ATE362474T1 - Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen - Google Patents
Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasenInfo
- Publication number
- ATE362474T1 ATE362474T1 AT03796321T AT03796321T ATE362474T1 AT E362474 T1 ATE362474 T1 AT E362474T1 AT 03796321 T AT03796321 T AT 03796321T AT 03796321 T AT03796321 T AT 03796321T AT E362474 T1 ATE362474 T1 AT E362474T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclin
- pyrazolo
- pyrimidines
- inhibitors
- dependent kinases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P7/06—Antianaemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40802902P | 2002-09-04 | 2002-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE362474T1 true ATE362474T1 (de) | 2007-06-15 |
Family
ID=32030632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03796321T ATE362474T1 (de) | 2002-09-04 | 2003-09-03 | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
Country Status (19)
Country | Link |
---|---|
US (2) | US7067661B2 (de) |
EP (1) | EP1534712B1 (de) |
JP (2) | JP4790265B2 (de) |
KR (1) | KR20050033659A (de) |
CN (1) | CN1701073B (de) |
AR (1) | AR041133A1 (de) |
AT (1) | ATE362474T1 (de) |
AU (1) | AU2003298571B2 (de) |
CA (1) | CA2497544C (de) |
DE (1) | DE60313872T2 (de) |
ES (1) | ES2283868T3 (de) |
HK (1) | HK1071572A1 (de) |
MX (1) | MXPA05002572A (de) |
MY (2) | MY145332A (de) |
NZ (1) | NZ539161A (de) |
PE (1) | PE20041000A1 (de) |
TW (1) | TWI329645B (de) |
WO (1) | WO2004026229A2 (de) |
ZA (1) | ZA200501846B (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU756699B2 (en) | 1996-12-03 | 2003-01-23 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
EP1388541A1 (de) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazine als Kinasehemmer |
EP2186811A1 (de) | 2002-08-23 | 2010-05-19 | Sloan-Kettering Institute For Cancer Research | Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
ATE362474T1 (de) * | 2002-09-04 | 2007-06-15 | Schering Corp | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
EP1599482A4 (de) * | 2003-02-28 | 2008-10-01 | Teijin Pharma Ltd | Pyrazolo¬1,5-a pyrimidinderivate |
WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
US20070060595A1 (en) * | 2003-10-10 | 2007-03-15 | Toshio Yoshizawa | Novel fused heterocyclic compound and use thereof |
WO2005112936A1 (en) * | 2004-05-14 | 2005-12-01 | The Regents Of The University Of Michigan | Compositions and methods relating to protein kinase inhibitors |
WO2006027346A2 (en) * | 2004-09-06 | 2006-03-16 | Altana Pharma Ag | Novel pyrazolopyrimidines |
FR2876582B1 (fr) * | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
WO2006068954A2 (en) * | 2004-12-21 | 2006-06-29 | Schering Corporation | PYRAZOLO[1,5-A]PYRIMIDINE ADENOSINE A2a RECEPTOR ANTAGONISTS |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
JP2009507843A (ja) | 2005-09-09 | 2009-02-26 | シェーリング コーポレイション | アザ縮合サイクリン依存性キナーゼ阻害剤 |
EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007118844A1 (de) * | 2006-04-13 | 2007-10-25 | Basf Se | Substituierte pyrazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
BRPI0712016A2 (pt) * | 2006-05-22 | 2011-12-27 | Schering Corp | pirazolo[1,5-a]pirimidinas |
US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
EP2099743B1 (de) * | 2006-12-05 | 2014-08-27 | Arena Pharmaceuticals, Inc. | Verfahren zur herstellung von (r)-8-chlor-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin und zwischenprodukten davon |
US8518931B2 (en) * | 2008-04-07 | 2013-08-27 | Irm Llc | Compounds and compositions as kinase inhibitors |
WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
CA2782684C (en) * | 2009-12-04 | 2018-09-04 | Mustapha Haddach | Pyrazolopyrimidines and related heterocycles as ck2 inhibitors |
US9180127B2 (en) | 2009-12-29 | 2015-11-10 | Dana-Farber Cancer Institute, Inc. | Type II Raf kinase inhibitors |
US10953012B2 (en) | 2011-04-26 | 2021-03-23 | Bioenergenix Llc | Heterocyclic compounds for the inhibition of pask |
