ATE378321T1 - Pyrazolopyrimidine - Google Patents

Pyrazolopyrimidine

Info

Publication number
ATE378321T1
ATE378321T1 AT05753794T AT05753794T ATE378321T1 AT E378321 T1 ATE378321 T1 AT E378321T1 AT 05753794 T AT05753794 T AT 05753794T AT 05753794 T AT05753794 T AT 05753794T AT E378321 T1 ATE378321 T1 AT E378321T1
Authority
AT
Austria
Prior art keywords
cyclin
pyrazolopyrimidines
dependent kinase
treatment
control
Prior art date
Application number
AT05753794T
Other languages
English (en)
Inventor
Qingjie Ding
Nan Jiang
John Roberts
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE378321T1 publication Critical patent/ATE378321T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT05753794T 2004-06-09 2005-06-01 Pyrazolopyrimidine ATE378321T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US57825304P 2004-06-09 2004-06-09

Publications (1)

Publication Number Publication Date
ATE378321T1 true ATE378321T1 (de) 2007-11-15

Family

ID=35170008

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05753794T ATE378321T1 (de) 2004-06-09 2005-06-01 Pyrazolopyrimidine

Country Status (14)

Country Link
US (1) US7405220B2 (de)
EP (1) EP1758871B1 (de)
JP (1) JP2008501744A (de)
CN (1) CN1964954B (de)
AT (1) ATE378321T1 (de)
AU (1) AU2005251892A1 (de)
BR (1) BRPI0511975A (de)
CA (1) CA2568722A1 (de)
DE (1) DE602005003362T2 (de)
ES (1) ES2296195T3 (de)
MX (1) MXPA06014161A (de)
PL (1) PL1758871T3 (de)
RU (1) RU2412186C2 (de)
WO (1) WO2005121107A1 (de)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2006134021A (ru) * 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные гетероарил-конденсированного пиразола
EP1737865A1 (de) * 2004-02-27 2007-01-03 F.Hoffmann-La Roche Ag Kondensierte pyrazolderivate
CN101243088B (zh) * 2005-08-25 2011-06-29 霍夫曼-拉罗奇有限公司 p38 MAP激酶抑制剂及使用它的方法
US7705009B2 (en) * 2005-11-22 2010-04-27 Hoffman-La Roche Inc. 4-aminopyrimidine-5-thione derivatives
BRPI0710950A2 (pt) 2006-04-28 2012-06-26 Shionogi & Co derivado de amina tendo atividade antagonìstica de receptor y5 de npi 53 a61p 3/04 a61p 9/04 a61p 9/12 a61p 15/00 a61p 25/08 a61p 25/20 a61p 25/24 a61p 43/00 c07c 311/07 c07c 317/36 c07d 207/325 c07d 211/14 c07d 213/38 c07d 213/74 c07d 213/82 c07d 215/38 c07d 217/04 c07d 217/14 c07d 217/22 c07d 219/10 c07d 231/38 c07d 233/61 c07d 235/30 c07d 237/20 c07d 237/22 c07d 237/34 c07d 239/42 c07d 241/20 c07d 261/14 c07d 261/20 c07d 263/58 c07d 265/30 c07d 265/36 c07d 267/14 c07d 275/02 c07d 277/28 c07d 277/62 c07d 277/82 c07d 295/12 c07d 295/18 c07d 333/36 c07d 333/40 c07d 333/66 c07d 333/72 c07d 403/04 c07d 409/04 c07d 413/04 c07d 417/12 c07d 498/04 c07d 513/04
US8314234B2 (en) 2006-09-25 2012-11-20 Janssen Pharmaceutica N.V. Bicyclic pyrimidine kinase inhibitors
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
SA08290668B1 (ar) 2007-10-25 2012-02-12 شيونوجي آند كو.، ليمتد مشتقات أمين لها نشاط مضاد لمستقبل npy y5 واستخداماتها
KR100963644B1 (ko) 2007-11-23 2010-06-15 한국과학기술연구원 피라졸로피리미딘온 유도체 및 그의 제조방법
US8220787B2 (en) * 2008-09-19 2012-07-17 Panasonic Corporation Part mounting device
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
US8227618B2 (en) 2009-04-23 2012-07-24 Shionogi & Co., Ltd. Amine-derivatives having NPY Y5 receptor antagonistic activity and the uses thereof
US8362023B2 (en) * 2011-01-19 2013-01-29 Hoffmann-La Roche Inc. Pyrazolo pyrimidines
JP2013142065A (ja) 2012-01-10 2013-07-22 Sumitomo Chemical Co Ltd 植物病害防除組成物およびその用途
CN102690270B (zh) * 2012-05-28 2014-02-05 苏州科捷生物医药有限公司 嘧啶类化合物及其用途
CN103058934A (zh) * 2013-01-07 2013-04-24 盛世泰科生物医药技术(苏州)有限公司 一种5-乙酰基-2,4-二氯嘧啶的合成方法
TWI629275B (zh) 2013-03-13 2018-07-11 賽諾菲公司 Ｎ－（４－（氮雜吲唑－６－基）－苯基）－磺醯胺及其作為醫藥之用途
US10087195B2 (en) * 2014-05-28 2018-10-02 Shanghai Fochon Pharmaceutical Co., Ltd. Certain protein kinase inhibitors
CR20170339A (es) 2015-01-23 2018-01-22 Glaxosmithkline Ip Dev Ltd Derivados de pirazol[3,4-d] pirimidina y su uso para el tratamiento de leshmaniasis
GB201501115D0 (en) 2015-01-23 2015-03-11 Univ Dundee Compounds
DE102016110830B4 (de) 2015-06-14 2022-01-13 Zema - Zentrum Für Mechatronik Und Automatisierungstechnik Gemeinnützige Gmbh Vorrichtung zur Befestigung einer Adaptionsplatte an einer Radnabe eines Fahrzeugs und Verfahren zum Betrieb einer Adaptionsplatte an einer Radnabe eines Fahrzeugs
US11066404B2 (en) 2018-10-11 2021-07-20 Incyte Corporation Dihydropyrido[2,3-d]pyrimidinone compounds as CDK2 inhibitors
WO2020168197A1 (en) 2019-02-15 2020-08-20 Incyte Corporation Pyrrolo[2,3-d]pyrimidinone compounds as cdk2 inhibitors
US11472791B2 (en) 2019-03-05 2022-10-18 Incyte Corporation Pyrazolyl pyrimidinylamine compounds as CDK2 inhibitors
WO2020205560A1 (en) 2019-03-29 2020-10-08 Incyte Corporation Sulfonylamide compounds as cdk2 inhibitors
WO2020223469A1 (en) 2019-05-01 2020-11-05 Incyte Corporation N-(1-(methylsulfonyl)piperidin-4-yl)-4,5-di hydro-1h-imidazo[4,5-h]quinazolin-8-amine derivatives and related compounds as cyclin-dependent kinase 2 (cdk2) inhibitors for treating cancer
US11447494B2 (en) 2019-05-01 2022-09-20 Incyte Corporation Tricyclic amine compounds as CDK2 inhibitors
WO2021030537A1 (en) 2019-08-14 2021-02-18 Incyte Corporation Imidazolyl pyrimidinylamine compounds as cdk2 inhibitors
PE20221905A1 (es) 2019-10-11 2022-12-23 Incyte Corp Aminas biciclicas como inhibidoras de la cdk2
CA3166986A1 (en) 2020-01-07 2021-07-15 Sumitomo Pharma Co., Ltd. Therapeutic agent for tauopathies
TW202309030A (zh) 2021-05-07 2023-03-01 美商凱麥拉醫療公司 Cdk2降解劑及其用途
US11981671B2 (en) 2021-06-21 2024-05-14 Incyte Corporation Bicyclic pyrazolyl amines as CDK2 inhibitors
EP4147700A1 (de) 2021-09-08 2023-03-15 LQT Therapeutics Inc. N-(4-(azaindazol-6-yl)-phenyl)-sulfonamide zur verwendung bei der behandlung von sichelzellenkrankheit
US11976073B2 (en) 2021-12-10 2024-05-07 Incyte Corporation Bicyclic amines as CDK2 inhibitors
US12084453B2 (en) 2021-12-10 2024-09-10 Incyte Corporation Bicyclic amines as CDK12 inhibitors

