BR112016002401A8 - Métodos para reduzir as taxas de exacerbação de asma usando benralizumab - Google Patents

Métodos para reduzir as taxas de exacerbação de asma usando benralizumab

Info

Publication number
BR112016002401A8
BR112016002401A8 BR112016002401A BR112016002401A BR112016002401A8 BR 112016002401 A8 BR112016002401 A8 BR 112016002401A8 BR 112016002401 A BR112016002401 A BR 112016002401A BR 112016002401 A BR112016002401 A BR 112016002401A BR 112016002401 A8 BR112016002401 A8 BR 112016002401A8
Authority
BR
Brazil
Prior art keywords
benralizumab
methods
reducing
asthma
asthma exacerbation
Prior art date
Application number
BR112016002401A
Other languages
English (en)
Other versions
BR112016002401A2 (pt
Inventor
Ward Christine
Roskos Lorin
Wang Bing
Raible Donald
Original Assignee
Medimmune Llc
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Llc, Astrazeneca Ab filed Critical Medimmune Llc
Publication of BR112016002401A2 publication Critical patent/BR112016002401A2/pt
Publication of BR112016002401A8 publication Critical patent/BR112016002401A8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Dermatology (AREA)

Abstract

USO DE BENRALIZUMAB OU DE UM SEU FRAGMENTO DE LIGAÇÃO AO ANTÍGENO PARA REDUZIR AS TAXAS DE EXACERBAÇÃO DE ASMA E BENRALIZUMAB OU DE UM SEU FRAGMENTO DE LIGAÇÃO AO ANTÍGENO PARA USO EM UM MÉTODO PARA REDUÇÃO DA TAXA DE EXACERBAÇÃO ANUAL DE ASMAN. Este documento são conferidos métodos para redução de exacerbações de asma em um paciente com asma, compreendendo a administração ao paciente de uma quantidade eficaz de um anticorpo receptor da anti-interleucina-5 (IL-5R) benralizumab ou de um seu fragmento de ligação ao antígeno.
BR112016002401A 2013-08-12 2014-08-07 Métodos para reduzir as taxas de exacerbação de asma usando benralizumab BR112016002401A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361864944P 2013-08-12 2013-08-12
PCT/US2014/050080 WO2015023504A1 (en) 2013-08-12 2014-08-07 Methods for reducing exacerbation rates of asthma using benralizumab

Publications (2)

Publication Number Publication Date
BR112016002401A2 BR112016002401A2 (pt) 2017-09-12
BR112016002401A8 true BR112016002401A8 (pt) 2018-06-12

Family

ID=52448837

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016002401A BR112016002401A8 (pt) 2013-08-12 2014-08-07 Métodos para reduzir as taxas de exacerbação de asma usando benralizumab

Country Status (25)

Country Link
US (2) US9441037B2 (pt)
EP (1) EP3033101B1 (pt)
JP (4) JP6746495B2 (pt)
KR (2) KR20220057637A (pt)
CN (2) CN111588848A (pt)
AU (2) AU2014306956B2 (pt)
BR (1) BR112016002401A8 (pt)
CA (1) CA2918105C (pt)
CY (1) CY1122132T1 (pt)
DK (1) DK3033101T3 (pt)
ES (1) ES2716906T3 (pt)
HK (2) HK1221644A1 (pt)
HR (1) HRP20190405T1 (pt)
HU (1) HUE042607T2 (pt)
LT (1) LT3033101T (pt)
ME (1) ME03348B (pt)
MX (1) MX368508B (pt)
PL (1) PL3033101T3 (pt)
PT (1) PT3033101T (pt)
RS (1) RS58404B1 (pt)
RU (1) RU2676333C2 (pt)
SG (2) SG11201600481UA (pt)
SI (1) SI3033101T1 (pt)
TR (1) TR201903312T4 (pt)
WO (1) WO2015023504A1 (pt)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3520811T (pt) * 2013-08-12 2021-03-15 Astrazeneca Ab Métodos para aumentar o volume expiratório forçado em asmáticos usando benralizumabe
RU2020123894A (ru) 2013-08-12 2020-09-18 Астразенека Аб Способы нормализации симптомов астмы с применением бенрализумаба
SG10201807318RA (en) * 2013-10-15 2018-09-27 Astrazeneca Ab Methods for treating chronic obstructive pulmonary disease using benralizumab
CN113350278B (zh) * 2013-10-24 2023-03-24 阿斯利康(瑞典)有限公司 稳定的水性抗体配制品
EP3092253B1 (en) 2014-01-10 2021-03-17 AnaptysBio, Inc. Antibodies directed against interleukin-33 (il-33)
US10846696B2 (en) 2015-08-24 2020-11-24 Samsung Electronics Co., Ltd. Apparatus and method for trusted execution environment based secure payment transactions
US10699274B2 (en) 2015-08-24 2020-06-30 Samsung Electronics Co., Ltd. Apparatus and method for secure electronic payment
AU2016349113A1 (en) 2015-11-04 2018-06-07 Astrazeneca Ab Dipeptidyl peptidase-4 and periostin as predictors of clinical response to eosinophil-targeted therapeutic agents in eosinophilic diseases
ES2981555T3 (es) 2017-01-04 2024-10-09 Worg Pharmaceuticals Zhejiang Co Ltd Péptidos de S-arrestina y usos terapéuticos de los mismos
RU2698048C2 (ru) * 2017-10-03 2019-08-21 Закрытое Акционерное Общество "Биокад" МОНОКЛОНАЛЬНОЕ АНТИТЕЛО К IL-5Rα
TW202021983A (zh) * 2018-09-21 2020-06-16 美商安納普提斯生物公司 用於嗜伊紅性氣喘之抗il-33療法
TW202214692A (zh) * 2020-06-05 2022-04-16 瑞典商阿斯特捷利康公司 治療患有鼻瘜肉的患者的重度氣喘之方法

