BR0009887A - Pirazolbenzodiazepinas como inibidores de cdk2 - Google Patents
Pirazolbenzodiazepinas como inibidores de cdk2Info
- Publication number
- BR0009887A BR0009887A BR0009887-6A BR0009887A BR0009887A BR 0009887 A BR0009887 A BR 0009887A BR 0009887 A BR0009887 A BR 0009887A BR 0009887 A BR0009887 A BR 0009887A
- Authority
- BR
- Brazil
- Prior art keywords
- pyrazolbenzodiazepines
- cdk2
- cdk2 inhibitors
- specifically
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/22—Sulfur atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Patente de Invenção: "PIRAZOLBENZODIAZEPINAS COMO INIBIDORES DE CDK2". Novas pirazolbenzodiazepinas possuindo a fórmula (I) e sais farmaceuticamente aceitáveis das mesmas, onde R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são conforme definidos aqui, inibindo quinases dependentes de ciclina (CDKs), especificamente CDK2, são agentes antiproliferativos úteis no tratamento ou controle de distúrbios proliferativos de células, especificamente de tumores de mama, cólon, pulmão e próstata.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13037099P | 1999-04-21 | 1999-04-21 | |
PCT/EP2000/003394 WO2000064900A1 (en) | 1999-04-21 | 2000-04-14 | Pyrazolobenzodiazepines as cdk2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0009887A true BR0009887A (pt) | 2002-01-22 |
Family
ID=22444382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0009887-6A BR0009887A (pt) | 1999-04-21 | 2000-04-14 | Pirazolbenzodiazepinas como inibidores de cdk2 |
Country Status (33)
Country | Link |
---|---|
US (3) | US6440959B1 (pt) |
EP (1) | EP1185529B1 (pt) |
JP (1) | JP3746680B2 (pt) |
KR (1) | KR100481757B1 (pt) |
CN (2) | CN1279029C (pt) |
AR (1) | AR023542A1 (pt) |
AT (1) | ATE279413T1 (pt) |
AU (1) | AU768667B2 (pt) |
BR (1) | BR0009887A (pt) |
CA (1) | CA2367704C (pt) |
CO (1) | CO5170444A1 (pt) |
CZ (1) | CZ20013738A3 (pt) |
DE (1) | DE60014893T2 (pt) |
DK (1) | DK1185529T3 (pt) |
ES (1) | ES2228522T3 (pt) |
HK (1) | HK1046278B (pt) |
HR (1) | HRP20010742A2 (pt) |
HU (1) | HUP0300318A3 (pt) |
IL (1) | IL145764A0 (pt) |
JO (1) | JO2248B1 (pt) |
MA (1) | MA26782A1 (pt) |
NO (1) | NO20015065D0 (pt) |
NZ (1) | NZ514523A (pt) |
PE (1) | PE20010054A1 (pt) |
PL (1) | PL200933B1 (pt) |
PT (1) | PT1185529E (pt) |
RU (1) | RU2249593C2 (pt) |
SI (1) | SI1185529T1 (pt) |
TR (1) | TR200103016T2 (pt) |
TW (1) | TW585866B (pt) |
WO (1) | WO2000064900A1 (pt) |
YU (1) | YU73101A (pt) |
ZA (1) | ZA200108016B (pt) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20050044413A (ko) * | 2001-11-13 | 2005-05-12 | 3-디멘져널 파마슈티칼즈 인코오포레이티드 | 치환된 1,4-벤조디아제핀 및 암 치료를 위한 그의 용도 |
FR2847253B1 (fr) * | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
MXPA05009151A (es) * | 2003-02-27 | 2005-10-20 | Abbott Lab | Inhibidores de cinasa heterociclica. |
CN101899049A (zh) * | 2004-10-13 | 2010-12-01 | 霍夫曼-拉罗奇有限公司 | 二取代吡唑并苯并二氮杂*类 |
KR20110010813A (ko) * | 2005-10-14 | 2011-02-07 | 에프. 호프만-라 로슈 아게 | 5-(2-클로로페닐)-1,2-디히드로-7-플루오로-8-메톡시-3-메틸-피라졸로[3,4-b][1,4] 벤조디아제핀의 투여 섭생 |
US9193730B2 (en) | 2006-07-10 | 2015-11-24 | Paion Uk Limited | Short-acting benzodiazepine salts and their polymorphic forms |
KR20100073454A (ko) * | 2008-12-23 | 2010-07-01 | 국립암센터 | 트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물 |
EP2305647A1 (en) | 2009-09-18 | 2011-04-06 | PAION UK Limited | Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process |
EP2450039A1 (en) | 2010-11-08 | 2012-05-09 | PAION UK Ltd. | Dosing regimen for sedation with CNS 7056 (Remimazolam) |
UA117342C2 (uk) * | 2012-02-02 | 2018-07-25 | Сенекс Біотекнолоджи Інк. | Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку |
CN103288828A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法 |
CN103288830A (zh) * | 2012-02-24 | 2013-09-11 | 中国科学院大连化学物理研究所 | 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法 |
CN102603743B (zh) * | 2012-02-24 | 2014-05-28 | 南京天易生物科技有限公司 | 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途 |
AR094963A1 (es) | 2013-03-04 | 2015-09-09 | Ono Pharmaceutical Co | Reacción de oxidación excelente en el índice de conversión |
CN106608877B (zh) * | 2015-10-21 | 2018-11-13 | 新发药业有限公司 | 一种依鲁替尼中间体4-氨基-3-(4-苯氧基)苯基-1H-吡唑并[3,4-d]嘧啶的制备方法 |
EP3535253A1 (en) * | 2016-11-01 | 2019-09-11 | H. Hoffnabb-La Roche Ag | 1,3-dihydro-1,4-benzodiazepine-2-thiones for the treatment of cns related diseases |
AU2017376353B2 (en) * | 2016-12-13 | 2020-02-06 | Transthera Sciences (Nanjing), Inc. | Multi-kinase inhibitor compound, and crystal form and use thereof |
CN109020980B (zh) * | 2017-06-09 | 2020-11-20 | 华东师范大学 | 一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物 |
US11066404B2 (en) | 2018-10-11 | 2021-07-20 | Incyte Corporation | Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors |
WO2020168197A1 (en) | 2019-02-15 | 2020-08-20 | Incyte Corporation | Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors |
WO2020180959A1 (en) | 2019-03-05 | 2020-09-10 | Incyte Corporation | Pyrazolyl pyrimidinylamine compounds as cdk2 inhibitors |
WO2020205560A1 (en) | 2019-03-29 | 2020-10-08 | Incyte Corporation | Sulfonylamide compounds as cdk2 inhibitors |
US11440914B2 (en) | 2019-05-01 | 2022-09-13 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
US11447494B2 (en) | 2019-05-01 | 2022-09-20 | Incyte Corporation | Tricyclic amine compounds as CDK2 inhibitors |
TW202115024A (zh) | 2019-08-14 | 2021-04-16 | 美商英塞特公司 | 作為cdk2 抑制劑之咪唑基嘧啶基胺化合物 |
CA3157681A1 (en) | 2019-10-11 | 2021-04-15 | Incyte Corporation | Bicyclic amines as cdk2 inhibitors |
CN113620949A (zh) * | 2020-05-08 | 2021-11-09 | 南京药捷安康生物科技有限公司 | 抗肿瘤化合物的合成方法及其中间体 |
WO2022113003A1 (en) | 2020-11-27 | 2022-06-02 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
WO2022149057A1 (en) | 2021-01-05 | 2022-07-14 | Rhizen Pharmaceuticals Ag | Cdk inhibitors |
CN115322196A (zh) * | 2021-05-10 | 2022-11-11 | 药捷安康(南京)科技股份有限公司 | 多激酶抑制剂的药物组合物及其用途 |
US11981671B2 (en) | 2021-06-21 | 2024-05-14 | Incyte Corporation | Bicyclic pyrazolyl amines as CDK2 inhibitors |
US11976073B2 (en) | 2021-12-10 | 2024-05-07 | Incyte Corporation | Bicyclic amines as CDK2 inhibitors |
WO2024030399A2 (en) * | 2022-08-02 | 2024-02-08 | Lab1636, Llc | Use of a gaba-a pam for reduction of tactile hypersensitivity |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0929553B1 (en) | 1996-10-02 | 2005-03-16 | Novartis AG | Pyrimidine derivatives and processes for the preparation thereof |
US6350786B1 (en) * | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
-
2000
- 2000-04-12 US US09/548,091 patent/US6440959B1/en not_active Expired - Fee Related
- 2000-04-14 PL PL354405A patent/PL200933B1/pl not_active IP Right Cessation
- 2000-04-14 YU YU73101A patent/YU73101A/sh unknown
- 2000-04-14 IL IL14576400A patent/IL145764A0/xx unknown
- 2000-04-14 AU AU47480/00A patent/AU768667B2/en not_active Ceased
- 2000-04-14 EP EP00929360A patent/EP1185529B1/en not_active Expired - Lifetime
- 2000-04-14 ES ES00929360T patent/ES2228522T3/es not_active Expired - Lifetime
- 2000-04-14 CA CA002367704A patent/CA2367704C/en not_active Expired - Fee Related
- 2000-04-14 AT AT00929360T patent/ATE279413T1/de active
- 2000-04-14 HU HU0300318A patent/HUP0300318A3/hu unknown
- 2000-04-14 JP JP2000614252A patent/JP3746680B2/ja not_active Expired - Fee Related
- 2000-04-14 DK DK00929360T patent/DK1185529T3/da active
- 2000-04-14 TR TR2001/03016T patent/TR200103016T2/xx unknown
- 2000-04-14 WO PCT/EP2000/003394 patent/WO2000064900A1/en active IP Right Grant
- 2000-04-14 DE DE60014893T patent/DE60014893T2/de not_active Expired - Lifetime
- 2000-04-14 SI SI200030524T patent/SI1185529T1/xx unknown
- 2000-04-14 KR KR10-2001-7013228A patent/KR100481757B1/ko not_active IP Right Cessation
- 2000-04-14 PT PT00929360T patent/PT1185529E/pt unknown
- 2000-04-14 CN CNB2004100682242A patent/CN1279029C/zh not_active Expired - Fee Related
- 2000-04-14 BR BR0009887-6A patent/BR0009887A/pt not_active IP Right Cessation
- 2000-04-14 RU RU2001130446/04A patent/RU2249593C2/ru not_active IP Right Cessation
- 2000-04-14 NZ NZ514523A patent/NZ514523A/en unknown
- 2000-04-14 CN CNB008065543A patent/CN1196703C/zh not_active Expired - Fee Related
- 2000-04-14 CZ CZ20013738A patent/CZ20013738A3/cs unknown
- 2000-04-17 JO JO200054A patent/JO2248B1/en active
- 2000-04-18 CO CO00028559A patent/CO5170444A1/es not_active Application Discontinuation
- 2000-04-18 AR ARP000101817A patent/AR023542A1/es not_active Application Discontinuation
- 2000-04-19 PE PE2000000370A patent/PE20010054A1/es not_active Application Discontinuation
- 2000-04-19 TW TW089107370A patent/TW585866B/zh not_active IP Right Cessation
-
2001
- 2001-09-29 ZA ZA200108016A patent/ZA200108016B/xx unknown
- 2001-10-12 HR HR20010742A patent/HRP20010742A2/hr not_active Application Discontinuation
- 2001-10-18 NO NO20015065A patent/NO20015065D0/no not_active Application Discontinuation
- 2001-10-19 MA MA26368A patent/MA26782A1/fr unknown
-
2002
- 2002-04-15 US US10/122,559 patent/US6838558B2/en not_active Expired - Fee Related
- 2002-10-29 HK HK02107815.6A patent/HK1046278B/zh not_active IP Right Cessation
-
2004
- 2004-04-19 US US10/827,667 patent/US6916923B2/en not_active Expired - Fee Related
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B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
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