JP2020518675A - ノリン誘発性の遺伝子発現および疾患を処置するためのその使用 - Google Patents
ノリン誘発性の遺伝子発現および疾患を処置するためのその使用 Download PDFInfo
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Abstract
Description
本出願は、2017年5月5日出願の米国仮特許出願第62/501,940号の優先権の利益を主張し、その内容は参照によって本明細書に組み込まれる。
gil4557789lreflNP_000257.1l ノリン前駆体[ホモサピエンス]
MRKHVLAASFSMLSLLVIMGDTDSKTDSSFIMDSDPRRCMRHHYVDSISHPLYKCSSKMVLLARCEGHCSQASRSEPLVSFSTVLKQPFRSSCHCCRPQTSKLKALRLRCSGGMRLTATYRYILSCHCEECNS (SEQ ID NO.1)
Claims (13)
- 血管バリアを処置する方法であって、該方法は:
ノリンに血管を暴露する工程;および
前記ノリンに十分な時間、BMP2、CLCL6、IL12B、SELPLG、CX3CL1、CASP3、THBD、COL18A1、CPB2、NPR1、BMP2、CLCL6、IL12B、SELPLG、CX3CL1、CASP3、THBD、COL18A1、CPB2、NPR1、CLDN5、CLD3、PIGF、BDNF、CNTF、VEGF−A、CAM−1、PGF、FOX−01、FOX−04、PDGFB、TGFA、HGF、VE−カドヘリン、またはPLAUの少なくとも1つの遺伝子の遺伝子発現を調節させる工程、
を含む、方法。 - 前記遺伝子のすべてが、前記ノリンによって調節される、請求項1に記載の方法。
- 血管バリアは、被験体のインビボの網膜血管である、請求項1に記載の方法。
- 被験体は、加齢黄斑変性または増殖性網膜症を有する、請求項3に記載の方法。
- 暴露する工程は、眼内注入によるものである、請求項3に記載の方法。
- 暴露する工程は、全身性の投与によるものである、請求項3に記載の方法。
- 前記被験体はヒトである、請求項3に記載の方法。
- 前記被験体は、ウシ、ウマ、ヒツジ、ブタ、ヤギ、ニワトリ、ネコ、イヌ、マウス、モルモット、ハムスター、ウサギ、ラット、または前述のものの1つに由来する細胞のうちの1つである、請求項3に記載の方法。
- 前記ノリンは、SEQ ID.NO.2のポリペプチドである、請求項1−8のいずれか1つに記載の方法。
- 前記ノリンは、網膜血管細胞のfrizzled−4受容体を結合する、SEQ ID.NO.1のフラグメントである、請求項1−8のいずれか1つに記載の方法。
- 前記ノリンは組換えである、請求項1−8のいずれか1つに記載の方法。
- 前記ノリンに十分な時間、遺伝子発現を調節させた後に、網膜血管細胞に染料を接触させる工程をさらに含む、請求項1−8のいずれか1つに記載の方法。
- 前記染料はエバンスブルー染料またはフルオレセインである、請求項12に記載の方法。
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JP (2) | JP2020518675A (ja) |
KR (1) | KR20200015523A (ja) |
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WO (1) | WO2018204909A2 (ja) |
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US9114078B2 (en) * | 2009-03-17 | 2015-08-25 | Retinol Solutions Llc | Methods and compositions for genetic and retinal disease |
BR112014017518A2 (pt) * | 2012-01-18 | 2018-09-04 | Genentech Inc | anticorpo e ácido nucleico isolados, célula hospedeira, métodos, imunoconjugado, formulação farmacêutica e uso do anticorpo |
CN105431161A (zh) * | 2013-02-21 | 2016-03-23 | 范安德尔研究所 | Norrin突变体多肽、其制造方法和用途 |
EP2968452A4 (en) * | 2013-03-15 | 2016-10-05 | Michael Thomas Trese | COMPOSITIONS AND METHOD FOR THE TREATMENT OF NETWORK DISEASES |
US10206978B2 (en) * | 2015-06-08 | 2019-02-19 | Retinal Solutions Llc | Norrin regulation of junction proteins and the use thereof to treat epithelial or endothelial membrane leakage induced edema |
TWI721274B (zh) * | 2018-05-29 | 2021-03-11 | 趙效明 | 組合物用於製備治療發育性視網膜血管疾病的藥物之用途 |
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US20160355559A1 (en) * | 2015-06-08 | 2016-12-08 | Michael T. Trese | Norrin regulation of cellular production of junction proteins and use to treat retinal vasculature edema |
Non-Patent Citations (1)
Title |
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DAILEY, W.A. ET AL.: "Norrin Increases Vessel Integrity upon VEGF Induced Permeability", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, [ONLINE], vol. 55, JPN7022000664, 2014, pages 5400, XP055334689, ISSN: 0004841995 * |
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CN110891593A (zh) | 2020-03-17 |
EP3618851A4 (en) | 2020-04-15 |
JP2023027172A (ja) | 2023-03-01 |
EP3618851A2 (en) | 2020-03-11 |
WO2018204909A3 (en) | 2019-02-21 |
WO2018204909A2 (en) | 2018-11-08 |
KR20200015523A (ko) | 2020-02-12 |
US20200268838A1 (en) | 2020-08-27 |
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