US9309250B2 (en) | 2011-06-22 | 2016-04-12 | Vertex Pharmaceuticals Incorporated | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors |
EP3569598A1 (de) | 2011-11-17 | 2019-11-20 | Dana Farber Cancer Institute, Inc. | Inhibitoren der c-jun-n-terminal-kinase (jnk) |
GEP201706687B (en) | 2012-02-17 | 2017-06-26 | Millennium Pharmaceuticals Inc (A Delaware Corporation) | Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme |
CN102633803A (zh) * | 2012-05-03 | 2012-08-15 | 盛世泰科生物医药技术(苏州)有限公司 | 一种5,7-二氯吡唑并[1,5-a]嘧啶的合成方法 |
WO2014063061A1 (en) | 2012-10-19 | 2014-04-24 | Dana-Farber Cancer Institute, Inc. | Hydrophobically tagged small molecules as inducers of protein degradation |
WO2014066795A1 (en) | 2012-10-25 | 2014-05-01 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
WO2014066743A1 (en) | 2012-10-25 | 2014-05-01 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
EP3418281B1 (de) | 2012-12-07 | 2020-09-30 | Vertex Pharmaceuticals Inc. | Pyrazolo[1,5-a]pyrimidine als atr-kinase-inhibitoren nützliche verbindungen zur behandlung von krebserkrankungen |
KR20150130491A (ko) | 2013-03-13 | 2015-11-23 | 제넨테크, 인크. | 피라졸로 화합물 및 그것의 용도 |
EP2970286A1 (de) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Kondensierte pyrazolopyrimidinderivate als inhibitoren der atr-kinase |
WO2014143242A1 (en) | 2013-03-15 | 2014-09-18 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase |
EP2970289A1 (de) | 2013-03-15 | 2016-01-20 | Vertex Pharmaceuticals Inc. | Als atr-kinaseinhibitoren nützliche verbindungen |
JP6378759B2 (ja) | 2013-07-02 | 2018-08-22 | ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. | Sumo活性化酵素阻害剤として有用なヘテロアリール化合物 |
ES2676734T3 (es) | 2013-10-18 | 2018-07-24 | Syros Pharmaceuticals, Inc. | Compuestos heteroatómicos útiles para el tratamiento de enfermedades proliferativas |
AU2014337044A1 (en) | 2013-10-18 | 2016-05-05 | Dana-Farber Cancer Institute, Inc. | Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7) |
MX370390B (es) | 2013-12-06 | 2019-12-11 | Vertex Pharma | Compuesto de 2-amino-6-fluoro-n-[5-fluoro-piridin-3-il]pirazolo[1, 5-a]pirimidin-3-carboxamida util como inhibidor de cinasa de ataxia telangiectasia mutada (atm) y rad3 relacionados (atr), su preparacion, diferentes formas solidas y sus derivados radiomarcados. |
EP3087069B1 (de) | 2013-12-23 | 2019-01-30 | Norgine B.V. | Als ccr9-modulatoren verwendbare verbindungen |
CN106061975B (zh) * | 2014-01-22 | 2019-09-24 | 库洛维公司 | 作为抗病毒化合物的吡唑并[1,5-a]嘧啶 |
CN110590787A (zh) | 2014-06-05 | 2019-12-20 | 沃泰克斯药物股份有限公司 | Atr激酶抑制剂的制备方法及其不同的固体形式 |
JP6936007B2 (ja) | 2014-06-17 | 2021-09-15 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Chk1阻害剤とatr阻害剤との組み合わせを使用してがんを処置する方法 |
CN106999479B (zh) | 2014-07-01 | 2021-07-16 | 米伦纽姆医药公司 | 可用作sumo活化酶抑制剂的杂芳基化合物 |
CN105294655B (zh) * | 2014-07-26 | 2019-03-15 | 广东东阳光药业有限公司 | Cdk类小分子抑制剂的化合物及其用途 |
JP6854762B2 (ja) | 2014-12-23 | 2021-04-07 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼ7(cdk7)の阻害剤 |
JP6861166B2 (ja) | 2015-03-27 | 2021-04-21 | ダナ−ファーバー キャンサー インスティテュート, インコーポレイテッド | サイクリン依存性キナーゼの阻害剤 |
AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
CA2996978A1 (en) | 2015-09-09 | 2017-03-16 | Dana-Farber Cancer Institute, Inc. | Inhibitors of cyclin-dependent kinases |
MX2018003657A (es) | 2015-09-30 | 2018-04-30 | Vertex Pharma | Metodo para tratar cancer usando una combinacion de agentes que dañan el adn e inhibidores de proteina relacionada con ataxia telangiectasia y rad3 (atr). |
US11116755B2 (en) | 2015-11-18 | 2021-09-14 | Genzyme Corporation | Biomarker of polycystic kidney disease and uses thereof |
TWI703149B (zh) * | 2017-11-16 | 2020-09-01 | 美商美國禮來大藥廠 | 用於抑制cdk7之化合物 |
CN112638915B (zh) | 2018-09-10 | 2023-04-07 | 伊莱利利公司 | 用于治疗银屑病和系统性红斑狼疮的吡唑并[1,5-a]嘧啶-3-甲酰胺衍生物 |
AU2019370200A1 (en) * | 2018-10-30 | 2021-06-10 | Kronos Bio, Inc. | Compounds, compositions, and methods for modulating CDK9 activity |
