DE602005017370D1 - Ligationscodierung unter verwendung von oligonukleotidbausteinen - Google Patents

Ligationscodierung unter verwendung von oligonukleotidbausteinen

Info

Publication number
DE602005017370D1
DE602005017370D1 DE602005017370T DE602005017370T DE602005017370D1 DE 602005017370 D1 DE602005017370 D1 DE 602005017370D1 DE 602005017370 T DE602005017370 T DE 602005017370T DE 602005017370 T DE602005017370 T DE 602005017370T DE 602005017370 D1 DE602005017370 D1 DE 602005017370D1
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DE
Germany
Prior art keywords
oligonucleotide
template
present
chemical entities
codon
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
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DE602005017370T
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English (en)
Inventor
Alex Haahr Gouliaev
Henrik Pedersen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nuevolution AS
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Nuevolution AS
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Filing date
Publication date
Priority claimed from PCT/DK2004/000195 external-priority patent/WO2004083427A2/en
Application filed by Nuevolution AS filed Critical Nuevolution AS
Publication of DE602005017370D1 publication Critical patent/DE602005017370D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1068Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE602005017370T 2004-03-22 2005-03-22 Ligationscodierung unter verwendung von oligonukleotidbausteinen Active DE602005017370D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PCT/DK2004/000195 WO2004083427A2 (en) 2003-03-20 2004-03-22 Ligational encoding of small molecules
US58500804P 2004-07-06 2004-07-06
DKPA200401067 2004-07-06
PCT/DK2005/000199 WO2005090566A2 (en) 2004-03-22 2005-03-22 Ligational encoding using building block oligonucleotides

Publications (1)

Publication Number Publication Date
DE602005017370D1 true DE602005017370D1 (de) 2009-12-10

Family

ID=40221922

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017370T Active DE602005017370D1 (de) 2004-03-22 2005-03-22 Ligationscodierung unter verwendung von oligonukleotidbausteinen

Country Status (6)

Country Link
US (1) US7704925B2 (de)
EP (1) EP1730277B1 (de)
AT (1) ATE447020T1 (de)
DE (1) DE602005017370D1 (de)
DK (1) DK1730277T3 (de)
WO (1) WO2005090566A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
EP2186897B1 (de) 2002-03-15 2016-02-17 Nuevolution A/S Eine verbesserte Methode zur Synthese von matritzenabhängigen Molekülen
WO2004013070A2 (en) * 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
CA2539890A1 (en) 2002-09-27 2004-04-08 Carlsberg A/S Spatially encoded polymer matrix
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
WO2005026387A1 (en) * 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
AU2004299145B2 (en) 2003-12-17 2011-08-25 Glaxosmithkline Llc Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
EP1723255B1 (de) * 2004-02-17 2010-12-29 Nuevolution A/S Anreicherungsverfahren mit eliminierung durch fehlpaarungshybridisierung
US7883848B2 (en) * 2005-07-08 2011-02-08 Olink Ab Regulation analysis by cis reactivity, RACR
JP2009513135A (ja) * 2005-10-28 2009-04-02 プリーシス・ファーマシューティカルズ・インコーポレイテッド エンコードされたライブラリーを用いて興味のある化合物を同定する方法
ATE490318T1 (de) * 2005-12-01 2010-12-15 Nuevolution As Enzymvermittelnde kodierungsmethoden für eine effiziente synthese von grossen bibliotheken
ES2638324T3 (es) 2009-02-13 2017-10-19 X-Chem, Inc. Métodos de creación y examen de bibliotecas codificadas por ADN
CA2832672A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
US10865409B2 (en) 2011-09-07 2020-12-15 X-Chem, Inc. Methods for tagging DNA-encoded libraries
JP5820320B2 (ja) * 2012-03-27 2015-11-24 株式会社東芝 情報処理端末及び方法、並びに、情報管理装置及び方法
KR102270554B1 (ko) 2012-07-13 2021-06-28 엑스-켐, 인크. 폴리머라제에 의해 판독가능하지 않은 코딩 올리고뉴클레오티드 연결을 갖는 dna-코딩된 라이브러리
US20180340174A1 (en) 2014-11-11 2018-11-29 Nanocore Aps Method for identification of molecules with desired characteristics
WO2016165621A1 (zh) * 2015-04-14 2016-10-20 成都先导药物开发有限公司 一种固相合成dna编码化合物库的方法
GB201603789D0 (en) 2016-03-04 2016-04-20 Apta Biosciences Ltd Oligonucleotides and methods for preparing
KR102379048B1 (ko) 2016-05-02 2022-03-28 엔코디아, 인코포레이티드 암호화 핵산을 사용한 거대분자 분석
WO2017218293A1 (en) 2016-06-16 2017-12-21 Richard Edward Watts Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules
EP3619340A4 (de) 2017-05-02 2021-01-20 Haystack Sciences Corporation Moleküle zur verifizierung von oligonukleotidgerichteter kombinatorischer synthese und verfahren zur herstellung und verwendung davon
WO2019089836A1 (en) 2017-10-31 2019-05-09 Encodia, Inc. Kits for analysis using nucleic acid encoding and/or label
EP3899521A4 (de) 2018-12-20 2022-08-24 Sergey N. Krylov Auswahl von bindemitteln unter verwendung von kapillarelektrophorese
AU2020267119A1 (en) 2019-04-30 2021-11-18 Encodia, Inc. Methods for preparing analytes and related kits
EP3885437A1 (de) * 2020-03-27 2021-09-29 Technische Universität Dortmund Dna-codierte chemische bibliothek, verwendung davon und verfahren zur synthese der bibliothek

