BRPI0511975A - pirazolopirimidinas - Google Patents

pirazolopirimidinas

Info

Publication number
BRPI0511975A
BRPI0511975A BRPI0511975-8A BRPI0511975A BRPI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A BR PI0511975 A BRPI0511975 A BR PI0511975A
Authority
BR
Brazil
Prior art keywords
cyclin
pyrazolopyrimidines
dependent kinase
treatment
control
Prior art date
Application number
BRPI0511975-8A
Other languages
English (en)
Inventor
Qingjie Ding
Nan Jiang
John Lawson Roberts
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0511975A publication Critical patent/BRPI0511975A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

PIRAZOLOPIRIMIDINAS. A invenção refere-se a novas pirazolopirimidinas de fórmula (I). Estas pirazolopirimidinas são capazes de inibir a atividade das cinases dependentes da ciclina, mais particularmente a cinase 1 dependente da ciclina (Cdkl), cinase 2 dependente da ciclina (Cdk2), e cinase 4 dependente da ciclina (Cdk4) e são assim úteis, inter alia, no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção também refere-se a composições farmacêuticas contendo tais compostos e aos métodos de tratamento ou controle de câncer, mais particularmente o tratamento ou controle de tumores da mama, pulmão, cólon e próstata.
BRPI0511975-8A 2004-06-09 2005-06-01 pirazolopirimidinas BRPI0511975A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US57825304P 2004-06-09 2004-06-09
PCT/EP2005/005896 WO2005121107A1 (en) 2004-06-09 2005-06-01 Pyrazolo pyrimidines

Publications (1)

Publication Number Publication Date
BRPI0511975A true BRPI0511975A (pt) 2008-01-22

Family

ID=35170008

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0511975-8A BRPI0511975A (pt) 2004-06-09 2005-06-01 pirazolopirimidinas

Country Status (14)

Country Link
US (1) US7405220B2 (pt)
EP (1) EP1758871B1 (pt)
JP (1) JP2008501744A (pt)
CN (1) CN1964954B (pt)
AT (1) ATE378321T1 (pt)
AU (1) AU2005251892A1 (pt)
BR (1) BRPI0511975A (pt)
CA (1) CA2568722A1 (pt)
DE (1) DE602005003362T2 (pt)
ES (1) ES2296195T3 (pt)
MX (1) MXPA06014161A (pt)
PL (1) PL1758871T3 (pt)
RU (1) RU2412186C2 (pt)
WO (1) WO2005121107A1 (pt)

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MX2008002588A (es) * 2005-08-25 2008-03-18 Hoffmann La Roche Inhibidores de p38-map-cinasa y los metodos para utilizarlos.
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US8314234B2 (en) 2006-09-25 2012-11-20 Janssen Pharmaceutica N.V. Bicyclic pyrimidine kinase inhibitors
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
SA08290668B1 (ar) 2007-10-25 2012-02-12 شيونوجي آند كو.، ليمتد مشتقات أمين لها نشاط مضاد لمستقبل npy y5 واستخداماتها
KR100963644B1 (ko) 2007-11-23 2010-06-15 한국과학기술연구원 피라졸로피리미딘온 유도체 및 그의 제조방법
US8220787B2 (en) * 2008-09-19 2012-07-17 Panasonic Corporation Part mounting device
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
US8227618B2 (en) 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
US8362023B2 (en) 2011-01-19 2013-01-29 Hoffmann-La Roche Inc. Pyrazolo pyrimidines
JP2013142065A (ja) 2012-01-10 2013-07-22 Sumitomo Chemical Co Ltd 植物病害防除組成物およびその用途
CN102690270B (zh) * 2012-05-28 2014-02-05 苏州科捷生物医药有限公司 嘧啶类化合物及其用途
CN103058934A (zh) * 2013-01-07 2013-04-24 盛世泰科生物医药技术(苏州)有限公司 一种5-乙酰基-2,4-二氯嘧啶的合成方法
TWI629275B (zh) 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
DK3149008T3 (en) * 2014-05-28 2019-04-01 Shanghai Fochon Pharmaceutical Co Ltd Specific protein kinase inhibitors
GB201501115D0 (en) 2015-01-23 2015-03-11 Univ Dundee Compounds
KR102572178B1 (ko) * 2015-01-23 2023-08-28 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 피라졸로[3,4-d]피리미딘 유도체 및 리슈마니아증의 치료를 위한 그의 용도
DE102016110830B4 (de) 2015-06-14 2022-01-13 Zema - Zentrum Für Mechatronik Und Automatisierungstechnik Gemeinnützige Gmbh Vorrichtung zur Befestigung einer Adaptionsplatte an einer Radnabe eines Fahrzeugs und Verfahren zum Betrieb einer Adaptionsplatte an einer Radnabe eines Fahrzeugs
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
US11919904B2 (en) 2019-03-29 2024-03-05 Incyte Corporation Sulfonylamide compounds as CDK2 inhibitors
WO2020223558A1 (en) 2019-05-01 2020-11-05 Incyte Corporation Tricyclic amine compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
AR119765A1 (es) 2019-08-14 2022-01-12 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
WO2021072232A1 (en) * 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
WO2021141041A1 (ja) 2020-01-07 2021-07-15 大日本住友製薬株式会社 タウオパチーの治療剤
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4147700A1 (en) 2021-09-08 2023-03-15 LQT Therapeutics Inc. N-(4-(azaindazol-6-yl)-phenyl)-sulfonamides for use in the treatment of sickle cell disease
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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WO2005085248A1 (en) * 2004-02-27 2005-09-15 F.Hoffmann-La Roche Ag Heteroaryl-fused pyrazolo derivatives

Also Published As

Publication number Publication date
PL1758871T3 (pl) 2008-04-30
CN1964954A (zh) 2007-05-16
EP1758871B1 (en) 2007-11-14
MXPA06014161A (es) 2007-01-29
DE602005003362T2 (de) 2008-10-16
EP1758871A1 (en) 2007-03-07
CA2568722A1 (en) 2005-12-22
DE602005003362D1 (en) 2007-12-27
US7405220B2 (en) 2008-07-29
US20050277655A1 (en) 2005-12-15
ES2296195T3 (es) 2008-04-16
CN1964954B (zh) 2010-07-21
WO2005121107A1 (en) 2005-12-22
AU2005251892A1 (en) 2005-12-22
ATE378321T1 (de) 2007-11-15
RU2007100134A (ru) 2008-07-20
JP2008501744A (ja) 2008-01-24
RU2412186C2 (ru) 2011-02-20

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 7A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012.