07-03 2017-08-03 Abbvie Inc. Monovalent binding proteins
US9777073B2 (en) 2014-07-21 2017-10-03 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody EpCAM×CD3
US9611325B2 (en) 2014-07-21 2017-04-04 Wuhan Yzy Biopharma Co., Ltd. Construction and application of bispecific antibody HER2xCD3
CN106999556B (zh) 2014-07-21 2021-07-30 武汉友芝友生物制药有限公司 细胞因子诱导的杀伤细胞的双特异性抗体介导的癌症治疗
GB201413240D0 (en) 2014-07-25 2014-09-10 Hansa Medical Ab Method
CN107124884B (zh) 2014-07-25 2022-11-01 纪念斯隆-凯特林癌症中心 双特异性her2和cd3结合分子
US11820832B2 (en) 2014-07-25 2023-11-21 Memorial Sloan Kettering Cancer Center Bispecific HER2 and CD3 binding molecules
JP6431721B2 (ja) * 2014-08-13 2018-11-28 学校法人大阪医科薬科大学 劇症1型糖尿病の検出方法及びバイオマーカー並びにキット
WO2016027253A1 (en) 2014-08-21 2016-02-25 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides as rip1 kinase inhibitors as medicaments
AU2015306621B2 (en) 2014-08-27 2021-05-06 Memorial Sloan Kettering Cancer Center Antibodies, compositions, and uses
US11029317B2 (en) 2014-09-18 2021-06-08 The Johns Hopkins University Compositions and methods for detecting anti-endothelial cell antibodies in allograft rejection
WO2016044252A2 (en) 2014-09-19 2016-03-24 Siwa Corporation Anti-age antibodies for treating inflammation and auto-immune disorders
US10272050B2 (en) 2014-10-14 2019-04-30 The Brigham And Women's Hospital, Inc. Nanoparticles and methods of use
WO2016065306A1 (en) 2014-10-23 2016-04-28 The Brigham And Women's Hospital, Inc. Amphiphile-polymer particles
US11773166B2 (en) 2014-11-04 2023-10-03 Ichnos Sciences SA CD3/CD38 T cell retargeting hetero-dimeric immunoglobulins and methods of their production
JP6779873B2 (ja) 2014-11-12 2020-11-04 メモリアル スローン ケタリング キャンサー センター 抗コンドロイチン硫酸プロテオグリカン4抗体およびその使用
CR20170309A (es) 2014-12-05 2018-02-02 Celgene Corp Pirazolo [1,5-a] pirazinas 4,6-sustituidas como inhibidores de janus cinasas
WO2016089610A1 (en) 2014-12-06 2016-06-09 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
NZ732073A (en) 2014-12-08 2019-04-26 1Globe Biomedical Co Ltd Soluble universal adcc-enhancing synthetic fusion gene and peptide technology and its use thereof
US10941207B2 (en) 2014-12-19 2021-03-09 Chiome Bioscience, Inc Fusion protein comprising three binding domains to 5T4 and CD3
US10022347B2 (en) 2015-01-07 2018-07-17 The United States Of America, As Represented By The Secretary Of The Navy Compositions and methods for diagnosis and treatment of metabolic syndrome
ES2824167T3 (es) 2015-01-23 2021-05-11 Sanofi Sa Anticuerpos anti-CD3, anticuerpos anti-CD123 y anticuerpos biespecíficos que se unen específicamente a CD3 y/o CD123
CN113713091A (zh) 2015-02-06 2021-11-30 新加坡国立大学 工程免疫细胞及其用途和生产方法
EP3263599A4 (en) 2015-02-16 2018-12-19 Pharma Foods International Co., Ltd. Anti-cancer agent and antimetastatic agent using fstl1, and concomitant drug for same
JP6784687B2 (ja) 2015-02-24 2020-11-11 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 結合誘発型転写スイッチ及びその使用方法
GB201503500D0 (en) 2015-03-02 2015-04-15 Ucl Business Plc Cell
JP2018509413A (ja) 2015-03-09 2018-04-05 アルゲン−エックス ビーブイビーエー FcRnアンタゴニストを用いてFc含有剤の血清レベルを低下させる方法
JP2018512396A (ja) 2015-03-09 2018-05-17 キングス・カレッジ・ロンドン Th1応答を増強するためのrarアルファアゴニストを用いた併用療法
US10772917B2 (en) 2015-03-11 2020-09-15 Ccs Ventures Limited Pancreatic endocrine progenitor cell therapies for the treatment of obesity and type 2 diabetes (T2D)
WO2016154047A2 (en) 2015-03-20 2016-09-29 Memorial Sloan-Kettering Cancer Center Monoclonal antigen-binding proteins to intracellular oncogene products
US10378055B2 (en) 2015-04-08 2019-08-13 City Of Hope Methods and compositions for measuring beta cell death
US11000603B2 (en) 2015-04-14 2021-05-11 Benhealth Biopharmaceutic (Shenzhen) Co., Ltd. Multi-specific binding conjugate, related pharmaceutical compositions and use
US10449209B2 (en) 2015-04-29 2019-10-22 Arterez, Llc Methods and compositions for reversing disruption of the glycocalyx, inflammation, and oxidative damage
PT3288573T (pt) 2015-04-30 2020-03-25 Psioxus Therapeutics Ltd Adenovírus oncolítico que codifica uma proteína b7
JP2018520642A (ja) 2015-05-01 2018-08-02 ジェネンテック, インコーポレイテッド マスク抗cd3抗体及びその使用方法
CA3155251A1 (en) 2015-05-01 2016-11-10 The Regents Of The University Of California Glycan-dependent immunotherapeutic molecules