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001007657A1 (en) 1999-07-27 2001-02-01 Phylos, Inc. Peptide acceptor ligation methods
US4822731A (en) 1986-01-09 1989-04-18 Cetus Corporation Process for labeling single-stranded nucleic acids and hybridizaiton probes
US5449602A (en) 1988-01-13 1995-09-12 Amoco Corporation Template-directed photoligation
AU649217B2 (en) 1988-11-18 1994-05-19 Regents Of The University Of California, The Method for site-specifically incorporating unnatural amino acids into proteins
JP3127158B2 (ja) 1989-10-05 2001-01-22 オプテイン,インコーポレイティド 新規の遺伝子及びポリペチドの無細胞合成並びに単離
US5723289A (en) 1990-06-11 1998-03-03 Nexstar Pharmaceuticals, Inc. Parallel selex
WO1993003172A1 (en) 1991-08-01 1993-02-18 University Research Corporation Systematic polypeptide evolution by reverse translation
CA2118806A1 (en) 1991-09-18 1993-04-01 William J. Dower Method of synthesizing diverse collections of oligomers
US5639603A (en) 1991-09-18 1997-06-17 Affymax Technologies N.V. Synthesizing and screening molecular diversity
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
CA2160016C (en) 1993-04-12 2008-06-03 Robert L. Letsinger Method of forming oligonucleotides
US5681943A (en) 1993-04-12 1997-10-28 Northwestern University Method for covalently linking adjacent oligonucleotides
US5473060A (en) 1993-07-02 1995-12-05 Lynx Therapeutics, Inc. Oligonucleotide clamps having diagnostic applications
US5571903A (en) 1993-07-09 1996-11-05 Lynx Therapeutics, Inc. Auto-ligating oligonucleotide compounds
GB9315847D0 (en) 1993-07-30 1993-09-15 Isis Innovation Tag reagent and assay method
US5503805A (en) 1993-11-02 1996-04-02 Affymax Technologies N.V. Apparatus and method for parallel coupling reactions
US6165778A (en) 1993-11-02 2000-12-26 Affymax Technologies N.V. Reaction vessel agitation apparatus
CN1134156A (zh) 1993-11-02 1996-10-23 阿菲马克斯技术公司 合成和筛选多种分子
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
JPH10507160A (ja) 1994-06-23 1998-07-14 アフィマックス テクノロジーズ エヌ.ブイ. 光活性化合物およびその使用方法
US5604097A (en) 1994-10-13 1997-02-18 Spectragen, Inc. Methods for sorting polynucleotides using oligonucleotide tags
US5843650A (en) 1995-05-01 1998-12-01 Segev; David Nucleic acid detection and amplification by chemical linkage of oligonucleotides
US5830658A (en) 1995-05-31 1998-11-03 Lynx Therapeutics, Inc. Convergent synthesis of branched and multiply connected macromolecular structures
US5780613A (en) 1995-08-01 1998-07-14 Northwestern University Covalent lock for self-assembled oligonucleotide constructs
US6261804B1 (en) 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
DK1712623T3 (da) 1997-01-21 2012-02-06 Gen Hospital Corp Udvælgelse af proteiner ved anvendelse af RNA-proteinfusioner
WO1998054312A1 (en) 1997-05-28 1998-12-03 Babraham Institute Ribosome complexes as selection particles for in vitro display and evolution of proteins
US6969584B2 (en) 1997-06-12 2005-11-29 Rigel Pharmaceuticals, Inc. Combinatorial enzymatic complexes
US20030004122A1 (en) 1997-11-05 2003-01-02 Leonid Beigelman Nucleotide triphosphates and their incorporation into oligonucleotides
US6537749B2 (en) 1998-04-03 2003-03-25 Phylos, Inc. Addressable protein arrays
EP1073730A1 (de) 1998-04-17 2001-02-07 Whitehead For Biomedical Research Verwendung von ribozym zum verbinden von nukleinsäuren mit polypeptiden
WO2000021909A2 (en) 1998-10-09 2000-04-20 Pharmacopeia, Inc. Selecting codes to be used for encoding combinatorial libraries
EP1123305A1 (de) 1998-10-19 2001-08-16 The Board Of Trustees Of The Leland Stanford Junior University Chemie einer dna-templatisierten kombinatorischen bibliothek
ATE354675T1 (de) 1998-12-02 2007-03-15 Adnexus Therapeutics Inc Dna-protein fusionen sowie anwendungen derselben
