CR20160257A - Anticuerpos e inmunoconjugados anti-cd33 - Google Patents
Anticuerpos e inmunoconjugados anti-cd33Info
- Publication number
- CR20160257A CR20160257A CR20160257A CR20160257A CR20160257A CR 20160257 A CR20160257 A CR 20160257A CR 20160257 A CR20160257 A CR 20160257A CR 20160257 A CR20160257 A CR 20160257A CR 20160257 A CR20160257 A CR 20160257A
- Authority
- CR
- Costa Rica
- Prior art keywords
- antibodies
- immunocation
- immunoconjugates
- methods
- provides anti
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
- A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
- G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70596—Molecules with a "CD"-designation not provided for elsewhere in G01N2333/705
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
Abstract
La invención proporciona anticuerpos e inmunoconjugados anti-CD33 y métodos para usar los mismos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361916087P | 2013-12-13 | 2013-12-13 | |
PCT/US2014/069874 WO2015089344A1 (en) | 2013-12-13 | 2014-12-12 | Anti-cd33 antibodies and immunoconjugates |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20160257A true CR20160257A (es) | 2016-07-22 |
Family
ID=52282942
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20160257A CR20160257A (es) | 2013-12-13 | 2016-06-09 | Anticuerpos e inmunoconjugados anti-cd33 |
Country Status (20)
Country | Link |
---|---|
US (2) | US9951133B2 (es) |
EP (2) | EP3080164B1 (es) |
JP (3) | JP6502942B2 (es) |
KR (1) | KR20160098328A (es) |
CN (2) | CN105814084B (es) |
AR (1) | AR098743A1 (es) |
AU (1) | AU2014362238A1 (es) |
CA (1) | CA2931340A1 (es) |
CL (1) | CL2016001477A1 (es) |
CR (1) | CR20160257A (es) |
EA (1) | EA201691214A1 (es) |
IL (1) | IL245757A0 (es) |
MA (1) | MA39095A1 (es) |
MX (1) | MX2016007576A (es) |
PE (1) | PE20160712A1 (es) |
PH (1) | PH12016501143A1 (es) |
SG (1) | SG11201604784XA (es) |
TW (1) | TW201533060A (es) |
WO (1) | WO2015089344A1 (es) |
ZA (1) | ZA201603548B (es) |
Families Citing this family (33)
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PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
GB201510010D0 (en) | 2015-06-09 | 2015-07-22 | King S College London | PDD and BPD compounds |
AU2016276981B2 (en) | 2015-06-12 | 2022-10-06 | Alector Llc | Anti-CD33 antibodies and methods of use thereof |
JP2018518491A (ja) | 2015-06-12 | 2018-07-12 | アレクトル エルエルシー | 抗cd33抗体及びその使用方法 |
GB201514928D0 (en) | 2015-08-21 | 2015-10-07 | King S College London | PDD compounds |
US20180339985A1 (en) | 2015-08-21 | 2018-11-29 | Femtogenix Limited | Pdd compounds |
US20190203299A1 (en) * | 2016-04-06 | 2019-07-04 | University Of Florida Research Foundation, Incorporated | Biomarkers for anti-leukemic therapy |
US10975152B2 (en) * | 2016-05-03 | 2021-04-13 | The Scripps Research Institute | TrkB agonist antibodies and methods for treating an ocular degenerative disorder characterized by degeneration of retinal ganglion cells (RGCs) |
WO2017205587A1 (en) * | 2016-05-27 | 2017-11-30 | Actinium Pharmaceuticals, Inc. | Low dose antibody-based methods for treating hematologic malignancies |
CA3029003A1 (en) | 2016-06-27 | 2018-01-04 | The Regents Of The University Of California | Cancer treatment combinations |
WO2018017827A1 (en) * | 2016-07-22 | 2018-01-25 | Fred Hutchinson Cancer Research Center | Bi-specific molecule for cell-specific notch inhibition and related methods and compositions |
WO2018031662A1 (en) * | 2016-08-11 | 2018-02-15 | Genentech, Inc. | Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof |
MY191926A (en) | 2016-12-01 | 2022-07-18 | Regeneron Pharma | Radiolabeled anti-pd-l1 antibodies for immuno-pet imaging |
