DE602005017370D1 - Ligationscodierung unter verwendung von oligonukleotidbausteinen - Google Patents
Ligationscodierung unter verwendung von oligonukleotidbausteinenInfo
- Publication number
- DE602005017370D1 DE602005017370D1 DE602005017370T DE602005017370T DE602005017370D1 DE 602005017370 D1 DE602005017370 D1 DE 602005017370D1 DE 602005017370 T DE602005017370 T DE 602005017370T DE 602005017370 T DE602005017370 T DE 602005017370T DE 602005017370 D1 DE602005017370 D1 DE 602005017370D1
- Authority
- DE
- Germany
- Prior art keywords
- oligonucleotide
- template
- present
- chemical entities
- codon
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Computational Biology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/DK2004/000195 WO2004083427A2 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
US58500804P | 2004-07-06 | 2004-07-06 | |
DKPA200401067 | 2004-07-06 | ||
PCT/DK2005/000199 WO2005090566A2 (en) | 2004-03-22 | 2005-03-22 | Ligational encoding using building block oligonucleotides |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602005017370D1 true DE602005017370D1 (de) | 2009-12-10 |
Family
ID=40221922
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602005017370T Active DE602005017370D1 (de) | 2004-03-22 | 2005-03-22 | Ligationscodierung unter verwendung von oligonukleotidbausteinen |
Country Status (6)
Country | Link |
---|---|
US (1) | US7704925B2 (de) |
EP (1) | EP1730277B1 (de) |
AT (1) | ATE447020T1 (de) |
DE (1) | DE602005017370D1 (de) |
DK (1) | DK1730277T3 (de) |
WO (1) | WO2005090566A2 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
EP2186897B1 (de) | 2002-03-15 | 2016-02-17 | Nuevolution A/S | Eine verbesserte Methode zur Synthese von matritzenabhängigen Molekülen |
WO2004013070A2 (en) * | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
CA2539890A1 (en) | 2002-09-27 | 2004-04-08 | Carlsberg A/S | Spatially encoded polymer matrix |
CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
WO2005026387A1 (en) * | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
AU2004299145B2 (en) | 2003-12-17 | 2011-08-25 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
EP1723255B1 (de) * | 2004-02-17 | 2010-12-29 | Nuevolution A/S | Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung |
US7883848B2 (en) * | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
JP2009513135A (ja) * | 2005-10-28 | 2009-04-02 | プリーシス・ファーマシューティカルズ・インコーポレイテッド | エンコードされたライブラリーを用いて興味のある化合物を同定する方法 |
ATE490318T1 (de) * | 2005-12-01 | 2010-12-15 | Nuevolution As | Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken |
ES2638324T3 (es) | 2009-02-13 | 2017-10-19 | X-Chem, Inc. | Métodos de creación y examen de bibliotecas codificadas por ADN |
CA2832672A1 (en) | 2010-04-16 | 2011-10-20 | Nuevolution A/S | Bi-functional complexes and methods for making and using such complexes |
US10865409B2 (en) | 2011-09-07 | 2020-12-15 | X-Chem, Inc. | Methods for tagging DNA-encoded libraries |
JP5820320B2 (ja) * | 2012-03-27 | 2015-11-24 | 株式会社東芝 | 情報処理端末及び方法、並びに、情報管理装置及び方法 |
KR102270554B1 (ko) | 2012-07-13 | 2021-06-28 | 엑스-켐, 인크. | 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리 |
US20180340174A1 (en) | 2014-11-11 | 2018-11-29 | Nanocore Aps | Method for identification of molecules with desired characteristics |
WO2016165621A1 (zh) * | 2015-04-14 | 2016-10-20 | 成都先导药物开发有限公司 | 一种固相合成dna编码化合物库的方法 |
GB201603789D0 (en) | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
KR102379048B1 (ko) | 2016-05-02 | 2022-03-28 | 엔코디아, 인코포레이티드 | 암호화 핵산을 사용한 거대분자 분석 |
WO2017218293A1 (en) | 2016-06-16 | 2017-12-21 | Richard Edward Watts | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
EP3619340A4 (de) | 2017-05-02 | 2021-01-20 | Haystack Sciences Corporation | Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon |
WO2019089836A1 (en) | 2017-10-31 | 2019-05-09 | Encodia, Inc. | Kits for analysis using nucleic acid encoding and/or label |
EP3899521A4 (de) | 2018-12-20 | 2022-08-24 | Sergey N. Krylov | Auswahl von bindemitteln unter verwendung von kapillarelektrophorese |
AU2020267119A1 (en) | 2019-04-30 | 2021-11-18 | Encodia, Inc. | Methods for preparing analytes and related kits |
EP3885437A1 (de) * | 2020-03-27 | 2021-09-29 | Technische Universität Dortmund | Dna-codierte chemische bibliothek, verwendung davon und verfahren zur synthese der bibliothek |
Family Cites Families (64)
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WO2001007657A1 (en) | 1999-07-27 | 2001-02-01 | Phylos, Inc. | Peptide acceptor ligation methods |
US4822731A (en) | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
AU649217B2 (en) | 1988-11-18 | 1994-05-19 | Regents Of The University Of California, The | Method for site-specifically incorporating unnatural amino acids into proteins |
JP3127158B2 (ja) | 1989-10-05 | 2001-01-22 | オプテイン,インコーポレイティド | 新規の遺伝子及びポリペチドの無細胞合成並びに単離 |
US5723289A (en) | 1990-06-11 | 1998-03-03 | Nexstar Pharmaceuticals, Inc. | Parallel selex |
WO1993003172A1 (en) | 1991-08-01 | 1993-02-18 | University Research Corporation | Systematic polypeptide evolution by reverse translation |
CA2118806A1 (en) | 1991-09-18 | 1993-04-01 | William J. Dower | Method of synthesizing diverse collections of oligomers |
US5639603A (en) | 1991-09-18 | 1997-06-17 | Affymax Technologies N.V. | Synthesizing and screening molecular diversity |
US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
CA2160016C (en) | 1993-04-12 | 2008-06-03 | Robert L. Letsinger | Method of forming oligonucleotides |
US5681943A (en) | 1993-04-12 | 1997-10-28 | Northwestern University | Method for covalently linking adjacent oligonucleotides |
US5473060A (en) | 1993-07-02 | 1995-12-05 | Lynx Therapeutics, Inc. | Oligonucleotide clamps having diagnostic applications |
US5571903A (en) | 1993-07-09 | 1996-11-05 | Lynx Therapeutics, Inc. | Auto-ligating oligonucleotide compounds |
GB9315847D0 (en) | 1993-07-30 | 1993-09-15 | Isis Innovation | Tag reagent and assay method |
US5503805A (en) | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US6165778A (en) | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
CN1134156A (zh) | 1993-11-02 | 1996-10-23 | 阿菲马克斯技术公司 | 合成和筛选多种分子 |
US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
JPH10507160A (ja) | 1994-06-23 | 1998-07-14 | アフィマックス テクノロジーズ エヌ.ブイ. | 光活性化合物およびその使用方法 |
US5604097A (en) | 1994-10-13 | 1997-02-18 | Spectragen, Inc. | Methods for sorting polynucleotides using oligonucleotide tags |
US5843650A (en) | 1995-05-01 | 1998-12-01 | Segev; David | Nucleic acid detection and amplification by chemical linkage of oligonucleotides |
US5830658A (en) | 1995-05-31 | 1998-11-03 | Lynx Therapeutics, Inc. | Convergent synthesis of branched and multiply connected macromolecular structures |
US5780613A (en) | 1995-08-01 | 1998-07-14 | Northwestern University | Covalent lock for self-assembled oligonucleotide constructs |
US6261804B1 (en) | 1997-01-21 | 2001-07-17 | The General Hospital Corporation | Selection of proteins using RNA-protein fusions |
DK1712623T3 (da) | 1997-01-21 | 2012-02-06 | Gen Hospital Corp | Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner |
WO1998054312A1 (en) | 1997-05-28 | 1998-12-03 | Babraham Institute | Ribosome complexes as selection particles for in vitro display and evolution of proteins |
US6969584B2 (en) | 1997-06-12 | 2005-11-29 | Rigel Pharmaceuticals, Inc. | Combinatorial enzymatic complexes |
US20030004122A1 (en) | 1997-11-05 | 2003-01-02 | Leonid Beigelman | Nucleotide triphosphates and their incorporation into oligonucleotides |
US6537749B2 (en) | 1998-04-03 | 2003-03-25 | Phylos, Inc. | Addressable protein arrays |
EP1073730A1 (de) | 1998-04-17 | 2001-02-07 | Whitehead For Biomedical Research | Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden |
WO2000021909A2 (en) | 1998-10-09 | 2000-04-20 | Pharmacopeia, Inc. | Selecting codes to be used for encoding combinatorial libraries |
EP1123305A1 (de) | 1998-10-19 | 2001-08-16 | The Board Of Trustees Of The Leland Stanford Junior University | Chemie einer dna-templatisierten kombinatorischen bibliothek |
ATE354675T1 (de) | 1998-12-02 | 2007-03-15 | Adnexus Therapeutics Inc | Dna-protein fusionen sowie anwendungen derselben |
EP1208219A1 (de) | 1999-04-08 | 2002-05-29 | Pavel Sergeev | Synthese von biologisch-aktiven zusammensetzungen in zellen |
