IN2015KN00007A - - Google Patents

Info

Publication number
IN2015KN00007A
IN2015KN00007A IN7KON2015A IN2015KN00007A IN 2015KN00007 A IN2015KN00007 A IN 2015KN00007A IN 7KON2015 A IN7KON2015 A IN 7KON2015A IN 2015KN00007 A IN2015KN00007 A IN 2015KN00007A
Authority
IN
India
Prior art keywords
tau
antibodies
methods
relates
Prior art date
Application number
Inventor
David Holtzman
Hong Jiang
Marc Diamond
Najla Kfoury
Brandon Holmes
Original Assignee
Univ Washington
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Washington filed Critical Univ Washington
Publication of IN2015KN00007A publication Critical patent/IN2015KN00007A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/28—Neurological disorders
    • G01N2800/2814—Dementia; Cognitive disorders
    • G01N2800/2821—Alzheimer

Abstract

This invention relates to antibodies to tau and methods of use thereof.
IN7KON2015 2012-07-03 2013-07-03 IN2015KN00007A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261667515P 2012-07-03 2012-07-03
US201261694989P 2012-08-30 2012-08-30
PCT/US2013/049333 WO2014008404A1 (en) 2012-07-03 2013-07-03 Antibodies to tau

Publications (1)

Publication Number Publication Date
IN2015KN00007A true IN2015KN00007A (en) 2015-07-31

Family

ID=49882495

Family Applications (1)

Application Number Title Priority Date Filing Date
IN7KON2015 IN2015KN00007A (en) 2012-07-03 2013-07-03

Country Status (16)

