ATE447020T1 - Ligationscodierung unter verwendung von oligonukleotidbausteinen - Google Patents
Ligationscodierung unter verwendung von oligonukleotidbausteinenInfo
- Publication number
- ATE447020T1 ATE447020T1 AT05715120T AT05715120T ATE447020T1 AT E447020 T1 ATE447020 T1 AT E447020T1 AT 05715120 T AT05715120 T AT 05715120T AT 05715120 T AT05715120 T AT 05715120T AT E447020 T1 ATE447020 T1 AT E447020T1
- Authority
- AT
- Austria
- Prior art keywords
- oligonucleotide
- template
- present
- chemical entities
- codon
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/DK2004/000195 WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
| US58500804P | 2004-07-06 | 2004-07-06 | |
| DKPA200401067 | 2004-07-06 | ||
| PCT/DK2005/000199 WO2005090566A2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE447020T1 true ATE447020T1 (de) | 2009-11-15 |
Family
ID=40221922
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05715120T ATE447020T1 (de) | 2004-03-22 | 2005-03-22 | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US7704925B2 (de) |
| EP (1) | EP1730277B1 (de) |
| AT (1) | ATE447020T1 (de) |
| DE (1) | DE602005017370D1 (de) |
| DK (1) | DK1730277T3 (de) |
| WO (1) | WO2005090566A2 (de) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1401850A1 (de) * | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| IL163822A0 (en) * | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
| AU2003247266A1 (en) * | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| AU2003266932B2 (en) | 2002-09-27 | 2009-04-09 | Mpm-Holding Aps | Spatially encoded polymer matrix |
| PT1558744E (pt) | 2002-10-30 | 2011-09-22 | Nuevolution As | Codificação enzimática |
| WO2004056994A2 (en) | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
| DE602004023960D1 (de) | 2003-09-18 | 2009-12-17 | Nuevolution As | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
| US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
| EP1694693A2 (de) | 2003-12-17 | 2006-08-30 | Praecis Pharmaceuticals Inc. | Verfahren zur synthese codierter bibliotheken |
| EP1723255B1 (de) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung |
| US7883848B2 (en) * | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
| WO2007053358A2 (en) * | 2005-10-28 | 2007-05-10 | Praecis Pharmaceuticals, Inc. | Methods for identifying compounds of interest using encoded libraries |
| US9574189B2 (en) * | 2005-12-01 | 2017-02-21 | Nuevolution A/S | Enzymatic encoding methods for efficient synthesis of large libraries |
| EP3653763A1 (de) | 2009-02-13 | 2020-05-20 | X-Chem, Inc. | Verfahren zur erstellung und durchsuchung von dna-codierten bibliotheken |
| ES2713873T3 (es) | 2010-04-16 | 2019-05-24 | Nuevolution As | Complejos bifuncionales y métodos para hacer y utilizar tales complejos |
| DK2748357T3 (en) | 2011-09-07 | 2018-07-16 | X Chem Inc | Methods for labeling DNA-encoded libraries |
| JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
| CA2879018A1 (en) | 2012-07-13 | 2014-01-16 | X-Chem, Inc. | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
| EP3218479A1 (de) | 2014-11-11 | 2017-09-20 | Nanocore ApS | Verfahren zur identifizierung von molekülen mit gewünschten eigenschaften |
| CN106048736B (zh) * | 2015-04-14 | 2019-09-03 | 成都先导药物开发股份有限公司 | 一种固相合成dna编码化合物库的方法 |
| GB201603789D0 (en) | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
| CN119574873A (zh) | 2016-05-02 | 2025-03-07 | Encodia公司 | 采用核酸编码的大分子分析 |
| JP7283727B2 (ja) | 2016-06-16 | 2023-05-30 | ヘイスタック サイエンシィズ コーポレーション | コードプローブ分子のコンビナトリアル合成が指令されかつ記録されたオリゴヌクレオチド |
| EP3619340A4 (de) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon |
| US11513126B2 (en) | 2017-10-31 | 2022-11-29 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
| SG11202003923PA (en) | 2017-10-31 | 2020-05-28 | Encodia Inc | Methods and kits using nucleic acid encoding and/or label |
| US12203130B2 (en) | 2018-12-20 | 2025-01-21 | Krylov Sergey N | Binder selection using capillary electrophoresis |
