MA26782A1 - Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2. - Google Patents
Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2.Info
- Publication number
- MA26782A1 MA26782A1 MA26368A MA26368A MA26782A1 MA 26782 A1 MA26782 A1 MA 26782A1 MA 26368 A MA26368 A MA 26368A MA 26368 A MA26368 A MA 26368A MA 26782 A1 MA26782 A1 MA 26782A1
- Authority
- MA
- Morocco
- Prior art keywords
- pyrazolobenzodiazepines
- cdk2 inhibitors
- cdk2
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13037099P | 1999-04-21 | 1999-04-21 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA26782A1 true MA26782A1 (fr) | 2004-12-20 |
Family
ID=22444382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA26368A MA26782A1 (fr) | 1999-04-21 | 2001-10-19 | Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2. |
Country Status (33)
Country | Link |
---|---|
US (3) | US6440959B1 (fr) |
EP (1) | EP1185529B1 (fr) |
JP (1) | JP3746680B2 (fr) |
KR (1) | KR100481757B1 (fr) |
CN (2) | CN1279029C (fr) |
AR (1) | AR023542A1 (fr) |
AT (1) | ATE279413T1 (fr) |
AU (1) | AU768667B2 (fr) |
BR (1) | BR0009887A (fr) |
CA (1) | CA2367704C (fr) |
CO (1) | CO5170444A1 (fr) |
CZ (1) | CZ20013738A3 (fr) |
DE (1) | DE60014893T2 (fr) |
DK (1) | DK1185529T3 (fr) |
ES (1) | ES2228522T3 (fr) |
HK (1) | HK1046278B (fr) |
HR (1) | HRP20010742A2 (fr) |
HU (1) | HUP0300318A3 (fr) |
IL (1) | IL145764A0 (fr) |
JO (1) | JO2248B1 (fr) |
MA (1) | MA26782A1 (fr) |
NO (1) | NO20015065D0 (fr) |
NZ (1) | NZ514523A (fr) |
PE (1) | PE20010054A1 (fr) |
PL (1) | PL200933B1 (fr) |
PT (1) | PT1185529E (fr) |
RU (1) | RU2249593C2 (fr) |
SI (1) | SI1185529T1 (fr) |
TR (1) | TR200103016T2 (fr) |
TW (1) | TW585866B (fr) |
WO (1) | WO2000064900A1 (fr) |
YU (1) | YU73101A (fr) |
ZA (1) | ZA200108016B (fr) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2466055A1 (fr) * | 2001-11-13 | 2003-05-22 | 3-Dimensional Pharmaceuticals, Inc. | 1,4-benzodiazepines substituees et leurs utilisations pour le traitement du cancer |
FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
PL378116A1 (pl) * | 2003-02-27 | 2006-03-06 | Abbott Laboratories | Heterocykliczne inhibitory kinazy |
RU2394826C2 (ru) * | 2004-10-13 | 2010-07-20 | Ф.Хоффманн-Ля Рош Аг | Дизамещенные пиразолобензодиазепины, используемые в качестве ингибиторов cdk2 и ангиогенеза, а также для лечения злокачественных новообразований молочной железы, толстого кишечника, легкого и предстательной железы |
JP2009511535A (ja) * | 2005-10-14 | 2009-03-19 | エフ.ホフマン−ラ ロシュ アーゲー | 5−(2−クロロフェニル)−1,2−ジヒドロ−7−フルオロ−8−メトキシ−3−メチル−ピラゾロ[3,4−b][1,4]ベンゾジアゼピン |
EP2081921B1 (fr) | 2006-07-10 | 2010-09-08 | PAION UK Limited | Sels de benzodiazépine et leurs formes polymorphes à action brève |
KR20100073454A (ko) * | 2008-12-23 | 2010-07-01 | 국립암센터 | 트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물 |
EP2305647A1 (fr) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Procédé de préparation d'ester de méthyle d'acide 3-[(4S)-8-bromo-1-méthyl-6-(2-pyridinyl)-4H-imidazo[1,2-a][1,4]benzodiazépine-4-yl] propionique ou son sulfonate de benzène, et composants utiles dans ce procédé |
EP2450039A1 (fr) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Régime de dosage permettant la sédation avec CNS 7056 (Remimazolam) |
EA028595B1 (ru) * | 2012-02-02 | 2017-12-29 | Сенекс Биотекнолоджи Инк. | Селективные ингибиторы cdk8/cdk19 и их применение в качестве противометастатических и химиопрофилактических агентов для лечения рака |
CN103288828A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法 |
CN103288830A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法 |
CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
CN106608877B (zh) * | 2015-10-21 | 2018-11-13 | 新发药业有限公司 | 一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法 |
EP3535253A1 (fr) * | 2016-11-01 | 2019-09-11 | H. Hoffnabb-La Roche Ag | 1,3-dihydro -1,4-benzodiazépine-2-thiones pour le traitement de maladies liées au snc |
AU2017376353B2 (en) * | 2016-12-13 | 2020-02-06 | Transthera Sciences (Nanjing), Inc. | Multi-kinase inhibitor compound, and crystal form and use thereof |
CN109020980B (zh) * | 2017-06-09 | 2020-11-20 | 华东师范大学 | 一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物 |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
US11384083B2 (en) | 2019-02-15 | 2022-07-12 | Incyte Corporation | Substituted spiro[cyclopropane-1,5′-pyrrolo[2,3-d]pyrimidin]-6′(7′h)-ones as CDK2 inhibitors |
US11472791B2 (en) | 2019-03-05 | 2022-10-18 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors |
US11919904B2 (en) | 2019-03-29 | 2024-03-05 | Incyte Corporation | Sulfonylamide compounds as CDK2 inhibitors |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
KR20220064369A (ko) | 2019-08-14 | 2022-05-18 | 인사이트 코포레이션 | Cdk2 저해제로서의 이미다졸릴 피리디미딘일아민 화합물 |
CA3157681A1 (fr) | 2019-10-11 | 2021-04-15 | Incyte Corporation | Amines bicycliques utilisees en tant qu'inhibiteurs de cdk2 |
JP2023525732A (ja) * | 2020-05-08 | 2023-06-19 | 薬捷安康(南京)科技股▲分▼有限公司 | 抗腫瘍化合物の合成方法及びその中間体 |
TW202237585A (zh) | 2020-11-27 | 2022-10-01 | 瑞士商瑞森製藥公司 | Cdk抑制劑 |
WO2022149057A1 (fr) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Inhibiteurs de cdk |
WO2022237765A1 (fr) * | 2021-05-10 | 2022-11-17 | 药捷安康(南京)科技股份有限公司 | Composition pharmaceutique et utilisation d'un inhibiteur ciblant plusieurs kinases |
WO2024030399A2 (fr) * | 2022-08-02 | 2024-02-08 | Lab1636, Llc | Utilisation d'un modulateur allostérique positif de gaba-a pour la réduction de l'hypersensibilité tactile |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6251911B1 (en) | 1996-10-02 | 2001-06-26 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
-
2000
- 2000-04-12 US US09/548,091 patent/US6440959B1/en not_active Expired - Fee Related
- 2000-04-14 AT AT00929360T patent/ATE279413T1/de active
- 2000-04-14 DK DK00929360T patent/DK1185529T3/da active
- 2000-04-14 JP JP2000614252A patent/JP3746680B2/ja not_active Expired - Fee Related
- 2000-04-14 WO PCT/EP2000/003394 patent/WO2000064900A1/fr active IP Right Grant
- 2000-04-14 PT PT00929360T patent/PT1185529E/pt unknown
- 2000-04-14 CZ CZ20013738A patent/CZ20013738A3/cs unknown
- 2000-04-14 CN CNB2004100682242A patent/CN1279029C/zh not_active Expired - Fee Related
- 2000-04-14 KR KR10-2001-7013228A patent/KR100481757B1/ko not_active IP Right Cessation
- 2000-04-14 DE DE60014893T patent/DE60014893T2/de not_active Expired - Lifetime
- 2000-04-14 BR BR0009887-6A patent/BR0009887A/pt not_active IP Right Cessation
