BR0009887A - Pirazolbenzodiazepinas como inibidores de cdk2 - Google Patents

Pirazolbenzodiazepinas como inibidores de cdk2

Info

Publication number
BR0009887A
BR0009887A BR0009887-6A BR0009887A BR0009887A BR 0009887 A BR0009887 A BR 0009887A BR 0009887 A BR0009887 A BR 0009887A BR 0009887 A BR0009887 A BR 0009887A
Authority
BR
Brazil
Prior art keywords
pyrazolbenzodiazepines
cdk2
cdk2 inhibitors
specifically
inhibitors
Prior art date
Application number
BR0009887-6A
Other languages
English (en)
Inventor
Qingjie Ding
Jin-Jun Liu
Vicent Stewart Madison
Giacomo Pizzolato
Chung-Chen Wei
Peter Michael Wovkulich
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BR0009887A publication Critical patent/BR0009887A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/22—Sulfur atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Patente de Invenção: "PIRAZOLBENZODIAZEPINAS COMO INIBIDORES DE CDK2". Novas pirazolbenzodiazepinas possuindo a fórmula (I) e sais farmaceuticamente aceitáveis das mesmas, onde R^ 1^, R^ 2^, R^ 3^ e R^ 4^ são conforme definidos aqui, inibindo quinases dependentes de ciclina (CDKs), especificamente CDK2, são agentes antiproliferativos úteis no tratamento ou controle de distúrbios proliferativos de células, especificamente de tumores de mama, cólon, pulmão e próstata.
BR0009887-6A 1999-04-21 2000-04-14 Pirazolbenzodiazepinas como inibidores de cdk2 BR0009887A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13037099P 1999-04-21 1999-04-21
PCT/EP2000/003394 WO2000064900A1 (en) 1999-04-21 2000-04-14 Pyrazolobenzodiazepines as cdk2 inhibitors

Publications (1)

Publication Number Publication Date
BR0009887A true BR0009887A (pt) 2002-01-22

Family

ID=22444382

Family Applications (1)

Application Number Title Priority Date Filing Date
BR0009887-6A BR0009887A (pt) 1999-04-21 2000-04-14 Pirazolbenzodiazepinas como inibidores de cdk2

Country Status (33)

Country Link
US (3) US6440959B1 (pt)
EP (1) EP1185529B1 (pt)
JP (1) JP3746680B2 (pt)
KR (1) KR100481757B1 (pt)
CN (2) CN1196703C (pt)
AR (1) AR023542A1 (pt)
AT (1) ATE279413T1 (pt)
AU (1) AU768667B2 (pt)
BR (1) BR0009887A (pt)
CA (1) CA2367704C (pt)
CO (1) CO5170444A1 (pt)
CZ (1) CZ20013738A3 (pt)
DE (1) DE60014893T2 (pt)
DK (1) DK1185529T3 (pt)
ES (1) ES2228522T3 (pt)
HK (1) HK1046278B (pt)
HR (1) HRP20010742A2 (pt)
HU (1) HUP0300318A3 (pt)
IL (1) IL145764A0 (pt)
JO (1) JO2248B1 (pt)
MA (1) MA26782A1 (pt)
NO (1) NO20015065L (pt)
NZ (1) NZ514523A (pt)
PE (1) PE20010054A1 (pt)
PL (1) PL200933B1 (pt)
PT (1) PT1185529E (pt)
RU (1) RU2249593C2 (pt)
SI (1) SI1185529T1 (pt)
TR (1) TR200103016T2 (pt)
TW (1) TW585866B (pt)
WO (1) WO2000064900A1 (pt)
YU (1) YU73101A (pt)
ZA (1) ZA200108016B (pt)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002340464B2 (en) * 2001-11-13 2008-03-13 3-Dimensional Pharmaceuticals, Inc. Substituted 1,4-benzodiazepines and uses thereof for the treatment of cancer
FR2847253B1 (fr) * 2002-11-19 2007-05-18 Aventis Pharma Sa Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant
PL378116A1 (pl) * 2003-02-27 2006-03-06 Abbott Laboratories Heterocykliczne inhibitory kinazy
EP1802625B1 (en) * 2004-10-13 2008-06-18 F. Hoffmann-Roche AG Disubstituted pyrazolobenzodiazepines useful as inhibitors for cdk2 and angiogesis, and for the treatment of breast, colon, lung and prostate cancer
KR20080055914A (ko) * 2005-10-14 2008-06-19 에프. 호프만-라 로슈 아게 5-(2-클로로페닐)-1,2-디히드로-7-플루오로-8-메톡시-3-메틸-피라졸로[3,4-ｂ][1,4] 벤조디아제핀의 투여 섭생
MX2009000404A (es) 2006-07-10 2009-06-26 Paion Uk Ltd Sales de benzodiazepina de accion corta y sus formas polimorficas.
KR20100073454A (ko) * 2008-12-23 2010-07-01 국립암센터 트란스글루타미나제 억제제로 사용되는 신규한 피라졸로디아제핀계 화합물, 이의 제조방법 및 이를 포함하는 조성물
EP2305647A1 (en) 2009-09-18 2011-04-06 PAION UK Limited Process for preparing 3-[(4S)-8-bromo-1-methyl-6-(2-pyridinyl)-4 H-imidazo[1,2-a][1,4]benzodiazepine-4-yl] propionic acid methyl ester or the benzene sulfonate salt thereof, and compounds useful in that process
EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
CN104363913B (zh) * 2012-02-02 2018-08-21 申内克斯生物科技公司 Cdk8/cdk19选择性抑制剂及其在癌症的抗转移和化学预防方法中的用途
CN103288830A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-5H-吡咯并[2,1-c][1,4]-苯并二氮杂卓的方法
CN102603743B (zh) * 2012-02-24 2014-05-28 南京天易生物科技有限公司 抗肿瘤的氮杂苯并[f]薁衍生物其制备方法及其用途
CN103288828A (zh) * 2012-02-24 2013-09-11 中国科学院大连化学物理研究所 一种合成手性二氢-6H-吲哚并[2,1-c][1,4]-苯并二氮杂卓的方法
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
CN106608877B (zh) * 2015-10-21 2018-11-13 新发药业有限公司 一种依鲁替尼中间体4-氨基-3-（4-苯氧基）苯基-1H-吡唑并[3,4-d]嘧啶的制备方法
CN109906220A (zh) * 2016-11-01 2019-06-18 豪夫迈·罗氏有限公司 用于治疗cns相关疾病的1,3-二氢-1,4-苯并二氮杂*-2-硫酮化合物
AU2017376353B2 (en) * 2016-12-13 2020-02-06 Transthera Sciences (Nanjing), Inc. Multi-kinase inhibitor compound, and crystal form and use thereof
CN109020980B (zh) * 2017-06-09 2020-11-20 华东师范大学 一类抗肿瘤作用的吡唑并嘧啶二氮*衍生物
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2020223558A1 (en) * 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
KR20220064369A (ko) 2019-08-14 2022-05-18 인사이트 코포레이션 Cdk2 저해제로서의 이미다졸릴 피리디미딘일아민 화합물
CN115298177A (zh) 2019-10-11 2022-11-04 因赛特公司 作为cdk2抑制剂的双环胺
CA3182501A1 (en) * 2020-05-08 2021-11-11 Transthera Sciences (Nanjing), Inc. Method for synthesizing anti-tumor compound and intermediates thereof
TW202237585A (zh) 2020-11-27 2022-10-01 瑞士商瑞森製藥公司 Ｃｄｋ抑制劑
WO2022149057A1 (en) 2021-01-05 2022-07-14 Rhizen Pharmaceuticals Ag Cdk inhibitors
CN115322196A (zh) * 2021-05-10 2022-11-11 药捷安康(南京)科技股份有限公司 多激酶抑制剂的药物组合物及其用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
WO2024030399A2 (en) * 2022-08-02 2024-02-08 Lab1636, Llc Use of a gaba-a pam for reduction of tactile hypersensitivity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0929553B1 (en) 1996-10-02 2005-03-16 Novartis AG Pyrimidine derivatives and processes for the preparation thereof
US6350786B1 (en) * 1998-09-22 2002-02-26 Hoffmann-La Roche Inc. Stable complexes of poorly soluble compounds in ionic polymers