| CN114072499B (zh) | 2019-04-30 | 2024-08-06 | Encodia公司 | 用于制备分析物的方法和相关试剂盒 |
| EP3885437A1 (de) * | 2020-03-27 | 2021-09-29 | Technische Universität Dortmund | Dna-codierte chemische bibliothek, verwendung davon und verfahren zur synthese der bibliothek |
Family Cites Families (64)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4822731A (en) | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
| US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
| JPH04504651A (ja) | 1988-11-18 | 1992-08-20 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 自然に存在しないアミノ酸をタンパク質に部位特異的に導入する方法 |
| DK0494955T3 (da) | 1989-10-05 | 1998-10-26 | Optein Inc | Cellefri syntese og isolering af hidtil ukendte gener og polypeptider |
| US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
| WO1993003172A1 (en) | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
| US5770358A (en) | 1991-09-18 | 1998-06-23 | Affymax Technologies N.V. | Tagged synthetic oligomer libraries |
| US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| DE69433010T2 (de) | 1993-04-12 | 2004-06-09 | Northwestern University, Evanston | Verfahren zur darstellung von oligonukleotiden |
| US5681943A (en) | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
| US5473060A (en) | 1993-07-02 | 1995-12-05 | Lynx Therapeutics, Inc. | Oligonucleotide clamps having diagnostic applications |
| US5571903A (en) | 1993-07-09 | 1996-11-05 | Lynx Therapeutics, Inc. | Auto-ligating oligonucleotide compounds |
| GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
| US6165778A (en) | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
| US5503805A (en) | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
| NZ276860A (en) | 1993-11-02 | 1997-09-22 | Affymax Tech Nv | Apparatus and its use for synthesising diverse molecular products on substrates |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| CA2193228A1 (en) | 1994-06-23 | 1996-01-04 | Christopher Holmes | Photolabile compounds and methods for their use |
| US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
| US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
| US5830658A (en) | 1995-05-31 | 1998-11-03 | Lynx Therapeutics, Inc. | Convergent synthesis of branched and multiply connected macromolecular structures |
| US5780613A (en) | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
| US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
| ATE529509T1 (de) | 1997-01-21 | 2011-11-15 | Gen Hospital Corp | Selektion von proteinen unter verwendung von rna- protein-fusionen |
| US6620587B1 (en) | 1997-05-28 | 2003-09-16 | Discerna Limited | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
| US6969584B2 (en) | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
| US20030004122A1 (en) | 1997-11-05 | 2003-01-02 | Leonid Beigelman | Nucleotide triphosphates and their incorporation into oligonucleotides |
| AU3463699A (en) | 1998-04-03 | 1999-10-25 | Phylos, Inc. | Addressable protein arrays |
| EP1073730A1 (de) | 1998-04-17 | 2001-02-07 | Whitehead For Biomedical Research | Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden |
| EP1119530A2 (de) | 1998-10-09 | 2001-08-01 | Pharmacopeia, Inc. | Auswahl von codes für die codierung von kombinatorischen bibliotheken |
| CA2346989A1 (en) | 1998-10-19 | 2000-04-27 | The Board Of Trustees Of The Leland Stanford Junior University | Dna-templated combinatorial library chemistry |
| ATE354675T1 (de) | 1998-12-02 | 2007-03-15 | Adnexus Therapeutics Inc | Dna-protein fusionen sowie anwendungen derselben |
| AU2951599A (en) * | 1999-04-08 | 2000-11-14 | Pavel Sergeev | Synthesis of biologically active compounds in cells |
| CA2376623C (en) | 1999-06-25 | 2011-04-19 | Nanosphere, Inc. | Nanoparticles having oligonucleotides attached thereto and uses therefor |
| EP1196637B1 (de) | 1999-07-27 | 2007-04-25 | Adnexus Therapeutics, Inc. | Peptidakzeptor ligationsverfahren |