IL293719B2 (en) 2015-05-21 2023-07-01 Harpoon Therapeutics Inc Trispecific binding proteins and methods of use
HUE048284T2 (hu) 2015-05-29 2020-07-28 Abbvie Inc Anti-CD40 antitestek és alkalmazásuk
CN107708741A (zh) 2015-06-12 2018-02-16 免疫医疗公司 用嵌合抗原受体(car)构建体和表达car构建体的t细胞(car‑t)或nk细胞(car‑nk)进行的疾病疗法
WO2016204966A1 (en) 2015-06-16 2016-12-22 Genentech, Inc. Anti-cd3 antibodies and methods of use
US10975112B2 (en) 2015-06-16 2021-04-13 Hangzhou Dac Biotech Co., Ltd. Linkers for conjugation of cell-binding molecules
US20190135894A1 (en) 2015-06-25 2019-05-09 iCell Gene Therapeuticics LLC COMPOUND CHIMERIC ANTIGEN RECEPTOR (cCAR) TARGETING MULTIPLE ANTIGENS, COMPOSITIONS AND METHODS OF USE THEREOF
WO2017008844A1 (en) 2015-07-14 2017-01-19 Biontech Ag Peptide mimotopes of the cd3 t-cell co-receptor epsilon chain and uses thereof
US11147886B2 (en) 2015-07-15 2021-10-19 Zymeworks Inc. Drug-conjugated bi-specific antigen-binding constructs
SG10202101105XA (en) 2015-08-13 2021-03-30 Amgen Inc Charged depth filtration of antigen-binding proteins
CN116063481A (zh) 2015-09-04 2023-05-05 普里玛托普医疗股份有限公司 人源化抗-cd40抗体及其用途
WO2017062920A1 (en) 2015-10-07 2017-04-13 Chopra Sunandini Nanoparticles with ph triggered drug release
US10752686B2 (en) 2015-10-30 2020-08-25 Zonhon Biopharma Institute Inc. Bispecific antibody binding to human CD26 and human CD3, production method therefor and use thereof
CN113599533A (zh) 2015-11-25 2021-11-05 乐高化学生物科学股份有限公司 包含分支接头的抗体-药物缀合物及其相关方法
AU2016359234B2 (en) 2015-11-25 2022-09-08 Legochem Biosciences, Inc. Conjugates comprising peptide groups and methods related thereto
AU2016372576A1 (en) 2015-12-17 2018-06-21 Psioxus Therapeutics Limited Virus encoding an anti-TCR-complex antibody or fragment
US20180291114A1 (en) 2015-12-17 2018-10-11 University Of Maryland, Baltimore County Recombinant bi-specific polypeptide for coordinately activating tumor-reactive t-cells and neutralizing immune suppression
JP7012645B2 (ja) 2016-01-11 2022-01-28 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー キメラタンパク質および免疫治療の方法
EP3192810A1 (en) 2016-01-14 2017-07-19 Deutsches Krebsforschungszentrum Psma binding antibody and uses thereof
CA3011331A1 (en) 2016-01-14 2017-07-20 Intrexon Actobiotics N.V. Compositions and methods for the treatment of type 1 diabetes
CN109071630B (zh) 2016-01-15 2022-05-31 马里兰大学帕克分校 作为糖苷合酶的Endo-S2突变体、制备方法以及用于糖蛋白的糖工程化的用途
EP3851457A1 (en) 2016-01-21 2021-07-21 Novartis AG Multispecific molecules targeting cll-1
US10465003B2 (en) 2016-02-05 2019-11-05 Janssen Biotech, Inc. Anti-TNF antibodies, compositions, methods and use for the treatment or prevention of type 1 diabetes
EP3416981A1 (en) 2016-02-18 2018-12-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Polypeptides for preparing drug conjugates capable of promoting apoptosis in a cell expressing an orexin receptor
US10745478B2 (en) 2016-02-19 2020-08-18 Dignity Health Antibody fusion protein and related compositions for targeting cancer
US20190077856A1 (en) 2016-03-15 2019-03-14 Memorial Sloan Kettering Cancer Center Method of treating diseases using kinase modulators
CA3019137A1 (en) 2016-04-04 2017-10-12 Chemocentryx, Inc. Soluble c5ar antagonists
EP3448427A1 (en) 2016-04-29 2019-03-06 CureVac AG Rna encoding an antibody
EP3448874A4 (en) 2016-04-29 2020-04-22 Voyager Therapeutics, Inc. COMPOSITIONS FOR TREATING A DISEASE
US11339225B2 (en) 2016-05-12 2022-05-24 Asclepius (Suzhou) Technology Company Group, Co., Ltd. Bispecific antigen-binding construct and preparation method and use thereof
CN107365387B (zh) 2016-05-12 2022-03-15 阿思科力(苏州)生物科技有限公司 一种双特异性抗原结合构建体及其制备方法和应用
US11414491B2 (en) 2016-05-18 2022-08-16 Mayo Foundation For Medical Education And Research Targeting PD-L1 on tumor cells
WO2017205726A1 (en) 2016-05-27 2017-11-30 Altor Bioscience Corporation Construction and characterization of multimeric il-15-based molecules with cd3 binding domains
US20210347901A9 (en) 2016-06-27 2021-11-11 Agomab Therapeutics Methods for promoting pancreatic islet cell growth
IT201800000534A1 (it) 2018-01-03 2019-07-03 Procedimenti per la promozione della crescita cellulare degli isolotti pancreatici.
