ATE378336T1 - Imidazopyridine als hemmstoffe cyclin abhängiger kinasen - Google Patents

Imidazopyridine als hemmstoffe cyclin abhängiger kinasen

Info

Publication number
ATE378336T1
ATE378336T1 AT03786514T AT03786514T ATE378336T1 AT E378336 T1 ATE378336 T1 AT E378336T1 AT 03786514 T AT03786514 T AT 03786514T AT 03786514 T AT03786514 T AT 03786514T AT E378336 T1 ATE378336 T1 AT E378336T1
Authority
AT
Austria
Prior art keywords
imidazopyridines
inhibitors
cyclin dependent
dependent kinases
kinases
Prior art date
Application number
AT03786514T
Other languages
English (en)
Inventor
Michael Dwyer
Timothy Guzi
Kamil Paruch
Ronald Doll
Kartik Keertikar
Viyyoor Girijavallabhan
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ATE378336T1 publication Critical patent/ATE378336T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT03786514T 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen ATE378336T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41206302P 2002-09-19 2002-09-19

Publications (1)

Publication Number Publication Date
ATE378336T1 true ATE378336T1 (de) 2007-11-15

Family

ID=32030794

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03786514T ATE378336T1 (de) 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen

Country Status (18)

Country Link
US (2) US6992080B2 (de)
EP (1) EP1539756B1 (de)
JP (1) JP4845379B2 (de)
KR (1) KR20050052500A (de)
CN (1) CN100549011C (de)
AR (1) AR041291A1 (de)
AT (1) ATE378336T1 (de)
AU (1) AU2003295332B2 (de)
CA (1) CA2499639C (de)
DE (1) DE60317529T2 (de)
ES (1) ES2293068T3 (de)
IL (1) IL167433A (de)
MX (1) MXPA05003058A (de)
MY (1) MY133311A (de)
NZ (1) NZ538566A (de)
TW (1) TWI351405B (de)
WO (1) WO2004026867A2 (de)
ZA (1) ZA200502278B (de)

