DK2236606T3 - Kodning af små molekyler ved ligering - Google Patents
Kodning af små molekyler ved ligeringInfo
- Publication number
- DK2236606T3 DK2236606T3 DK09154197.9T DK09154197T DK2236606T3 DK 2236606 T3 DK2236606 T3 DK 2236606T3 DK 09154197 T DK09154197 T DK 09154197T DK 2236606 T3 DK2236606 T3 DK 2236606T3
- Authority
- DK
- Denmark
- Prior art keywords
- chemical entities
- template
- encoded molecule
- codon
- identifier polynucleotide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1068—Template (nucleic acid) mediated chemical library synthesis, e.g. chemical and enzymatical DNA-templated organic molecule synthesis, libraries prepared by non ribosomal polypeptide synthesis [NRPS], DNA/RNA-polymerase mediated polypeptide synthesis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/04—Libraries containing only organic compounds
- C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
- C40B50/04—Methods of creating libraries, e.g. combinatorial synthesis using dynamic combinatorial chemistry techniques
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Computational Biology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US45585803P | 2003-03-20 | 2003-03-20 | |
DKPA200300430 | 2003-03-20 | ||
EP04722237A EP1608748B1 (en) | 2003-03-20 | 2004-03-22 | Ligational encoding of small molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2236606T3 true DK2236606T3 (da) | 2014-02-10 |
Family
ID=33031172
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04722237T DK1608748T3 (da) | 2003-03-20 | 2004-03-22 | Ligeringskodning af små molekyler |
DK09154197.9T DK2236606T3 (da) | 2003-03-20 | 2004-03-22 | Kodning af små molekyler ved ligering |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK04722237T DK1608748T3 (da) | 2003-03-20 | 2004-03-22 | Ligeringskodning af små molekyler |
Country Status (6)
Country | Link |
---|---|
US (1) | US7915201B2 (da) |
EP (2) | EP2236606B1 (da) |
AT (1) | ATE424455T1 (da) |
DE (1) | DE602004019764D1 (da) |
DK (2) | DK1608748T3 (da) |
WO (1) | WO2004083427A2 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
CA2495881C (en) * | 2002-08-19 | 2014-07-08 | The President And Fellows Of Harvard College | Evolving new molecular function |
WO2004028682A2 (en) * | 2002-09-27 | 2004-04-08 | Carlsberg A/S | Spatially encoded polymer matrix |
WO2004039825A2 (en) | 2002-10-30 | 2004-05-13 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
AU2003291964A1 (en) | 2002-12-19 | 2004-07-14 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
ATE424455T1 (de) | 2003-03-20 | 2009-03-15 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
US8017323B2 (en) * | 2003-03-26 | 2011-09-13 | President And Fellows Of Harvard College | Free reactant use in nucleic acid-templated synthesis |
EP1670939B1 (en) | 2003-09-18 | 2009-11-04 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
RU2470077C2 (ru) | 2003-12-17 | 2012-12-20 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Биологически активное соединение, содержащее кодирующий олигонуклеотид (варианты), способ его синтеза, библиотека соединений (варианты), способ ее синтеза и способ поиска соединения, связывающегося с биологической мишенью (варианты) |
US7972994B2 (en) | 2003-12-17 | 2011-07-05 | Glaxosmithkline Llc | Methods for synthesis of encoded libraries |
WO2005078122A2 (en) * | 2004-02-17 | 2005-08-25 | Nuevolution A/S | Method for enrichment involving elimination by mismatch hybridisation |
US7704925B2 (en) | 2004-03-22 | 2010-04-27 | Nuevolution A/S | Ligational encoding using building block oligonucleotides |
WO2006053571A2 (en) | 2004-11-22 | 2006-05-26 | Peter Birk Rasmussen | Template directed split and mix systhesis of small molecule libraries |
PT1910538E (pt) * | 2005-06-09 | 2011-07-28 | Praecis Pharm Inc | Métodos para a síntese de bibliotecas codificadas |
US7883848B2 (en) * | 2005-07-08 | 2011-02-08 | Olink Ab | Regulation analysis by cis reactivity, RACR |
AU2006309096B2 (en) * | 2005-10-28 | 2013-07-04 | Glaxosmithkline Llc | Methods for identifying compounds of interest using encoded libraries |
