DE602004012559D1 - 4-SUBSTITUIERTE DERIVATE VON PYRAZOLOi3,4-D PYRIMIDIN UND DEREN VERWENDUNGEN - Google Patents
4-SUBSTITUIERTE DERIVATE VON PYRAZOLOi3,4-D PYRIMIDIN UND DEREN VERWENDUNGENInfo
- Publication number
- DE602004012559D1 DE602004012559D1 DE602004012559T DE602004012559T DE602004012559D1 DE 602004012559 D1 DE602004012559 D1 DE 602004012559D1 DE 602004012559 T DE602004012559 T DE 602004012559T DE 602004012559 T DE602004012559 T DE 602004012559T DE 602004012559 D1 DE602004012559 D1 DE 602004012559D1
- Authority
- DE
- Germany
- Prior art keywords
- pyrimidine
- pyrazoloi3
- substituted derivatives
- nhch2c6h5
- nhc4h9
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title 1
- -1 NHcyclohexyl Chemical group 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- QUKPALAWEPMWOS-UHFFFAOYSA-N 1h-pyrazolo[3,4-d]pyrimidine Chemical compound C1=NC=C2C=NNC2=N1 QUKPALAWEPMWOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM20030264 | 2003-05-28 | ||
| ITRM20030263 | 2003-05-28 | ||
| IT000264A ITRM20030264A1 (it) | 2003-05-28 | 2003-05-28 | Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)- |
| IT000263A ITRM20030263A1 (it) | 2003-05-28 | 2003-05-28 | Derivati 4-sostituiti della 1-(2-cloro-2-feniletil)- |
| PCT/IT2004/000303 WO2004106340A2 (en) | 2003-05-28 | 2004-05-26 | 4-SUBSTITUTED DERIVATIVES OF PYRAZOLO [3,4-d] PYRIMIDINE AND PYRROLO [2,3-d] PYRIMIDINE AND USES THEREOF |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602004012559D1 true DE602004012559D1 (de) | 2008-04-30 |
| DE602004012559T2 DE602004012559T2 (de) | 2009-04-30 |
Family
ID=33492308
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004012559T Expired - Lifetime DE602004012559T2 (de) | 2003-05-28 | 2004-05-26 | 4-SUBSTITUIERTE DERIVATE VON PYRAZOLOi3,4-D PYRIMIDIN UND DEREN VERWENDUNGEN |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7589086B2 (de) |
| EP (1) | EP1638966B1 (de) |
| JP (1) | JP4642766B2 (de) |
| AT (1) | ATE389653T1 (de) |
| CA (1) | CA2527496C (de) |
| DE (1) | DE602004012559T2 (de) |
| ES (1) | ES2304252T3 (de) |
| WO (2) | WO2004106339A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1746099A1 (de) | 2004-12-23 | 2007-01-24 | DeveloGen Aktiengesellschaft | Mnk1 or Mnk2 Inhibitoren |
| JP5274842B2 (ja) * | 2004-12-28 | 2013-08-28 | エグゼリクシス， インコーポレイテッド | 免疫疾患、炎症疾患および増殖疾患の処置のためのセリン−スレオニンキナーゼモジュレーター（ｐ７０Ｓ６Ｋ、Ａｋｔ−１およびＡｋｔ−２）としての［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジンまたは［１Ｈ−ピペラゾ［３，４−ｄ］ピリミジン−４−イル］−ピペラジン化合物 |
| US7558755B2 (en) * | 2005-07-13 | 2009-07-07 | Mott Antony R | Methods and systems for valuing investments, budgets and decisions |
| GB0524436D0 (en) * | 2005-11-30 | 2006-01-11 | Novartis Ag | Organic compounds |
| EA200802118A1 (ru) | 2006-04-07 | 2009-04-28 | Девелоджен Ациенгезельшафт | Обладающие ингибирующей активностью в отношении mnk1/mnk2 тиенопиримидины, предназначенные для применения в фармацевтических композициях |
| EP1889847A1 (de) | 2006-07-10 | 2008-02-20 | DeveloGen Aktiengesellschaft | Pyrrolopyrimidine zur pharmazeutischen Anwendung |
| US8466164B2 (en) * | 2007-09-14 | 2013-06-18 | Universita Degli Studi Di Siena | 4-substituted derivatives of pyrazolo[3,4-d]pyrimidine and pyrrolo[2,3-d]pyrimidine and uses thereof |
| ES2593495T3 (es) | 2008-08-26 | 2016-12-09 | Evotec International Gmbh | Tienopirimidinas para composiciones farmacéuticas |