EP3507367A4 (en) 2016-07-05 2020-03-25 Aduro BioTech, Inc. CYCLIC DINUCLEOTID COMPOUNDS WITH INCLUDED NUCLEIC ACIDS AND USES THEREOF
CA3030841A1 (en) 2016-07-14 2018-01-18 Fred Hutchinson Cancer Research Center Multiple bi-specific binding domain constructs with different epitope binding to treat cancer
JP6994223B2 (ja) 2016-07-26 2022-02-04 静岡県 抗b7-h4抗体
US20190170752A1 (en) 2016-08-08 2019-06-06 Beigene, Ltd. Method for predicting efficacy of immune checkpoint inhibitors in cancer patients
CN109715819A (zh) 2016-08-10 2019-05-03 马里兰大学帕克分校 设计者α1,6-岩藻糖苷酶突变体实现完整N-糖肽和N-糖蛋白的直接核心岩藻糖基化
EP3502143A4 (en) 2016-08-19 2020-07-15 Ampsource Biopharma Shanghai Inc. BINDING PEPTIDE FOR THE CONSTRUCTION OF A FUSION PROTEIN
WO2018037416A1 (en) 2016-08-25 2018-03-01 Yeda Research And Development Co. Ltd. Methods and compositions for treating autoimmune diseases
AU2017319318A1 (en) 2016-08-29 2019-02-21 Tiziana Life Sciences Plc Anti-CD3 antibody formulations
SG11201901716TA (en) 2016-08-29 2019-03-28 Psioxus Therapeutics Ltd Adenovirus armed with bispecific t cell engager (bite)
GB201713765D0 (en) 2017-08-28 2017-10-11 Psioxus Therapeutics Ltd Modified adenovirus
AU2017321426B2 (en) 2016-08-29 2022-09-29 Hackensack University Medical Center Methods for treating an immune disorder-related disease by reducing autoreactivity in a T cell compartment
KR102497742B1 (ko) 2016-08-30 2023-02-10 다나-파버 캔서 인스티튜트 인크. 약물 전달 조성물 및 그의 용도
US11160876B2 (en) 2016-09-01 2021-11-02 Mayo Foundation For Medical Education And Research Methods and compositions for targeting t-cell cancers
AU2017319707B2 (en) 2016-09-02 2023-11-09 Intrexon Actobiotics N.V. Genetically modified bacteria stably expressing IL-10 and insulin
CA3035653A1 (en) 2016-09-06 2018-03-15 Mayo Foundation For Medical Education And Research Paclitaxel-albumin-binding agent compositions and methods for using and making the same
AU2017336867B2 (en) 2016-09-29 2024-03-14 Beijing Hanmi Pharmaceutical Co., Ltd. Heterodimeric immunoglobulin constructs and preparation methods thereof
JP7275027B2 (ja) 2016-10-06 2023-05-17 アムジェン インコーポレイテッド 粘度低下タンパク質医薬製剤
CN106632681B (zh) 2016-10-11 2017-11-14 北京东方百泰生物科技有限公司 抗egfr和抗cd3双特异抗体及其应用
US11220551B2 (en) 2016-10-19 2022-01-11 The Governing Council Of The University Of Toronto CD133-binding agents and uses thereof
AU2017348306A1 (en) 2016-10-27 2019-05-23 The Trustees Of Columbia University In The City Of New York Immunosuppressive mesenchymal cells and methods for forming same
EP3541847A4 (en) 2016-11-17 2020-07-08 Seattle Genetics, Inc. COMPOUNDS INTERACTING WITH GLYCANE AND METHODS OF USE
KR102085798B1 (ko) 2016-12-28 2020-03-06 주식회사 인투셀 베타-갈락토사이드가 도입된 자가-희생 기를 포함하는 화합물
WO2018120843A1 (zh) 2016-12-30 2018-07-05 上海近岸生物科技有限公司 一种三功能分子及其应用
EP3575319A4 (en) 2016-12-30 2021-03-10 Shanghai Sinobio Biotech Co., Ltd. BIFUNCTIONAL MOLECULE AND USE OF IT
US11046768B2 (en) 2017-01-27 2021-06-29 Memorial Sloan Kettering Cancer Center Bispecific HER2 and CD3 binding molecules
US20200181260A1 (en) 2017-02-22 2020-06-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Bispecific antibody for cancer immunotherapy
TW202122576A (zh) 2017-03-29 2021-06-16 臺北醫學大學 具抗原專一性的t細胞及其用途
WO2018178123A1 (en) 2017-03-29 2018-10-04 Glycotope Gmbh BISPECIFIC MUC-1 x PD-L1 ANTIBODIES
EP3619235A1 (en) 2017-04-11 2020-03-11 Inhibrx, Inc. Multispecific polypeptide constructs having constrained cd3 binding and methods of using the same
CN108728465A (zh) 2017-04-14 2018-11-02 深圳新诺微环生物科技有限公司 一种表达靶细胞-效应细胞桥接器的微环dna载体及其制备方法和应用
CA3059444A1 (en) 2017-04-14 2018-10-18 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
UY37695A (es) 2017-04-28 2018-11-30 Novartis Ag Compuesto dinucleótido cíclico bis 2’-5’-rr-(3’f-a)(3’f-a) y usos del mismo
US11807662B2 (en) 2017-05-16 2023-11-07 The Johns Hopkins University MANAbodies and methods of using
EP3642228A1 (en) 2017-06-21 2020-04-29 Gsbio, LLC Heterodimeric bispecific antibodies
US11753431B2 (en) 2017-07-04 2023-09-12 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
GB201710838D0 (en) 2017-07-05 2017-08-16 Ucl Business Plc Bispecific antibodies
US11648269B2 (en) 2017-08-10 2023-05-16 National University Of Singapore T cell receptor-deficient chimeric antigen receptor T-cells and methods of use thereof
