MA55529A - Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite - Google Patents

Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite

Info

Publication number
MA55529A
MA55529A MA055529A MA55529A MA55529A MA 55529 A MA55529 A MA 55529A MA 055529 A MA055529 A MA 055529A MA 55529 A MA55529 A MA 55529A MA 55529 A MA55529 A MA 55529A
Authority
MA
Morocco
Prior art keywords
binding polypeptides
alpha beta
tcr binding
beta tcr
reduced fragmentation
Prior art date
Application number
MA055529A
Other languages
English (en)
Inventor
Huawei Qiu
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of MA55529A publication Critical patent/MA55529A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
MA055529A 2019-04-03 2020-04-02 Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite MA55529A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962828601P 2019-04-03 2019-04-03

Publications (1)

Publication Number Publication Date
MA55529A true MA55529A (fr) 2022-02-09

Family

ID=70457130

Family Applications (1)

Application Number Title Priority Date Filing Date
MA055529A MA55529A (fr) 2019-04-03 2020-04-02 Polypeptides de liaison anti-alpha bêta tcr à fragmentation réduite

Country Status (8)

Country Link
US (1) US20220153840A1 (fr)
EP (1) EP3947458A1 (fr)
JP (1) JP2022521850A (fr)
CN (1) CN113939534A (fr)
AU (1) AU2020253455A1 (fr)
CA (1) CA3135032A1 (fr)
MA (1) MA55529A (fr)
WO (1) WO2020206063A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201506088RA (en) 2013-03-11 2015-09-29 Genzyme Corp Hyperglycosylated binding polypeptides
RS64072B1 (sr) 2014-03-19 2023-04-28 Genzyme Corp Mesto-specifični glikoinženjering ciljnih delova
JP7137696B2 (ja) 2019-05-14 2022-09-14 プロヴェンション・バイオ・インコーポレイテッド １型糖尿病を予防するための方法および組成物

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Also Published As

Publication number Publication date
CA3135032A1 (fr) 2020-10-08
US20220153840A1 (en) 2022-05-19
EP3947458A1 (fr) 2022-02-09
JP2022521850A (ja) 2022-04-12
CN113939534A (zh) 2022-01-14
AU2020253455A1 (en) 2021-11-04
WO2020206063A1 (fr) 2020-10-08

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