| AU2011219764A1 (en) | 2010-02-26 | 2012-08-16 | Boehringer Ingelheim International Gmbh | Thienopyrimidines containing a substituted alkyl group for pharmaceutical compositions |
| UY33241A (es) | 2010-02-26 | 2011-09-30 | Boehringer Ingelheim Int | ?Tienopirimidinas que contienen heterocicloalquilo para composiciones farmacéuticas?. |
| BR112012021364A2 (pt) | 2010-02-26 | 2016-10-25 | Boehringer Ingelheim Int | "compostos cicloalquila contendo tienopirimidinas e composições farmacêuticas". |
| WO2011146313A1 (en) * | 2010-05-19 | 2011-11-24 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| US8692001B2 (en) | 2010-10-27 | 2014-04-08 | Dynamix Pharmaceuticals Ltd. | Sulfonamides for the modulation of PKM2 |
| KR102063098B1 (ko) | 2011-10-03 | 2020-01-08 | 더 유니버시티 오브 노쓰 캐롤라이나 엣 채플 힐 | 암 치료를 위한 피롤로피리미딘 화합물 |
| US9567326B2 (en) | 2012-05-22 | 2017-02-14 | The University Of North Carolina At Chapel Hill | Pyrimidine compounds for the treatment of cancer |
| CN103570723B (zh) | 2012-07-27 | 2016-07-13 | 广西梧州制药（集团）股份有限公司 | 吡唑并嘧啶衍生物及其制备方法和在药物制备中的用途 |
| US9562047B2 (en) | 2012-10-17 | 2017-02-07 | The University Of North Carolina At Chapel Hill | Pyrazolopyrimidine compounds for the treatment of cancer |
| EP2925752A4 (de) | 2012-11-27 | 2016-06-01 | Univ North Carolina | Pyrimidinverbindungen zur krebsbehandlung |
| AU2015244171A1 (en) | 2014-04-11 | 2016-11-03 | The University Of North Carolina At Chapel Hill | MerTK-specific pyrimidine compounds |
| US10709708B2 (en) | 2016-03-17 | 2020-07-14 | The University Of North Carolina At Chapel Hill | Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58208293A (ja) * | 1982-05-20 | 1983-12-03 | Lion Corp | １Ｈ−ピラゾロ〔３，４−ｄ〕ピリミジン誘導体及び該化合物を含有する抗腫瘍剤 |
| PT819129E (pt) * | 1995-04-03 | 2001-01-31 | Novartis Ag | Derivados pirazole e processos para a sua preparacao |
| DE60228103D1 (de) * | 2001-10-02 | 2008-09-18 | Smithkline Beecham Corp | Chemische verbindungen |
-
2004
- 2004-05-26 DE DE602004012559T patent/DE602004012559T2/de not_active Expired - Lifetime
- 2004-05-26 WO PCT/IT2004/000302 patent/WO2004106339A2/en active Application Filing
- 2004-05-26 AT AT04734885T patent/ATE389653T1/de active
- 2004-05-26 JP JP2006531028A patent/JP4642766B2/ja not_active Expired - Fee Related
- 2004-05-26 CA CA2527496A patent/CA2527496C/en not_active Expired - Fee Related
- 2004-05-26 ES ES04734885T patent/ES2304252T3/es not_active Expired - Lifetime
- 2004-05-26 US US10/558,553 patent/US7589086B2/en not_active Expired - Fee Related
- 2004-05-26 EP EP04734885A patent/EP1638966B1/de not_active Expired - Lifetime
- 2004-05-26 WO PCT/IT2004/000303 patent/WO2004106340A2/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP1638966B1 (de) | 2008-03-19 |
| WO2004106339A2 (en) | 2004-12-09 |
| CA2527496C (en) | 2012-08-14 |
| EP1638966A2 (de) | 2006-03-29 |
| US20070010510A1 (en) | 2007-01-11 |
| ES2304252T3 (es) | 2008-10-01 |
| JP4642766B2 (ja) | 2011-03-02 |
| CA2527496A1 (en) | 2004-12-09 |
| DE602004012559T2 (de) | 2009-04-30 |
| JP2007500206A (ja) | 2007-01-11 |
| WO2004106340A3 (en) | 2005-02-17 |
| WO2004106339A3 (en) | 2005-02-17 |
| ATE389653T1 (de) | 2008-04-15 |
| WO2004106340A2 (en) | 2004-12-09 |
| US7589086B2 (en) | 2009-09-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |