UA117342C2 - Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку - Google Patents

Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку

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Publication number
UA117342C2
UA117342C2 UAA201409643A UAA201409643A UA117342C2 UA 117342 C2 UA117342 C2 UA 117342C2 UA A201409643 A UAA201409643 A UA A201409643A UA A201409643 A UAA201409643 A UA A201409643A UA 117342 C2 UA117342 C2 UA 117342C2
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Ukraine
Prior art keywords
methods
cancer
сdkі
relates
compounds
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UAA201409643A
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English (en)
Inventor
Ігор Б. Ронінсон
Дональд К. Портер
Марк П. Вентланд
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Сенекс Біотекнолоджи Інк.
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Publication of UA117342C2 publication Critical patent/UA117342C2/uk

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general

Abstract

Даний винахід стосується сполук та способів інгібування шляху інгібітора циклінзалежної кінази (CDKI). Конкретніше, даний винахід стосується сполук та способів інгібування шляху CDKI для досліджень та впливу на пов'язані зі старінням та інші пов'язані з CDKI захворювання. Даний винахід пропонує нові сполуки, які мають покращену розчинність та/або дієвість, та способи їх застосування. У різних аспектах даний винахід стосується лікування раку. Даний винахід пропонує способи хіміопрофілактики та попередження рецидивів та метастазування пухлини. Даний винахід додатково пропонує діагностичні методики для лікування певних типів раку. Згідно з даним винаходом використовують специфічні інгібітори CDK8/19 та/або вимірювання рівнів CDK8 у пацієнта.
UAA201409643A 2012-02-02 2013-02-01 Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку UA117342C2 (uk)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US201261673419P 2012-07-19 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

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UA117342C2 true UA117342C2 (uk) 2018-07-25

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UAA201409643A UA117342C2 (uk) 2012-02-02 2013-02-01 Селективні інгібітори cdk8/cdk19 та їх застосування як протиметастатичних та хіміопрофілактичних засобів у способах лікування раку

Country Status (16)

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US (2) US9321737B2 (uk)
EP (2) EP2809324B1 (uk)
JP (1) JP6193268B2 (uk)
KR (1) KR20150023223A (uk)
CN (1) CN104363913B (uk)
AU (1) AU2013214783B2 (uk)
BR (1) BR112014019052A8 (uk)
CL (1) CL2014002062A1 (uk)
CO (1) CO7151516A2 (uk)
EA (2) EA028595B1 (uk)
GE (1) GEP201706688B (uk)
MY (1) MY165446A (uk)
PH (1) PH12014501862A1 (uk)
SG (1) SG11201404596UA (uk)
UA (1) UA117342C2 (uk)
WO (1) WO2013116786A1 (uk)

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US10993945B2 (en) 2021-05-04
US20140038958A1 (en) 2014-02-06
CN104363913A (zh) 2015-02-18
SG11201404596UA (en) 2014-10-30
BR112014019052A8 (pt) 2017-07-11
US9321737B2 (en) 2016-04-26
EA028595B1 (ru) 2017-12-29
WO2013116786A1 (en) 2013-08-08
EP2809324A1 (en) 2014-12-10
MY165446A (en) 2018-03-22
AU2013214783A1 (en) 2014-08-28
EA201791284A1 (ru) 2017-10-31
CN104363913B (zh) 2018-08-21
US20170071942A1 (en) 2017-03-16
EA201491399A1 (ru) 2015-04-30
BR112014019052A2 (uk) 2017-06-20
GEP201706688B (en) 2017-06-26
JP6193268B2 (ja) 2017-09-06
PH12014501862A1 (en) 2014-11-24
CL2014002062A1 (es) 2015-03-20
KR20150023223A (ko) 2015-03-05
JP2015506376A (ja) 2015-03-02
CO7151516A2 (es) 2014-12-29
EP2809324B1 (en) 2018-08-01
AU2013214783B2 (en) 2017-07-06
EA032429B1 (ru) 2019-05-31

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