LT2336315T (lt) | 2005-12-01 | 2017-11-10 | Nuevolution A/S | Fermentiniai kodavimo būdai, skirti efektyviai didelių bibliotekų sintezei |
US7727745B2 (en) | 2006-08-14 | 2010-06-01 | Bio-Id Diagnostic Inc. | Synthesis of single-stranded DNA |
WO2009077173A2 (en) * | 2007-12-19 | 2009-06-25 | Philochem Ag | Dna-encoded chemical libraries |
WO2009097673A1 (en) * | 2008-02-07 | 2009-08-13 | Bio-Id Diagnostic Inc. | Synthesis of single-stranded dna |
WO2010094036A1 (en) | 2009-02-13 | 2010-08-19 | X-Chem, Inc. | Methods of creating and screening dna-encoded libraries |
SI2558577T1 (sl) | 2010-04-16 | 2019-05-31 | Nuevolution A/S | Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov |
EP2405000A1 (en) * | 2010-07-06 | 2012-01-11 | Alacris Theranostics GmbH | Synthesis of chemical libraries |
DK2748357T3 (da) | 2011-09-07 | 2018-07-16 | X Chem Inc | Fremgangsmåder til mærkning af DNA-kodede biblioteker |
CA2879018A1 (en) | 2012-07-13 | 2014-01-16 | X-Chem, Inc. | Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases |
US9765375B2 (en) | 2013-06-28 | 2017-09-19 | General Electric Company | Methods for developing binding-elements and uses thereof |
GB201322692D0 (en) | 2013-12-20 | 2014-02-05 | Philochem Ag | Production of encoded chemical libraries |
GB201603789D0 (en) * | 2016-03-04 | 2016-04-20 | Apta Biosciences Ltd | Oligonucleotides and methods for preparing |
US11186836B2 (en) | 2016-06-16 | 2021-11-30 | Haystack Sciences Corporation | Oligonucleotide directed and recorded combinatorial synthesis of encoded probe molecules |
US11795580B2 (en) | 2017-05-02 | 2023-10-24 | Haystack Sciences Corporation | Molecules for verifying oligonucleotide directed combinatorial synthesis and methods of making and using the same |
CN107802276B (zh) * | 2017-09-01 | 2020-11-27 | 深圳市菲森科技有限公司 | 头颅影像的描迹图绘制装置和方法 |
GB2604481A (en) | 2019-10-10 | 2022-09-07 | 1859 Inc | Methods and systems for microfluidic screening |
WO2021104514A1 (en) * | 2019-11-29 | 2021-06-03 | Bgi Shenzhen Co., Ltd. | Enzymatic synthesis of oligonucleotides |
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US4822731A (en) * | 1986-01-09 | 1989-04-18 | Cetus Corporation | Process for labeling single-stranded nucleic acids and hybridizaiton probes |
US5449602A (en) | 1988-01-13 | 1995-09-12 | Amoco Corporation | Template-directed photoligation |
AU649217B2 (en) | 1988-11-18 | 1994-05-19 | Regents Of The University Of California, The | Method for site-specifically incorporating unnatural amino acids into proteins |
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CA2160016C (en) | 1993-04-12 | 2008-06-03 | Robert L. Letsinger | Method of forming oligonucleotides |
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US6165778A (en) * | 1993-11-02 | 2000-12-26 | Affymax Technologies N.V. | Reaction vessel agitation apparatus |
BR9407947A (pt) | 1993-11-02 | 1996-11-26 | Affymax Tech Nv | Processo para sintetizar moléculas diversas em uma pluralidade de substratos e uma coleçao molecular etiquetade para realizaçao reaçoes de copulaçao em contas em paralelo para triar uma coleçao molecular etiquetada para detectar a presença de um ou mais diferentes etiquetas e para determinar a sequência de síntese aparelho para reaçoes de copulaçao paralelas em suportes sólidos bloco de alinhamento ótico para uso com um detector ótico sistemas de distribuiçao para distribuir reagentes dispositiv |
US5503805A (en) * | 1993-11-02 | 1996-04-02 | Affymax Technologies N.V. | Apparatus and method for parallel coupling reactions |
US5605793A (en) * | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
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US6593088B1 (en) * | 1999-08-27 | 2003-07-15 | Japan Science And Technology Corporation | Reversible photocoupling nucleic acid and phosphoroamidite |
US7070928B2 (en) * | 2001-03-19 | 2006-07-04 | President And Fellows Of Harvard College | Evolving new molecular function |
EP1905829B1 (en) * | 2001-06-20 | 2016-02-17 | Nuevolution A/S | Templated molecules and methods for using such molecules |
WO2004001042A2 (en) | 2002-06-20 | 2003-12-31 | Nuevolution A/S | Microarrays displaying encoded molecules |
EP1401850A1 (en) | 2001-06-20 | 2004-03-31 | Nuevolution A/S | Nucleoside derivatives for library preparation |
WO2003078445A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c=c double bond upon reaction |
WO2003078446A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c or a c-hetero atom bond upon reaction |
WO2003078050A2 (en) | 2002-03-15 | 2003-09-25 | Nuevolution A/S | A building block forming a c-c bond upon reaction |
IL163822A0 (en) | 2002-03-15 | 2005-12-18 | Nuevolution As | An improved method for synthesising templated molecules |
AU2003214033A1 (en) | 2002-03-15 | 2003-09-29 | Nuevolution A/S | A building block capable of transferring a functional entity |
EP1488009A4 (en) | 2002-03-22 | 2007-07-11 | Univ Emory | TEMPLATE CONTROLLED PROCESSES FOR SYNTHESIS OF POLYMERS AND COMPONENTS ASSOCIATED WITH SUCH PROCEDURES |
EP1527173A1 (en) | 2002-07-23 | 2005-05-04 | Nuevolution A/S | Gene shuffing by template switching |
WO2004013070A2 (en) | 2002-08-01 | 2004-02-12 | Nuevolution A/S | Multi-step synthesis of templated molecules |
CA2495881C (en) * | 2002-08-19 | 2014-07-08 | The President And Fellows Of Harvard College | Evolving new molecular function |
WO2004024929A2 (en) | 2002-09-12 | 2004-03-25 | Nuevolution A/S | Proximity-aided synthesis of templated molecules |
WO2004039825A2 (en) | 2002-10-30 | 2004-05-13 | Nuevolution A/S | Method for the synthesis of a bifunctional complex |
AU2003291964A1 (en) | 2002-12-19 | 2004-07-14 | Nuevolution A/S | Quasirandom structure and function guided synthesis methods |
EP1597394A2 (en) | 2003-02-21 | 2005-11-23 | Nuevolution A/S | A method for obtaining structural information about an encoded molecule |
WO2004074429A2 (en) | 2003-02-21 | 2004-09-02 | Nuevolution A/S | Method for producing second-generation library |
ATE424455T1 (de) | 2003-03-20 | 2009-03-15 | Nuevolution As | Ligationsvermittelnde codierung von kleinen molekülen |
WO2004099441A2 (en) | 2003-05-09 | 2004-11-18 | Hyscite Discovery As | Selection and evolution of chemical libraries |
WO2004110964A2 (en) | 2003-06-16 | 2004-12-23 | Nuevolution A/S | Encoded molecules by translation (emt) |
WO2005003778A2 (en) | 2003-07-02 | 2005-01-13 | Nuevolution A/S | A method for identifying a synthetic molecule having affinity towards a target |
EP1533385A1 (en) | 2003-09-05 | 2005-05-25 | Nuevolution A/S | Templated compounds for generation of encoded molecules and directional methods using such compounds |
EP1670939B1 (en) | 2003-09-18 | 2009-11-04 | Nuevolution A/S | A method for obtaining structural information concerning an encoded molecule and method for selecting compounds |
EP1809743B1 (en) | 2004-11-08 | 2008-12-31 | Vipergen APS | Structural nucleid acid guided chemical synthesis |
WO2006053571A2 (en) | 2004-11-22 | 2006-05-26 | Peter Birk Rasmussen | Template directed split and mix systhesis of small molecule libraries |
-
2004
- 2004-03-22 AT AT04722237T patent/ATE424455T1/de not_active IP Right Cessation
- 2004-03-22 DK DK04722237T patent/DK1608748T3/da active
- 2004-03-22 US US10/549,619 patent/US7915201B2/en active Active
- 2004-03-22 DK DK09154197.9T patent/DK2236606T3/da active
- 2004-03-22 WO PCT/DK2004/000195 patent/WO2004083427A2/en active Application Filing
- 2004-03-22 DE DE602004019764T patent/DE602004019764D1/de not_active Expired - Lifetime
- 2004-03-22 EP EP09154197.9A patent/EP2236606B1/en not_active Expired - Lifetime
- 2004-03-22 EP EP04722237A patent/EP1608748B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP2236606A2 (en) | 2010-10-06 |
EP1608748B1 (en) | 2009-03-04 |
US20060246450A1 (en) | 2006-11-02 |
ATE424455T1 (de) | 2009-03-15 |
EP1608748A2 (en) | 2005-12-28 |
WO2004083427A2 (en) | 2004-09-30 |
EP2236606A3 (en) | 2010-10-20 |
DE602004019764D1 (de) | 2009-04-16 |
US7915201B2 (en) | 2011-03-29 |
EP2236606B1 (en) | 2013-11-06 |
WO2004083427A3 (en) | 2005-02-17 |
DK1608748T3 (da) | 2009-06-29 |
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