WO2004001042A3 - Microarrays displaying encoded molecules - Google Patents

Microarrays displaying encoded molecules Download PDF

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Publication number
WO2004001042A3
WO2004001042A3 PCT/DK2003/000417 DK0300417W WO2004001042A3 WO 2004001042 A3 WO2004001042 A3 WO 2004001042A3 DK 0300417 W DK0300417 W DK 0300417W WO 2004001042 A3 WO2004001042 A3 WO 2004001042A3
Authority
WO
WIPO (PCT)
Prior art keywords
encoded molecules
molecule
template
codes
displaying encoded
Prior art date
Application number
PCT/DK2003/000417
Other languages
French (fr)
Other versions
WO2004001042A2 (en
Inventor
Per-Ola Freskgaard
Henrik Pedersen
Original Assignee
Nuevolution As
Per-Ola Freskgaard
Henrik Pedersen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/DK2002/000419 external-priority patent/WO2002103008A2/en
Priority claimed from US10/175,539 external-priority patent/US7727713B2/en
Application filed by Nuevolution As, Per-Ola Freskgaard, Henrik Pedersen filed Critical Nuevolution As
Priority to EP03729909A priority Critical patent/EP1520040A2/en
Priority to AU2003240436A priority patent/AU2003240436A1/en
Priority to US10/518,056 priority patent/US20060234231A1/en
Publication of WO2004001042A2 publication Critical patent/WO2004001042A2/en
Publication of WO2004001042A3 publication Critical patent/WO2004001042A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips

Abstract

Disclosed is a microarray comprising a plurality of single stranded nucleic acid probes immobilized in discrete areas of a solid support, said probes being hybridised to a library of complexes, wherein each complex comprises an encoded molecule and a template which codes for said molecule, said template comprising a number of codons which codes for chemical entities which upon reaction form a reaction product which at least partly form part of the encoded molecule.
PCT/DK2003/000417 2001-06-20 2003-06-20 Microarrays displaying encoded molecules WO2004001042A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
EP03729909A EP1520040A2 (en) 2002-06-20 2003-06-20 Microarrays displaying encoded molecules
AU2003240436A AU2003240436A1 (en) 2002-06-20 2003-06-20 Microarrays displaying encoded molecules
US10/518,056 US20060234231A1 (en) 2001-06-20 2003-06-20 Microarrays displaying encoded molecules

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
PCT/DK2002/000419 WO2002103008A2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
US10/175,539 US7727713B2 (en) 2001-06-20 2002-06-20 Templated molecules and methods for using such molecules
DKPCT/DK02/00419 2002-06-20
US10/175,539 2002-06-20
DKPA200201953 2002-12-19
DKPA200201953 2002-12-19
US43466402P 2002-12-20 2002-12-20
US60/434,664 2002-12-20

Publications (2)

Publication Number Publication Date
WO2004001042A2 WO2004001042A2 (en) 2003-12-31
WO2004001042A3 true WO2004001042A3 (en) 2004-03-18

Family

ID=30003869

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK2003/000417 WO2004001042A2 (en) 2001-06-20 2003-06-20 Microarrays displaying encoded molecules

Country Status (3)

Country Link
EP (1) EP1520040A2 (en)
AU (1) AU2003240436A1 (en)
WO (1) WO2004001042A2 (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8206901B2 (en) 2002-10-30 2012-06-26 Nuevolution A/S Method for the synthesis of a bifunctional complex
US8808984B2 (en) 2002-03-15 2014-08-19 Neuvolution A/S Method for synthesising templated molecules
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158000A0 (en) 2001-03-19 2004-03-28 Harvard College Evolving new molecular function
WO2004013070A2 (en) 2002-08-01 2004-02-12 Nuevolution A/S Multi-step synthesis of templated molecules
DE602004019764D1 (en) 2003-03-20 2009-04-16 Nuevolution As LIGATION-RELATED CODING OF SMALL MOLECULES
DK1670939T3 (en) 2003-09-18 2010-03-01 Nuevolution As Method for obtaining structural information on a coded molecule and method for selecting compounds
NZ547723A (en) 2003-12-17 2009-09-25 Praecis Pharm Inc Methods for synthesis of encoded libraries
US7972994B2 (en) 2003-12-17 2011-07-05 Glaxosmithkline Llc Methods for synthesis of encoded libraries
DE602005017370D1 (en) 2004-03-22 2009-12-10 Nuevolution As LIGATION CODING USING OLIGONUCLEOTIDE COMPONENTS
RU2400538C2 (en) * 2005-03-05 2010-09-27 Сиджен, Инк. Oligonucleotide with double specificity and methods, which it is used in
WO2006095941A1 (en) * 2005-03-05 2006-09-14 Seegene, Inc. Processes using dual specificity oligonucleotide and dual specificity oligonucleotide
EP2368868A1 (en) 2005-10-28 2011-09-28 Praecis Pharmaceuticals Inc. Methods for identifying compounds of interest using encoded libraries
GB0712245D0 (en) * 2007-06-25 2007-08-01 Cythera Technologies Ltd Combinatorial libraries and related methods
EP3653763A1 (en) 2009-02-13 2020-05-20 X-Chem, Inc. Methods of creating and screening dna-encoded libraries
WO2011127933A1 (en) 2010-04-16 2011-10-20 Nuevolution A/S Bi-functional complexes and methods for making and using such complexes
SG11201400374TA (en) 2011-09-07 2014-09-26 Chem Inc X Methods for tagging dna-encoded libraries
CA2879018A1 (en) 2012-07-13 2014-01-16 X-Chem, Inc. Dna-encoded libraries having encoding oligonucleotide linkages not readable by polymerases
WO2014187314A1 (en) 2013-05-21 2014-11-27 成都先导药物开发有限公司 Drug target capturing method