US20200181264A1 (en) 2017-08-11 2020-06-11 City Of Hope Bispecific antigen-binding molecule
JP2020533317A (ja) 2017-09-07 2020-11-19 オーガスタ ユニバーシティ リサーチ インスティテュート,インコーポレーテッド 特異的akt3活性化剤およびその使用
RS62725B1 (sr) * 2017-09-08 2022-01-31 Diamyd Medical Ab Stratifikacija genotipa pri tretmanu i prevenciji dijabetesa
US20200281976A1 (en) 2017-10-04 2020-09-10 City Of Hope Prevention and treatment of gvhd and autoimmune diseases
JP2020536559A (ja) 2017-10-12 2020-12-17 アイセル・ジーン・セラピューティクス・エルエルシー 複数の抗原を標的とするcompoundキメラ抗原受容体(cCAR)の組成物およびその使用方法
FR3072880A1 (fr) 2017-10-30 2019-05-03 Institut National De La Sante Et De La Recherche Medicale (Inserm) Formulation liposomale et son utilisation en therapie anti-tumorale
EP3706803A4 (en) 2017-11-08 2021-08-04 Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. CONJUGATES OF BIOMOLECULES AND THEIR USES
US20210380641A1 (en) 2017-11-09 2021-12-09 University Of Washington Self-assembling protein structures and components thereof
BR112020009453A2 (pt) 2017-11-13 2020-10-27 Extremochem, Lda. amidas glicosiladas neutras e ácidos glucuronidados dianiônicos como estabilizadores de moléculas biológicas
WO2019126133A1 (en) 2017-12-20 2019-06-27 Alexion Pharmaceuticals, Inc. Liquid formulations of anti-cd200 antibodies
BR112020012374A2 (pt) 2017-12-22 2020-11-24 Chemocentryx, Inc. compostos de anel 5,5-fundido substituído por diarila como inibidores de c5ar
WO2019133847A1 (en) 2017-12-29 2019-07-04 Oncorus, Inc. Oncolytic viral delivery of therapeutic polypeptides
EP3740505A1 (en) 2018-01-16 2020-11-25 Lakepharma Inc. Bispecific antibody that binds cd3 and another target
TWI804572B (zh) 2018-02-09 2023-06-11 日商小野藥品工業股份有限公司 雙特異性抗體
WO2019157533A1 (en) 2018-02-12 2019-08-15 The General Hospital Corporation Chimeric antigen receptors targeting the tumor microenvironment
GB201805329D0 (en) 2018-03-30 2018-05-16 Katholieke Univ Leuven K U Leuven R&D Biomakers for diabetes therapy
SG11202009588PA (en) 2018-04-02 2020-10-29 Chemocentryx Inc PRODRUGS OF FUSED-BICYCLIC C5aR ANTAGONISTS
US20210163620A1 (en) 2018-04-05 2021-06-03 Brian Granda Trispecific binding molecules against cancers and uses thereof
US10633458B2 (en) 2018-04-10 2020-04-28 Y-Biologics Inc. Cell engaging binding molecules
US20210113519A1 (en) 2018-04-17 2021-04-22 Carnegie Mellon University Compositions and Methods for Modulating Permeability of Biological Barriers
BR112020022288A2 (pt) 2018-05-01 2021-02-23 Ambrx, Inc. método para otimizar a expressão de anticorpos
IT201800005182A1 (it) 2018-05-09 2019-11-09 siRNA contro la variante C1858T del gene PTPN22
SG11202010589YA (en) 2018-05-14 2020-11-27 Oncoimmune Inc Anti-cd24 compositions and uses thereof
KR20210011002A (ko) 2018-05-16 2021-01-29 얀센 바이오테크 인코포레이티드 암을 치료하는 방법 및 t-세포 재유도 치료제의 효능을 향상시키는 방법
EP3569617A1 (en) 2018-05-18 2019-11-20 Trion Research GmbH Pharmaceutical preparation for use in treating epstein- barr virus positive patients with reactivation phenomenon- associated diseases
CN112512573A (zh) 2018-05-23 2021-03-16 百提威生技股份有限公司 双特异性t细胞衔接蛋白及其用途
TW202015726A (zh) 2018-05-30 2020-05-01 瑞士商諾華公司 Entpd2抗體、組合療法、及使用該等抗體和組合療法之方法
US20200040056A1 (en) 2018-05-31 2020-02-06 Washington University Genome-edited invariant natural killer t (inkt) cells for the treatment of hematologic malignancies
CN112912493A (zh) 2018-05-31 2021-06-04 华盛顿大学 用于治疗癌症的嵌合抗原受体t细胞(car-t)
CA3098415A1 (en) 2018-06-07 2019-12-12 Oncoone Research & Development Gmbh Anti-oxmif/anti-cd3 antibody for cancer treatment
AU2019292580A1 (en) 2018-06-29 2021-02-04 Krystal Biotech, Inc. Compositions and methods for antibody delivery
WO2020001344A1 (en) 2018-06-29 2020-01-02 Beijing Biocytogen Co., Ltd ANTI-CD3e ANTIBODIES AND USES THEREOF
JP2021529834A (ja) 2018-07-03 2021-11-04 アイエフエム デュー インコーポレイテッド Sting活性に関連する状態を治療するための化合物および組成物
US20210261646A1 (en) 2018-07-03 2021-08-26 Sotio, LLC Chimeric receptors in combination with trans metabolism molecules enhancing glucose import and therapeutic uses thereof
EP3820571A1 (en) 2018-07-10 2021-05-19 University of Connecticut Reagents and methods for treating cancer and autoimmune disease
US10640562B2 (en) 2018-07-17 2020-05-05 Mcmaster University T cell-antigen coupler with various construct optimizations
