SA518391028B1 - Cd37 أجسام مضادة واختبارات للكشف عن - Google Patents
Cd37 أجسام مضادة واختبارات للكشف عنInfo
- Publication number
- SA518391028B1 SA518391028B1 SA518391028A SA518391028A SA518391028B1 SA 518391028 B1 SA518391028 B1 SA 518391028B1 SA 518391028 A SA518391028 A SA 518391028A SA 518391028 A SA518391028 A SA 518391028A SA 518391028 B1 SA518391028 B1 SA 518391028B1
- Authority
- SA
- Saudi Arabia
- Prior art keywords
- antibodies
- assays
- detection
- relates
- ihc
- Prior art date
Links
- 238000003556 assay Methods 0.000 title abstract 3
- 238000001514 detection method Methods 0.000 title abstract 2
- 101000777628 Homo sapiens Leukocyte antigen CD37 Proteins 0.000 abstract 3
- 102100031586 Leukocyte antigen CD37 Human genes 0.000 abstract 2
- 230000002055 immunohistochemical effect Effects 0.000 abstract 2
- 102000048426 human CD37 Human genes 0.000 abstract 1
- 238000010186 staining Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/531—Production of immunochemical test materials
- G01N33/532—Production of labelled immunochemicals
- G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Hospice & Palliative Care (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Abstract
يتعلق الاختراع بشكل عام بأجسام مضادة ترتبط مع CD37 بشري واختبارات تشخيصية لعلاجات معتمدة على CD37. بصفة خاصة أكثر، يتعلق الاختراع بأجسام مضادة للكشف عن CD37 بواسطة التبقع، مثلاً للاستخدام في اختبارات الكيمياء الهيستولوجية المناعية (IHC).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562211455P | 2015-08-28 | 2015-08-28 | |
US201562212183P | 2015-08-31 | 2015-08-31 | |
PCT/US2016/048887 WO2017040247A1 (en) | 2015-08-28 | 2016-08-26 | Antibodies and assays for detection of cd37 |
Publications (1)
Publication Number | Publication Date |
---|---|
SA518391028B1 true SA518391028B1 (ar) | 2022-07-19 |
Family
ID=58188089
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SA518391028A SA518391028B1 (ar) | 2015-08-28 | 2018-02-27 | Cd37 أجسام مضادة واختبارات للكشف عن |
Country Status (15)
Country | Link |
---|---|
US (1) | US11104740B2 (ar) |
EP (1) | EP3341414A4 (ar) |
JP (1) | JP6890581B2 (ar) |
KR (1) | KR20180042423A (ar) |
CN (1) | CN108699144B (ar) |
AU (1) | AU2016316758B2 (ar) |
BR (1) | BR112018003147A2 (ar) |
CA (1) | CA2995243A1 (ar) |
EA (1) | EA201890347A1 (ar) |
HK (1) | HK1257199A1 (ar) |
IL (1) | IL257354B2 (ar) |
MA (1) | MA42706A (ar) |
MX (1) | MX2018002467A (ar) |
SA (1) | SA518391028B1 (ar) |
WO (1) | WO2017040247A1 (ar) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
LT2544719T (lt) | 2010-03-12 | 2019-10-25 | Debiopharm Int Sa | Cd37 surišančios molekulės, ir jų imunokonjugatai |
JP6018622B2 (ja) | 2011-04-01 | 2016-11-02 | イミュノジェン, インコーポレイテッド | Cd37結合性分子及びその免疫複合体 |
MX2017015039A (es) | 2015-06-08 | 2018-08-09 | Debiopharm Int Sa | Combinaciones de inmunoconjugado anti-cd37 y anticuerpo anti-cd20. |
CA2995243A1 (en) | 2015-08-28 | 2017-03-09 | Debiopharm International, S.A. | Antibodies and assays for detection of cd37 |
EP3535297B1 (en) | 2016-11-02 | 2022-08-10 | Debiopharm International, S.A. | Methods for improving anti-cd37 immunoconjugate therapy |