| DE60002821T2 (de) | 1999-08-27 | 2004-05-06 | Japan Science And Technology Corp., Kawaguchi | Reversibel photokuppelnde nukleinsäure und phosphoramidit |
| IL158000A0 (en) | 2001-03-19 | 2004-03-28 | Harvard College | Evolving new molecular function |
| EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
| EP2305808B1 (de) * | 2001-06-20 | 2016-03-02 | Nuevolution A/S | Matrizenabhängige Moleküle und Verfahren zur Verwendung derartiger Moleküle |
| DK1461300T3 (da) * | 2001-11-30 | 2011-10-24 | Biogen Idec Inc | Antistoffer mod kemotaktiske monocytproteiner |
| WO2003078445A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c=c double bond upon reaction |
| IL163822A0 (en) * | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
| WO2003078627A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block capable of functional entity transfer to nucleophil |
| WO2003078446A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond upon reaction |
| EP1490384A2 (de) | 2002-03-15 | 2004-12-29 | Nuevolution A/S | Ein baublock zur c-c bindungsbildung |
| US7255991B2 (en) | 2002-03-22 | 2007-08-14 | Emory University | Template-drive processes for synthesizing polymers and components related to such processes |
| EP1520040A2 (de) | 2002-06-20 | 2005-04-06 | Nuevolution A/S | Mikroarrays zur darstellung von kodierten molekülen |
| AU2003242516A1 (en) | 2002-07-23 | 2004-02-09 | Nuevolution A/S | Gene shuffling by template switching |
| AU2003247266A1 (en) * | 2002-08-01 | 2004-02-23 | Nuevolution A/S | Multi-step synthesis of templated molecules |
| WO2004016767A2 (en) | 2002-08-19 | 2004-02-26 | The President And Fellows Of Harvard College | Evolving new molecular function |
| AU2003260291A1 (en) | 2002-09-12 | 2004-04-30 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
| PT1558744E (pt) | 2002-10-30 | 2011-09-22 | Nuevolution As | Codificação enzimática |
| WO2004056994A2 (en) | 2002-12-19 | 2004-07-08 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
| EP1597394A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Eine methode zur erlangung struktureller information über ein kodiertes molekül |
| EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
| DK1608748T3 (da) | 2003-03-20 | 2009-06-29 | Nuevolution As | Ligeringskodning af små molekyler |
| WO2004099441A2 (en) | 2003-05-09 | 2004-11-18 | Hyscite Discovery As | Selection and evolution of chemical libraries |
| WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
| WO2005003778A2 (en) | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
| EP1533385A1 (de) | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen |
| DE602004023960D1 (de) | 2003-09-18 | 2009-12-17 | Nuevolution As | Methode zur Gewinnung struktureller Informationen kodierter Moleküle und zur Selektion von Verbindungen |
| AU2005300886B2 (en) | 2004-11-08 | 2009-11-12 | Vipergen Aps | Structural nucleic acid guided chemical synthesis |
| WO2006053571A2 (en) | 2004-11-22 | 2006-05-26 | Peter Birk Rasmussen | Template directed split and mix systhesis of small molecule libraries |
-
2005
- 2005-03-22 AT AT05715120T patent/ATE447020T1/de not_active IP Right Cessation
- 2005-03-22 EP EP05715120A patent/EP1730277B1/de not_active Expired - Lifetime
- 2005-03-22 DK DK05715120.1T patent/DK1730277T3/da active
- 2005-03-22 US US10/593,868 patent/US7704925B2/en not_active Expired - Lifetime
- 2005-03-22 DE DE602005017370T patent/DE602005017370D1/de not_active Expired - Lifetime
- 2005-03-22 WO PCT/DK2005/000199 patent/WO2005090566A2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1730277B1 (de) | 2009-10-28 |
| WO2005090566A3 (en) | 2006-03-09 |
| US20090011957A1 (en) | 2009-01-08 |
| DE602005017370D1 (de) | 2009-12-10 |
| US7704925B2 (en) | 2010-04-27 |
| DK1730277T3 (da) | 2010-03-01 |
| EP1730277A2 (de) | 2006-12-13 |
| WO2005090566A2 (en) | 2005-09-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |