MX2007007604A - Antagonistas del receptor de pirazolo[1,5-a]pirimidina adenosina a2a. - Google Patents
Antagonistas del receptor de pirazolo[1,5-a]pirimidina adenosina a2a.Info
- Publication number
- MX2007007604A MX2007007604A MX2007007604A MX2007007604A MX2007007604A MX 2007007604 A MX2007007604 A MX 2007007604A MX 2007007604 A MX2007007604 A MX 2007007604A MX 2007007604 A MX2007007604 A MX 2007007604A MX 2007007604 A MX2007007604 A MX 2007007604A
- Authority
- MX
- Mexico
- Prior art keywords
- optionally substituted
- alkyl
- cycloalkyl
- hydrogen
- optionally
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Se describen los compuestos que tienen la formula estructural I (ver formula I) en donde A es alquileno, o arileno, cicloalquileno o heteroarildiilo opcionalmente sustituido; X es -C(O)- o -S(O)2-; R1 es alquilo o cicloalquilo; R2 es hidrogeno, halo o -CN; R3 es hidrogeno o alquilo; R4 es hidrogeno, alquilo, alcoxi, hidroxialquilo, aminoalquilo-, cicloalquilo, heterocicloalquilo, heterocicloalquilo sustituido por alquilo, arilalquilo opcionalmente sustituido o heteroarilalquilo opcionalmente sustituido; o R3 y R4, a partir de un anillo de 5-7 miembros opcionalmente sustituido, dicho anillo comprende opcionalmente un miembro de anillo heteroatomo adicional; R7 es alquilo, fenilo opcionalmente sustituido, heteroarilo opcionalmente sustituido, cicloalquilo, halo, morfolinilo, piperazinilo opcionalmente sustituido, o azacicloalquilo opcionalmente sustituido; tambien se describe el uso de los compuestos en el tratamiento de la enfermedad de Parkinson, solos o en combinaciones con otros agentes para el tratamiento de la enfermedad de Parkinson, composiciones farmaceuticas que los comprenden y equipos que comprenden los componentes de las combinaciones.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US63802804P | 2004-12-21 | 2004-12-21 | |
PCT/US2005/045658 WO2006068954A2 (en) | 2004-12-21 | 2005-12-19 | PYRAZOLO[1,5-A]PYRIMIDINE ADENOSINE A2a RECEPTOR ANTAGONISTS |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007007604A true MX2007007604A (es) | 2007-08-02 |
Family
ID=36602229
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007007604A MX2007007604A (es) | 2004-12-21 | 2005-12-19 | Antagonistas del receptor de pirazolo[1,5-a]pirimidina adenosina a2a. |
Country Status (11)
Country | Link |
---|---|
US (1) | US7741318B2 (es) |
EP (1) | EP1836205B1 (es) |
JP (1) | JP2008524330A (es) |
CN (1) | CN101119998A (es) |
AT (1) | ATE433454T1 (es) |
CA (1) | CA2591125A1 (es) |
DE (1) | DE602005014891D1 (es) |
ES (1) | ES2327145T3 (es) |
HK (1) | HK1108882A1 (es) |
MX (1) | MX2007007604A (es) |
WO (1) | WO2006068954A2 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7196078B2 (en) * | 2002-09-04 | 2007-03-27 | Schering Corpoartion | Trisubstituted and tetrasubstituted pyrazolopyrimidines as cyclin dependent kinase inhibitors |
US20060128694A1 (en) * | 2002-12-19 | 2006-06-15 | Michael Grzelak | Adenosine A2a receptor antagonists for the treatment of extra-pyramidal syndrome and other movement disorders |
ES2685837T3 (es) * | 2006-08-28 | 2018-10-11 | Merck Sharp & Dohme Corp. | Proceso y productos intermedios para la síntesis de derivados de (3-alquil-5-piperidin-1-il-3,3a-dihidropirazolo[1,5-a]pirimidin-7-il)-amino |
CA2720944C (en) * | 2008-04-07 | 2012-12-18 | Irm Llc | Compounds and compositions as kinase inhibitors |
US20100093721A1 (en) * | 2008-10-13 | 2010-04-15 | Barbay J Kent | PHENYL AND HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
EP2210891A1 (en) * | 2009-01-26 | 2010-07-28 | Domain Therapeutics | New adenosine receptor ligands and uses thereof |
WO2010140339A1 (ja) * | 2009-06-01 | 2010-12-09 | 武田薬品工業株式会社 | 複素環化合物 |
CN101906105B (zh) * | 2009-06-08 | 2013-01-16 | 河北医科大学 | 吡唑并[1,5-a]嘧啶酮衍生物及其药物组合物以及其用途 |
WO2011061754A1 (en) * | 2009-11-18 | 2011-05-26 | Council Of Scientific & Industrial Research | A novel 3-substituted 7-imino-2-thioxo-3, 7-dihydro-2h-thiazolo [4,5-di pyrimidin-6-yl - and process for preparation thereof |
