BR112021015907A2 - Ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis - Google Patents

Ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis

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Publication number
BR112021015907A2
BR112021015907A2 BR112021015907A BR112021015907A BR112021015907A2 BR 112021015907 A2 BR112021015907 A2 BR 112021015907A2 BR 112021015907 A BR112021015907 A BR 112021015907A BR 112021015907 A BR112021015907 A BR 112021015907A BR 112021015907 A2 BR112021015907 A2 BR 112021015907A2
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BR
Brazil
Prior art keywords
catvert
catvern
regulatable
targeting
virus
Prior art date
Application number
BR112021015907A
Other languages
English (en)
Inventor
Brian Hutzen
Chun-Yu Chen
Dawn Chandler
Mark Currier
Pin-Yi Wang
P Cripe Timothy
Original Assignee
Res Inst Nationwide Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Res Inst Nationwide Childrens Hospital filed Critical Res Inst Nationwide Childrens Hospital
Publication of BR112021015907A2 publication Critical patent/BR112021015907A2/pt

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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Abstract

ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis. são fornecidos polinucleotídeos e vetores recombinantes contendo uma estrutura de gene éxon-íntron-éxon engenheirada (artificial) em um transgene, que sofre emenda quando é expresso em uma célula alvo.
BR112021015907A 2019-02-20 2020-02-19 Ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis BR112021015907A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962808264P 2019-02-20 2019-02-20
PCT/US2020/018806 WO2020172259A1 (en) 2019-02-20 2020-02-19 Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers

Publications (1)

Publication Number Publication Date
BR112021015907A2 true BR112021015907A2 (pt) 2021-11-03

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BR112021015907A BR112021015907A2 (pt) 2019-02-20 2020-02-19 Ligantes de células t (catvert) ou nk (catvern) direcionados a câncer, codificados por vírus e reguláveis

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US (1) US20220257760A1 (pt)
EP (1) EP3927750A4 (pt)
JP (1) JP2022521183A (pt)
KR (1) KR20210128399A (pt)
CN (1) CN113646334A (pt)
AU (1) AU2020226524A1 (pt)
BR (1) BR112021015907A2 (pt)
CA (1) CA3129506A1 (pt)
IL (1) IL285617A (pt)
SG (1) SG11202108924RA (pt)
WO (1) WO2020172259A1 (pt)

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KR102503349B1 (ko) 2019-05-14 2023-02-23 프로벤션 바이오, 인코포레이티드 제1형 당뇨병을 예방하기 위한 방법 및 조성물
CN115124625A (zh) * 2021-03-24 2022-09-30 圣安生医股份有限公司 免疫调节及抗肿瘤相关纳米抗体、其核酸编码序列及应用
CN112794916B (zh) * 2021-04-08 2021-08-10 正大天晴药业集团南京顺欣制药有限公司 三特异性抗原结合构建体及构建方法和应用
CA3214540A1 (en) * 2021-04-22 2022-10-27 Pasi A. Janne Compositions and methods for treating cancer
JP2023176123A (ja) * 2022-05-31 2023-12-13 株式会社 光バイオ ウイルスベクター及びそれを含むがん細胞増殖抑制剤

Family Cites Families (10)

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US7879992B2 (en) * 2005-01-31 2011-02-01 Isis Pharmaceuticals, Inc. Modification of MyD88 splicing using modified oligonucleotides
CN104592395B (zh) * 2015-01-27 2017-11-14 中国药科大学 Vegfr2单链抗体与mica融合蛋白的制备方法及用途
KR20180083868A (ko) * 2015-10-30 2018-07-23 알레타 바이오쎄라퓨틱스, 인크. 종양 형질도입용 조성물 및 방법
FR3043914B1 (fr) * 2015-11-23 2017-12-29 Univ Limoges Utilisation d'oligonucleotides antisens pour produire des ig tronquees par saut d'exon pour le traitement de maladies impliquant des cellules de la lignee b.
SG11201808911SA (en) * 2016-04-13 2018-11-29 Sanofi Sa Trispecific and/or trivalent binding proteins
BR112018070676A2 (pt) * 2016-04-15 2019-02-05 Zymeworks Inc construtos de ligação a antígeno multiespecífico que têm como alvo agentes imunoterapêuticos
WO2017186928A1 (en) * 2016-04-29 2017-11-02 Curevac Ag Rna encoding an antibody
US20180126003A1 (en) * 2016-05-04 2018-05-10 Curevac Ag New targets for rna therapeutics
EP3503919B1 (en) * 2016-08-29 2024-04-10 Akamis Bio Limited Adenovirus armed with bispecific t cell engager
US20230242876A1 (en) * 2016-12-30 2023-08-03 Shanghai Sinobio Biotech Co., Ltd. Bifunctional molecule and use thereof

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CA3129506A1 (en) 2020-08-27
JP2022521183A (ja) 2022-04-06
CN113646334A (zh) 2021-11-12
EP3927750A4 (en) 2022-11-02
IL285617A (en) 2021-09-30
US20220257760A1 (en) 2022-08-18
AU2020226524A1 (en) 2021-08-12
WO2020172259A1 (en) 2020-08-27

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