NO20020348D0 - Peptid acceptor ligeringsmetoder - Google Patents

Peptid acceptor ligeringsmetoder

Info

Publication number
NO20020348D0
NO20020348D0 NO20020348A NO20020348A NO20020348D0 NO 20020348 D0 NO20020348 D0 NO 20020348D0 NO 20020348 A NO20020348 A NO 20020348A NO 20020348 A NO20020348 A NO 20020348A NO 20020348 D0 NO20020348 D0 NO 20020348D0
Authority
NO
Norway
Prior art keywords
peptide acceptor
ligation methods
acceptor ligation
methods
peptide
Prior art date
Application number
NO20020348A
Other languages
English (en)
Norwegian (no)
Other versions
NO20020348L (no
Inventor
Markus Kurz
Peter Lohse
Richard Wagner
Original Assignee
Phylos Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phylos Inc filed Critical Phylos Inc
Publication of NO20020348D0 publication Critical patent/NO20020348D0/no
Publication of NO20020348L publication Critical patent/NO20020348L/no

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/26Preparation of nitrogen-containing carbohydrates
    • C12P19/28N-glycosides
    • C12P19/30Nucleotides
    • C12P19/34Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K17/00Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02Peptides being immobilised on, or in, an organic carrier
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1062Isolating an individual clone by screening libraries mRNA-Display, e.g. polypeptide and encoding template are connected covalently
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034Isolating an individual clone by screening libraries
    • C12N15/1075Isolating an individual clone by screening libraries by coupling phenotype to genotype, not provided for in other groups of this subclass

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
NO20020348A 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder NO20020348L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14583499P 1999-07-27 1999-07-27
PCT/US2000/019653 WO2001007657A1 (en) 1999-07-27 2000-07-19 Peptide acceptor ligation methods

Publications (2)

Publication Number Publication Date
NO20020348D0 true NO20020348D0 (no) 2002-01-23
NO20020348L NO20020348L (no) 2002-01-23

Family

ID=22514769

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20020348A NO20020348L (no) 1999-07-27 2002-01-23 Peptid acceptor ligeringsmetoder

Country Status (16)

Country Link
US (3) US6429300B1 (de)
EP (2) EP1870417B9 (de)
JP (2) JP4766808B2 (de)
KR (1) KR20020033743A (de)
AT (2) ATE551352T1 (de)
AU (2) AU781783B2 (de)
CA (2) CA2693274C (de)
CY (1) CY1113185T1 (de)
DE (1) DE60034566T2 (de)
DK (2) DK1196637T3 (de)
ES (2) ES2383332T3 (de)
HK (2) HK1045334A1 (de)
IL (1) IL147037A0 (de)
NO (1) NO20020348L (de)
PT (2) PT1196637E (de)
WO (1) WO2001007657A1 (de)

