SG11201901716TA - Adenovirus armed with bispecific t cell engager (bite) - Google Patents

Adenovirus armed with bispecific t cell engager (bite)

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Publication number
SG11201901716TA
SG11201901716TA SG11201901716TA SG11201901716TA SG11201901716TA SG 11201901716T A SG11201901716T A SG 11201901716TA SG 11201901716T A SG11201901716T A SG 11201901716TA SG 11201901716T A SG11201901716T A SG 11201901716TA SG 11201901716T A SG11201901716T A SG 11201901716TA
Authority
SG
Singapore
Prior art keywords
enad
psioxus
international
house
virus
Prior art date
Application number
SG11201901716TA
Inventor
Brian Champion
Alice Bromley
Joshua Freedman
Kerry Fisher
Leonard Seymour
Original Assignee
Psioxus Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1614607.8A external-priority patent/GB201614607D0/en
Priority claimed from GBGB1700663.6A external-priority patent/GB201700663D0/en
Priority claimed from GBGB1706219.1A external-priority patent/GB201706219D0/en
Priority claimed from GBGB1713765.4A external-priority patent/GB201713765D0/en
Application filed by Psioxus Therapeutics Ltd filed Critical Psioxus Therapeutics Ltd
Publication of SG11201901716TA publication Critical patent/SG11201901716TA/en

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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/761—Adenovirus
    • A—HUMAN NECESSITIES
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    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/522—Alpha-chemokines, e.g. NAP-2, ENA-78, GRO-alpha/MGSA/NAP-3, GRO-beta/MIP-2alpha, GRO-gamma/MIP-2beta, IP-10, GCP-2, MIG, PBSF, PF-4, KC
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • A61K2039/525—Virus
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    • A61K2039/55522—Cytokines; Lymphokines; Interferons
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    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
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    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/75—Agonist effect on antigen
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    • C07K2319/92—Fusion polypeptide containing a motif for post-translational modification containing an intein ("protein splicing")domain
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    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/44—Vectors comprising a special translation-regulating system being a specific part of the splice mechanism, e.g. donor, acceptor

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 08 March 2018 (08.03.2018) WIPO I PCT ill IIIIIl °million °nolo otiminumo oimIE (10) International Publication Number WO 2018/041827 Al No T-cells added Uninfected EnAd EnAd-CMV-ControlBiTE EnAd-CMV-EpCAMBiTE EnAd-SA-ControlBiTE EnAd-SA-EpCAMBiTE (51) International Patent Classification: A61K 39/395 (2006.01) C07K 16/30 (2006.01) A61K 35/761 (2015.01) C07K 16/40 (2006.01) C07K 16/28 (2006.01) C12N 15/861 (2006.01) (21) International Application Number: PCT/EP2017/071655 (22) International Filing Date: 29 August 2017 (29.08.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 1614607.8 29 August 2016 (29.08.2016) GB 1700663.6 13 January 2017 (13.01.2017) GB 1706219.1 19 April 2017 (19.04.2017) GB 1713765.4 28 August 2017 (28.08.2017) GB (71) Applicant: PSIOXUS THERAPEUTICS LIMITED [GB/GB]; PsiOxus House, 4-10 The Quadrant, Barton Lane, Abingdon, Oxfordshire OX14 3YS (GB). (72) Inventors: CHAMPION, Brian, Robert; PsiOxus Ther- apeutics Ltd, PsiOxus House, 4-10 The Quadrant, Barton Lane, Abingdon, Oxfordshire OX14 3YS (GB). BROWN, Alice, Claire, Noel; PsiOxus Therapeutics Ltd, PsiOxus House, 4-10 The Quadrant, Barton Lane, Abingdon, Ox- fordshire OX14 3YS (GB). FREEDMAN, Joshua, David; 83 Manor Road, Chigwell IG7 5PH (GB). FISHER, Kerry, David; 11 Cassington Road Eynsham, Witney OX29 4LH (GB). SEYMOUR, Leonard, William; 5 Workhouse Yard Chapel Hill, Wootton by Woodstock OX20 1YD (GB). (74) Agent: STERLING IP LTD; Orion House, Bessemer Road, Welwyn Garden City, UNITED KINGDOM AL7 1HH (GB). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (54) Title: ADENOVIRUS ARMED WITH BISPECIFIC T CELL ENGAGER (BITE) Figure 31 -N- With T-cells added Uninfected .4 6 EnN.: -CAN-ControtBITE EnAci.- Cti,V-Er.) ;A111:31TE EnAd-SA-EpGA;4;i3iTE co O (57) : A modified adenovirus, in particular Enadenotucirev (EnAd), armed with at least two bispecific T cell engager (BiTE) co each comprising at least two binding domains, wherein at least one of the domains is specific for a surface antigen on an immune cell of interest, such as a T-cell of interest. Also provided are a composition, such as a pharmaceutical formulation comprising the virus, O use of the virus and virus formulations for treatment, such as in the treatment of cancer. The disclosure also extends to processes for preparing the virus. C [Continued on next page] WO 2018/041827 Al MIDEDIMOMOIDEIREEMOOVIVHEIDIDEBER OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
SG11201901716TA 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite) SG11201901716TA (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1614607.8A GB201614607D0 (en) 2016-08-29 2016-08-29 Modified adenovirus
GBGB1700663.6A GB201700663D0 (en) 2017-01-13 2017-01-13 Modified adenovirus
GBGB1706219.1A GB201706219D0 (en) 2017-04-19 2017-04-19 Modified adenovirus
GBGB1713765.4A GB201713765D0 (en) 2017-08-28 2017-08-28 Modified adenovirus
PCT/EP2017/071655 WO2018041827A1 (en) 2016-08-29 2017-08-29 Adenovirus armed with bispecific t cell engager (bite)

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SG11201901716TA true SG11201901716TA (en) 2019-03-28

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US (2) US20190194690A1 (en)
EP (3) EP4273252A3 (en)
JP (3) JP2019532621A (en)
KR (2) KR102491752B1 (en)
CN (2) CN110214025A (en)
AU (1) AU2017320776A1 (en)
BR (1) BR112019003866A2 (en)
CA (2) CA3033267A1 (en)
CL (1) CL2019000510A1 (en)
CO (1) CO2019002371A2 (en)
IL (2) IL264902B2 (en)
MX (1) MX2019002328A (en)
MY (1) MY197324A (en)
PH (1) PH12019500436A1 (en)
SG (2) SG11201901716TA (en)
WO (2) WO2018041838A1 (en)
ZA (1) ZA201900644B (en)

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US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US9605084B2 (en) 2013-03-15 2017-03-28 Xencor, Inc. Heterodimeric proteins
US10968276B2 (en) 2013-03-12 2021-04-06 Xencor, Inc. Optimized anti-CD3 variable regions
AU2014205086B2 (en) 2013-01-14 2019-04-18 Xencor, Inc. Novel heterodimeric proteins
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
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