EP3838921A3 - Antibodies to tau - Google Patents

Antibodies to tau Download PDF

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Publication number
EP3838921A3
EP3838921A3 EP20199802.8A EP20199802A EP3838921A3 EP 3838921 A3 EP3838921 A3 EP 3838921A3 EP 20199802 A EP20199802 A EP 20199802A EP 3838921 A3 EP3838921 A3 EP 3838921A3
Authority
EP
European Patent Office
Prior art keywords
tau
antibodies
methods
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP20199802.8A
Other languages
German (de)
French (fr)
Other versions
EP3838921A2 (en
Inventor
David Holtzman
Hong Jiang
Marc Diamond
Najla KFOURY
Brandon HOLMES
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington University in St Louis WUSTL
Original Assignee
University of Washington
Washington University in St Louis WUSTL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington University in St Louis WUSTL filed Critical University of Washington
Publication of EP3838921A2 publication Critical patent/EP3838921A2/en
Publication of EP3838921A3 publication Critical patent/EP3838921A3/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

This invention relates to antibodies to tau and methods of use thereof.
EP20199802.8A 2012-07-03 2013-07-03 Antibodies to tau Withdrawn EP3838921A3 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261667515P 2012-07-03 2012-07-03
US201261694989P 2012-08-30 2012-08-30
EP13813988.6A EP2870176A4 (en) 2012-07-03 2013-07-03 Antibodies to tau
PCT/US2013/049333 WO2014008404A1 (en) 2012-07-03 2013-07-03 Antibodies to tau

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
EP13813988.6A Division EP2870176A4 (en) 2012-07-03 2013-07-03 Antibodies to tau

Publications (2)

Publication Number Publication Date
EP3838921A2 EP3838921A2 (en) 2021-06-23
EP3838921A3 true EP3838921A3 (en) 2021-09-01

Family

ID=49882495

Family Applications (2)

Application Number Title Priority Date Filing Date
EP13813988.6A Withdrawn EP2870176A4 (en) 2012-07-03 2013-07-03 Antibodies to tau
EP20199802.8A Withdrawn EP3838921A3 (en) 2012-07-03 2013-07-03 Antibodies to tau

Family Applications Before (1)

Application Number Title Priority Date Filing Date
EP13813988.6A Withdrawn EP2870176A4 (en) 2012-07-03 2013-07-03 Antibodies to tau

Country Status (16)