Families Citing this family (102)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2383332T3 (es) * 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
CA2397091A1 (en) 2000-01-11 2001-07-19 Markus Schweitzer Biomolecules having multiple attachment moieties for binding to a substrate surface
EP1268769A2 (de) * 2000-03-31 2003-01-02 Memorec Stoffel GmbH Medizinisch-Molekulare Entwicklung Verfahren zur extraktion von nukleinsäuren
US20040229271A1 (en) 2000-05-19 2004-11-18 Williams Richard B. Compositions and methods for the identification and selection of nucleic acids and polypeptides
US6962781B1 (en) * 2000-05-19 2005-11-08 Proteonova, Inc. In vitro evolution of nucleic acids and encoded polypeptide
WO2003044194A1 (en) * 2001-11-16 2003-05-30 Proteonova, Inc. Selection and evolution of nucleic acids and polypeptides
US7410761B2 (en) * 2000-05-19 2008-08-12 Proteonova, Inc. System for rapid identification and selection of nucleic acids and polypeptides, and method thereof
DE60136715D1 (de) * 2000-08-11 2009-01-08 Nanogen Recognomics Gmbh Hydrazidbausteine und hydratin-modifizierte biomoleküle
US7129229B2 (en) 2000-08-11 2006-10-31 Nanogen Recognomics Gmbh Hydrazide building blocks and hydrazide modified biomolecules
JP4963142B2 (ja) * 2000-12-14 2012-06-27 学校法人慶應義塾 遺伝子型と表現型の対応付け分子とその構成要素、および対応付け分子の製造方法と利用方法
WO2002102820A1 (en) * 2001-06-20 2002-12-27 Nuevolution A/S Nucleoside derivatives for library preparation
US20060234231A1 (en) * 2001-06-20 2006-10-19 Nuevolution A/S Microarrays displaying encoded molecules
US6893822B2 (en) 2001-07-19 2005-05-17 Nanogen Recognomics Gmbh Enzymatic modification of a nucleic acid-synthetic binding unit conjugate
US20030027194A1 (en) * 2001-07-31 2003-02-06 Markus Kurz Modular assembly of nucleic acid-protein fusion multimers
DE10147074A1 (de) * 2001-09-25 2003-05-08 Beru Ag Verfahren zum Betreiben einer aus mehreren Heizelementen bestehenden mehrstufigen elektrischen Heizung
US7125669B2 (en) 2001-11-27 2006-10-24 Compound Therapeutics, Inc. Solid-phase immobilization of proteins and peptides
DE20200926U1 (de) * 2002-01-23 2002-04-18 Hegenscheidt Mfd Gmbh & Co Kg Festwalzgerät einer Festwalzmaschine für Kurbelwellen
DK1487978T3 (da) * 2002-03-15 2009-03-23 Nuevolution As Forbedret fremgangsmåde til syntese af templatemolekyler
WO2003078626A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block capable of transferring a functional entity
WO2003078050A2 (en) * 2002-03-15 2003-09-25 Nuevolution A/S A building block forming a c-c bond upon reaction
US20050247001A1 (en) * 2002-03-15 2005-11-10 Nuevolution A/S Building block forming a c-c or a c-hetero atom bond uponreaction
EP1539980B1 (de) 2002-08-01 2016-02-17 Nuevolution A/S MEHRSTUFENSYNTHESE VON MIT MATRIZEN ASSOZIIERTE MOLEKüLEN
US20040058886A1 (en) * 2002-08-08 2004-03-25 Dharmacon, Inc. Short interfering RNAs having a hairpin structure containing a non-nucleotide loop
EP1558744B1 (de) 2002-10-30 2011-06-15 Nuevolution A/S Enzymatisches codieren
WO2004056994A2 (en) * 2002-12-19 2004-07-08 Nuevolution A/S Quasirandom structure and function guided synthesis methods
WO2004074501A2 (en) * 2003-02-21 2004-09-02 Nuevolution A/S A method for obtaining structural information about an encoded molecule
WO2004074429A2 (en) * 2003-02-21 2004-09-02 Nuevolution A/S Method for producing second-generation library
WO2004083427A2 (en) * 2003-03-20 2004-09-30 Nuevolution A/S Ligational encoding of small molecules
WO2004110964A2 (en) * 2003-06-16 2004-12-23 Nuevolution A/S Encoded molecules by translation (emt)
WO2005074417A2 (en) * 2003-09-03 2005-08-18 Salk Institute For Biological Studies Multiple antigen detection assays and reagents
US11118215B2 (en) * 2003-09-18 2021-09-14 Nuevolution A/S Method for obtaining structural information concerning an encoded molecule and method for selecting compounds
KR101337320B1 (ko) * 2003-11-20 2013-12-06 사노피 파스퇴르 인크 백일해 독소의 정제방법 및 이에 유용한 펩타이드
EP1711196A4 (de) 2003-12-05 2011-09-14 Bristol Myers Squibb Co Inhibitoren von typ-2 vaskulären endothelialen wachstumsfaktor-rezeptoren
JP2007513631A (ja) * 2003-12-12 2007-05-31 プロテオノヴァ、 インコーポレイテッド 核酸およびポリペプチドを選択する系ならびに方法
US20090239211A1 (en) * 2004-02-17 2009-09-24 Nuevolution A/S Method For Enrichment Involving Elimination By Mismatch Hybridisation
EP1730277B1 (de) * 2004-03-22 2009-10-28 Nuevolution A/S Ligationscodierung unter verwendung von oligonukleotidbausteinen
CA2467321A1 (en) * 2004-05-14 2005-11-14 Paul J. Santerre Polymeric coupling agents and pharmaceutically-active polymers made therefrom
EP1816192B1 (de) * 2004-10-15 2012-12-12 National Institute of Advanced Industrial Science and Technology Linker zur konstruktion eines mrna-puromycin-proteinkonjugats
EP3431503A1 (de) 2005-01-12 2019-01-23 Proteonova, Inc. Verfahren zur herstellung zielgerichteter therapeutika
US10206998B2 (en) 2005-01-12 2019-02-19 Proteonova, Inc. Modular targeted therapeutic agents and methods of making same
PT2339014E (pt) 2005-11-16 2015-10-13 Ambrx Inc Métodos e composições compreendendo aminoácidos não-naturais
LT3018206T (lt) 2005-12-01 2021-12-10 Nuevolution A/S Fermentiniai kodavimo būdai, skirti didelių bibliotekų efektyviai sintezei
US7749957B2 (en) 2006-04-06 2010-07-06 E.I. Du Pont De Nemours And Company Clay-binding peptides and methods of use
EP2727936B1 (de) 2006-11-22 2016-09-07 Bristol-Myers Squibb Company Gezielte Therapeutik auf Grundlage manipulierter Proteine für Tyrosinkinaserezeptoren, einschließlich IGF-IR
AU2008216303A1 (en) 2007-02-12 2008-08-21 Proteonova, Inc. Generation of library of soluble random polypeptides linked to mRNA
US7951559B2 (en) * 2007-07-25 2011-05-31 E.I. Du Pont De Nemours And Company Recombinant peptide production using a cross-linkable solubility tag
US7829311B2 (en) 2007-07-25 2010-11-09 E.I. Du Pont De Nemours And Company Ketosteroid isomerase inclusion body tag engineered to be acid-resistant by replacing aspartates with glutamate
US7678883B2 (en) 2007-07-25 2010-03-16 E.I. Du Pont De Nemours And Company Solubility tags for the expression and purification of bioactive peptides
WO2009135212A2 (en) * 2008-05-02 2009-11-05 Epicentre Technologies Corporation Selective 5' ligation tagging of rna
US7794963B2 (en) 2007-11-02 2010-09-14 E.I. Du Pont De Nemours And Company Use of tetracysteine tags in fluorescence-activated cell sorting analysis of prokaryotic cells producing peptides or proteins
US8883146B2 (en) 2007-11-30 2014-11-11 Abbvie Inc. Protein formulations and methods of making same
CA2904458C (en) 2007-11-30 2017-07-25 Wolfgang Fraunhofer Protein formulations and methods of making same
EP2247615B1 (de) 2008-02-14 2014-07-30 Bristol-Myers Squibb Company Zielgerichtete therapeutika auf der basis von egfr gentechnisch hergestellten proteinen
US9296810B2 (en) 2008-05-02 2016-03-29 Novartis Ag Fibronectin-based binding molecules and uses thereof
AR071874A1 (es) 2008-05-22 2010-07-21 Bristol Myers Squibb Co Proteinas de dominio de armazon basadas en fibronectina multivalentes
WO2010011944A2 (en) 2008-07-25 2010-01-28 Wagner Richard W Protein screeing methods
AU2009298499A1 (en) * 2008-09-30 2010-04-08 Abbvie Inc. Improved method of RNA display
TWI496582B (zh) 2008-11-24 2015-08-21 必治妥美雅史谷比公司 雙重專一性之egfr/igfir結合分子
US20100158822A1 (en) 2008-12-18 2010-06-24 E .I. Du Pont De Nemours And Company Peptides that bind to silica-coated particles
US20100158837A1 (en) 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Iron oxide-binding peptides
US20100158846A1 (en) * 2008-12-18 2010-06-24 E. I. Du Pont De Nemours And Company Hair-binding peptides
US8287845B2 (en) * 2008-12-18 2012-10-16 E I Du Pont De Nemours And Company Hair-binding peptides
US8481678B2 (en) 2009-03-30 2013-07-09 E I Du Pont De Nemours And Company Peptide-based tooth whitening reagents
US20100247590A1 (en) * 2009-03-30 2010-09-30 Johnson & Johnson Peptide-Based Systems For Delivery Of Cosmetic Agents
JP5733784B2 (ja) * 2009-09-24 2015-06-10 国立大学法人埼玉大学 cDNA/mRNA−タンパク質連結体の効率的合成法
WO2011051327A2 (en) 2009-10-30 2011-05-05 Novartis Ag Small antibody-like single chain proteins