Families Citing this family (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4579351B2 (ja) 1996-12-03 2010-11-10 スローン−ケッタリング インスティトュート フォア キャンサー リサーチ エポチロンの合成とその中間体及びその類似物並びにその使用
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
GB9819530D0 (en) 1998-09-09 1998-10-28 Smithkline Beecham Plc Novel compositions and use
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
PT1506203E (pt) 2002-08-23 2007-04-30 Sloan Kettering Inst Cancer Síntese de epotilonas, seus intermediários, seus análogos e suas utilizações
US6921769B2 (en) 2002-08-23 2005-07-26 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
NZ544756A (en) 2003-07-22 2009-09-25 Astex Therapeutics Ltd 3,4-Disubstituted 1H-pyrazole compounds and their use as cyclin dependent kinases (CDK) and glycogen synthase kinase-3 (GSK-3) modulators
GB0418328D0 (en) * 2004-08-17 2004-09-22 Imp College Innovations Ltd Cancer methods and medicaments
EP1845975A1 (de) * 2005-01-21 2007-10-24 Astex Therapeutics Limited Zusammensetzungen von pyrazolkinase-inhibitoren und weiteren antitumormitteln
EP1845973B1 (de) * 2005-01-21 2015-08-12 Astex Therapeutics Limited Pharmazeutische verbindungen
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AU2006207321B2 (en) * 2005-01-21 2012-09-06 Astex Therapeutics Limited Pharmaceutical compounds
EP1861095A1 (de) * 2005-03-24 2007-12-05 Glaxo Group Limited Derivate von imidazo(1,2-a)pyridin als nützliche medikamente zur behandlung von magen-darm-erkrankungen
EP1931641B1 (de) 2005-09-09 2010-08-25 Schering Corporation Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazolo[1,5-a]pyridinen, pyrazolo[1,5-c]pyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazo[1,2-a]pyridinen, und imidazo[1,5-a]pyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
CN101415674A (zh) 2006-02-16 2009-04-22 先灵公司 作为erk抑制剂的吡咯烷衍生物
US20090142337A1 (en) * 2006-05-08 2009-06-04 Astex Therapeutics Limited Pharmaceutical Combinations of Diazole Derivatives for Cancer Treatment
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
US7951818B2 (en) 2006-12-01 2011-05-31 Galapagos Nv Imidazolopyridine compounds useful for the treatment of degenerative and inflammatory diseases
MX2009006706A (es) 2006-12-22 2009-07-02 Astex Therapeutics Ltd Compuestos heterociclicos biciclicos como inhibidores del receptor del factor de crecimiento de fibroblastos.
MX2009006704A (es) 2006-12-22 2009-06-30 Astex Therapeutics Ltd Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.
TWI428132B (zh) * 2007-07-02 2014-03-01 Lilly Co Eli 癌症化療效果之強化
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
US8426441B2 (en) 2007-12-14 2013-04-23 Roche Palo Alto Llc Inhibitors of bruton's tyrosine kinase
JP5643105B2 (ja) * 2007-12-14 2014-12-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 新規イミダゾ［１，２−ａ］ピリジン及びイミダゾ［１，２−ｂ］ピリダジン誘導体
EP2690101B1 (de) * 2007-12-19 2015-06-24 Genentech, Inc. 5-Anilin-Imidazopyridine und Verfahren zu ihrer Verwendung
EP2252617A1 (de) 2008-02-13 2010-11-24 CGI Pharmaceuticals, Inc. 6-arylimidazo[1,2-a]pyrazinderivate, herstellungsverfahren und verfahren zu deren anwendung
NZ587504A (en) 2008-02-21 2012-09-28 Merck Sharp & Dohme Benzopyrazole derivatives as ERK inhibitors
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
US8338604B2 (en) 2008-06-20 2012-12-25 Bristol-Myers Squibb Company Imidazopyridine and imidazopyrazine compounds useful as kinase inhibitors
EP2307413B1 (de) * 2008-07-15 2015-09-09 F. Hoffmann-La Roche AG Neuartige phenyl-imidazopyridine und -pyridazine
WO2010035745A1 (ja) * 2008-09-25 2010-04-01 杏林製薬株式会社 ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤
SG171991A1 (en) 2008-12-08 2011-07-28 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
EA021293B1 (ru) 2008-12-08 2015-05-29 Джилид Коннектикут, Инк. ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИМИДАЗОПИРАЗИНОВЫЕ ИНГИБИТОРЫ Syk, И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
JP5641664B2 (ja) 2009-10-30 2014-12-17 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ イミダゾ［１，２−ｂ］ピリダジン誘導体およびＰＤＥ１０阻害剤としてのそれらの使用
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
PT2545052E (pt) * 2010-03-11 2015-02-18 Gilead Connecticut Inc Inibidores da syk à base de imidazopiridinas
US20140255392A1 (en) * 2011-04-06 2014-09-11 Bayer Intellectual Property Gmbh Substituted imidazopyridines and intermediates thereof
BR112013033375B1 (pt) 2011-06-27 2022-05-10 Janssen Pharmaceutica N.V Derivados de 1-aril-4-metil-[1,2,4]triazolo[4,3-a]quinoxa-lina, seu uso, composição farmacêutica que os compreende, processo de preparação dos mesmos, solução estéril e composto intermediário
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
AU2013283426B2 (en) 2012-06-26 2018-02-22 Janssen Pharmaceutica Nv Combinations comprising PDE 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and PDE 10 inhibitors for use in the treatment of neurological or metabolic disorders
WO2014009305A1 (en) 2012-07-09 2014-01-16 Janssen Pharmaceutica Nv Inhibitors of phosphodiesterase 10 enzyme
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
MD4684B1 (ro) 2013-07-30 2020-03-31 Gilead Connecticut INc. Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
ES2822285T3 (es) 2013-07-30 2021-04-30 Kronos Bio Inc Polimorfo de inhibidores de SYK
EP3076976B1 (de) 2013-12-04 2020-09-02 Gilead Sciences, Inc. Methode zur behandlung von krebs
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
AU2015290000B2 (en) 2014-07-14 2018-05-17 Gilead Sciences, Inc. Combinations for treating cancers
EP3377908B1 (de) 2015-11-18 2020-08-05 Genzyme Corporation Biomarker von polyzystischer nierenkrankheit und verwendungen davon
WO2017123058A1 (en) 2016-01-14 2017-07-20 Handok Inc. Compounds antagonizing a3 adenosine receptor, method for preparing them, and medical-use thereof
EP3575298B1 (de) 2017-01-24 2022-03-02 Sumitomo Chemical Company, Limited Kondensierte heterocyclische verbindung und zusammensetzung damit
TW201841916A (zh) * 2017-04-12 2018-12-01 美商麥珍塔治療學股份有限公司 芳香烴受體拮抗劑及其用途
TWI778050B (zh) 2017-04-21 2022-09-21 美商醫肯納腫瘤學公司 吲哚ahr抑制劑及其用途
US11384082B2 (en) 2017-08-25 2022-07-12 Kronos Bio, Inc. Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors
US11339168B2 (en) 2019-02-22 2022-05-24 Kronos Bio, Inc. Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors
PL4065582T3 (pl) 2019-11-26 2025-08-18 Ikena Oncology, Inc. Polimorficzne pochodne karbazolu i ich zastosowania
CN120019056A (zh) * 2022-09-28 2025-05-16 原真股份有限公司 新型cdk9抑制剂
WO2025058459A1 (ko) * 2023-09-15 2025-03-20 (주)휴온스 신규한 이미다조피리딘계 화합물 및 이를 유효성분으로 포함하는 위장관 염증질환 또는 위산-관련 질환의 예방, 개선 또는 치료용 조성물