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ES2741643T3 (es) | 2013-06-07 | 2020-02-11 | Nordic Nanovector Asa | Terapia de combinación que comprende un anticuerpo anti-CD20 y el anticuerpo monoclonal HH1 radiomarcado |
EP3043775B1 (en) | 2013-09-11 | 2020-11-04 | Eagle Biologics, Inc. | Liquid protein formulations containing viscosity-lowering agents |
CN114632158A (zh) | 2013-11-07 | 2022-06-17 | 豪夫迈·罗氏有限公司 | 抗cd20抗体与btk抑制剂的组合疗法 |
WO2015116729A2 (en) * | 2014-01-28 | 2015-08-06 | Emergent Product Development Seattle, Llc | Anti-cd37 antibody and anti-cd20 antibody combination therapy for treatment of b-cell malignancies and disorders |
WO2015175533A2 (en) | 2014-05-13 | 2015-11-19 | Immunogen, Inc. | Anti-cd37 immunoconjugate dosing regimens |
MX2017015039A (es) | 2015-06-08 | 2018-08-09 | Debiopharm Int Sa | Combinaciones de inmunoconjugado anti-cd37 y anticuerpo anti-cd20. |
CA2995243A1 (en) | 2015-08-28 | 2017-03-09 | Debiopharm International, S.A. | Antibodies and assays for detection of cd37 |
EP3535297B1 (en) | 2016-11-02 | 2022-08-10 | Debiopharm International, S.A. | Methods for improving anti-cd37 immunoconjugate therapy |
AU2019277836A1 (en) | 2018-05-30 | 2021-01-21 | Debiopharm International, S.A. | Anti-CD37 immunoconjugate dosing regimens |
-
2016
- 2016-08-26 CA CA2995243A patent/CA2995243A1/en active Pending
- 2016-08-26 KR KR1020187008906A patent/KR20180042423A/ko not_active Application Discontinuation
- 2016-08-26 MA MA042706A patent/MA42706A/fr unknown
- 2016-08-26 MX MX2018002467A patent/MX2018002467A/es unknown
- 2016-08-26 BR BR112018003147A patent/BR112018003147A2/pt active Search and Examination
- 2016-08-26 WO PCT/US2016/048887 patent/WO2017040247A1/en active Application Filing
- 2016-08-26 CN CN201680047510.1A patent/CN108699144B/zh active Active
- 2016-08-26 EP EP16842668.2A patent/EP3341414A4/en active Pending
- 2016-08-26 US US15/756,345 patent/US11104740B2/en active Active
- 2016-08-26 EA EA201890347A patent/EA201890347A1/ru unknown
- 2016-08-26 JP JP2018510734A patent/JP6890581B2/ja active Active
- 2016-08-26 AU AU2016316758A patent/AU2016316758B2/en active Active
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2018
- 2018-02-05 IL IL257354A patent/IL257354B2/en unknown
- 2018-02-27 SA SA518391028A patent/SA518391028B1/ar unknown
- 2018-12-18 HK HK18116201.1A patent/HK1257199A1/zh unknown
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Publication number | Publication date |
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CA2995243A1 (en) | 2017-03-09 |
EA201890347A1 (ru) | 2018-09-28 |
CN108699144A (zh) | 2018-10-23 |
JP2018532699A (ja) | 2018-11-08 |
AU2016316758A1 (en) | 2018-03-15 |
US20180244795A1 (en) | 2018-08-30 |
CN108699144B (zh) | 2022-07-19 |
HK1257199A1 (zh) | 2019-10-18 |
IL257354B2 (en) | 2023-08-01 |
WO2017040247A1 (en) | 2017-03-09 |
KR20180042423A (ko) | 2018-04-25 |
MA42706A (fr) | 2021-04-14 |
IL257354B1 (en) | 2023-04-01 |
IL257354A (en) | 2018-04-30 |
MX2018002467A (es) | 2018-06-15 |
EP3341414A4 (en) | 2019-03-27 |
US11104740B2 (en) | 2021-08-31 |
BR112018003147A2 (pt) | 2018-09-18 |
AU2016316758B2 (en) | 2023-02-02 |
EP3341414A1 (en) | 2018-07-04 |
JP6890581B2 (ja) | 2021-06-18 |
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