Family Cites Families (17)

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AU690474B2 (en) 1995-09-11 1998-04-23 Kyowa Hakko Kirin Co., Ltd. Antibody againts alpha-chain of human interleukin 5 receptor
US6746839B1 (en) * 1998-01-12 2004-06-08 Interleukin Genetics, Inc. Diagnostics and therapeutics for an obstructive airway disease
EP2275541B1 (en) 1999-04-09 2016-03-23 Kyowa Hakko Kirin Co., Ltd. Method for controlling the activity of immunologically functional molecule
US7404953B2 (en) 2000-02-15 2008-07-29 Kyowa Hakko Kogyo Co., Ltd. Methods using eosinophil-specific apoptosis inducer
US6946292B2 (en) 2000-10-06 2005-09-20 Kyowa Hakko Kogyo Co., Ltd. Cells producing antibody compositions with increased antibody dependent cytotoxic activity
US7662925B2 (en) 2002-03-01 2010-02-16 Xencor, Inc. Optimized Fc variants and methods for their generation
JPWO2005035583A1 (ja) 2003-10-08 2007-11-22 協和醗酵工業株式会社 Ｉｌ−５受容体に特異的に結合する抗体組成物
US20060014680A1 (en) 2004-07-13 2006-01-19 Caiding Xu Peptides and compounds that bind to the IL-5 receptor
CA2624189A1 (en) 2005-10-03 2007-04-12 Xencor, Inc. Fc variants with optimized fc receptor binding properties
BRPI0811526A2 (pt) * 2007-05-14 2017-05-16 Biowa Inc uso de um anticorpo monoclonal, quimérico, humanizado ou humano que liga o il-5r, anticorpo anti-il-5r isolado, e, epítopo isolado de il-5r alfa
RU2383345C1 (ru) * 2008-08-07 2010-03-10 Государственное образовательное учреждение высшего профессионального образования "Нижегородская государственная медицинская академия Росздрава" (ГОУ ВПО "НИЖГМА РОСЗДРАВА") Способ лечения больных бронхиальной астмой
WO2011062984A1 (en) * 2009-11-18 2011-05-26 Medicinova, Inc. Treatment of acute exacerbation of asthma and reduction of likelihood of hospitalization of patients suffering therefrom
CA2817380C (en) * 2010-12-16 2019-06-04 Genentech, Inc. Diagnosis and treatments relating to th2 inhibition
EP2710370A4 (en) * 2011-05-18 2015-01-07 Medimmune Llc METHODS OF DIAGNOSING AND TREATING PULMONARY DISEASES OR DISORDERS
KR20140097217A (ko) 2011-11-01 2014-08-06 메디뮨 엘엘씨 급성 천식 악화의 빈도 및 중증도를 감소시키는 방법
PT3520811T (pt) * 2013-08-12 2021-03-15 Astrazeneca Ab Métodos para aumentar o volume expiratório forçado em asmáticos usando benralizumabe
RU2020123894A (ru) 2013-08-12 2020-09-18 Астразенека Аб Способы нормализации симптомов астмы с применением бенрализумаба

Also Published As

Publication number Publication date
CA2918105C (en) 2023-02-28
EP3033101B1 (en) 2018-12-19
JP6746495B2 (ja) 2020-08-26
HUE042607T2 (hu) 2019-07-29
HRP20190405T1 (hr) 2019-04-19
HK1225302B (zh) 2017-09-08
CA2918105A1 (en) 2015-02-19
CN105451760A (zh) 2016-03-30
KR20160042121A (ko) 2016-04-18
MX368508B (es) 2019-10-07
JP2020128375A (ja) 2020-08-27
US20170198049A1 (en) 2017-07-13
EP3033101A4 (en) 2017-07-12
RU2016108723A (ru) 2017-09-19
RU2016108723A3 (pt) 2018-06-18
CN111588848A (zh) 2020-08-28
JP2024129139A (ja) 2024-09-26
ME03348B (me) 2019-10-20
MX2016001383A (es) 2016-08-03
SG10202005560UA (en) 2020-07-29
ES2716906T3 (es) 2019-06-17
PL3033101T3 (pl) 2019-06-28
TR201903312T4 (tr) 2019-04-22
JP2016527324A (ja) 2016-09-08
US20150044202A1 (en) 2015-02-12
AU2020201327A1 (en) 2020-03-12
JP2022120009A (ja) 2022-08-17
WO2015023504A1 (en) 2015-02-19
BR112016002401A2 (pt) 2017-09-12
KR20220057637A (ko) 2022-05-09
LT3033101T (lt) 2019-03-25
SG11201600481UA (en) 2016-02-26
DK3033101T3 (en) 2019-04-08
AU2014306956A1 (en) 2016-02-04
WO2015023504A8 (en) 2015-09-24
SI3033101T1 (sl) 2019-04-30
AU2014306956B2 (en) 2019-11-21
EP3033101A1 (en) 2016-06-22
US9441037B2 (en) 2016-09-13
RS58404B1 (sr) 2019-04-30
RU2676333C2 (ru) 2018-12-28
KR102390714B1 (ko) 2022-04-26
PT3033101T (pt) 2019-04-02
HK1221644A1 (zh) 2017-06-09
CY1122132T1 (el) 2020-11-25

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Owner name: ASTRAZENECA AB (SE)

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B25A Requested transfer of rights approved

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B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]