WO2011051466A1 (en) 2009-11-02 2011-05-05 Novartis Ag Anti-idiotypic fibronectin-based binding molecules and uses thereof
WO2011092233A1 (en) 2010-01-29 2011-08-04 Novartis Ag Yeast mating to produce high-affinity combinations of fibronectin-based binders
WO2011098449A1 (en) 2010-02-10 2011-08-18 Novartis Ag Methods and compounds for muscle growth
HUE030724T2 (en) * 2010-04-09 2017-06-28 Univ Utrecht Holding Bv Recombinant multimer influenza proteins
SI2558577T1 (sl) 2010-04-16 2019-05-31 Nuevolution A/S Bifunkcionalni kompleksi in metode za pripravo in uporabo takšnih kompleksov
TW201138808A (en) 2010-05-03 2011-11-16 Bristol Myers Squibb Co Serum albumin binding molecules
US9562089B2 (en) 2010-05-26 2017-02-07 Bristol-Myers Squibb Company Fibronectin based scaffold proteins having improved stability
EP3222631A3 (de) 2010-07-30 2017-11-22 Novartis AG Fibronectin-cradle-moleküle und bibliotheken
DE102010056289A1 (de) 2010-12-24 2012-06-28 Geneart Ag Verfahren zur Herstellung von Leseraster-korrekten Fragment-Bibliotheken
EP3798236B1 (de) 2011-03-15 2022-08-10 X-Body, Inc. Antikörper-screening-verfahren
ES2861595T3 (es) 2011-04-28 2021-10-06 Univ Leland Stanford Junior Identificación de polinucleótidos asociados a una muestra
CA2843955A1 (en) 2011-08-01 2013-02-07 The General Hospital Corporation Protein and peptide libraries
CA2851667A1 (en) 2011-10-11 2013-04-18 Medimmune, Llc Cd40l-specific tn3-derived scaffolds and methods of use thereof
EP3712173B1 (de) 2011-12-05 2023-07-12 X-Body, Inc. Pdgf-rezeptor-beta bindende polypeptide
EP2975121A4 (de) * 2013-03-13 2016-07-20 Univ Tokyo Nukleinsäurelinker
EP3739336B1 (de) 2013-06-28 2022-05-11 X-Body, Inc. Zielantigenerkennung, phänotypische masken und verwendung davon zur identifikation zielzellspezifischer zielepitope
CN103382579B (zh) * 2013-07-06 2015-10-21 中国科学院成都生物研究所 一种体外筛选多肽的方法
CN110058023B (zh) 2013-09-23 2022-10-14 X博迪公司 用于生成对抗细胞表面抗原的结合剂的方法和组合物
US20150184214A1 (en) * 2013-12-31 2015-07-02 Roche Nimblegen, Inc. Enrichment of full length oligonucleotides via transcription/translation mediated purification
EP3102245B1 (de) 2014-02-05 2021-09-08 Molecular Templates, Inc. Verfahren zum abtasten, auswählen und identifizieren von cytotoxischen rekombinanten polypeptiden auf grundlage einer vorläufigen minderung der ribotoxizität
CN113150117A (zh) 2014-03-20 2021-07-23 百时美施贵宝公司 新的结合血清白蛋白的纤连蛋白iii型结构域
JP6478392B2 (ja) * 2014-12-26 2019-03-06 国立研究開発法人産業技術総合研究所 核酸リンカー
EP3268389B1 (de) 2015-03-12 2020-09-30 Medimmune, LLC Verfahren zur aufreinigung von albuminfusionsproteinen
EP3708580B1 (de) 2015-09-23 2023-11-01 Bristol-Myers Squibb Company Schnell ablaufende serumalbuminbindende fibronektin-typ-iii-domänen
MX2018013341A (es) 2016-05-02 2019-09-18 Encodia Inc Analisis de macromoleculas que emplea la codificacion de acido nucleico.
WO2017218858A1 (en) * 2016-06-15 2017-12-21 Genecapture, Inc. Compositions, methods and devices comprising stem-loop captor molecules
MA45491A (fr) 2016-06-27 2019-05-01 Juno Therapeutics Inc Épitopes à restriction cmh-e, molécules de liaison et procédés et utilisations associés
EP3475446A1 (de) 2016-06-27 2019-05-01 Juno Therapeutics, Inc. Verfahren zur identifizierung von peptidepitopen, moleküle zur bindung derartiger epitope und verwendungen davon
WO2018174078A1 (ja) 2017-03-21 2018-09-27 富士フイルム株式会社 ペプチド化合物およびその製造方法、スクリーニング用組成物、並びにペプチド化合物の選択方法
JP7390027B2 (ja) * 2017-10-31 2023-12-01 エンコディア, インコーポレイテッド 核酸エンコーディングおよび/または標識を使用する解析のためのキット
US11807623B2 (en) 2017-11-30 2023-11-07 Arrakis Therapeutics, Inc. Nucleic acid-binding photoprobes and uses thereof
KR20200121816A (ko) 2018-02-02 2020-10-26 리플 테라퓨틱스 코포레이션 스테로이드 이량체를 포함하는 유리 제제 및 이의 용도
TWI830718B (zh) * 2018-02-09 2024-02-01 日商住友化學股份有限公司 核酸分子之製造方法
JP6817493B2 (ja) * 2018-03-30 2021-01-20 住友化学株式会社 一本鎖rnaの製造方法
WO2019236644A1 (en) * 2018-06-05 2019-12-12 Arrakis Therapeutics, Inc. Encoded libraries and methods of use for screening nucleic acid targets
CA3176134A1 (en) 2020-05-01 2021-11-04 Ripple Therapeutics Corporation Heterodimer compositions and methods for the treatment of ocular disorders

