BR112014019052A8 - Inibidores seletivos de cdk8/cdk19 e seu uso em métodos antimetastáticos e quimiopreventivos para câncer - Google Patents

Inibidores seletivos de cdk8/cdk19 e seu uso em métodos antimetastáticos e quimiopreventivos para câncer

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Publication number
BR112014019052A8
BR112014019052A8 BR112014019052A BR112014019052A BR112014019052A8 BR 112014019052 A8 BR112014019052 A8 BR 112014019052A8 BR 112014019052 A BR112014019052 A BR 112014019052A BR 112014019052 A BR112014019052 A BR 112014019052A BR 112014019052 A8 BR112014019052 A8 BR 112014019052A8
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Brazil
Prior art keywords
methods
cancer
cdk8
antimetastatic
cdki
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BR112014019052A
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English (en)
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BR112014019052A2 (pt
Inventor
B Robinson Igor
C Porter Donald
P Wentland Mark
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Senex Biotechnology Inc
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Application filed by Senex Biotechnology Inc filed Critical Senex Biotechnology Inc
Publication of BR112014019052A2 publication Critical patent/BR112014019052A2/pt
Publication of BR112014019052A8 publication Critical patent/BR112014019052A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14—Antivirals for RNA viruses
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D239/72—Quinazolines; Hydrogenated quinazolines
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    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57415—Specifically defined cancers of breast
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Abstract

INIBIDORES SELETIVOS DE CDK8/CDK19, SEU USO, FORMULAÇÃO FARMACÊUTICA, MÉTODOS ANTIMETASTÁTICOS E QUIMIOPREVENTIVOS PARA O CÂNCER. A presente invenção refere-se a compostos e métodos para inibição da via de Inibidor de Quinase Dependente de Ciclina (CDKI). Mais particularmente, a invenção refere-se a compostos e métodos para inibição da via de CDKI para estudos e intervenção em doenças relacionadas à senescência ou outras relacionadas à CDKI. A invenção proporciona novos compostos que têm solubilidade e/ou potência aprimorada e métodos para seu uso. Em vários aspectos, a invenção refere-se ao tratamento de câncer. A invenção fornece métodos para quimioprevenção e prevenção de recorrência de tumores ou metástases. A invenção proporciona ainda técnicas diagnósticas para o tratamento de determinados tipos de câncer. A presente invenção usa inibidores específicos de CDK8/19 e/ou medição do nível de CDK8 em um paciente.
BR112014019052A 2012-02-02 2013-02-01 Inibidores seletivos de cdk8/cdk19 e seu uso em métodos antimetastáticos e quimiopreventivos para câncer BR112014019052A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261594023P 2012-02-02 2012-02-02
US201261673419P 2012-07-19 2012-07-19
PCT/US2013/024515 WO2013116786A1 (en) 2012-02-02 2013-02-01 Cdk8/cdk19 selective inhibitors and their use in anti-metastatic and chemopreventative methods for cancer

Publications (2)

Publication Number Publication Date
BR112014019052A2 BR112014019052A2 (pt) 2017-06-20
BR112014019052A8 true BR112014019052A8 (pt) 2017-07-11

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ID=47716178

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BR112014019052A BR112014019052A8 (pt) 2012-02-02 2013-02-01 Inibidores seletivos de cdk8/cdk19 e seu uso em métodos antimetastáticos e quimiopreventivos para câncer

Country Status (16)

Country Link
US (2) US9321737B2 (pt)
EP (2) EP2809324B1 (pt)
JP (1) JP6193268B2 (pt)
KR (1) KR20150023223A (pt)
CN (1) CN104363913B (pt)
AU (1) AU2013214783B2 (pt)
BR (1) BR112014019052A8 (pt)
CL (1) CL2014002062A1 (pt)
CO (1) CO7151516A2 (pt)
EA (2) EA028595B1 (pt)
GE (1) GEP201706688B (pt)
MY (1) MY165446A (pt)
PH (1) PH12014501862A1 (pt)
SG (1) SG11201404596UA (pt)
UA (1) UA117342C2 (pt)
WO (1) WO2013116786A1 (pt)

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