ATE378321T1 - Pyrazolopyrimidine - Google Patents

Pyrazolopyrimidine

Info

Publication number
ATE378321T1
ATE378321T1 AT05753794T AT05753794T ATE378321T1 AT E378321 T1 ATE378321 T1 AT E378321T1 AT 05753794 T AT05753794 T AT 05753794T AT 05753794 T AT05753794 T AT 05753794T AT E378321 T1 ATE378321 T1 AT E378321T1
Authority
AT
Austria
Prior art keywords
cyclin
pyrazolopyrimidines
dependent kinase
treatment
control
Prior art date
Application number
AT05753794T
Other languages
English (en)
Inventor
Qingjie Ding
Nan Jiang
John Roberts
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE378321T1 publication Critical patent/ATE378321T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05753794T 2004-06-09 2005-06-01 Pyrazolopyrimidine ATE378321T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57825304P 2004-06-09 2004-06-09

Publications (1)

Publication Number Publication Date
ATE378321T1 true ATE378321T1 (de) 2007-11-15

Family

ID=35170008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05753794T ATE378321T1 (de) 2004-06-09 2005-06-01 Pyrazolopyrimidine

Country Status (14)

Country Link
US (1) US7405220B2 (de)
EP (1) EP1758871B1 (de)
JP (1) JP2008501744A (de)
CN (1) CN1964954B (de)
AT (1) ATE378321T1 (de)
AU (1) AU2005251892A1 (de)
BR (1) BRPI0511975A (de)
CA (1) CA2568722A1 (de)
DE (1) DE602005003362T2 (de)
ES (1) ES2296195T3 (de)
MX (1) MXPA06014161A (de)
PL (1) PL1758871T3 (de)
RU (1) RU2412186C2 (de)
WO (1) WO2005121107A1 (de)

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WO2007023111A2 (en) * 2005-08-25 2007-03-01 F. Hoffmann-La Roche Ag P38 map kinase inhibitors and methods for using the same
US7705009B2 (en) * 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
US9150507B2 (en) 2006-04-28 2015-10-06 Shionogi & Co., Ltd. Amine derivative having NPY Y5 receptor antagonistic activity
WO2008039359A2 (en) * 2006-09-25 2008-04-03 Janssen Pharmaceutica N.V. Bicyclic pyrimidine kinase inhibitors
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
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KR100963644B1 (ko) 2007-11-23 2010-06-15 한국과학기술연구원 피라졸로피리미딘온 유도체 및 그의 제조방법
US8220787B2 (en) * 2008-09-19 2012-07-17 Panasonic Corporation Part mounting device
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
US8227618B2 (en) 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
US8362023B2 (en) * 2011-01-19 2013-01-29 Hoffmann-La Roche Inc. Pyrazolo pyrimidines
JP2013142065A (ja) 2012-01-10 2013-07-22 Sumitomo Chemical Co Ltd 植物病害防除組成物およびその用途
CN102690270B (zh) * 2012-05-28 2014-02-05 苏州科捷生物医药有限公司 嘧啶类化合物及其用途
CN103058934A (zh) * 2013-01-07 2013-04-24 盛世泰科生物医药技术(苏州)有限公司 一种5-乙酰基-2,4-二氯嘧啶的合成方法
TWI629275B (zh) 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
CN110372720B (zh) * 2014-05-28 2021-03-05 锦州奥鸿药业有限责任公司 一类激酶抑制剂
GB201501115D0 (en) 2015-01-23 2015-03-11 Univ Dundee Compounds
MY190895A (en) 2015-01-23 2022-05-18 Glaxosmithkline Ip Dev Ltd Pyrazolo [3,4-d] pyrimidin derivative and its use for the treatment of leishmaniasis
DE102016110830B4 (de) 2015-06-14 2022-01-13 Zema - Zentrum Für Mechatronik Und Automatisierungstechnik Gemeinnützige Gmbh Vorrichtung zur Befestigung einer Adaptionsplatte an einer Radnabe eines Fahrzeugs und Verfahren zum Betrieb einer Adaptionsplatte an einer Radnabe eines Fahrzeugs
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
US11440914B2 (en) 2019-05-01 2022-09-13 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
CR20220066A (es) 2019-08-14 2022-11-28 Incyte Corp Compuestos de imidazolil pirimidinilamina como inhibidores de cdk2
WO2021072232A1 (en) * 2019-10-11 2021-04-15 Incyte Corporation Bicyclic amines as cdk2 inhibitors
EP4104861A4 (de) 2020-01-07 2024-01-17 Sumitomo Pharma Co Ltd Therapeutikum für tauopathien
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4147700A1 (de) 2021-09-08 2023-03-15 LQT Therapeutics Inc. N-(4-(azaindazol-6-yl)-phenyl)-sulfonamide zur verwendung bei der behandlung von sichelzellenkrankheit
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors

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US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
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ATE355841T1 (de) * 1997-12-13 2007-03-15 Bristol Myers Squibb Co Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer
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WO2001019825A1 (en) 1999-09-15 2001-03-22 Warner-Lambert Company Pteridinones as kinase inhibitors
EP1235815A1 (de) 1999-11-22 2002-09-04 Warner-Lambert Company Chinazoline und ihre verwendung als cyclin-dependent kinase enzym- inhibitoren
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GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
CA2398446A1 (en) 2000-04-18 2001-10-25 Agouron Pharmaceuticals, Inc. Pyrazoles for inhibiting protein kinases
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
WO2002090360A1 (en) 2001-05-10 2002-11-14 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
ES2309206T3 (es) * 2001-10-02 2008-12-16 Smithkline Beecham Corporation Compuestos quimicos.
US6818663B2 (en) 2002-05-17 2004-11-16 Hoffmann-La Roches Diaminothiazoles
WO2004014368A1 (en) * 2002-08-12 2004-02-19 Sugen, Inc. 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
US7157455B2 (en) 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
EP1608652A1 (de) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidinverbindungen und deren verwendung in der medizin
KR100844864B1 (ko) * 2004-02-27 2008-07-09 에프. 호프만-라 로슈 아게 헤테로아릴-융합 피라졸로 유도체

Also Published As

Publication number Publication date
MXPA06014161A (es) 2007-01-29
ES2296195T3 (es) 2008-04-16
RU2007100134A (ru) 2008-07-20
CN1964954A (zh) 2007-05-16
US20050277655A1 (en) 2005-12-15
DE602005003362T2 (de) 2008-10-16
PL1758871T3 (pl) 2008-04-30
DE602005003362D1 (en) 2007-12-27
RU2412186C2 (ru) 2011-02-20
US7405220B2 (en) 2008-07-29
EP1758871A1 (de) 2007-03-07
CN1964954B (zh) 2010-07-21
BRPI0511975A (pt) 2008-01-22
JP2008501744A (ja) 2008-01-24
AU2005251892A1 (en) 2005-12-22
EP1758871B1 (de) 2007-11-14
CA2568722A1 (en) 2005-12-22
WO2005121107A1 (en) 2005-12-22

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