SG11201907299XA (en) | 2017-02-08 | 2019-09-27 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
EP3580238A1 (en) | 2017-02-10 | 2019-12-18 | Regeneron Pharmaceuticals, Inc. | Radiolabeled anti-lag3 antibodies for immuno-pet imaging |
WO2018152518A1 (en) | 2017-02-20 | 2018-08-23 | Adimab, Llc | Proteins binding her2, nkg2d and cd16 |
WO2018218207A1 (en) * | 2017-05-26 | 2018-11-29 | Fred Hutchinson Cancer Research Center | Anti-cd33 antibodies and uses thereof |
WO2019006280A1 (en) * | 2017-06-30 | 2019-01-03 | Lentigen Technology, Inc. | HUMAN MONOCLONAL ANTIBODIES SPECIFIC TO CD33 AND METHODS OF USE |
JP7304846B2 (ja) | 2017-07-24 | 2023-07-07 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 抗cd8抗体およびその使用 |
EP3589658A1 (en) | 2017-08-03 | 2020-01-08 | Alector LLC | Anti-cd33 antibodies and methods of use thereof |
CN112368012A (zh) | 2018-02-08 | 2021-02-12 | 蜻蜓疗法股份有限公司 | 靶向nkg2d受体的抗体可变结构域 |
BR112020016944A2 (pt) * | 2018-02-20 | 2020-12-15 | Dragonfly Therapeutics, Inc. | Domínios variáveis de anticorpo que alvejam cd33 e uso dos mesmos |
JOP20190116A1 (ar) | 2018-05-24 | 2019-11-24 | Janssen Biotech Inc | الأجسام المضادة لتكتل التمايز 33 (cd33)، والأجسام المضادة ثنائية النوعية لتكتل التمايز 33 (cd33)/تكتل التمايز 3 (cd3) واستخداماتها |
EP3856242A4 (en) * | 2018-09-25 | 2022-05-18 | Academia Sinica | ANTI-SIGLEC ANTIBODIES, PHARMACEUTICAL COMPOSITION COMPRISING IT, AND THEIR USES |
US11666672B2 (en) * | 2018-11-21 | 2023-06-06 | City Of Hope | Anti-CD33 antibody-guided imaging and treatment of acute myeloid leukemia |
WO2020227072A1 (en) * | 2019-05-04 | 2020-11-12 | Inhibrx, Inc. | Cd33-binding polypeptides and uses thereof |
US20220298105A1 (en) | 2019-08-08 | 2022-09-22 | Toagosei Co., Ltd. | 2-cyanoacrylate compound and adhesive composition |
CN114616251A (zh) * | 2019-10-21 | 2022-06-10 | 南京维立志博生物科技有限公司 | 靶向PD-1和TGFβ的重组蛋白 |
WO2021138407A2 (en) | 2020-01-03 | 2021-07-08 | Marengo Therapeutics, Inc. | Multifunctional molecules that bind to cd33 and uses thereof |
US20230365676A1 (en) * | 2020-09-15 | 2023-11-16 | University Of Florida Research Foundation, Incorporated | Cd33 antibodies |
JP2024504728A (ja) | 2021-01-26 | 2024-02-01 | サイトケアズ (シャンハイ) インコーポレイテッド | キメラ抗原受容体(car)構築物およびcar構築物を発現するnk細胞 |
CN112940132B (zh) * | 2021-03-22 | 2022-04-01 | 深圳市亚辉龙生物科技股份有限公司 | Chi3l1抗体及其应用、核酸、重组表达载体系统和宿主细胞 |
CN113667114B (zh) * | 2021-08-02 | 2023-07-14 | 北京大学深圳医院 | 一种主链可消除的so2纳米前药的制备方法及其用途 |
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EP3461845A8 (en) | 2019-05-29 |
ZA201603548B (en) | 2018-11-28 |
SG11201604784XA (en) | 2016-07-28 |
CN105814084B (zh) | 2019-09-24 |
PE20160712A1 (es) | 2016-07-26 |
IL245757A0 (en) | 2016-07-31 |
TW201533060A (zh) | 2015-09-01 |
EA201691214A1 (ru) | 2016-12-30 |
JP6502942B2 (ja) | 2019-04-17 |
CA2931340A1 (en) | 2015-06-18 |
AU2014362238A1 (en) | 2016-06-09 |
CN110590950A (zh) | 2019-12-20 |
EP3080164A1 (en) | 2016-10-19 |
EP3461845B1 (en) | 2020-09-16 |
US10556951B2 (en) | 2020-02-11 |
US20170002074A1 (en) | 2017-01-05 |
JP2017505604A (ja) | 2017-02-23 |
PH12016501143A1 (en) | 2016-08-15 |
CN105814084A (zh) | 2016-07-27 |
EP3080164B1 (en) | 2019-01-16 |
JP2021104019A (ja) | 2021-07-26 |
WO2015089344A1 (en) | 2015-06-18 |
JP2019146572A (ja) | 2019-09-05 |
AR098743A1 (es) | 2016-06-08 |
MX2016007576A (es) | 2016-10-03 |
US20180312586A1 (en) | 2018-11-01 |
WO2015089344A9 (en) | 2016-01-14 |
MA39095A1 (fr) | 2018-08-31 |
KR20160098328A (ko) | 2016-08-18 |
EP3461845A1 (en) | 2019-04-03 |
CL2016001477A1 (es) | 2017-01-20 |
US9951133B2 (en) | 2018-04-24 |
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