Country Link
US (2) US9834596B2 (en)
EP (2) EP2870176A4 (en)
JP (3) JP6345655B2 (en)
KR (3) KR20200013072A (en)
CN (2) CN104781278B (en)
AU (3) AU2013286680B2 (en)
CA (1) CA2877397A1 (en)
HK (1) HK1209768A1 (en)
IL (3) IL236409B (en)
IN (1) IN2015KN00007A (en)
MX (2) MX359555B (en)
MY (1) MY171473A (en)
NZ (2) NZ703423A (en)
RU (2) RU2668159C2 (en)
SG (3) SG10201913370PA (en)
WO (1) WO2014008404A1 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY171473A (en) 2012-07-03 2019-10-15 Univ Washington Antibodies to tau
MX359817B (en) 2012-08-16 2018-10-11 Ipierian Inc Methods of treating a tauopathy.
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
EA035943B1 (en) * 2013-03-13 2020-09-03 Протена Биосайенсес Лимитед Antibody binding to human tau protein
NZ630610A (en) 2014-02-14 2019-05-31 Ipierian Inc Tau peptides, anti-tau antibodies, and methods of use thereof
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
ZA201608812B (en) 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
EP3160999B1 (en) * 2014-06-26 2018-11-28 Janssen Vaccines & Prevention B.V. Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
TWI664190B (en) * 2014-06-27 2019-07-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies
CA2962969C (en) 2014-09-30 2023-03-21 Washington University Tau kinetic measurements
MA41451A (en) * 2015-02-04 2017-12-12 Univ Washington ANTI-TAU CONSTRUCTIONS
TWI669314B (en) 2015-02-26 2019-08-21 美國禮來大藥廠 Antibodies to tau and uses thereof
SG10201911349YA (en) 2015-06-05 2020-01-30 Genentech Inc Anti-tau antibodies and methods of use
MY193677A (en) * 2015-07-06 2022-10-25 UCB Biopharma SRL Tau-binding antibodies
US10344081B2 (en) 2015-07-06 2019-07-09 Ucb Biopharma Sprl Tau-binding antibodies
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
EP3334761B1 (en) * 2015-08-13 2023-07-19 New York University Antibody-based molecules selective for the {p}ser404 epitope of tau and their uses in the diagnosis and treatment of tauopathy
CN105158483A (en) * 2015-09-16 2015-12-16 北京九强生物技术股份有限公司 Quantitative determination kit for hypersensitivity of Troponin I and detection method
CA3022673A1 (en) 2016-05-02 2017-11-09 Prothena Biosciences Limited Tau immunotherapy
MY197413A (en) 2016-05-02 2023-06-16 Prothena Biosciences Ltd Antibodies recognizing tau
IL262726B1 (en) 2016-05-02 2024-03-01 Prothena Biosciences Ltd Antibodies recognizing tau
SI3484916T1 (en) 2016-07-12 2021-08-31 H. Lundbeck A/S Antibodies specific for hyperphosphorylated tau and methods of use thereof
JP6949102B2 (en) 2016-08-09 2021-10-13 イーライ リリー アンド カンパニー Combination therapy
AR110074A1 (en) 2016-11-15 2019-02-20 H Lundbeck As AGENTS, USES AND METHODS FOR THE TREATMENT OF SINUCLEINOPATHY
WO2018106776A2 (en) 2016-12-07 2018-06-14 Genentech, Inc. Anti-tau antibodies and methods of use
WO2018106781A1 (en) 2016-12-07 2018-06-14 Genentech, Inc Anti-tau antibodies and methods of use
CN106749658B (en) * 2016-12-15 2019-11-12 北京师范大学 Inhibit the anitibody type molecular chaperones of Tau albumen aggregation
WO2018109058A1 (en) 2016-12-16 2018-06-21 H. Lundbeck A/S Agents, uses and methods
US10364286B2 (en) * 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
EP3583123A1 (en) 2017-02-17 2019-12-25 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
EP3592387A4 (en) * 2017-03-09 2021-03-31 The Board of Trustees of the Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
EP3619233A4 (en) 2017-05-02 2021-03-03 Prothena Biosciences Limited Antibodies recognizing tau
KR102225178B1 (en) 2017-10-16 2021-03-10 에자이 알앤드디 매니지먼트 가부시키가이샤 Anti-tau antibodies and uses thereof
MX2020009935A (en) 2018-03-23 2021-01-08 Abbvie Deutschland Stable aqueous anti-tau antibody formulations.
EP3784687A1 (en) 2018-04-27 2021-03-03 Ecole Polytechnique Federale De Lausanne (Epfl) A method for preparing phfs-like tau aggregates
EP3829634A1 (en) 2018-07-31 2021-06-09 Eli Lilly and Company Combination therapy
CN109613242A (en) * 2018-11-01 2019-04-12 深圳天辰医疗科技有限公司 A kind of creatine kinase isozyme detection kit and preparation method thereof
TW202100550A (en) 2019-03-03 2021-01-01 愛爾蘭商普羅帝納生物科學公司 Antibodies recognizing tau
KR20210141522A (en) * 2019-03-18 2021-11-23 리제너론 파마슈티칼스 인코포레이티드 CRISPR/Cas Screening Platform to Identify Genetic Modifiers of Tau Seeding or Aggregation
SG11202108090XA (en) 2019-03-18 2021-08-30 Regeneron Pharma Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
CN110055280A (en) * 2019-03-19 2019-07-26 深圳大学 A kind of cell line and its construction method and application of stable expression mCherry-tau
MX2022000603A (en) * 2019-07-15 2022-05-20 Adel Inc Anti-tau antibody and use of same.
MX2022004107A (en) 2019-10-09 2022-08-10 Bluerock Therapeutics Lp Cells with sustained transgene expression.
MX2022006676A (en) * 2019-12-04 2022-07-05 Ac Immune Sa Novel molecules for therapy and diagnosis.
EP4241088A1 (en) * 2020-11-09 2023-09-13 Meso Scale Technologies, LLC Methods and kits for detecting tau
EP4271708A1 (en) 2020-12-29 2023-11-08 Neurimmune AG Human anti-tau antibodies
TW202304974A (en) 2021-03-26 2023-02-01 美商健生生物科技公司 Anti-tau antibodies and uses thereof
WO2022201122A1 (en) 2021-03-26 2022-09-29 Janssen Biotech, Inc. Humanized antibodies against paired helical filament tau and uses thereof