Also Published As

Publication number Publication date
NO20015065D0 (no) 2001-10-18
US6440959B1 (en) 2002-08-27
DE60014893T2 (de) 2005-10-13
RU2249593C2 (ru) 2005-04-10
CZ20013738A3 (cs) 2002-08-14
HK1046278A1 (en) 2003-01-03
KR100481757B1 (ko) 2005-04-11
SI1185529T1 (en) 2005-02-28
HK1046278B (zh) 2005-08-12
HUP0300318A2 (hu) 2003-06-28
HUP0300318A3 (en) 2004-11-29
YU73101A (sh) 2004-05-12
TR200103016T2 (tr) 2002-04-22
NZ514523A (en) 2003-11-28
EP1185529B1 (en) 2004-10-13
NO20015065L (no) 2001-10-18
CA2367704A1 (en) 2000-11-02
WO2000064900A1 (en) 2000-11-02
KR20010112435A (ko) 2001-12-20
ZA200108016B (en) 2003-03-26
AU4748000A (en) 2000-11-10
DK1185529T3 (da) 2005-02-07
IL145764A0 (en) 2002-07-25
CN1603314A (zh) 2005-04-06
US20020183514A1 (en) 2002-12-05
US6838558B2 (en) 2005-01-04
AU768667B2 (en) 2003-12-18
AR023542A1 (es) 2002-09-04
JP3746680B2 (ja) 2006-02-15
JP2002543081A (ja) 2002-12-17
PL354405A1 (en) 2004-01-12
TW585866B (en) 2004-05-01
PE20010054A1 (es) 2001-02-07
HRP20010742A2 (en) 2002-12-31
JO2248B1 (en) 2004-10-07
DE60014893D1 (de) 2004-11-18
EP1185529A1 (en) 2002-03-13
ES2228522T3 (es) 2005-04-16
US20040198976A1 (en) 2004-10-07
ATE279413T1 (de) 2004-10-15
CN1348455A (zh) 2002-05-08
CO5170444A1 (es) 2002-06-27
MA26782A1 (fr) 2004-12-20
CN1196703C (zh) 2005-04-13
CN1279029C (zh) 2006-10-11
US6916923B2 (en) 2005-07-12
CA2367704C (en) 2008-06-17
PT1185529E (pt) 2005-02-28
PL200933B1 (pl) 2009-02-27

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07F Notification of approval that there is no relation to art. 229 of lpi (pipeline patents) [chapter 7.6 patent gazette]

Free format text: NOTIFICACAO DE NAO ANUENCIA RELACIONADA COM O ART. 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 14A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2259 DE 22/04/2014.