AR095596A1 - Moléculas de unión de cadena única comprendiendo n-terminal abp - Google Patents
Moléculas de unión de cadena única comprendiendo n-terminal abpInfo
- Publication number
- AR095596A1 AR095596A1 ARP140101221A ARP140101221A AR095596A1 AR 095596 A1 AR095596 A1 AR 095596A1 AR P140101221 A ARP140101221 A AR P140101221A AR P140101221 A ARP140101221 A AR P140101221A AR 095596 A1 AR095596 A1 AR 095596A1
- Authority
- AR
- Argentina
- Prior art keywords
- binding
- molecule
- understanding
- binding molecule
- cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
Una molécula de unión de cadena simple que comprende al menos tres dominios de unión, donde el primer dominio de unión es capaz de unirse a albúmina sérica y se posiciona en el extremo N del segundo dominio de unión, dicho segundo dominio de unión es capaz de unirse a una molécula de superficie celular en una célula diana y el tercer dominio de unión es capaz de unirse al complejo de receptor de CD3 de células T. Además métodos para la producción de tal molécula de unión, una secuencia de ácido nucleico que la codifica, un vector que comprende dicha secuencia de ácido nucleico y una célula hospedadora que expresa la molécula de unión. Además, una composición farmacéutica que comprende una molécula de unión, métodos para el tratamiento que comprenden el paso de administrar una molécula de unión y el uso médico de una molécula de unión.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361792073P | 2013-03-15 | 2013-03-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR095596A1 true AR095596A1 (es) | 2015-10-28 |
Family
ID=50513887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP140101221A AR095596A1 (es) | 2013-03-15 | 2014-03-17 | Moléculas de unión de cadena única comprendiendo n-terminal abp |
Country Status (14)
Country | Link |
---|---|
US (2) | US20160122436A1 (es) |
EP (2) | EP2970449B1 (es) |
AR (1) | AR095596A1 (es) |
CY (1) | CY1122564T1 (es) |
DK (1) | DK2970449T3 (es) |
ES (1) | ES2753950T3 (es) |
HU (1) | HUE045859T2 (es) |
LT (1) | LT2970449T (es) |
PL (1) | PL2970449T3 (es) |
PT (1) | PT2970449T (es) |
SI (1) | SI2970449T1 (es) |
TW (1) | TW201525001A (es) |
UY (1) | UY35484A (es) |
WO (1) | WO2014140358A1 (es) |
Families Citing this family (33)
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IL293719B2 (en) | 2015-05-21 | 2023-07-01 | Harpoon Therapeutics Inc | Trispecific binding proteins and methods of use |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
EP3377103B1 (en) * | 2015-11-19 | 2021-03-17 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
EP3411404B1 (en) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging antibody constructs |
KR20180103084A (ko) | 2016-02-03 | 2018-09-18 | 암젠 리서치 (뮌헨) 게엠베하 | Bcma 및 cd3 이중특이성 t 세포 맞물림 항체 작제물 |
US10100106B2 (en) | 2016-05-20 | 2018-10-16 | Harpoon Therapeutics, Inc. | Single domain serum albumin binding protein |
AU2017267793B2 (en) | 2016-05-20 | 2024-01-25 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
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MX2019006043A (es) | 2016-11-23 | 2019-09-26 | Harpoon Therapeutics Inc | Proteína de unión de antígeno prostático específico de membrana. |
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KR102569133B1 (ko) | 2017-10-13 | 2023-08-21 | 하푼 테라퓨틱스, 인크. | 삼중특이적 단백질 및 사용 방법 |
JP7425049B2 (ja) * | 2018-09-25 | 2024-01-30 | ハープーン セラピューティクス,インク. | Dll3結合タンパク質および使用方法 |
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TW202043253A (zh) | 2019-01-28 | 2020-12-01 | 美商安進公司 | 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程 |
KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
TW202132340A (zh) | 2019-11-04 | 2021-09-01 | 美商安進公司 | 治療白血病之方法 |
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-
2014
- 2014-03-17 AR ARP140101221A patent/AR095596A1/es unknown
- 2014-03-17 UY UY0001035484A patent/UY35484A/es not_active Application Discontinuation
- 2014-03-17 HU HUE14718334A patent/HUE045859T2/hu unknown
- 2014-03-17 PT PT147183347T patent/PT2970449T/pt unknown
- 2014-03-17 ES ES14718334T patent/ES2753950T3/es active Active
- 2014-03-17 EP EP14718334.7A patent/EP2970449B1/en active Active
- 2014-03-17 SI SI201431376T patent/SI2970449T1/sl unknown
- 2014-03-17 LT LT14718334T patent/LT2970449T/lt unknown
- 2014-03-17 EP EP19198850.0A patent/EP3653642A1/en not_active Withdrawn
- 2014-03-17 PL PL14718334T patent/PL2970449T3/pl unknown
- 2014-03-17 TW TW103109995A patent/TW201525001A/zh unknown
- 2014-03-17 DK DK14718334T patent/DK2970449T3/da active
- 2014-03-17 WO PCT/EP2014/055223 patent/WO2014140358A1/en active Application Filing
- 2014-03-17 US US14/774,301 patent/US20160122436A1/en not_active Abandoned
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2019
- 2019-06-18 US US16/444,144 patent/US20200040099A1/en not_active Abandoned
- 2019-11-28 CY CY20191101251T patent/CY1122564T1/el unknown
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CY1122564T1 (el) | 2021-01-27 |
WO2014140358A1 (en) | 2014-09-18 |
EP2970449B1 (en) | 2019-09-25 |
PL2970449T3 (pl) | 2020-04-30 |
LT2970449T (lt) | 2019-11-25 |
UY35484A (es) | 2014-10-31 |
TW201525001A (zh) | 2015-07-01 |
PT2970449T (pt) | 2019-11-06 |
EP2970449A1 (en) | 2016-01-20 |
ES2753950T3 (es) | 2020-04-15 |
DK2970449T3 (da) | 2019-11-25 |
EP3653642A1 (en) | 2020-05-20 |
US20200040099A1 (en) | 2020-02-06 |
SI2970449T1 (sl) | 2019-11-29 |
US20160122436A1 (en) | 2016-05-05 |
HUE045859T2 (hu) | 2020-01-28 |
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