Country Link
US (2) US9834596B2 (en)
EP (2) EP2870176A4 (en)
JP (3) JP6345655B2 (en)
KR (3) KR20200013072A (en)
CN (2) CN104781278B (en)
AU (3) AU2013286680B2 (en)
CA (1) CA2877397A1 (en)
HK (1) HK1209768A1 (en)
IL (3) IL236409B (en)
IN (1) IN2015KN00007A (en)
MX (2) MX359555B (en)
MY (1) MY171473A (en)
NZ (2) NZ703423A (en)
RU (2) RU2668159C2 (en)
SG (3) SG10201708959WA (en)
WO (1) WO2014008404A1 (en)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104781278B (en) 2012-07-03 2018-06-12 华盛顿大学 For the antibody of TAU
MX359817B (en) 2012-08-16 2018-10-11 Ipierian Inc Methods of treating a tauopathy.
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
AU2014248515B2 (en) * 2013-03-13 2019-03-07 Prothena Biosciences Limited Tau immunotherapy
NZ630610A (en) 2014-02-14 2019-05-31 Ipierian Inc Tau peptides, anti-tau antibodies, and methods of use thereof
WO2015165961A1 (en) 2014-04-29 2015-11-05 Affiris Ag Treatment and prevention of alzheimer's disease (ad)
CN107074935B (en) * 2014-06-26 2021-08-03 扬森疫苗与预防公司 Antibodies and antigen binding fragments that specifically bind to microtubule-associated protein TAU
ZA201608812B (en) 2014-06-26 2019-08-28 Janssen Vaccines & Prevention Bv Antibodies and antigen-binding fragments that specifically bind to microtubule-associated protein tau
TWI664190B (en) * 2014-06-27 2019-07-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies
KR102502356B1 (en) 2014-09-30 2023-02-21 워싱턴 유니버시티 Tau kinetic measurements
MA41451A (en) * 2015-02-04 2017-12-12 Univ Washington ANTI-TAU CONSTRUCTIONS
AR103713A1 (en) 2015-02-26 2017-05-31 Lilly Co Eli ANTIBODIES AGAINST TAU AND ITS USES
CN107849124B (en) 2015-06-05 2021-09-24 基因泰克公司 anti-TAU antibodies and methods of use
US10287343B2 (en) * 2015-07-06 2019-05-14 Ucb Biopharma Sprl Tau-binding antibodies
MA41669A1 (en) 2015-07-06 2018-05-31 Ucb Biopharma Sprl Antibodies binding to tau
GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
JO3711B1 (en) 2015-07-13 2021-01-31 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
PT3334761T (en) * 2015-08-13 2023-08-17 Univ New York Antibody-based molecules selective for the {p}ser404 epitope of tau and their uses in the diagnosis and treatment of tauopathy
CN105158483A (en) * 2015-09-16 2015-12-16 北京九强生物技术股份有限公司 Quantitative determination kit for hypersensitivity of Troponin I and detection method
CN109415434B (en) 2016-05-02 2022-12-30 普罗塞纳生物科学有限公司 Antibodies recognizing TAU
KR102471787B1 (en) 2016-05-02 2022-11-29 프로테나 바이오사이언시즈 리미티드 Tau recognition antibody
ES2933491T3 (en) 2016-05-02 2023-02-09 Prothena Biosciences Ltd tau immunotherapy
MY197836A (en) 2016-07-12 2023-07-20 H Lundbeck As Antibodies specific for hyperphosphorylated tau and methods of use thereof
WO2018031361A2 (en) 2016-08-09 2018-02-15 Eli Lilly And Company Combination therapy
KR102593669B1 (en) 2016-11-15 2023-10-25 하. 룬드벡 아크티에셀스카브 Agents, uses and methods for the treatment of synucleinopathies
AU2017373884A1 (en) 2016-12-07 2019-05-30 Ac Immune Sa Anti-tau antibodies and methods of their use
CR20230163A (en) 2016-12-07 2023-07-06 Genentech Inc Anti-tau antibodies and methods of use
CN106749658B (en) * 2016-12-15 2019-11-12 北京师范大学 Inhibit the anitibody type molecular chaperones of Tau albumen aggregation
MA47019A (en) 2016-12-16 2021-04-21 H Lundbeck As AGENTS, USES AND METHODS
US10364286B2 (en) 2016-12-22 2019-07-30 H. Lundbeck A/S Monoclonal anti-alpha-synuclein antibodies for preventing tau aggregation
EP3583123A1 (en) * 2017-02-17 2019-12-25 Denali Therapeutics Inc. Anti-tau antibodies and methods of use thereof
EP3592387A4 (en) * 2017-03-09 2021-03-31 The Board of Trustees of the Leland Stanford Junior University Treatment of pediatric brain tumors with targeting of cd47 pathway
CA3061516A1 (en) 2017-05-02 2018-11-08 Prothena Biosciences Limited Antibodies recognizing tau
TWI750419B (en) * 2017-10-16 2021-12-21 日商衛材R&D企管股份有限公司 Anti-tau antibodies and uses thereof
CA3094934A1 (en) 2018-03-23 2019-09-26 AbbVie Deutschland GmbH & Co. KG Stable aqueous anti-tau antibody formulations
US11629175B2 (en) 2018-04-27 2023-04-18 Ecole Polytechnique Federale De Lausanne (Epfl) Method for preparing PHFS-like Tau aggregates
JP2021530552A (en) 2018-07-31 2021-11-11 イーライ リリー アンド カンパニー Combination therapy
CN109613242A (en) * 2018-11-01 2019-04-12 深圳天辰医疗科技有限公司 A kind of creatine kinase isozyme detection kit and preparation method thereof
WO2020180819A1 (en) 2019-03-03 2020-09-10 Prothena Biosciences Limited Antibodies recognizing tau
EP3769090B1 (en) 2019-03-18 2023-11-15 Regeneron Pharmaceuticals, Inc. Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
KR20210141522A (en) 2019-03-18 2021-11-23 리제너론 파마슈티칼스 인코포레이티드 CRISPR/Cas Screening Platform to Identify Genetic Modifiers of Tau Seeding or Aggregation
CN110055280A (en) * 2019-03-19 2019-07-26 深圳大学 A kind of cell line and its construction method and application of stable expression mCherry-tau
GB2600599A (en) * 2019-07-15 2022-05-04 Adel Inc Anti-tau antibody and use of same
CA3156678A1 (en) 2019-10-09 2021-04-15 Bluerock Therapeutics Lp Cells with sustained transgene expression
EP4069734A1 (en) * 2019-12-04 2022-10-12 AC Immune SA Novel molecules for therapy and diagnosis
EP4241088A1 (en) * 2020-11-09 2023-09-13 Meso Scale Technologies, LLC Methods and kits for detecting tau
WO2022144406A1 (en) 2020-12-29 2022-07-07 Neurimmune Ag Human anti-tau antibodies
IL307170A (en) 2021-03-26 2023-11-01 Janssen Biotech Inc Anti-tau antibodies and uses thereof
AU2022246275A1 (en) 2021-03-26 2023-11-09 Janssen Biotech, Inc. Humanized antibodies against paired helical filament tau and uses thereof