ES2540867T3 (es) * | 2010-02-26 | 2015-07-14 | Mitsubishi Tanabe Pharma Corporation | Compuestos de pirazolopirimidina y su uso como inhibidores de PDE10 |
MA34299B1 (fr) * | 2010-06-04 | 2013-06-01 | Hoffmann La Roche | Dérivés d'aminopyrimidine au titre de modulateurs de lrrk2 |
BR112014009531A8 (pt) | 2011-10-20 | 2018-01-16 | Glaxosmithkline Llc | aza-heterociclos bicíclicos substituídos e análogos como moduladores de sirtuína |
RU2014120180A (ru) * | 2011-10-20 | 2015-11-27 | ГЛЭКСОСМИТКЛАЙН ЭлЭлСи | Замещенные бициклические аза-гетероциклы и аналоги в качестве модуляторов сиртуина |
MX2015011898A (es) * | 2013-03-13 | 2016-05-05 | Genentech Inc | Compuestos de pirazolo y usos de los mismos. |
CN103626776B (zh) * | 2013-12-05 | 2017-02-15 | 北京师范大学 | 吡唑并[1,5‑a]嘧啶氮芥衍生物及其制备方法和肿瘤治疗应用 |
EP3778605A3 (en) * | 2015-02-13 | 2021-03-10 | Dana Farber Cancer Institute, Inc. | Lrrk2 inhibitors and methods of making and using the same |
MA54092A (fr) | 2018-10-30 | 2021-09-08 | Kronos Bio Inc | Composés, compositions et procédés de modulation de l'activité de cdk9 |
EP3886988A1 (en) | 2018-11-30 | 2021-10-06 | Merck Sharp & Dohme Corp. | 9-substituted amino triazolo quinazoline derivatives as adenosine receptor antagonists, pharmaceutical compositions and their use |
CN112921405B (zh) * | 2019-12-05 | 2023-06-27 | 成都先导药物开发股份有限公司 | 一种合成On-DNA吡唑并[1,5-a]嘧啶化合物的方法 |
TW202245774A (zh) * | 2021-02-05 | 2022-12-01 | 大陸商上海齊魯製藥研究中心有限公司 | 嘧啶或吡啶並雜環類腺苷受體抑制劑及其製備方法和用途 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2057089A1 (en) * | 1990-12-07 | 1992-06-08 | Eric E. Allen | Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists |
US5571813A (en) * | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
AU743910B2 (en) | 1997-03-24 | 2002-02-07 | Kyowa Hakko Kirin Co., Ltd. | {1,2,4}triazolo{1,5-c}pyrimidine derivatives |
US6355653B1 (en) * | 1999-09-06 | 2002-03-12 | Hoffmann-La Roche Inc. | Amino-triazolopyridine derivatives |
DE60032249T2 (de) * | 1999-09-30 | 2007-07-19 | Neurogen Corp., Branford | Amino-substituierte Pyrazolo-[1,5-a]-1,5-Pyrimidine und Pyrazolo-[1,5-a]-1,3,5-Triazine |
MY137843A (en) | 2002-09-04 | 2009-03-31 | Schering Corp | Pyrazolopyrimidines as cyclin dependent kinase inhibitors |
MXPA05008955A (es) * | 2003-02-28 | 2006-02-22 | Teijin Pharma Ltd | Derivados de pirazolo [1,5-a] pirimidina. |
US20070179161A1 (en) * | 2003-03-31 | 2007-08-02 | Vernalis (Cambridge) Limited. | Pyrazolopyrimidine compounds and their use in medicine |
US20080070932A1 (en) | 2003-04-09 | 2008-03-20 | Chi Vu | Triazolo[ 1,5-A] Pyrimidines And Pyrazolo[ 1,5-A] Pyrimidines And Methods Of Making And Using The Same |
-
2005
- 2005-12-19 CA CA002591125A patent/CA2591125A1/en not_active Abandoned
- 2005-12-19 MX MX2007007604A patent/MX2007007604A/es active IP Right Grant
- 2005-12-19 DE DE602005014891T patent/DE602005014891D1/de active Active
- 2005-12-19 US US11/311,195 patent/US7741318B2/en active Active
- 2005-12-19 CN CNA2005800482380A patent/CN101119998A/zh active Pending
- 2005-12-19 ES ES05854388T patent/ES2327145T3/es active Active
- 2005-12-19 WO PCT/US2005/045658 patent/WO2006068954A2/en active Application Filing
- 2005-12-19 AT AT05854388T patent/ATE433454T1/de not_active IP Right Cessation
- 2005-12-19 JP JP2007548334A patent/JP2008524330A/ja active Pending
- 2005-12-19 EP EP05854388A patent/EP1836205B1/en active Active
-
2007
- 2007-12-20 HK HK07113993.3A patent/HK1108882A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
HK1108882A1 (en) | 2008-05-23 |
US7741318B2 (en) | 2010-06-22 |
ES2327145T3 (es) | 2009-10-26 |
WO2006068954A3 (en) | 2006-12-07 |
CN101119998A (zh) | 2008-02-06 |
EP1836205B1 (en) | 2009-06-10 |
EP1836205A2 (en) | 2007-09-26 |
US20060135526A1 (en) | 2006-06-22 |
CA2591125A1 (en) | 2006-06-29 |
ATE433454T1 (de) | 2009-06-15 |
DE602005014891D1 (de) | 2009-07-23 |
WO2006068954A2 (en) | 2006-06-29 |
JP2008524330A (ja) | 2008-07-10 |
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Legal Events
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FG | Grant or registration |