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9012592D0 (en) 1990-06-06 1990-07-25 Smithkline Beecham Intercredit Compounds
US5679683A (en) * 1994-01-25 1997-10-21 Warner-Lambert Company Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family
SK5212000A3 (en) 1997-10-27 2001-04-09 Agouron Pharmaceuticals Inc Ag 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin-dependent kinases
AU747705C (en) * 1997-12-13 2004-09-23 Bristol-Myers Squibb Company Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors
ES2276515T3 (es) * 1998-02-25 2007-06-16 Emory University 2'-fluoronucleosidos.
AU5438299A (en) 1998-08-29 2000-03-21 Astrazeneca Ab Pyrimidine compounds
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
MXPA02001108A (es) 1999-09-15 2002-08-20 Warner Lambert Co Pieridinonas como inhibidores de la cinasa.
CA2386955A1 (en) 1999-11-22 2001-05-31 Warner-Lambert Company Quinazolines and their use for inhibiting cyclin-dependent kinase enzymes
GB0004887D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004888D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
GB0004886D0 (en) 2000-03-01 2000-04-19 Astrazeneca Uk Ltd Chemical compounds
JP2004501083A (ja) 2000-04-18 2004-01-15 アゴーロン・ファーマシューティカルズ・インコーポレイテッド プロテインキナーゼを阻害するためのピラゾール
US6756374B2 (en) 2001-01-22 2004-06-29 Hoffmann-La Roche Inc. Diaminothiazoles having antiproliferative activity
WO2002090360A1 (en) 2001-05-10 2002-11-14 Smithkline Beecham Corporation Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases
AU2002341920A1 (en) * 2001-10-02 2003-04-14 Smithkline Beecham Corporation Chemical compounds
US6818663B2 (en) 2002-05-17 2004-11-16 Hoffmann-La Roches Diaminothiazoles
EP1545515A1 (de) * 2002-08-12 2005-06-29 Sugen, Inc. 3-pyrrolyl-pyridopyrazole und 3-pyrrolyl-indazole als neue kinase-hemmer
KR100468352B1 (ko) * 2002-09-24 2005-01-27 한국과학기술연구원 신규 피라졸로피리미딘계 유도체, 그의 제조방법 및 이를 유효성분으로 하는 약학적 조성물
US7157455B2 (en) 2003-02-10 2007-01-02 Hoffmann-La Roche Inc. 4-Aminopyrimidine-5-one derivatives
EP1608652A1 (de) 2003-03-31 2005-12-28 Vernalis (Cambridge) Limited Pyrazolopyrimidinverbindungen und deren verwendung in der medizin
RU2006134021A (ru) * 2004-02-27 2008-04-10 Ф.Хоффманн-Ля Рош Аг (Ch) Производные гетероарил-конденсированного пиразола

Also Published As

Publication number Publication date
RU2412186C2 (ru) 2011-02-20
CN1964954A (zh) 2007-05-16
WO2005121107A1 (en) 2005-12-22
DE602005003362T2 (de) 2008-10-16
ES2296195T3 (es) 2008-04-16
US20050277655A1 (en) 2005-12-15
MXPA06014161A (es) 2007-01-29
US7405220B2 (en) 2008-07-29
BRPI0511975A (pt) 2008-01-22
PL1758871T3 (pl) 2008-04-30
AU2005251892A1 (en) 2005-12-22
EP1758871A1 (de) 2007-03-07
EP1758871B1 (de) 2007-11-14
JP2008501744A (ja) 2008-01-24
CN1964954B (zh) 2010-07-21
RU2007100134A (ru) 2008-07-20
CA2568722A1 (en) 2005-12-22
DE602005003362D1 (en) 2007-12-27

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