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI884505A (en) 1987-10-02 1989-04-03 Du Pont IMMUNOANALYS, I VILKEN ANVAENDS IGG-UPPSNAPPANDE ANTIKROPPAR OCH DETEKTERINGSSYSTEM FOER FLERA MONOCLONALA ANTIKROPPAR.
EP0600951A4 (en) 1991-08-01 1996-10-30 Paul H Voorheis Diagnostic method for alzheimer's disease.
US5733734A (en) 1991-08-14 1998-03-31 The Trustees Of The University Of Pennsylvania Method of screening for Alzheimer's disease or disease associated with the accumulation of paired helical filaments
JP3909084B2 (en) 1991-10-25 2007-04-25 エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム Monoclonal antibody against microtubule-associated protein tau
ATE438716T1 (en) 1991-12-06 2009-08-15 Max Planck Gesellschaft USE OF PROTEIN KINASES TO DIAGNOSE AND TREAT ALZHEIMER'S DISEASE
US7408027B1 (en) 1991-12-06 2008-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften Tools for the diagnosis and treatment of Alzheimer's disease
JPH06239899A (en) 1993-02-12 1994-08-30 Teijin Ltd Antibody for human tau protein and determination of human tau protein in body fluid utilizing the same
AU710952B2 (en) 1994-07-29 1999-09-30 Innogenetics N.V. Monoclonal antibodies specific for an epitope of a particular subclass or form of phosphorylated tau, hybridomas secreting them, antigen recognition of these antibodies and their applications
WO1997034145A1 (en) 1996-03-13 1997-09-18 Mitsubishi Chemical Corporation Antiphosphorylated tau protein antibody and method for detecting alzheimer's disease with the use of the same
WO1998022120A1 (en) 1996-11-19 1998-05-28 The Wistar Institute Of Anatomy & Biology Diagnostic and therapeutic reagents for alzheimer's disease
US6797478B1 (en) 1998-03-05 2004-09-28 University Of Cincinnati Method of detecting axonal damage, from associated disease states using tau monoclonal antibodies
RU2238947C2 (en) * 1998-07-14 2004-10-27 Янссен Фармацевтика Н.В. Human neurotrophic growth factor (enovin), isolated nucleic acid molecule encoding its, vector (variants), pharmaceutical composition (variants), antibody, method for detection of growth factor, set, method for identification of agonist or antagonist (variants)
CA2340433A1 (en) 1998-09-08 2000-03-16 Innogenetics N.V. Tau as a marker for early cns damage
US6495376B1 (en) * 1999-02-18 2002-12-17 Beth Israel Deaconess Medical Center Methods and compositions for regulating protein-protein interactions
US6589746B1 (en) 1999-10-21 2003-07-08 University Of Cincinnati Method of detecting axonally-derived protein tau in patients with traumatic CNS injury
US20020182660A1 (en) 2000-02-18 2002-12-05 Fong Kei-Lai L. N- and C-terminus specific immunoassays for full length beta-amyloid peptide-Abeta(1-40), Abeta(1-39), Abeta(1-40), Abeta(1-42) , and Abeta(1-43)
AT500379B8 (en) 2001-02-02 2009-08-15 Axon Neuroscience TAU PROTEINS
AR035119A1 (en) 2001-08-16 2004-04-14 Lilly Co Eli ANTI-HTNFSF13B HUMAN ANTI-BODIES
WO2003057881A1 (en) 2001-12-28 2003-07-17 Chugai Seiyaku Kabushiki Kaisha Method of stabilizing protein
HUE030806T2 (en) 2002-05-02 2017-05-29 Wyeth Holdings Llc Calicheamicin derivative-carrier conjugates
GB0210121D0 (en) 2002-05-02 2002-06-12 Celltech R&D Ltd Biological products
DK1521831T3 (en) 2002-07-12 2008-06-30 Axon Neuroscience Transgenic animals expressing truncated Alzheimer's tau protein
EP1535930B1 (en) 2002-08-14 2010-10-06 Mitsubishi Chemical Medience Corporation Antibody specific to central nervous system tau protein
