ATE362474T1 - Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen - Google Patents
Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasenInfo
- Publication number
- ATE362474T1 ATE362474T1 AT03796321T AT03796321T ATE362474T1 AT E362474 T1 ATE362474 T1 AT E362474T1 AT 03796321 T AT03796321 T AT 03796321T AT 03796321 T AT03796321 T AT 03796321T AT E362474 T1 ATE362474 T1 AT E362474T1
- Authority
- AT
- Austria
- Prior art keywords
- cyclin
- pyrazolo
- pyrimidines
- inhibitors
- dependent kinases
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P9/06—Antiarrhythmics
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- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Virology (AREA)
- Hematology (AREA)
- Communicable Diseases (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Vascular Medicine (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40802902P | 2002-09-04 | 2002-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE362474T1 true ATE362474T1 (de) | 2007-06-15 |
Family
ID=32030632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03796321T ATE362474T1 (de) | 2002-09-04 | 2003-09-03 | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
Country Status (19)
Country | Link |
---|---|
US (2) | US7067661B2 (de) |
EP (1) | EP1534712B1 (de) |
JP (2) | JP4790265B2 (de) |
KR (1) | KR20050033659A (de) |
CN (1) | CN1701073B (de) |
AR (1) | AR041133A1 (de) |
AT (1) | ATE362474T1 (de) |
AU (1) | AU2003298571B2 (de) |
CA (1) | CA2497544C (de) |
DE (1) | DE60313872T2 (de) |
ES (1) | ES2283868T3 (de) |
HK (1) | HK1071572A1 (de) |
MX (1) | MXPA05002572A (de) |
MY (2) | MY145332A (de) |
NZ (1) | NZ539161A (de) |
PE (1) | PE20041000A1 (de) |
TW (1) | TWI329645B (de) |
WO (1) | WO2004026229A2 (de) |
ZA (1) | ZA200501846B (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1386922B1 (de) * | 1996-12-03 | 2012-04-11 | Sloan-Kettering Institute For Cancer Research | Synthese von Epitholonen, Zwischenprodukte, Analoga und ihre Verwendung |
EP1388541A1 (de) * | 2002-08-09 | 2004-02-11 | Centre National De La Recherche Scientifique (Cnrs) | Pyrrolopyrazine als Kinasehemmer |
WO2004018478A2 (en) | 2002-08-23 | 2004-03-04 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto, analogues and uses thereof |
US7649006B2 (en) | 2002-08-23 | 2010-01-19 | Sloan-Kettering Institute For Cancer Research | Synthesis of epothilones, intermediates thereto and analogues thereof |
ATE362474T1 (de) * | 2002-09-04 | 2007-06-15 | Schering Corp | Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen |
US7601724B2 (en) * | 2002-09-04 | 2009-10-13 | Schering Corporation | Substituted pyrazolo[1,5-a]pyrimidines as protein kinase inhibitors |
US7205308B2 (en) * | 2002-09-04 | 2007-04-17 | Schering Corporation | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors |
CA2516824A1 (en) * | 2003-02-28 | 2004-09-10 | Teijin Pharma Limited | Pyrazolo[1,5-a]pyrimidine derivatives |
WO2004087707A1 (en) * | 2003-03-31 | 2004-10-14 | Vernalis (Cambridge) Limited | Pyrazolopyrimidine compounds and their use in medicine |
EP1671962A1 (de) * | 2003-10-10 | 2006-06-21 | Ono Pharmaceutical Co., Ltd. | Neue kondensierte heterocyclische verbindung und deren verwendung |
WO2005112936A1 (en) * | 2004-05-14 | 2005-12-01 | The Regents Of The University Of Michigan | Compositions and methods relating to protein kinase inhibitors |
WO2006027346A2 (en) * | 2004-09-06 | 2006-03-16 | Altana Pharma Ag | Novel pyrazolopyrimidines |
FR2876582B1 (fr) * | 2004-10-15 | 2007-01-05 | Centre Nat Rech Scient Cnrse | Utilisation de derives de pyrrolo-pyrazines pour la fabrication de medicaments pour le traitement de la mucoviscidose et de maladies liees a un defaut d'adressage des proteines dans les cellules |