ATE502117T1 (de) | 1999-06-25 | 2011-04-15 | Nanosphere Inc | Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen |
WO2001016151A1 (fr) | 1999-08-27 | 2001-03-08 | Japan Science And Technology Corporation | Acide nucleique a photocouplage reversible et phosphoroamidite |
ES2271306T5 (es) | 2001-03-19 | 2013-10-16 | President And Fellows Of Harvard College | Evolución de una nueva función molecular |
EP1402024B1 (de) | 2001-06-20 | 2007-08-22 | Nuevolution A/S | Eine methode zur synthese von matrizenabhängigen molekülen |
EP1401850A1 (de) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nukleosidderivate zur herstellung einer verbindungsbibliothek |
CA2468733C (en) * | 2001-11-30 | 2013-06-11 | Biogen Idec Ma Inc. | Antibodies against monocyte chemotactic proteins |
US20070213519A1 (en) | 2002-03-01 | 2007-09-13 | Nuevolution A/S | Building Block Forming A C=C Double Bond Upon Reaction |
EP2186897B1 (de) | 2002-03-15 | 2016-02-17 | Nuevolution A/S | Eine verbesserte Methode zur Synthese von matritzenabhängigen Molekülen |
US20050176948A1 (en) | 2002-03-15 | 2005-08-11 | Gouliaev Alex H. | Building block capable of functional entity transfer to nucleophil |
WO2003078050A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c bond upon reaction |
EP1487850A2 (de) | 2002-03-15 | 2004-12-22 | Nuevolution A/S | Ein baublock zur c-c bindungsbildung oder c-heteroatom bindungsbildung |
WO2003082901A2 (en) | 2002-03-22 | 2003-10-09 | Emory University | Template-driven processes for synthesizing polymers and components related to such processes |
AU2003240436A1 (en) | 2002-06-20 | 2004-01-06 | Nuevolution A/S | Microarrays displaying encoded molecules |
AU2003242516A1 (en) | 2002-07-23 | 2004-02-09 | Nuevolution A/S | Gene shuffling by template switching |
WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
EP1540013B1 (de) | 2002-08-19 | 2015-07-08 | The President and Fellows of Harvard College | Entwicklung einer neuen molekularen funktion |
AU2003260291A1 (en) | 2002-09-12 | 2004-04-30 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
CN106337046B (zh) | 2002-10-30 | 2021-03-23 | 纽韦卢森公司 | 合成双功能复合物的方法 |
US9121110B2 (en) | 2002-12-19 | 2015-09-01 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
EP1597395A2 (de) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | Methode zur herstellung einer bibliothek der zweiten generation |
US20060269920A1 (en) | 2003-02-21 | 2006-11-30 | Nuevolution A/S | Method for obtaining structural information about an encoded molecule |
DE602004019764D1 (de) | 2003-03-20 | 2009-04-16 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
EP1625230A2 (de) | 2003-05-09 | 2006-02-15 | Thorleif Möller | Selektion und evolution von chemischen biobliotheken |
WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
WO2005003778A2 (en) | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
EP1533385A1 (de) | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen |
WO2005026387A1 (en) | 2003-09-18 | 2005-03-24 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
CN101056980B (zh) | 2004-11-08 | 2012-05-23 | 威泊根私人有限公司 | 结构型核酸指导的化学合成 |
DK1828381T3 (da) | 2004-11-22 | 2009-02-23 | Peter Birk Rasmussen | Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker |
-
2005
- 2005-03-22 DE DE602005017370T patent/DE602005017370D1/de active Active
- 2005-03-22 WO PCT/DK2005/000199 patent/WO2005090566A2/en active Application Filing
- 2005-03-22 DK DK05715120.1T patent/DK1730277T3/da active
- 2005-03-22 US US10/593,868 patent/US7704925B2/en active Active
- 2005-03-22 EP EP05715120A patent/EP1730277B1/de not_active Not-in-force
- 2005-03-22 AT AT05715120T patent/ATE447020T1/de not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2005090566A2 (en) | 2005-09-29 |
EP1730277B1 (de) | 2009-10-28 |
US20090011957A1 (en) | 2009-01-08 |
US7704925B2 (en) | 2010-04-27 |
EP1730277A2 (de) | 2006-12-13 |
DK1730277T3 (da) | 2010-03-01 |
ATE447020T1 (de) | 2009-11-15 |
WO2005090566A3 (en) | 2006-03-09 |
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Legal Events
Date | Code | Title | Description |
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8364 | No opposition during term of opposition |