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK546988A (en) 1987-10-02 1989-04-03 Du Pont IMMUNE DETERMINATION AND THE REAGENT SITE USED HEREIN
AU2414092A (en) 1991-08-01 1993-03-02 Paul H. Voorheis Diagnostic method for alzheimer's disease
US5733734A (en) 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
ATE154642T1 (en) 1991-10-25 1997-07-15 Innogenetics Nv MONOCLONAL ANTIBODIES AGAINST THE MICROTUBULUS-ASSOCIATED PROTEIN TAU.
DE69230148T2 (en) 1991-12-06 2000-05-04 Max Planck Gesellschaft Tools for the diagnosis and treatment of Alzheimer's disease.
US7408027B1 (en) 1991-12-06 2008-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften Tools for the diagnosis and treatment of Alzheimer's disease
JPH06239899A (en) 1993-02-12 1994-08-30 Teijin Ltd Antibody for human tau protein and determination of human tau protein in body fluid utilizing the same
CA2195672A1 (en) 1994-07-29 1996-02-15 Eugeen Vanmechelen Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
US20020086009A1 (en) 1996-03-13 2002-07-04 Koichi Ishiguro Anti-phosphorylated tau protein antibodies and methods for detecting alzheimer`s disease with the use of the same
AU5508798A (en) 1996-11-19 1998-06-10 Trustees Of The University Of Pennsylvania, The Diagnostic and therapeutic reagents for alzheimer's disease
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
RU2238947C2 (en) * 1998-07-14 2004-10-27 Янссен Фармацевтика Н.В. Human neurotrophic growth factor (enovin), isolated nucleic acid molecule encoding its, vector (variants), pharmaceutical composition (variants), antibody, method for detection of growth factor, set, method for identification of agonist or antagonist (variants)
AU772151B2 (en) 1998-09-08 2004-04-08 Innogenetics N.V. Tau as a marker for early CNS damage
US6495376B1 (en) * 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US6589746B1 (en) 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
US20020182660A1 (en) 2000-02-18 2002-12-05 Fong Kei-Lai L. N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43)
AT500379B8 (en) 2001-02-02 2009-08-15 Axon Neuroscience TAU PROTEINS
AR035119A1 (en) 2001-08-16 2004-04-14 Lilly Co Eli ANTI-HTNFSF13B HUMAN ANTI-BODIES
EP3960855A1 (en) 2001-12-28 2022-03-02 Chugai Seiyaku Kabushiki Kaisha Method for stabilizing proteins
TWI379693B (en) 2002-05-02 2012-12-21 Wyeth Corp Calicheamicin derivative-carrier conjugates
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
EP1521831B1 (en) 2002-07-12 2008-04-09 Axon Neuroscience Forschungs- und Entwicklungs Gmbh Transgenic animal expressing truncated alzheimer's tau protein
AU2003257850A1 (en) 2002-08-14 2004-03-03 Mitsubishi Kagaku Iatron, Inc. ANTIBODY SPECIFIC TO CENTRAL Tau-PROTEIN
FI20030652A0 (en) 2003-04-30 2003-04-30 Susann Eriksson Improved immune determination
CA2536408A1 (en) 2003-08-22 2005-03-03 Biogen Idec Ma Inc. Improved antibodies having altered effector function and methods for making the same
US7238788B2 (en) 2004-02-18 2007-07-03 University Of Iowa Foundation Antibodies to phosphorylated tau, methods of making and methods of use
EP1848817B1 (en) 2005-02-19 2013-04-24 Peoplebio, Inc. Method for differentially detecting multimeric form from monomeric form of multimer-forming polypeptides
JP2009506302A (en) 2005-08-04 2009-02-12 イェシバ・ユニバーシティ Tau phosphorylation by ABL
ES2321996B1 (en) 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas USE OF COMPOUNDS THAT JOIN THE DOMAIN OF UNION TO TAU MICROTUBLES IN THE DEVELOPMENT OF PHARMACEUTICAL COMPOSITIONS, SUCH PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION IN THE TREATMENT OF TAUOPATIAS.
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US20080220449A1 (en) 2007-02-08 2008-09-11 Oligomerix, Inc. Biomarkers and assays for Alzheimer's disease
PL2276485T3 (en) 2008-04-24 2014-12-31 Bristol Myers Squibb Co Use of epothilone d in treating tau-associated diseases including alzheimer's disease
CN101307108B (en) 2008-06-25 2012-04-04 南京川博生物技术有限公司 Anti-phosphorylation Tau protein antibody use for detecting AD sign abnormal phosphation Tau protein level
CA2743491C (en) * 2008-11-11 2016-10-11 Zelton Dave Sharp Inhibition of mammalian target of rapamycin
US20110305706A1 (en) 2009-02-23 2011-12-15 Scott Thomas Brady Compositions and Methods for Treating a Disease Mediated by Soluble Oligomeric Amyloid Beta
