BRPI0616987A2 - pirazolopirimidinas como inibidores de cinase dependente de ciclina - Google Patents

pirazolopirimidinas como inibidores de cinase dependente de ciclina

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Publication number
BRPI0616987A2
BRPI0616987A2 BRPI0616987-2A BRPI0616987A BRPI0616987A2 BR PI0616987 A2 BRPI0616987 A2 BR PI0616987A2 BR PI0616987 A BRPI0616987 A BR PI0616987A BR PI0616987 A2 BRPI0616987 A2 BR PI0616987A2
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BR
Brazil
Prior art keywords
compounds
kinase inhibitors
dependent kinase
cyclin
pyrazolopyrimidines
Prior art date
Application number
BRPI0616987-2A
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English (en)
Inventor
Timothy J Guzi
Kamil Paruch
Michael P Dwyer
Marc Labroli
Kartik M Keertikar
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Schering Corp
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Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of BRPI0616987A2 publication Critical patent/BRPI0616987A2/pt
Publication of BRPI0616987B1 publication Critical patent/BRPI0616987B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Powder Metallurgy (AREA)

Abstract

PIRAZOLOPIRIMIDINAS COMO INIBIDORES DE CINASE DEPENDENTE DE CICLINA. Em suas muitas modalidades, a presente invenção fornece uma nova classe de compostos de pirazol[1 ,5-a]pirimidina como inibidores de cinases dependentes de ciclina, métodos de preparar tais compostos, composições farmacêuticas contendo um ou mais tais compostos, métodos de preparar formulações farmacêuticas compreendendo um ou mais tais compostos, e métodos de tratamento, prevenção, inibição, ou melhora de uma ou mais doenças associadas com as CDKs usando tais compostos ou composições farmacêuticas.
BRPI0616987-2A 2005-10-06 2006-10-04 Compostos pirazolopirimidinas como inibidores de cinase dependente de ciclina e composições contendo os mesmos BRPI0616987B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/245,401 2005-10-06
US11/245,401 US7196078B2 (en) 2002-09-04 2005-10-06 Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors
PCT/US2006/038939 WO2007044449A2 (en) 2005-10-06 2006-10-04 Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
BRPI0616987A2 true BRPI0616987A2 (pt) 2009-08-04
BRPI0616987B1 BRPI0616987B1 (pt) 2021-08-31

Family

ID=37866152

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0616987-2A BRPI0616987B1 (pt) 2005-10-06 2006-10-04 Compostos pirazolopirimidinas como inibidores de cinase dependente de ciclina e composições contendo os mesmos

Country Status (20)

Country Link
US (2) US7196078B2 (pt)
EP (1) EP1931677B1 (pt)
JP (2) JP4925226B2 (pt)
KR (2) KR101661405B1 (pt)
CN (2) CN101321756A (pt)
AR (1) AR056873A1 (pt)
AU (1) AU2006302443B2 (pt)
BR (1) BRPI0616987B1 (pt)
CA (1) CA2624829C (pt)
EC (1) ECSP088345A (pt)
ES (1) ES2574782T3 (pt)
IL (2) IL190510A (pt)
MY (1) MY162134A (pt)
NO (1) NO20082091L (pt)
NZ (1) NZ567187A (pt)
PE (1) PE20070496A1 (pt)
RU (1) RU2441005C2 (pt)
TW (2) TWI372625B (pt)
WO (1) WO2007044449A2 (pt)
ZA (1) ZA200802996B (pt)

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EP1931677A2 (en) 2008-06-18
TWI372625B (en) 2012-09-21
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