EP3829636A1 (en) 2018-07-27 2021-06-09 NGM Biopharmaceuticals, Inc. Use of glucagon receptor antagonists with immunotherapeutic agent
CA3107675A1 (en) 2018-07-30 2020-02-06 University Of Southern California Improving the efficacy and safety of adoptive cellular therapies
WO2020033499A1 (en) 2018-08-09 2020-02-13 Duke University Enhanced delivery of drugs and other compounds to the brain and other tissues
CN112840019A (zh) 2018-08-14 2021-05-25 Sotio有限责任公司 与调节克雷布斯循环的反式代谢分子组合的嵌合抗原受体多肽及其治疗用途
CN111417655A (zh) 2018-08-28 2020-07-14 润俊(中国)有限公司 抗cd3抗体叶酸生物偶联物及其用途
AU2019336229A1 (en) 2018-09-07 2021-03-18 Sotio, LLC Chimeric receptor polypeptides in combination with trans metabolism molecules modulating intracellular lactate concentrations and therapeutic uses thereof
EP3849513A1 (en) 2018-09-11 2021-07-21 Ichnos Sciences SA Compositions comprising a bispecific antibody, bufffer and one or more stabilizing agents
EP4268831A2 (en) 2018-09-12 2023-11-01 Fred Hutchinson Cancer Center Reducing cd33 expression to selectively protect therapeutic cells
WO2020056037A1 (en) 2018-09-13 2020-03-19 Board Of Regents Of The University Of Nebraska Biomarkers for type 1 diabetes
US11066476B2 (en) 2018-09-14 2021-07-20 Shanghai tongji hospital Asymmetric bispecific antibody
US20210353751A1 (en) 2018-10-18 2021-11-18 The Regents Of The University Of California Combination therapies for treatment of inflammatory diseases
WO2020086423A1 (en) 2018-10-22 2020-04-30 Icell Kealex Therapeutics Mutant vaccinia viruses and use thereof
EP3873521A2 (en) 2018-10-31 2021-09-08 Tiziana Life Sciences PLC Composition and methods of treating inflammatory and autoimmune diseases
CA3118397A1 (en) 2018-11-01 2020-05-07 Shandong Newtime Pharmaceutical Co., Ltd. Bispecific antibody targeting cd3 and bcma, and uses thereof
WO2020092743A2 (en) 2018-11-01 2020-05-07 Memorial Sloan Kettering Cancer Center Methods of treating diseases using kinase modulators
TW202039537A (zh) 2018-11-27 2020-11-01 美商昂科賽克醫療公司 用於治療癌症之質體建構體和使用方法
EP3902834A4 (en) 2018-11-30 2022-08-24 Memorial Sloan Kettering Cancer Center HETERODIMERIC COMPOSITIONS OF SPECIFIC AND TETRAVALENT ANTIBODIES, AND USES THEREOF
WO2020118136A1 (en) 2018-12-06 2020-06-11 Board Of Regents, The University Of Texas System Selectively cleavable therapeutic nanoparticles
WO2020124032A1 (en) 2018-12-14 2020-06-18 Fred Hutchinson Cancer Research Center Transferrin receptor targeting peptides
WO2020123806A1 (en) 2018-12-14 2020-06-18 Beth Israel Deaconess Medical Center. Inc. Modulation of pd-1
KR20210104816A (ko) 2018-12-19 2021-08-25 시티 오브 호프 Baff-r 이중특이적 t 세포 인게이저 항체
WO2020141460A2 (en) 2019-01-03 2020-07-09 Intocell, Inc. Compounds comprising cleavable linker and uses thereof
JP2022515884A (ja) 2019-01-03 2022-02-22 イントゥーセル,インコーポレーティッド 切断可能なリンカーを含む化合物及びその使用
WO2020150402A2 (en) 2019-01-15 2020-07-23 Caerus Therapeutics, Corp. Advanced chimeric antigen receptor vectors for targeting solid tumors
JP2022520163A (ja) 2019-01-30 2022-03-29 ザ ウィスター インスティテュート オブ アナトミー アンド バイオロジー 癌抗原を標的とするdnaコード化二重特異性t細胞エンゲージャーおよび癌治療薬における使用方法
JPWO2020166592A1 (ja) 2019-02-13 2021-12-09 大日本住友製薬株式会社 ヘミアスタリン誘導体とその抗体薬物複合体
BR112021015907A2 (pt) 2019-02-20 2021-11-03 Res Institute At Nationwide Childrens Hospital Ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis
EP3929212A4 (en) 2019-02-22 2022-11-23 Wuhan Yzy Biopharma Co., Ltd. MODIFIED FC FRAGMENT, ANTIBODY COMPRISING THEM AND THEIR APPLICATION
WO2020168555A1 (zh) 2019-02-22 2020-08-27 武汉友芝友生物制药有限公司 Cd3抗原结合片段及其应用
EP3938400A4 (en) 2019-03-11 2022-11-23 Memorial Sloan Kettering Cancer Center CD22 ANTIBODIES AND METHODS OF USE THEREOF
CN109776683B (zh) 2019-03-19 2020-04-07 益科思特(北京)医药科技发展有限公司 一种双特异性抗体及其制备方法与应用
CA3134056A1 (en) 2019-03-20 2020-09-24 The Regents Of The University Of California Claudin-6 bispecific antibodies
WO2020190217A2 (en) 2019-03-21 2020-09-24 Agency For Science, Technology And Research Composition
CA3131052A1 (en) 2019-03-25 2020-10-01 Soon Jae Park Pharmaceutical composition for subcutaneous injection comprising human hyaluronidase ph20 variant and drug
EP3947689A4 (en) 2019-03-27 2023-03-29 National Research Council of Canada ANTIGEN BINDING AGENTS THAT SPECIFICALLY BIND TO VARIANT III OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
MA55529A (fr) 2019-04-03 2022-02-09 Genzyme Corp Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite
JP2022525435A (ja) 2019-04-08 2022-05-13 メモリアル スローン ケタリング キャンサー センター Cd19抗体およびこれを使用する方法
US20220249696A1 (en) 2019-04-12 2022-08-11 The Johns Hopkins University Tolerogenic artificial antigen-presenting cells
US20220160891A1 (en) 2019-04-12 2022-05-26 The Johns Hopkins University Tolerogenic artificial antigen-presenting cells
US20220348657A1 (en) 2019-04-18 2022-11-03 Five Prime Therapeutics, Inc. Bioassay for t-cell co-stimulatory proteins containing fc domains
WO2020223279A1 (en) 2019-04-29 2020-11-05 Voyager Therapeutics, Inc. VECTORIZED ANTIBODIES (vAb) AND USES THEREOF
CR20210578A (es) 2019-04-30 2022-02-22 Sitryx Therapeutics Ltd Derivados de ácido itacónico y usos de estos en el tratamiento de una enfermedad inflamatoria asociada con una respuesta inmunotaria indeseable
EP3966248A4 (en) 2019-05-08 2023-04-12 Memorial Sloan Kettering Cancer Center HUMANIZED ANTIBODIES TO MUCIN-16 AND METHODS OF USE THEREOF
GB201906685D0 (en) 2019-05-13 2019-06-26 Ultrahuman Six Ltd Activatable protein constructs and uses thereof
KR102503349B1 (ko) * 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
JP2022534783A (ja) 2019-06-03 2022-08-03 イミュノルクス インターナショナル コーポレーション 疾患を処置するための天然痘ワクチン及び幹細胞
WO2020247871A2 (en) 2019-06-06 2020-12-10 Janux Therapeutics, Inc. Compositions and methods relating to tumor activated t cell engagers
AU2020300002A1 (en) 2019-07-01 2022-02-24 Tonix Pharma Limited Anti-CD154 antibodies and uses thereof
AU2020316422A1 (en) 2019-07-22 2022-02-17 University Of Florida Research Foundation, Incorporated Multimeric protein domains for multifunctionality and enhanced secretion of therapeutic proteins
US20210130464A1 (en) 2019-07-30 2021-05-06 Provention Bio, Inc. Methods and Compositions for Reducing Immunogenicity By Non-Depletional B Cell Inhibitors
JP2022544053A (ja) 2019-07-30 2022-10-17 プロヴェンション・バイオ・インコーポレイテッド 非枯渇性b細胞阻害剤によって免疫原性を低下させるための方法および組成物
JP2022548509A (ja) 2019-08-27 2022-11-21 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア IL13Rα2陽性ヒト腫瘍およびイヌ腫瘍を処置するための合成CAR
EP4023245A4 (en) 2019-08-28 2023-08-30 Azusapharma Sciences, Inc. BIFIDOBACTERIUM SPP. WITH EXPRESSION AND SECRETION OF DIABODY-TYPE BSAB
WO2021041958A1 (en) 2019-08-30 2021-03-04 Shattuck Labs. Inc. Chimeric proteins in autoimmunity
GB201912681D0 (en) 2019-09-04 2019-10-16 Eth Zuerich Bispecific binding agent that binds to cd117/c-kit and cd3
CN112480263A (zh) 2019-09-12 2021-03-12 普米斯生物技术(苏州)有限公司 一种双特异t细胞激活器活化t细胞的设计及其应用
EP3791931A1 (en) 2019-09-13 2021-03-17 Ichnos Sciences SA Bispecific antibodies for the treatment of solid tumors
KR102081418B1 (ko) 2019-09-24 2020-05-26 주식회사 이뮤니스바이오 말초혈액단핵구 유래 조절 t 세포 배양용 조성물 및 이를 이용한 조절 t 세포 배양방법
WO2021064069A1 (en) 2019-10-02 2021-04-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for the treatment of adult t-cell leukemia/lymphoma
WO2021071319A1 (ko) 2019-10-10 2021-04-15 주식회사 와이바이오로직스 다중 특이적 융합 단백질 및 이의 용도
US20240093158A1 (en) 2019-10-10 2024-03-21 Arizona Board Of Regents On Behalf Of Arizona State University Oncolytic viruses that express multi-specific immune cell engagers
AU2020379319A1 (en) 2019-11-05 2022-06-23 Yeda Research And Development Co. Ltd. Use of veto cells in treatment of T cell mediated autoimmune diseases
US20230227547A1 (en) 2019-11-12 2023-07-20 Iprogen Biotech Inc. Antibody-payload conjugates with enhanced delivery domain and uses thereof
US20230039858A1 (en) 2019-12-02 2023-02-09 Intocell, Inc. Compositions and methods related to molecular conjugation
CN115943160A (zh) 2019-12-06 2023-04-07 翁科奥内研发有限责任公司 抗oxMIF/抗CD3双特异性抗体构建体
EP4073067A1 (en) 2019-12-12 2022-10-19 Fresenius Kabi Deutschland GmbH Glycosylated polypeptides
WO2021119585A1 (en) 2019-12-13 2021-06-17 Dnalite Therapeutics, Inc. Compositions and methods for biological delivery vehicles
AU2020405183A1 (en) 2019-12-18 2022-06-09 TeneoFour, Inc. Heavy chain antibodies binding to CD38
JOP20220150A1 (ar) 2019-12-18 2023-01-30 Janssen Biotech Inc مواد وطرق للاستهداف البيولوجي في الجسم الحي
TW202138356A (zh) 2019-12-23 2021-10-16 英商喜翠克斯治療有限公司 新穎之化合物
AU2020417305A1 (en) 2019-12-31 2022-07-21 Fred Hutchinson Cancer Center Nanoparticle systems to stimulate and maintain immune system responsiveness at treatment sites
WO2021146328A1 (en) 2020-01-13 2021-07-22 Aptevo Research And Development Llc Formulations for protein therapeutics
EP4090377A1 (en) 2020-01-13 2022-11-23 Synaffix B.V. Conjugates of antibodies an immune cell engagers
AU2021208642A1 (en) 2020-01-17 2022-07-28 Immune Targeting, Inc. Pro-antibody that reduces off-target toxicity
IL294879A (en) 2020-01-29 2022-09-01 Inhibrx Inc Monodomain antibodies of cd28 and their multivalent and multispecific constructs
EP4103583A1 (en) 2020-02-14 2022-12-21 Chang Gung Memorial Hospital Tandem repeat cancer-targeting peptides for molecular conjugation or engineering and uses thereof in cancer theranostics
EP3865513A1 (en) 2020-02-17 2021-08-18 Fundación Para La Investigación Biomédica Del Hospital 12 De Octubre Anti-cd19/anti-cd3 bispecific antibody, t cells secreting the same, method of preparation and use thereof
EP4110398A1 (en) 2020-02-27 2023-01-04 Phanes Therapeutics, Inc. Antibodies conjugated with fatty acid molecules and uses thereof
KR20220152316A (ko) 2020-03-12 2022-11-15 이뮨-온크 테라퓨틱스, 인코포레이티드 신규한 항-lilrb4 항체 및 유도체 생성물
CN115667314A (zh) 2020-03-16 2023-01-31 美真达治疗公司 T细胞双特异性结合蛋白
WO2021195067A1 (en) 2020-03-23 2021-09-30 Cytoarm Co. Ltd. Bi-specific antibodies for use in producing armed immune cells
CN115397515A (zh) 2020-03-31 2022-11-25 弗莱德哈钦森癌症中心 人抗cd33抗体和其用途
EP4126245A2 (en) 2020-03-31 2023-02-08 Fred Hutchinson Cancer Center Anti-cd33 antibodies and uses thereof
MX2022012812A (es) 2020-04-13 2023-01-30 Univ Health Network Métodos para tratar el síndrome de liberación de citocinas.
WO2021216460A1 (en) 2020-04-19 2021-10-28 Figene, Llc Gene modified fibroblasts for therapeutic applications
CN113527510A (zh) 2020-04-22 2021-10-22 上海交通大学 融合蛋白分子及其制备方法和用途
EP4139347A1 (en) 2020-04-24 2023-03-01 Memorial Sloan Kettering Cancer Center Anti-cd3 antibodies and uses thereof
JP2023524238A (ja) 2020-04-30 2023-06-09 アーチ オンコロジー,インコーポレイテッド 治療用SIRPα抗体
WO2021222861A1 (en) 2020-04-30 2021-11-04 Children's Medical Center Corporation Antibodies specific to abcb5 and uses thereof
US20210349094A1 (en) 2020-05-11 2021-11-11 Musc Foundation For Research Development Detection of autoreactive fecal immunoglobulin a (iga) for diagnosis of lupus
CA3180572A1 (en) 2020-05-29 2021-12-02 Johan Skog Use of microvesicle signature for the diagnosis and treatment of kidney transplant rejection
IL298867A (en) 2020-06-11 2023-02-01 Tizona Therapeutics Combines bispecific immune cells with binding specificity for HLA-G and another antigen
JP2023530109A (ja) 2020-06-11 2023-07-13 プロヴェンション・バイオ・インコーポレイテッド 1型糖尿病を予防するための方法および組成物
WO2021254574A2 (en) 2020-06-17 2021-12-23 Y-Mabs Therapeutics, Inc. Cd38 antibodies for the treatment of human diseases
EP4182447A1 (en) 2020-07-14 2023-05-24 Ichilov Tech Ltd. Pseudotyped viruses configured to express car in t-cells
WO2022018262A1 (en) 2020-07-24 2022-01-27 Cellectis S.A. T-cells expressing immune cell engagers in allogenic settings
US20230270857A1 (en) 2020-07-28 2023-08-31 Memorial Sloan Kettering Cancer Center Compositions including ex vivo armed t cells with multi-specific antibodies and uses thereof
CN116234828A (zh) 2020-07-29 2023-06-06 米纳瓦生物技术公司 抗可变muc1*抗体及其用途
WO2022026939A2 (en) 2020-07-31 2022-02-03 Soteria Biotherapeutics, Inc. Single and dual targeting ligand induced t-cell engager compositions
US20240018111A1 (en) 2020-08-05 2024-01-18 Sitryx Therapeutics Limited Alpha, beta unsaturated methacrylic esters with anti-inflammatory properties
EP4192879A2 (en) 2020-08-06 2023-06-14 Abpro Corporation Anti-claudin 18.2 multi-specific antibodies and uses thereof
US20230303695A1 (en) 2020-08-10 2023-09-28 Tengfei XIAO Compositions and methods for treating autoimmune diseases and cancers by targeting igsf8
WO2022035888A2 (en) 2020-08-10 2022-02-17 Seattle Children's Hospital D/B/A Seattle Children's Research Institute Sars-cov-2-neutralizing antibodies, biomarkers to predict protection from re-infection, and high efficiency antibody screening methods
WO2022036495A1 (en) 2020-08-17 2022-02-24 Utc Therapeutics Inc. Lymphocytes-antigen presenting cells co-stimulators and uses thereof
CA3189708A1 (en) 2020-08-19 2022-02-24 Mahiuddin Ahmed Vaccine compositions and antibodies for lyme disease
US11124568B1 (en) 2020-08-19 2021-09-21 Vitruviae LLC CD3/CD25 antibodies for neuro-immune diseases
EP4200275A2 (en) 2020-08-21 2023-06-28 Sitryx Therapeutics Limited Fumarate derivatives and their medical use
WO2022040603A2 (en) 2020-08-21 2022-02-24 The Rockefeller University Single-domain antibodies that bind sars-cov-2
CN116322763A (zh) 2020-08-27 2023-06-23 学校法人顺天堂 抗切断型突变calr-cd3双特异性抗体及医药组合物
CN116368152A (zh) 2020-09-13 2023-06-30 山东博安生物技术股份有限公司 通过受体tac技术的膜结合蛋白的下调
US20230365676A1 (en) 2020-09-15 2023-11-16 University Of Florida Research Foundation, Incorporated Cd33 antibodies
TW202227478A (zh) 2020-09-15 2022-07-16 德商拜恩迪克公司 對細胞靶向遞送的藥劑及方法
WO2022063302A1 (zh) 2020-09-25 2022-03-31 克莱格医学有限公司 免疫细胞活性调节
CN116390733A (zh) 2020-09-28 2023-07-04 纳夫罗根公司 用于治疗癌症的替代性格式化的抗间皮素抗体的组合物和用途
EP4225797A1 (en) 2020-10-09 2023-08-16 Seattle Children's Hospital (DBA Seattle Children's Research Institute) Binders and chimeric antigen receptors which specifically bind fibroblast growth factor receptor 4
US20220119549A1 (en) 2020-10-15 2022-04-21 Tavotek Biotherapeutics (Hong Kong) Limited Shielded biologics with masking domains to shield antigen binding capability of biologics and uses thereof
CN116745289A (zh) 2020-10-20 2023-09-12 奥洛治疗有限公司 游离脂肪酸受体1的激动剂及其在与所述受体相关的疾病中的用途
TWI815194B (zh) 2020-10-22 2023-09-11 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法

Also Published As

Publication number Publication date
JP2023002501A (ja) 2023-01-10
JP7137696B2 (ja) 2022-09-14
IL288024A (en) 2022-01-01
KR20220034029A (ko) 2022-03-17
US20200399368A1 (en) 2020-12-24
WO2020232247A1 (en) 2020-11-19
KR102503349B1 (ko) 2023-02-23
JP2021534224A (ja) 2021-12-09
KR20230031981A (ko) 2023-03-07
US11434291B2 (en) 2022-09-06
BR112021022682A2 (pt) 2022-02-22
US20230013752A1 (en) 2023-01-19

Similar Documents

Publication Publication Date Title
JOP20210298A1 (ar) طرق وتركيبات للوقاية من مرض السكري من النوع الأول
Nemeth et al. Hepcidin and iron in health and disease
Lian et al. Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
EP4249068A3 (en) Anti-cd38 antibodies and combinations with anti-cd3 and anti-cd28 antibodies
MX2020008445A (es) Metodos para tratar el cancer con anticuerpos anti-pd-1.
JP2018514550A5 (ar)
NZ623319A (en) Human antibodies that bind lymphocyte activation gene-3 (lag-3), and uses thereof
Gao et al. Differential regulation of glucose transporters mediated by CRH receptor type 1 and type 2 in human placental trophoblasts
PE20140673A1 (es) Nuevos moduladores y metodos para su uso
BRPI0410261A (pt) método de detecção de probnp natural
WO2008045962A3 (en) Methods and materials related to anti-a (beta) antibodies
WO2004035537A8 (en) Antibodies that bind cell-associated ca 125/o772p and methods of use thereof
PH12013501456A1 (en) Use of anti~amyloid beta antibody
MX2020012613A (es) Composiciones y usos de las mismas para el tratamiento de enfermedades o afecciones.
WO2020112889A3 (en) Methods for treating dysregulated lipid metabolism
MX2020008446A (es) Metodos para el tratamiento contra el cancer mediante anticuerpos anti-pd-1 y anticuerpos anti-ctla4.
WO2015187087A3 (en) Novel combinations for antigen based therapy
Bazi et al. Hypothyroidism and hypoparathyroidism in thalassemia major patients: a study in Sistan and Baluchestan Province, Iran
MX2022015872A (es) Metodos y composiciones para prevenir diabetes tipo 1.
MX2020009879A (es) Anticuerpos anti-il-27 y sus usos.
Verouti et al. Vitamin D receptor activators upregulate and rescue podocalyxin expression in high glucose-treated human podocytes
MX2022001403A (es) Metodos de administracion de anticuerpos anti-siglec-8 y corticosteroides.
BRPI0807601B8 (pt) método para identificação de um paciente que esteja em risco com relação ao desenvolvimento de um distúrbio na tireoide e uso de um agente depletivo de linfócitos
Libetta et al. Sirolimus vs cyclosporine after induction with basiliximab does not promote regulatory T cell expansion in de novo kidney transplantation: Results from a single-center randomized trial
MX2022003719A (es) Anticuerpos anti-il-27 y sus usos.