- 2000-04-14 PL PL354405A patent/PL200933B1/pl not_active IP Right Cessation
- 2000-04-14 NZ NZ514523A patent/NZ514523A/en unknown
- 2000-04-14 AU AU47480/00A patent/AU768667B2/en not_active Ceased
- 2000-04-14 YU YU73101A patent/YU73101A/sh unknown
- 2000-04-14 IL IL14576400A patent/IL145764A0/xx unknown
- 2000-04-14 CN CNB008065543A patent/CN1196703C/zh not_active Expired - Fee Related
- 2000-04-14 HU HU0300318A patent/HUP0300318A3/hu unknown
- 2000-04-14 ES ES00929360T patent/ES2228522T3/es not_active Expired - Lifetime
- 2000-04-14 RU RU2001130446/04A patent/RU2249593C2/ru not_active IP Right Cessation
- 2000-04-14 TR TR2001/03016T patent/TR200103016T2/xx unknown
- 2000-04-14 EP EP00929360A patent/EP1185529B1/fr not_active Expired - Lifetime
- 2000-04-14 SI SI200030524T patent/SI1185529T1/xx unknown
- 2000-04-14 CA CA002367704A patent/CA2367704C/fr not_active Expired - Fee Related
- 2000-04-17 JO JO200054A patent/JO2248B1/en active
- 2000-04-18 AR ARP000101817A patent/AR023542A1/es not_active Application Discontinuation
- 2000-04-18 CO CO00028559A patent/CO5170444A1/es not_active Application Discontinuation
- 2000-04-19 TW TW089107370A patent/TW585866B/zh not_active IP Right Cessation
- 2000-04-19 PE PE2000000370A patent/PE20010054A1/es not_active Application Discontinuation
-
2001
- 2001-09-29 ZA ZA200108016A patent/ZA200108016B/xx unknown
- 2001-10-12 HR HR20010742A patent/HRP20010742A2/hr not_active Application Discontinuation
- 2001-10-18 NO NO20015065A patent/NO20015065D0/no not_active Application Discontinuation
- 2001-10-19 MA MA26368A patent/MA26782A1/fr unknown
-
2002
- 2002-04-15 US US10/122,559 patent/US6838558B2/en not_active Expired - Fee Related
- 2002-10-29 HK HK02107815.6A patent/HK1046278B/zh not_active IP Right Cessation
-
2004
- 2004-04-19 US US10/827,667 patent/US6916923B2/en not_active Expired - Fee Related
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MA26782A1 (fr) | Pyrazolobenzodiazepines en tant qu'inhibiteurs de cdk2. | |
TR200000520A3 (tr) | 4-Fenil-piridin türevleri. | |
DE60019577D1 (de) | 4, 5, 6, 7-tetrahydroindazolderivate als antitumormittel | |
BR9810801B1 (pt) | composição lìquida aquosa. | |
MA25499A1 (fr) | Contacteur-disjoncteur. | |
BR0013417B1 (pt) | composiÇço aquosa. | |
BR0014932B1 (pt) | conjunto de retenção. | |
MA26794A1 (fr) | Derives de 5-phenyl-pyrimidine. | |
MA26849A1 (fr) | 4-pyridinyle-n-acyl-l-phenylalanines. | |
MA26775A1 (fr) | Inhibiteurs de metalloproteases dihetero substituees. | |
ID28483A (id) | 2-(3,5-bis-trifluorometil-fenil)-metil-n-(6-morfolin-4-il-4-0-tolil-piridin-3-il)-isobutiramida | |
ITBO990359A0 (it) | Elettromandrino . | |
MA26793A1 (fr) | Derives de 4-phenyl-pyrimidine. | |
DE60025958D1 (de) | 14,15-beta-methylen substituierte androgene | |
DE60029755D1 (de) | Congawandschutz. | |
IT1310915B1 (it) | Occhiali. | |
ITBO990358A0 (it) | Elettromandrino . | |
ES1042496Y (es) | "pilona sumible". | |
ES1044838Y (es) | Friegasuelos. | |
ITSS990004V0 (it) | Piramide - ricordo. | |
IT1317869B1 (it) | Doccia. | |
IT1317829B1 (it) | Processo per la preparazione di cefonicid per via enzimatica. | |
ITMI990856A1 (it) | Composizione funghicida. | |
ITCS990004V0 (it) | "termocamin0 c.c.m." | |
IT1310059B1 (it) | Coltivatore di ingombro riducibile. |