ATE389653T1 - 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen - Google Patents

4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Info

Publication number
ATE389653T1
ATE389653T1 AT04734885T AT04734885T ATE389653T1 AT E389653 T1 ATE389653 T1 AT E389653T1 AT 04734885 T AT04734885 T AT 04734885T AT 04734885 T AT04734885 T AT 04734885T AT E389653 T1 ATE389653 T1 AT E389653T1
Authority
AT
Austria
Prior art keywords
pyrazolo
pyrimidine
substituted derivatives
nhch2c6h5
nhc4h9
Prior art date
Application number
AT04734885T
Other languages
English (en)
Inventor
Francesco Bondavalli
Maurizio Botta
Olga Bruno
Fabrizio Manetti
Silvia Schenone
Fabio Carraro
Original Assignee
Univ Siena
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT000264A external-priority patent/ITRM20030264A1/it
Priority claimed from IT000263A external-priority patent/ITRM20030263A1/it
Application filed by Univ Siena filed Critical Univ Siena
Application granted granted Critical
Publication of ATE389653T1 publication Critical patent/ATE389653T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT04734885T 2003-05-28 2004-05-26 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen ATE389653T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000264A ITRM20030264A1 (it) 2003-05-28 2003-05-28 Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-
IT000263A ITRM20030263A1 (it) 2003-05-28 2003-05-28 Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)-

Publications (1)

Publication Number Publication Date
ATE389653T1 true ATE389653T1 (de) 2008-04-15

Family

ID=33492308

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04734885T ATE389653T1 (de) 2003-05-28 2004-05-26 4-substituierte derivate von pyrazolo 3,4-d pyrimidin und deren verwendungen

Country Status (8)

Country Link
US (1) US7589086B2 (de)
EP (1) EP1638966B1 (de)
JP (1) JP4642766B2 (de)
AT (1) ATE389653T1 (de)
CA (1) CA2527496C (de)
DE (1) DE602004012559T2 (de)
ES (1) ES2304252T3 (de)
WO (2) WO2004106339A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1746099A1 (de) * 2004-12-23 2007-01-24 DeveloGen Aktiengesellschaft Mnk1 or Mnk2 Inhibitoren
JP5274842B2 (ja) * 2004-12-28 2013-08-28 エグゼリクシス， インコーポレイテッド 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物
US7558755B2 (en) * 2005-07-13 2009-07-07 Mott Antony R Methods and systems for valuing investments, budgets and decisions
GB0524436D0 (en) * 2005-11-30 2006-01-11 Novartis Ag Organic compounds
KR20090047391A (ko) 2006-04-07 2009-05-12 데벨로겐 악틴게젤샤프트 약제학적 조성물을 위한 Ｍｎｋ1/Ｍｎｋ2 억제 활성을 갖는티에노피리미딘
EP1889847A1 (de) 2006-07-10 2008-02-20 DeveloGen Aktiengesellschaft Pyrrolopyrimidine zur pharmazeutischen Anwendung
WO2009034547A2 (en) * 2007-09-14 2009-03-19 Università Degli Studi Di Siena New 4-substituted derivatives of pyrazolo[3,4-d pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof
AU2009286734A1 (en) 2008-08-26 2010-03-04 Boehringer Ingelheim International Gmbh Thienopyrimidines for pharmaceutical compositions
AR080328A1 (es) 2010-02-26 2012-03-28 Boehringer Ingelheim Int Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros
UY33241A (es) 2010-02-26 2011-09-30 Boehringer Ingelheim Int ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?.
EA201201191A1 (ru) 2010-02-26 2013-04-30 Бёрингер Ингельхайм Интернациональ Гмбх 4-[циклоалкилокси(гетеро)ариламино]тиено[2,3-d]пиримидины, обладающие ингибирующей активностью по отношению к mnkl/mnk2, предназначенные для фармацевтических композиций
US9290499B2 (en) 2010-05-19 2016-03-22 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2012056319A1 (en) 2010-10-27 2012-05-03 Dynamix Pharmaceuticals Ltd. Sulfonamides for the modulation of pkm2
KR102063098B1 (ko) 2011-10-03 2020-01-08 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 암 치료를 위한 피롤로피리미딘 화합물
BR112014028424A2 (pt) 2012-05-22 2018-04-24 Univ North Carolina Chapel Hill compostos de pirimidina para o tratamento de câncer
CN103570723B (zh) * 2012-07-27 2016-07-13 广西梧州制药（集团）股份有限公司 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途
US9562047B2 (en) 2012-10-17 2017-02-07 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
US9603850B2 (en) 2014-04-11 2017-03-28 The University Of North Carolina At Chapel Hill MerTK-specific pyrazolopyrimidine compounds
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58208293A (ja) * 1982-05-20 1983-12-03 Lion Corp １Ｈ−ピラゾロ〔３，４−ｄ〕ピリミジン誘導体及び該化合物を含有する抗腫瘍剤
WO1996031510A1 (en) * 1995-04-03 1996-10-10 Novartis Ag Pyrazole derivatives and processes for the preparation thereof
WO2003029209A2 (en) * 2001-10-02 2003-04-10 Smithkline Beecham Corporation Chemical compounds

Also Published As

Publication number Publication date
WO2004106340A2 (en) 2004-12-09
CA2527496C (en) 2012-08-14
EP1638966A2 (de) 2006-03-29
JP4642766B2 (ja) 2011-03-02
WO2004106339A2 (en) 2004-12-09
DE602004012559D1 (de) 2008-04-30
CA2527496A1 (en) 2004-12-09
DE602004012559T2 (de) 2009-04-30
EP1638966B1 (de) 2008-03-19
ES2304252T3 (es) 2008-10-01
US20070010510A1 (en) 2007-01-11
US7589086B2 (en) 2009-09-15
WO2004106340A3 (en) 2005-02-17
JP2007500206A (ja) 2007-01-11
WO2004106339A3 (en) 2005-02-17

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