EP1208219A1 (de) 1999-04-08 2002-05-29 Pavel Sergeev Synthese von biologisch-aktiven zusammensetzungen in zellen
ATE502117T1 (de) 1999-06-25 2011-04-15 Nanosphere Inc Nanopartikel mit gebundenen oligonukleotiden und deren verwendungen
WO2001016151A1 (fr) 1999-08-27 2001-03-08 Japan Science And Technology Corporation Acide nucleique a photocouplage reversible et phosphoroamidite
ES2271306T5 (es) 2001-03-19 2013-10-16 President And Fellows Of Harvard College Evolución de una nueva función molecular
EP1402024B1 (de) 2001-06-20 2007-08-22 Nuevolution A/S Eine methode zur synthese von matrizenabhängigen molekülen
EP1401850A1 (de) 2001-06-20 2004-03-31 Nuevolution A/S Nukleosidderivate zur herstellung einer verbindungsbibliothek
CA2468733C (en) * 2001-11-30 2013-06-11 Biogen Idec Ma Inc. Antibodies against monocyte chemotactic proteins
US20070213519A1 (en) 2002-03-01 2007-09-13 Nuevolution A/S Building Block Forming A C=C Double Bond Upon Reaction
EP2186897B1 (de) 2002-03-15 2016-02-17 Nuevolution A/S Eine verbesserte Methode zur Synthese von matritzenabhängigen Molekülen
US20050176948A1 (en) 2002-03-15 2005-08-11 Gouliaev Alex H. Building block capable of functional entity transfer to nucleophil
WO2003078050A2 (en) 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
EP1487850A2 (de) 2002-03-15 2004-12-22 Nuevolution A/S Ein baublock zur c-c bindungsbildung oder c-heteroatom bindungsbildung
WO2003082901A2 (en) 2002-03-22 2003-10-09 Emory University Template-driven processes for synthesizing polymers and components related to such processes
AU2003240436A1 (en) 2002-06-20 2004-01-06 Nuevolution A/S Microarrays displaying encoded molecules
AU2003242516A1 (en) 2002-07-23 2004-02-09 Nuevolution A/S Gene shuffling by template switching
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
EP1540013B1 (de) 2002-08-19 2015-07-08 The President and Fellows of Harvard College Entwicklung einer neuen molekularen funktion
AU2003260291A1 (en) 2002-09-12 2004-04-30 Nuevolution A/S Proximity-aided synthesis of templated molecules
CN106337046B (zh) 2002-10-30 2021-03-23 纽韦卢森公司 合成双功能复合物的方法
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
EP1597395A2 (de) 2003-02-21 2005-11-23 Nuevolution A/S Methode zur herstellung einer bibliothek der zweiten generation
US20060269920A1 (en) 2003-02-21 2006-11-30 Nuevolution A/S Method for obtaining structural information about an encoded molecule
DE602004019764D1 (de) 2003-03-20 2009-04-16 Nuevolution As Ligationsvermittelnde codierung von kleinen molekülen
EP1625230A2 (de) 2003-05-09 2006-02-15 Thorleif Möller Selektion und evolution von chemischen biobliotheken
WO2004110964A2 (en) 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005003778A2 (en) 2003-07-02 2005-01-13 Nuevolution A/S A method for identifying a synthetic molecule having affinity towards a target
EP1533385A1 (de) 2003-09-05 2005-05-25 Nuevolution A/S Matrizenabhängigen Verbindungen zur Herstellung von kodierten Molekülen und gesteuerten Verfahren unter Verwendung dieser Verbindungen
WO2005026387A1 (en) 2003-09-18 2005-03-24 Nuevolution A/S A method for obtaining structural information concerning an encoded molecule and method for selecting compounds
CN101056980B (zh) 2004-11-08 2012-05-23 威泊根私人有限公司 结构型核酸指导的化学合成
DK1828381T3 (da) 2004-11-22 2009-02-23 Peter Birk Rasmussen Templatedirigeret split-and-mix-syntese af småmolekylebiblioteker

Also Published As

Publication number Publication date
WO2005090566A2 (en) 2005-09-29
EP1730277B1 (de) 2009-10-28
US20090011957A1 (en) 2009-01-08
US7704925B2 (en) 2010-04-27
EP1730277A2 (de) 2006-12-13
DK1730277T3 (da) 2010-03-01
ATE447020T1 (de) 2009-11-15
WO2005090566A3 (en) 2006-03-09

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