AR111249A1 - Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares - Google Patents

Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares

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Publication number
AR111249A1
AR111249A1 ARP180100673A ARP180100673A AR111249A1 AR 111249 A1 AR111249 A1 AR 111249A1 AR P180100673 A ARP180100673 A AR P180100673A AR P180100673 A ARP180100673 A AR P180100673A AR 111249 A1 AR111249 A1 AR 111249A1
Authority
AR
Argentina
Prior art keywords
hvr
seq
amino acid
acid sequence
antibody
Prior art date
Application number
ARP180100673A
Other languages
English (en)
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=61837830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR111249(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of AR111249A1 publication Critical patent/AR111249A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Abstract

Reivindicación 1: Un conjugado de anticuerpo que comprende (i) un anticuerpo y (ii) un polímero de ácido hialurónico (HA) unido de forma covalente al anticuerpo, en donde el polímero de HA tiene un índice de polidispersión (PDI) de 1,1 o menos. Reivindicación 19: El conjugado de anticuerpo de cualquiera de las reivindicaciones 1 - 18, en donde el anticuerpo se une específicamente a una molécula biológica seleccionada del grupo que consiste en el factor de crecimiento endotelial vascular (VEGF); IL-1b; IL-6; IL-6R; IL-13; IL-13R; PDGF; angiopoyetina; angiopoyetina 2; Tie2; S1P; integrinas avb3, avb5 y a5b1; betacelulina; apelina/APJ; eritropoyetina; factor de complemento D; TNFa; HtrA1; un receptor de VEGF; receptor de ST-2 y una proteína genéticamente vinculada al riesgo de AMD. Reivindicación 22: El conjugado de anticuerpo de la reivindicación 19, en donde el anticuerpo se une específicamente a VEGF. Reivindicación 23: El conjugado de anticuerpo de la reivindicación 22, en donde el anticuerpo comprende las siguientes seis regiones hipervariables (HVR): (a) una HVR-H1 que comprende la secuencia de aminoácidos de DYWIH (SEQ ID Nº 1); (b) una HVR-H2 que comprende la secuencia de aminoácidos de GX¹TPX²GGX³X⁴X⁵YX⁶DSVX⁷X⁸ (SEQ ID Nº 2), en donde X¹ es Ile o His, X² es Ala o Arg, X³ es Tyr o Lys, X⁴ es Thr o Glu, X⁵ es Arg, Tyr, Gln o Glu, X⁶ es Ala o Glu, X⁷ es Lys o Glu, y X⁸ es Gly o Glu; (c) una HVR-H3 que comprende la secuencia de aminoácidos de FVFFLPYAMDY (SEQ ID Nº 3); (d) una HVR-L1 que comprende la secuencia de aminoácidos de RASQX¹VSTAVA (SEQ ID Nº 4), en donde X¹ es Asp o Arg; (e) una HVR-L2 que comprende la secuencia de aminoácidos de X¹ASFLYS (SEQ ID Nº 5), en donde X¹ es Ser o Met; y (f) una HVR-L3 que comprende la secuencia de aminoácidos de X¹QGYGX²PFT (SEQ ID Nº 6), en donde X¹ es Gln, Asn o Thr, y X² es Ala, Asn, Gln o Arg. Reivindicación 123: La composición farmacéutica de cualquiera de las reivindicaciones 106 - 121 para su uso en la fabricación de un medicamento para el tratamiento de un trastorno ocular en un sujeto.
ARP180100673A 2017-03-22 2018-03-22 Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares AR111249A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762475163P 2017-03-22 2017-03-22

Publications (1)

Publication Number Publication Date
AR111249A1 true AR111249A1 (es) 2019-06-19

Family

ID=61837830

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP180100673A AR111249A1 (es) 2017-03-22 2018-03-22 Composiciones de anticuerpo optimizadas para el tratamiento de trastornos oculares

Country Status (19)

Country Link
US (2) US11111291B2 (es)
EP (1) EP3600442A1 (es)
JP (2) JP7227151B2 (es)
KR (1) KR20190138636A (es)
CN (1) CN110612124B (es)
AR (1) AR111249A1 (es)
AU (1) AU2018237359A1 (es)
BR (1) BR112019019706A2 (es)
CA (1) CA3056248A1 (es)
CL (1) CL2019002658A1 (es)
CO (1) CO2019011582A2 (es)
CR (1) CR20190481A (es)
IL (1) IL269378A (es)
MA (1) MA49279A (es)
MX (1) MX2019011141A (es)
PE (1) PE20191758A1 (es)
PH (1) PH12019502149A1 (es)
SG (1) SG11201908650PA (es)
WO (1) WO2018175752A1 (es)

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