ATE433454T1 (de) * | 2004-12-21 | 2009-06-15 | Schering Corp | Pyrazoloä1,5-aüpyrimidine als antagonisten des adenosin-a2a-rezeptors |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
ATE478852T1 (de) | 2005-09-09 | 2010-09-15 | Schering Corp | Neue 4-cyano-, 4-amino-, und 4- aminomethylderivative von pyrazoloä1,5- aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h- indazolverbindungen und 5-cyano-, 5-amino- und 5- aminomethylderivative von imidazoä1,2-aüpyridinen,und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
WO2007118844A1 (de) * | 2006-04-13 | 2007-10-25 | Basf Se | Substituierte pyrazolopyrimidine, verfahren zu ihrer herstellung und ihre verwendung zur bekämpfung von schadpilzen sowie sie enthaltende mittel |
EP2377531A2 (de) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenese mittels Angiotensin-Modulation |
EP2027127A1 (de) * | 2006-05-22 | 2009-02-25 | Shering Corporation | Pyrazolo [1,5-a] pyrimidine als cdk-hemmer |
US8008307B2 (en) | 2006-08-08 | 2011-08-30 | Millennium Pharmaceuticals, Inc. | Heteroaryl compounds useful as inhibitors of E1 activating enzymes |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
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CN102056925A (zh) * | 2008-04-07 | 2011-05-11 | Irm责任有限公司 | 作为激酶抑制剂的化合物和组合物 |
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US8993535B2 (en) | 2009-09-04 | 2015-03-31 | Merck Sharp & Dohme Corp. | Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors |
CN102762208A (zh) * | 2009-12-04 | 2012-10-31 | 赛林药物股份有限公司 | 作为ck2抑制剂的吡唑嘧啶和相关杂环 |
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AU2012340200B2 (en) | 2011-11-17 | 2017-10-12 | Dana-Farber Cancer Institute, Inc. | Inhibitors of c-Jun-N-Terminal Kinase (JNK) |
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RU2687276C2 (ru) | 2013-12-06 | 2019-05-13 | Вертекс Фармасьютикалз Инкорпорейтед | Соединения, пригодные для использования в качестве ингибиторов atr киназы |
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CN106061975B (zh) * | 2014-01-22 | 2019-09-24 | 库洛维公司 | 作为抗病毒化合物的吡唑并[1,5-a]嘧啶 |
LT3152212T (lt) | 2014-06-05 | 2020-05-11 | Vertex Pharmaceuticals Inc. | Radioaktyviai žymėti 2-amino-6-fluor-n-[5-fluor-piridin-il]- pirazolo[1,5-a]pirimidin-3-karboksamido junginio dariniai, naudingi kaip atr kinazės inhibitoriai, minėto junginio gamybos būdas ir jo skirtingos kietos formos |
SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
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JP2010180235A (ja) | 2010-08-19 |
MY137843A (en) | 2009-03-31 |
WO2004026229A2 (en) | 2004-04-01 |
EP1534712B1 (de) | 2007-05-16 |
TWI329645B (en) | 2010-09-01 |
PE20041000A1 (es) | 2004-12-29 |
JP4790265B2 (ja) | 2011-10-12 |
EP1534712A2 (de) | 2005-06-01 |
MY145332A (en) | 2012-01-31 |
TW200413376A (en) | 2004-08-01 |
AR041133A1 (es) | 2005-05-04 |
DE60313872D1 (de) | 2007-06-28 |
AU2003298571B2 (en) | 2006-10-19 |
JP2006502184A (ja) | 2006-01-19 |
WO2004026229A3 (en) | 2004-06-17 |
US7514442B2 (en) | 2009-04-07 |
CA2497544C (en) | 2010-11-02 |
ES2283868T3 (es) | 2007-11-01 |
HK1071572A1 (en) | 2005-07-22 |
US7067661B2 (en) | 2006-06-27 |
ZA200501846B (en) | 2005-09-12 |
KR20050033659A (ko) | 2005-04-12 |
MXPA05002572A (es) | 2005-09-08 |
US20040106624A1 (en) | 2004-06-03 |
CA2497544A1 (en) | 2004-04-01 |
CN1701073A (zh) | 2005-11-23 |
AU2003298571A1 (en) | 2004-04-08 |
DE60313872T2 (de) | 2008-01-17 |
CN1701073B (zh) | 2011-06-22 |
US20060178371A1 (en) | 2006-08-10 |
NZ539161A (en) | 2006-05-26 |
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