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6361943B1 (en) * 1996-10-17 2002-03-26 Mitsubishi Chemical Corporation Molecule that homologizes genotype and phenotype and utilization thereof
US5391723A (en) * 1989-05-31 1995-02-21 Neorx Corporation Oligonucleotide conjugates
US5843701A (en) 1990-08-02 1998-12-01 Nexstar Pharmaceticals, Inc. Systematic polypeptide evolution by reverse translation
AU8124694A (en) * 1993-10-29 1995-05-22 Affymax Technologies N.V. In vitro peptide and antibody display libraries
DE19646372C1 (de) * 1995-11-11 1997-06-19 Evotec Biosystems Gmbh Genotyp und Phänotyp koppelnde Verbindung
DK0862656T3 (da) * 1995-11-21 2001-04-09 Univ Yale Unimolekylær segmentamplifikation og -detektering
US6117635A (en) * 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5842701A (en) * 1996-10-08 1998-12-01 Smith International, Inc. Dual functioning seal for rock bits
JP2001501483A (ja) 1996-10-10 2001-02-06 ガロフ,ヘンリク アルファウイルス―レトロウイルスベクター
ATE332368T1 (de) * 1997-01-21 2006-07-15 Gen Hospital Corp Selektion von proteinen mittels rns-protein fusionen
US6261804B1 (en) * 1997-01-21 2001-07-17 The General Hospital Corporation Selection of proteins using RNA-protein fusions
US5935791A (en) * 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
ATE236998T1 (de) * 1997-12-22 2003-04-15 Genset Sa Prostatakrebs-gen
US5985575A (en) 1998-05-20 1999-11-16 Wisconsin Alumni Research Foundation Tethered function assay for protein function
ES2383332T3 (es) * 1999-07-27 2012-06-20 Bristol-Myers Squibb Company Procedimiento de ligación de aceptores de péptidos
US6436665B1 (en) * 1999-08-27 2002-08-20 Phylos, Inc Methods for encoding and sorting in vitro translated proteins

