ATE389653T1 - 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen - Google Patents
4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungenInfo
- Publication number
- ATE389653T1 ATE389653T1 AT04734885T AT04734885T ATE389653T1 AT E389653 T1 ATE389653 T1 AT E389653T1 AT 04734885 T AT04734885 T AT 04734885T AT 04734885 T AT04734885 T AT 04734885T AT E389653 T1 ATE389653 T1 AT E389653T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrazolo
- pyrimidine
- substituted derivatives
- nhch2c6h5
- nhc4h9
- Prior art date
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- -1 NHcyclohexyl Chemical group 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical compound C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000263A ITRM20030263A1 (it) | 2003-05-28 | 2003-05-28 | Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)- |
| IT000264A ITRM20030264A1 (it) | 2003-05-28 | 2003-05-28 | Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)- |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE389653T1 true ATE389653T1 (de) | 2008-04-15 |
Family
ID=33492308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04734885T ATE389653T1 (de) | 2003-05-28 | 2004-05-26 | 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7589086B2 (de) |
| EP (1) | EP1638966B1 (de) |
| JP (1) | JP4642766B2 (de) |
| AT (1) | ATE389653T1 (de) |
| CA (1) | CA2527496C (de) |
| DE (1) | DE602004012559T2 (de) |
| ES (1) | ES2304252T3 (de) |
| WO (2) | WO2004106339A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1746099A1 (de) | 2004-12-23 | 2007-01-24 | DeveloGen Aktiengesellschaft | Mnk1 or Mnk2 Inhibitoren |
| US7994172B2 (en) * | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| US7558755B2 (en) * | 2005-07-13 | 2009-07-07 | Mott Antony R | Methods and systems for valuing investments, budgets and decisions |
| GB0524436D0 (en) * | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
| JP5302883B2 (ja) | 2006-04-07 | 2013-10-02 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物用のｍｎｋ１／ｍｎｋ２阻害活性を有するチエノピリミジン |
| EP1889847A1 (de) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidine zur pharmazeutischen Anwendung |
| EP2201013B1 (de) | 2007-09-14 | 2014-11-19 | Universita Degli Studi di Siena | Neue 4-substituierte derivate von pyrazolo[3,4-d]pyrimidin und pyrrolo[2,3-d]pyrimidin und anwendungen davon |
| KR20110045019A (ko) | 2008-08-26 | 2011-05-03 | 베링거 인겔하임 인터내셔날 게엠베하 | 약제학적 조성물을 위한 티에노피리미딘 |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| AR080328A1 (es) | 2010-02-26 | 2012-03-28 | Boehringer Ingelheim Int | Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros |
| EA201201191A1 (ru) | 2010-02-26 | 2013-04-30 | Бёрингер Ингельхайм Интернациональ Гмбх | 4-[циклоалкилокси(гетеро)ариламино]тиено[2,3-d]пиримидины, обладающие ингибирующей активностью по отношению к mnkl/mnk2, предназначенные для фармацевтических композиций |
| WO2011146313A1 (en) * | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| WO2012056319A1 (en) | 2010-10-27 | 2012-05-03 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of pkm2 |
| US9273056B2 (en) | 2011-10-03 | 2016-03-01 | The University Of North Carolina At Chapel Hill | Pyrrolopyrimidine compounds for the treatment of cancer |
| HK1206338A1 (en) | 2012-05-22 | 2016-01-08 | 北卡罗来纳大学教堂山分校 | Pyrimidine compounds for the treatment of cancer |
| CN103570723B (zh) | 2012-07-27 | 2016-07-13 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途 |
| EP2909211A4 (de) | 2012-10-17 | 2016-06-22 | Univ North Carolina | Pyrazolopyrimidinverbindungen zur krebsbehandlung |
| WO2014085225A1 (en) | 2012-11-27 | 2014-06-05 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| CN106459063A (zh) | 2014-04-11 | 2017-02-22 | 北卡罗来纳-查佩尔山大学 | Mertk‑特异性嘧啶化合物 |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58208293A (ja) * | 1982-05-20 | 1983-12-03 | Lion Corp | １Ｈ−ピラゾロ〔３，４−ｄ〕ピリミジン誘導体及び該化合物を含有する抗腫瘍剤 |
| JP4249804B2 (ja) | 1995-04-03 | 2009-04-08 | ノバルティス・アクチエンゲゼルシャフト | ピラゾール誘導体およびその製造法 |
| ES2309206T3 (es) * | 2001-10-02 | 2008-12-16 | Smithkline Beecham Corporation | Compuestos quimicos. |
-
2004
- 2004-05-26 CA CA2527496A patent/CA2527496C/en not_active Expired - Fee Related
- 2004-05-26 EP EP04734885A patent/EP1638966B1/de not_active Expired - Lifetime
- 2004-05-26 AT AT04734885T patent/ATE389653T1/de active
- 2004-05-26 US US10/558,553 patent/US7589086B2/en not_active Expired - Fee Related
- 2004-05-26 DE DE602004012559T patent/DE602004012559T2/de not_active Expired - Lifetime
- 2004-05-26 JP JP2006531028A patent/JP4642766B2/ja not_active Expired - Fee Related
- 2004-05-26 WO PCT/IT2004/000302 patent/WO2004106339A2/en not_active Ceased
- 2004-05-26 WO PCT/IT2004/000303 patent/WO2004106340A2/en not_active Ceased
- 2004-05-26 ES ES04734885T patent/ES2304252T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2304252T3 (es) | 2008-10-01 |
| JP4642766B2 (ja) | 2011-03-02 |
| US7589086B2 (en) | 2009-09-15 |
| WO2004106339A3 (en) | 2005-02-17 |
| DE602004012559D1 (de) | 2008-04-30 |
| WO2004106340A3 (en) | 2005-02-17 |
| US20070010510A1 (en) | 2007-01-11 |
| WO2004106339A2 (en) | 2004-12-09 |
| JP2007500206A (ja) | 2007-01-11 |
| EP1638966B1 (de) | 2008-03-19 |
| CA2527496C (en) | 2012-08-14 |
| DE602004012559T2 (de) | 2009-04-30 |
| CA2527496A1 (en) | 2004-12-09 |
| WO2004106340A2 (en) | 2004-12-09 |
| EP1638966A2 (de) | 2006-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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