FI20030652A0 (en) 2003-04-30 2003-04-30 Susann Eriksson Improved immune determination
CN1871259A (en) 2003-08-22 2006-11-29 比奥根艾迪克Ma公司 Improved antibodies having altered effector function and methods for making the same
WO2005080986A1 (en) 2004-02-18 2005-09-01 University Of Iowa Research Foundation Antibodies to phosphorylated tau, methods of making and methods of use
WO2006088281A1 (en) 2005-02-19 2006-08-24 Peoplebio, Inc. Method for differentially detecting multimeric form from monomeric form of multimer-forming polypeptides
US20070134724A1 (en) 2005-08-04 2007-06-14 Peter Davies Phosphorylation of tau by abl
ES2321996B1 (en) 2006-01-26 2010-03-05 Consejo Superior Investig. Cientificas USE OF COMPOUNDS THAT JOIN THE DOMAIN OF UNION TO TAU MICROTUBLES IN THE DEVELOPMENT OF PHARMACEUTICAL COMPOSITIONS, SUCH PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION IN THE TREATMENT OF TAUOPATIAS.
US8012936B2 (en) 2006-03-29 2011-09-06 New York University Tau fragments for immunotherapy
US20080220449A1 (en) 2007-02-08 2008-09-11 Oligomerix, Inc. Biomarkers and assays for Alzheimer's disease
CN102076339A (en) 2008-04-24 2011-05-25 百时美施贵宝公司 Use of epothelone d in treating tau-associated diseases including alzheimer's disease
CN101307108B (en) 2008-06-25 2012-04-04 南京川博生物技术有限公司 Anti-phosphorylation Tau protein antibody use for detecting AD sign abnormal phosphation Tau protein level
DK2365802T3 (en) * 2008-11-11 2017-11-13 Univ Texas RAPAMYCINE MICROCAPLES AND USE FOR CANCER TREATMENT
US9605054B2 (en) 2009-02-23 2017-03-28 The Board Of Trustees Of The University Of Illinois Composition and method for treating a tauopathy
WO2010096751A1 (en) 2009-02-23 2010-08-26 The Board Of Trustees Of The University Of Illinois Compositions and methods for treating a disease mediated by soluble oligomeric amyloid beta
UA107571C2 (en) 2009-04-03 2015-01-26 PHARMACEUTICAL COMPOSITION
US8409584B2 (en) 2009-05-05 2013-04-02 New York University Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins
CA3120504A1 (en) * 2009-06-10 2010-12-16 New York University Immunological targeting of pathological tau proteins
SG177637A1 (en) * 2009-07-30 2012-03-29 Pfizer Vaccines Llc Antigenic tau peptides and uses thereof
JP6124591B2 (en) 2009-08-28 2017-05-10 ザ ボード オブ リージェンツ オブ ザ ユニバーシティー オブ テキサス システム Antibodies that bind to tau oligomers
US20130022982A1 (en) * 2009-09-14 2013-01-24 Kevin Ka-Wang Wang Micro-rna, autoantibody and protein markers for diagnosis of neuronal injury
EP2480891B1 (en) 2009-09-24 2016-11-23 INSERM - Institut National de la Santé et de la Recherche Médicale Fkbp52-tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction
US20130095492A1 (en) 2010-03-05 2013-04-18 Albert Einstein College Of Medicine Of Yeshiva University Method of detecting tau protein and tau fragments in serum
AU2013205313B2 (en) 2010-10-07 2016-05-19 Ac Immune S.A. Phosphospecific antibodies recognising tau
TW201216985A (en) * 2010-10-07 2012-05-01 Ac Immune Sa Pharmaceutical composition
JP2014503178A (en) * 2010-10-11 2014-02-13 バイオジェン アイデック インターナショナル ニューロサイエンス ゲーエムベーハー Human anti-tau antibody
US20120244174A1 (en) 2011-01-31 2012-09-27 Intellect Neurosciences Inc. Treatment of tauopathies
US8697076B2 (en) 2011-04-27 2014-04-15 Northwestern University Antibodies selective for pathological tau dimers and prefibrillar pathological tau oligomers and their uses in treatment, diagnosis and monitoring of tauopathies
US20120321594A1 (en) 2011-05-06 2012-12-20 New York University Methods of controlling axon or dendrite development of neuronal cells
US9506051B2 (en) 2011-05-20 2016-11-29 Oligomerix, Inc. Tau protease compositions and methods of use
GB201111361D0 (en) * 2011-07-04 2011-08-17 Nordic Bioscience As Biochemical markers for neurodegenerative conditions
GB201112056D0 (en) 2011-07-14 2011-08-31 Univ Leuven Kath Antibodies
US9926353B2 (en) 2011-07-19 2018-03-27 New York University Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides
SG10201912964PA (en) 2011-09-19 2020-02-27 Axon Neuroscience Se Protein-based therapy and diagnosis of tau-mediated pathology in alzheimer's disease
EP2764022B9 (en) 2011-10-07 2017-02-22 AC Immune S.A. Phosphospecific antibodies recognising tau
US20140294724A1 (en) 2011-10-24 2014-10-02 Intellect Neurosciences, Inc. Compositions and methods for treatment of proteinopathies
JP6306513B2 (en) 2011-12-20 2018-04-04 ヤンセン バイオテツク，インコーポレーテツド Anti-PHF-tau antibody and use thereof
MX356800B (en) 2012-04-05 2018-06-13 Ac Immune Sa Humanized tau antibody.
WO2013177104A2 (en) 2012-05-21 2013-11-28 Felder Mitchell S Treatment for tauopathies
DK2857039T3 (en) 2012-05-31 2019-12-16 Univ Osaka City THERAPEUTIC AGENT OR PROPHYLACTIC AGENT AGAINST DEMENS
CN104781278B (en) 2012-07-03 2018-06-12 华盛顿大学 For the antibody of TAU
MX359817B (en) 2012-08-16 2018-10-11 Ipierian Inc Methods of treating a tauopathy.
US20140056901A1 (en) 2012-08-21 2014-02-27 The Institute For Molecular Medicine Anti-tau antibodies and compositions for and methods of making and using in treatment, diagnosis and monitoring of tauopathies
JP2015527369A (en) 2012-08-21 2015-09-17 インスティテュート フォー モレキュラー メディシン， インコーポレイテッド Compositions and methods relating to diseases associated with deposition of amyloid, tau and α-synuclein
EP2906596B1 (en) 2012-10-12 2023-12-27 Arizona Board of Regents on behalf of Arizona State University Antibody based reagents that specifically recognize toxic oligomeric forms of tau
WO2014089104A1 (en) 2012-12-03 2014-06-12 Washington University Method for detection of aggregates in biological samples
US8921150B2 (en) 2012-12-06 2014-12-30 Taiwan Semiconductor Manufacturing Co., Ltd. Process to achieve contact protrusion for single damascene via
US9200068B2 (en) 2012-12-18 2015-12-01 Regents Of The University Of Minnesota Compositions and methods related to tauopathy
WO2014096321A1 (en) 2012-12-21 2014-06-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies specific to tau phosphorylated at serine 422 and uses for the treatment and diagnosis of tauopathies
EA035932B1 (en) 2012-12-21 2020-09-02 Байоджен Ма Инк. Human anti-tau antibodies
US8980270B2 (en) 2013-01-18 2015-03-17 Ipierian, Inc. Methods of treating a tauopathy
AU2014248515B2 (en) 2013-03-13 2019-03-07 Prothena Biosciences Limited Tau immunotherapy
WO2014159244A2 (en) 2013-03-14 2014-10-02 Merck Patent Gmbh O-GlcNAc TAU ANTIBODY AND USE THEREOF
MX2015012872A (en) 2013-03-15 2016-02-03 Ac Immune Sa Anti-tau antibodies and methods of use.
CN105283196B (en) 2013-03-15 2018-10-12 贝丝以色列女执事医疗中心 For generate and using conformation-specific antibody method and composition
TWI664190B (en) 2014-06-27 2019-07-01 美商Ｃ２Ｎ醫療診斷有限責任公司 Humanized anti-tau antibodies

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