LT2970449T - Viengrandės surišančios molekulės, apimančios n galo abp - Google Patents
Viengrandės surišančios molekulės, apimančios n galo abpInfo
- Publication number
- LT2970449T LT2970449T LT14718334T LT14718334T LT2970449T LT 2970449 T LT2970449 T LT 2970449T LT 14718334 T LT14718334 T LT 14718334T LT 14718334 T LT14718334 T LT 14718334T LT 2970449 T LT2970449 T LT 2970449T
- Authority
- LT
- Lithuania
- Prior art keywords
- single chain
- binding molecules
- chain binding
- abp
- terminal
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361792073P | 2013-03-15 | 2013-03-15 | |
PCT/EP2014/055223 WO2014140358A1 (en) | 2013-03-15 | 2014-03-17 | Single chain binding molecules comprising n-terminal abp |
Publications (1)
Publication Number | Publication Date |
---|---|
LT2970449T true LT2970449T (lt) | 2019-11-25 |
Family
ID=50513887
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
LT14718334T LT2970449T (lt) | 2013-03-15 | 2014-03-17 | Viengrandės surišančios molekulės, apimančios n galo abp |
Country Status (14)
Country | Link |
---|---|
US (2) | US20160122436A1 (lt) |
EP (2) | EP3653642A1 (lt) |
AR (1) | AR095596A1 (lt) |
CY (1) | CY1122564T1 (lt) |
DK (1) | DK2970449T3 (lt) |
ES (1) | ES2753950T3 (lt) |
HU (1) | HUE045859T2 (lt) |
LT (1) | LT2970449T (lt) |
PL (1) | PL2970449T3 (lt) |
PT (1) | PT2970449T (lt) |
SI (1) | SI2970449T1 (lt) |
TW (1) | TW201525001A (lt) |
UY (1) | UY35484A (lt) |
WO (1) | WO2014140358A1 (lt) |
Families Citing this family (33)
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KR101997241B1 (ko) | 2015-05-21 | 2019-07-09 | 하푼 테라퓨틱스, 인크. | 삼중특이성 결합 단백질 및 사용 방법 |
TWI796283B (zh) | 2015-07-31 | 2023-03-21 | 德商安美基研究(慕尼黑)公司 | Msln及cd3抗體構築體 |
TWI744242B (zh) | 2015-07-31 | 2021-11-01 | 德商安美基研究(慕尼黑)公司 | Egfrviii及cd3抗體構築體 |
TWI829617B (zh) | 2015-07-31 | 2024-01-21 | 德商安美基研究(慕尼黑)公司 | Flt3及cd3抗體構築體 |
EP3903818A1 (en) * | 2015-11-19 | 2021-11-03 | Revitope Limited | Functional antibody fragment complementation for a two-components system for redirected killing of unwanted cells |
EP3411404B1 (en) | 2016-02-03 | 2022-11-09 | Amgen Research (Munich) GmbH | Psma and cd3 bispecific t cell engaging antibody constructs |
BR112018015715A2 (pt) | 2016-02-03 | 2019-02-05 | Amgen Inc | construtos de anticorpo de engate de célula t biespecífica bcma e cd3 |
EA039859B1 (ru) | 2016-02-03 | 2022-03-21 | Эмджен Рисерч (Мюник) Гмбх | Биспецифические конструкты антител, связывающие egfrviii и cd3 |
BR112018073739A2 (pt) | 2016-05-20 | 2019-02-26 | Harpoon Therapeutics, Inc. | proteína de ligação de albumina sérica de domínio único |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
JP7042467B2 (ja) | 2016-05-20 | 2022-03-28 | ハープーン セラピューティクス,インク. | 単鎖可変フラグメントcd3結合タンパク質 |
WO2018091621A1 (en) * | 2016-11-17 | 2018-05-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for increasing endogenous protein level |