US9605054B2 (en) 2009-02-23 2017-03-28 The Board Of Trustees Of The University Of Illinois Composition and method for treating a tauopathy
UA107571C2 (en) 2009-04-03 2015-01-26 PHARMACEUTICAL COMPOSITION
US8409584B2 (en) 2009-05-05 2013-04-02 New York University Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
JP5917394B2 (en) * 2009-06-10 2016-05-11 ニューヨーク・ユニバーシティ Immunological targeting method of pathological tau protein
JP2013500326A (en) * 2009-07-30 2013-01-07 ファイザー バクシーンズ エルエルシー Antigenic tau peptides and uses thereof
AU2010286501B2 (en) 2009-08-28 2015-06-11 The Board Of Regents Of The University Of Texas System Antibodies that bind Tau oligomers
AU2010291933B2 (en) * 2009-09-14 2016-09-08 Banyan Biomarkers, Inc. Micro-RNA, autoantibody and protein markers for diagnosis of neuronal injury
US8648044B2 (en) 2009-09-24 2014-02-11 Institut National De La Sante Et De La Recherche Medicale (Inserm) FKBP52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction
WO2011109112A2 (en) 2010-03-05 2011-09-09 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
DK2625198T3 (en) * 2010-10-07 2015-09-28 Ac Immune Sa Antibodies that recognize the phosphorylated tau
AU2013205313B2 (en) 2010-10-07 2016-05-19 Ac Immune S.A. Phosphospecific antibodies recognising tau
EA031698B1 (en) * 2010-10-11 2019-02-28 Байоджен Интернэшнл Нейросайенз Гмбх Human anti-tau antibodies
US20120244174A1 (en) * 2011-01-31 2012-09-27 Intellect Neurosciences Inc. Treatment of tauopathies
US8697076B2 (en) 2011-04-27 2014-04-15 Northwestern University Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies
US20120321594A1 (en) 2011-05-06 2012-12-20 New York University Methods of controlling axon or dendrite development of neuronal cells
EP2709728B1 (en) 2011-05-20 2019-01-23 Oligomerix, Inc. Tau protease methods of use
GB201111361D0 (en) * 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
WO2013012811A2 (en) 2011-07-19 2013-01-24 New York University Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
SG10201912964PA (en) 2011-09-19 2020-02-27 Axon Neuroscience Se Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
AR092779A1 (en) 2011-10-07 2015-05-06 Ac Immune Sa PHARMACEUTICAL COMPOSITION THAT INCLUDES ANTIBODIES THAT JOIN TAU PROTEIN CONFORMERS
US20140294724A1 (en) 2011-10-24 2014-10-02 Intellect Neurosciences, Inc. Compositions and methods for treatment of proteinopathies
CN104024274B (en) 2011-12-20 2017-07-18 詹森生物科技公司 Anti- PHF tau antibody and application thereof
EP2834270B1 (en) 2012-04-05 2019-10-30 AC Immune S.A. Humanized tau antibody
WO2013177104A2 (en) 2012-05-21 2013-11-28 Felder Mitchell S Treatment for tauopathies
KR102133610B1 (en) 2012-05-31 2020-07-14 고리쓰다이가쿠호진 오사카 시리쓰다이가쿠 Therapeutic agent or prophylactic agent for dementia
MY171473A (en) 2012-07-03 2019-10-15 Univ Washington Antibodies to tau
MX359817B (en) 2012-08-16 2018-10-11 Ipierian Inc Methods of treating a tauopathy.
US20140056901A1 (en) 2012-08-21 2014-02-27 The Institute For Molecular Medicine Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
AU2013305848B2 (en) 2012-08-21 2020-10-15 Institute For Molecular Medicine, Inc. Compositions and methods related to diseases associated with deposits of amyloid, Tau, and alpha-synuclein
WO2014059442A2 (en) 2012-10-12 2014-04-17 Arizona Board Agents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Antibody based reagents that specifically recognize toxic oligomeric forms of tau
US9910048B2 (en) 2012-12-03 2018-03-06 Washington University Method for detection of aggregates in biological samples
US8921150B2 (en) 2012-12-06 2014-12-30 Taiwan Semiconductor Manufacturing Co., Ltd. Process to achieve contact protrusion for single damascene via
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
EP2935326B1 (en) 2012-12-21 2020-06-10 Biogen MA Inc. Human anti-tau antibodies
WO2014096321A1 (en) 2012-12-21 2014-06-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
EA035943B1 (en) 2013-03-13 2020-09-03 Протена Биосайенсес Лимитед Antibody binding to human tau protein
WO2014159244A2 (en) 2013-03-14 2014-10-02 Merck Patent Gmbh O-GlcNAc TAU ANTIBODY AND USE THEREOF
AU2014240063B2 (en) 2013-03-15 2019-04-11 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US9598485B2 (en) 2013-03-15 2017-03-21 Ac Immune S.A. Anti-tau antibodies and methods of use
TWI664190B (en) 2014-06-27 2019-07-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies

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AU2018229564A1 (en) 2018-10-04
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IL236409B (en) 2020-10-29
BR112014033116A2 (en) 2018-03-06
JP2020125310A (en) 2020-08-20
JP2015530971A (en) 2015-10-29
MX2022000026A (en) 2022-03-22
EP3838921A2 (en) 2021-06-23
KR20200134339A (en) 2020-12-01
KR102494798B1 (en) 2023-02-06
MY171473A (en) 2019-10-15
IL289241A (en) 2022-02-01
US9834596B2 (en) 2017-12-05
US20180037641A1 (en) 2018-02-08
EP2870176A4 (en) 2016-09-28
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RU2018132044A (en) 2018-10-19
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WO2014008404A1 (en) 2014-01-09
CN104781278B (en) 2018-06-12
MX359555B (en) 2018-10-02
SG10201708959WA (en) 2017-11-29
IL236409A0 (en) 2015-02-26
KR20200013072A (en) 2020-02-05
CA2877397A1 (en) 2014-01-09
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US20150183855A1 (en) 2015-07-02
CN104781278A (en) 2015-07-15
HK1209768A1 (en) 2016-04-08
AU2020223765A1 (en) 2020-09-17
AU2013286680B2 (en) 2018-07-05
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AU2013286680A1 (en) 2015-01-22
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RU2015103228A (en) 2016-08-20
NZ703423A (en) 2018-02-23

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