Also Published As

Publication number Publication date
US7078197B2 (en) 2006-07-18
ES2383332T3 (es) 2012-06-20
WO2001007657A1 (en) 2001-02-01
CA2377468A1 (en) 2001-02-01
HK1112007A1 (en) 2008-08-22
EP1870417B9 (de) 2012-08-01
HK1045334A1 (zh) 2002-11-22
PT1870417E (pt) 2012-06-01
US20020182687A1 (en) 2002-12-05
PT1196637E (pt) 2007-07-04
US7790421B2 (en) 2010-09-07
CA2693274A1 (en) 2001-02-01
IL147037A0 (en) 2002-08-14
AU2005211548B2 (en) 2007-11-29
EP1196637B1 (de) 2007-04-25
ES2284508T3 (es) 2007-11-16
AU6111200A (en) 2001-02-13
CY1113185T1 (el) 2016-04-13
JP4766808B2 (ja) 2011-09-07
JP2010284172A (ja) 2010-12-24
DK1196637T3 (da) 2007-07-30
DE60034566T2 (de) 2008-01-03
EP1870417A2 (de) 2007-12-26
US20060246549A1 (en) 2006-11-02
CA2377468C (en) 2010-04-20
AU2005211548A1 (en) 2005-10-13
EP1870417A3 (de) 2008-06-11
DE60034566D1 (de) 2007-06-06
ATE551352T1 (de) 2012-04-15
CA2693274C (en) 2013-05-28
US6429300B1 (en) 2002-08-06
ATE360706T1 (de) 2007-05-15
EP1870417B1 (de) 2012-03-28
JP5512463B2 (ja) 2014-06-04
DK1870417T3 (da) 2012-07-16
NO20020348L (no) 2002-01-23
AU781783B2 (en) 2005-06-16
JP2003505094A (ja) 2003-02-12
KR20020033743A (ko) 2002-05-07
EP1196637A4 (de) 2003-11-12
EP1196637A1 (de) 2002-04-17

Similar Documents

Publication Publication Date Title
NO20020348D0 (no) Peptid acceptor ligeringsmetoder
DE60010098D1 (de) 28-epirapaloge
DK1032555T3 (da) Cykliske aminosyrer og derivater deraf, som er anvendelige som lægemidler
BG107861A (en) Isothermal amplification of nucleic acids on a solid support
MA26782A1 (fr) Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2.
MA26804A1 (fr) Acides 3-propyl-gamma-aminobutyriques mono- et disubstitues.
NO992102L (no) Peptidblanding, samt farmasøytisk sammensetning og kreftvaksine som innbefatter peptidblandingen
UA84284C2 (ru) Способы лечения, профилактики и диагностики инфекции helicobacter cerdo
NL1014361A1 (nl) Bevestigingsorgaan.
TR199802289A3 (tr) Fosfonasit-ikame etmis benzazepinon-n-asetikasit türevleri.
BR0007922A (pt) Compostos calcilìticos
BR0004161B1 (pt) solução de molho ácido.
TR200000441A3 (tr) Organik azitlerin imali için islem.
PT1064265E (pt) Sintese de 3-amino-2-cloro-4-metilpiridina a partir de malononitrilo e acetona
DK1123396T3 (da) Minimale promotorer og anvendelser deraf
NL1012028A1 (nl) Aminozuursequentie.
ITMI991227A0 (it) Apparecchio emettitore di gas anionico
IT243461Y1 (it) Espositore di gioielli,particolarmente per vetrine.
IT1317829B1 (it) Processo per la preparazione di cefonicid per via enzimatica.
BR0303226A (pt) Proteìnas de aderência e penetração de haemophilus
ES1044233Y (es) Calzado convertible.
IT1311574B1 (it) Chiodo endomidollare per omero.
IT1319156B1 (it) Estirpatore pneumatico per orticoltura.
IT1314233B1 (it) Vaccino per hiv.
ES1041336Y (es) Expositor de botellas, transformabable.

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application