MX2019006045A (es) | 2016-11-23 | 2019-11-11 | Harpoon Therapeutics Inc | Proteinas triespecificas dirigidas a psma y metodos de uso. |
KR102275008B1 (ko) | 2016-11-23 | 2021-07-13 | 하푼 테라퓨틱스, 인크. | 전립선 특이 막 항원 결합 단백질 |
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US11136403B2 (en) | 2017-10-13 | 2021-10-05 | Harpoon Therapeutics, Inc. | Trispecific proteins and methods of use |
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TW202043253A (zh) | 2019-01-28 | 2020-12-01 | 美商安進公司 | 藉由將藥物物質和藥物產品過程整體化的生物製劑製造之連續製造過程 |
KR102503349B1 (ko) | 2019-05-14 | 2023-02-23 | 프로벤션 바이오, 인코포레이티드 | 제1형 당뇨병을 예방하기 위한 방법 및 조성물 |
TW202132340A (zh) | 2019-11-04 | 2021-09-01 | 美商安進公司 | 治療白血病之方法 |
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WO2022060878A1 (en) | 2020-09-16 | 2022-03-24 | Amgen Inc. | Methods for treating prostate cancer |
AU2021345124A1 (en) | 2020-09-16 | 2023-03-30 | Amgen Inc. | Methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer |
TW202237654A (zh) | 2020-12-09 | 2022-10-01 | 美商詹努克斯治療有限公司 | 與經腫瘤活化之靶定psma及效應細胞抗原之抗體相關之組合物及方法 |
JP2024509878A (ja) | 2021-03-10 | 2024-03-05 | アムジエン・インコーポレーテツド | パラレルクロマトグラフィーシステム及び方法 |
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-
2014
- 2014-03-17 WO PCT/EP2014/055223 patent/WO2014140358A1/en active Application Filing
- 2014-03-17 EP EP19198850.0A patent/EP3653642A1/en not_active Withdrawn
- 2014-03-17 DK DK14718334T patent/DK2970449T3/da active
- 2014-03-17 EP EP14718334.7A patent/EP2970449B1/en active Active
- 2014-03-17 US US14/774,301 patent/US20160122436A1/en not_active Abandoned
- 2014-03-17 PL PL14718334T patent/PL2970449T3/pl unknown
- 2014-03-17 TW TW103109995A patent/TW201525001A/zh unknown
- 2014-03-17 PT PT147183347T patent/PT2970449T/pt unknown
- 2014-03-17 SI SI201431376T patent/SI2970449T1/sl unknown
- 2014-03-17 UY UY0001035484A patent/UY35484A/es not_active Application Discontinuation
- 2014-03-17 HU HUE14718334A patent/HUE045859T2/hu unknown
- 2014-03-17 AR ARP140101221A patent/AR095596A1/es unknown
- 2014-03-17 ES ES14718334T patent/ES2753950T3/es active Active
- 2014-03-17 LT LT14718334T patent/LT2970449T/lt unknown
-
2019
- 2019-06-18 US US16/444,144 patent/US20200040099A1/en not_active Abandoned
- 2019-11-28 CY CY20191101251T patent/CY1122564T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US20200040099A1 (en) | 2020-02-06 |
UY35484A (es) | 2014-10-31 |
EP2970449B1 (en) | 2019-09-25 |
PT2970449T (pt) | 2019-11-06 |
US20160122436A1 (en) | 2016-05-05 |
AR095596A1 (es) | 2015-10-28 |
ES2753950T3 (es) | 2020-04-15 |
PL2970449T3 (pl) | 2020-04-30 |
DK2970449T3 (da) | 2019-11-25 |
SI2970449T1 (sl) | 2019-11-29 |
EP3653642A1 (en) | 2020-05-20 |
EP2970449A1 (en) | 2016-01-20 |
HUE045859T2 (hu) | 2020-01-28 |
WO2014140358A1 (en) | 2014-09-18 |
TW201525001A (zh) | 2015-07-01 |
CY1122564T1 (el) | 2021-01-27 |
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