AR121251A1 (es) | 2020-02-12 | 2022-05-04 | Lilly Co Eli | Compuestos de 7-(metilamino)pirazolo[1,5-a]pirimidina-3-carboxamida |
CN116396298A (zh) * | 2023-06-06 | 2023-07-07 | 四川维亚本苑生物科技有限公司 | CDK Ligand-1的中间体XII及CDK Ligand-1的制备方法 |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US626096A (en) * | 1899-05-30 | Dust-pan | ||
JPS4116288Y1 (de) | 1964-11-07 | 1966-07-28 | ||
JPS6157587A (ja) | 1984-08-29 | 1986-03-24 | Shionogi & Co Ltd | 縮合複素環誘導体および抗潰瘍剤 |
JP2585462B2 (ja) | 1989-10-25 | 1997-02-26 | 株式会社大塚製薬工場 | ピラゾロ[1,5―a]ピリミジン誘導体 |
JP2811020B2 (ja) | 1990-04-17 | 1998-10-15 | 日本特殊陶業株式会社 | セラミックスと鋼の接合体及びその製造方法 |
KR100191774B1 (ko) | 1991-04-22 | 1999-06-15 | 오스카 아끼히꼬 | 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 |
US5571813A (en) | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
EP0628559B1 (de) | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidinverbindungen und ihre Verwendung als Pharmazeutika |
EP0714898B1 (de) | 1994-06-21 | 2001-11-14 | Otsuka Pharmaceutical Factory, Inc. | PYRAZOLO[1,5-a] PYRIMIDIN-DERIVATE |
US5919815A (en) | 1996-05-22 | 1999-07-06 | Neuromedica, Inc. | Taxane compounds and compositions |
US6191131B1 (en) | 1997-07-23 | 2001-02-20 | Dupont Pharmaceuticals Company | Azolo triazines and pyrimidines |
US6262096B1 (en) | 1997-11-12 | 2001-07-17 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
US6413974B1 (en) | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
US6190131B1 (en) * | 1999-08-31 | 2001-02-20 | General Electric Co. | Non-integral balanced coverplate and coverplate centering slot for a turbine |
FR2805160B1 (fr) | 2000-02-23 | 2002-04-05 | Oreal | Compositions pour la teinture d'oxydation des fibres keratiniques comprenant un n(2-hydroxybenzene)-carbramate ou un n-(2-hydroxybenzene)-uree et une pyrazolopyrimidine, et procedes de teinture |
US7067520B2 (en) | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
FR2817469B1 (fr) | 2000-12-04 | 2003-04-18 | Oreal | Composition de coloration, procede d'obtention et utilisation pour la coloration de fibres keratiniques |
JP2004516297A (ja) | 2000-12-20 | 2004-06-03 | ソシエテ・ド・コンセイユ・ド・ルシエルシエ・エ・ダアツプリカーション・シヤンテイフイツク・(エス.セー.エール.アー.エス) | サイクリン依存性キナーゼ(cdk)及びグリコーゲンシンターゼキナーゼ−3(gsk−3)の阻害剤 |
US20040102455A1 (en) * | 2001-01-30 | 2004-05-27 | Burns Christopher John | Method of inhibiting kinases |
CA2483306A1 (en) | 2002-04-23 | 2003-11-06 | Shionogi & Co., Ltd. | Pyrazolo[1,5-a]pyrimidine derivative and nad(p)h oxidase inhibitor containing the same |
DE10223917A1 (de) | 2002-05-29 | 2003-12-11 | Bayer Cropscience Ag | Pyrazolopyrimidine |
ATE362474T1 (de) * | 2002-09-04 | 2007-06-15 | Schering Corp | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
ES2285164T3 (es) | 2002-09-04 | 2007-11-16 | Schering Corporation | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. |
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US7514442B2 (en) | 2009-04-07 |
EP1534712A2 (de) | 2005-06-01 |
MY137843A (en) | 2009-03-31 |
TWI329645B (en) | 2010-09-01 |
US7067661B2 (en) | 2006-06-27 |
EP1534712B1 (de) | 2007-05-16 |
AU2003298571B2 (en) | 2006-10-19 |
CA2497544C (en) | 2010-11-02 |
MXPA05002572A (es) | 2005-09-08 |
NZ539161A (en) | 2006-05-26 |
PE20041000A1 (es) | 2004-12-29 |
KR20050033659A (ko) | 2005-04-12 |
CN1701073A (zh) | 2005-11-23 |
WO2004026229A3 (en) | 2004-06-17 |
DE60313872D1 (de) | 2007-06-28 |
TW200413376A (en) | 2004-08-01 |
US20060178371A1 (en) | 2006-08-10 |
CA2497544A1 (en) | 2004-04-01 |
JP2006502184A (ja) | 2006-01-19 |
DE60313872T2 (de) | 2008-01-17 |
JP4790265B2 (ja) | 2011-10-12 |
ES2283868T3 (es) | 2007-11-01 |
US20040106624A1 (en) | 2004-06-03 |
ZA200501846B (en) | 2005-09-12 |
AR041133A1 (es) | 2005-05-04 |
MY145332A (en) | 2012-01-31 |
HK1071572A1 (en) | 2005-07-22 |
CN1701073B (zh) | 2011-06-22 |
AU2003298571A1 (en) | 2004-04-08 |
WO2004026229A2 (en) | 2004-04-01 |
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