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
WO1996041011A1 (en) * 1995-06-07 1996-12-19 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
EP0778280A2 (en) * 1993-07-30 1997-06-11 Isis Innovation Limited Tag reagent and assay method
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
US5723598A (en) * 1992-03-30 1998-03-03 The Scripps Research Institute Encoded combinatorial chemical libraries
WO1999042605A1 (en) * 1998-02-21 1999-08-26 Schwabacher Alan W One dimensional chemical compound arrays and methods for assaying them
WO2000023458A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0971946T3 (en) * 1997-01-21 2006-10-30 Gen Hospital Corp Selection of proteins using RNA-protein fusions
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723598A (en) * 1992-03-30 1998-03-03 The Scripps Research Institute Encoded combinatorial chemical libraries
WO1994008051A1 (en) * 1992-10-01 1994-04-14 The Trustees Of Columbia University In The City Of New York Complex combinatorial chemical libraries encoded with tags
EP0778280A2 (en) * 1993-07-30 1997-06-11 Isis Innovation Limited Tag reagent and assay method
WO1996041011A1 (en) * 1995-06-07 1996-12-19 Lynx Therapeutics, Inc. Oligonucleotide tags for sorting and identification
WO1997027317A1 (en) * 1996-01-23 1997-07-31 Affymetrix, Inc. Nucleic acid analysis techniques
WO1999042605A1 (en) * 1998-02-21 1999-08-26 Schwabacher Alan W One dimensional chemical compound arrays and methods for assaying them
WO2000023458A1 (en) * 1998-10-19 2000-04-27 The Board Of Trustees Of The Leland Stanford Junior University Dna-templated combinatorial library chemistry

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BRUICK R K ET AL: "TEMPLATE-DIRECTED LIGATION OF PEPTIDES TO OLIGONUCLEOTIDES", CHEMISTRY AND BIOLOGY, CURRENT BIOLOGY, LONDON, GB, vol. 3, no. 1, January 1996 (1996-01-01), pages 49 - 56, XP000856876, ISSN: 1074-5521 *
LOCKHART D J ET AL: "EXPRESSION MONITORING BY HYBRIDIZATION TO HIGH-DENSITY OLIGONUCLEOTIDE ARRAYS", BIO/TECHNOLOGY, NATURE PUBLISHING CO. NEW YORK, US, vol. 14, no. 13, 1 December 1996 (1996-12-01), pages 1675 - 1680, XP002022521, ISSN: 0733-222X *
See also references of EP1520040A2 *
SUMMERER D ET AL: "DNA-TEMPLATED SYNTHESIS: MORE VERSATILE THAN EXPECTED", ANGEWANDTE CHEMIE. INTERNATIONAL EDITION, VERLAG CHEMIE. WEINHEIM, DE, vol. 41, no. 1, 4 January 2002 (2002-01-04), pages 89 - 90, XP001170352, ISSN: 0570-0833 *
WALDER J A ET AL: "COMPLEMENTARY CARRIER PEPTIDE SYNTHESIS: GENERAL STRATEGY AND IMPLICATIONS FOR PREBIOTIC ORIGIN OF PEPTIDE SYNTHESIS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 76, no. 1, January 1979 (1979-01-01), pages 51 - 55, XP000857351, ISSN: 0027-8424 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8932992B2 (en) 2001-06-20 2015-01-13 Nuevolution A/S Templated molecules and methods for using such molecules
US8808984B2 (en) 2002-03-15 2014-08-19 Neuvolution A/S Method for synthesising templated molecules
US8206901B2 (en) 2002-10-30 2012-06-26 Nuevolution A/S Method for the synthesis of a bifunctional complex
US8722583B2 (en) 2002-10-30 2014-05-13 Nuevolution A/S Method for selecting a chemical entity from a tagged library
US9109248B2 (en) 2002-10-30 2015-08-18 Nuevolution A/S Method for the synthesis of a bifunctional complex
US9121110B2 (en) 2002-12-19 2015-09-01 Nuevolution A/S Quasirandom structure and function guided synthesis methods
US9096951B2 (en) 2003-02-21 2015-08-04 Nuevolution A/S Method for producing second-generation library
US9574189B2 (en) 2005-12-01 2017-02-21 Nuevolution A/S Enzymatic encoding methods for efficient synthesis of large libraries

Also Published As

Publication number Publication date
WO2004001042A2 (en) 2003-12-31
AU2003240436A8 (en) 2004-01-06
AU2003240436A1 (en) 2004-01-06
EP1520040A2 (en) 2005-04-06

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