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
CN1221533C (zh) * 1993-09-10 2005-10-05 卫材株式会社 7－氨基－1h－吲哚衍生物
JPH11505524A (ja) * 1995-05-01 1999-05-21 藤沢薬品工業株式会社 イミダゾ１，２−ａピリジンおよびイミダゾ１，２−ａピリデジン誘導体、および骨吸収阻害剤としてのその用途
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9801526D0 (sv) 1998-04-29 1998-04-29 Astra Ab New compounds
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
JP4007743B2 (ja) * 1999-02-26 2007-11-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害剤
WO2001056607A1 (en) 2000-02-03 2001-08-09 Eisai Co., Ltd. Integrin expression inhibitors
SE0003186D0 (sv) 2000-09-07 2000-09-07 Astrazeneca Ab New process
EE05234B1 (et) * 2001-03-08 2009-12-15 Astrazeneca Ab 6-karboksamidoimidaso[1,2-a] pridiinihendite kasutamine ravimi p?hjustatud maohaavandi v„ltimiseks

Also Published As

Publication number Publication date
EP1539756A2 (de) 2005-06-15
DE60317529D1 (de) 2007-12-27
AR041291A1 (es) 2005-05-11
WO2004026867A2 (en) 2004-04-01
TW200407322A (en) 2004-05-16
MY133311A (en) 2007-11-30
NZ538566A (en) 2008-02-29
ZA200502278B (en) 2006-05-31
US20040097517A1 (en) 2004-05-20
AU2003295332B2 (en) 2007-01-18
MXPA05003058A (es) 2005-05-27
JP2006507254A (ja) 2006-03-02
EP1539756B1 (de) 2007-11-14
HK1071757A1 (en) 2005-07-29
JP4845379B2 (ja) 2011-12-28
AU2003295332A1 (en) 2004-04-08
IL167433A (en) 2011-03-31
CN1703414A (zh) 2005-11-30
CN100549011C (zh) 2009-10-14
DE60317529T2 (de) 2008-09-25
US6992080B2 (en) 2006-01-31
CA2499639C (en) 2011-11-08
WO2004026867A3 (en) 2004-08-05
TWI351405B (en) 2011-11-01
KR20050052500A (ko) 2005-06-02
ES2293068T3 (es) 2008-03-16
US20060030555A1 (en) 2006-02-09
US7452902B2 (en) 2008-11-18
CA2499639A1 (en) 2004-04-01

Similar Documents

Publication Publication Date Title
ATE378336T1 (de) Imidazopyridine als hemmstoffe cyclin abhängiger kinasen
ATE364608T1 (de) Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen
ATE376548T1 (de) Pyrazolopyrimidine als hemmstoffe cyclin- abhängiger kinasen
DE60321808D1 (de) Flavon derivate als inhibitoren von cyclin-abhängigen kinasen
NO20045220L (no) Heterocykliske inhibitorer for kinaser
IL192351A0 (en) Azaindole inhibitors of aurora kinases
ATE529421T1 (de) Chinolinderivate als phosphodiesterase-hemmer
EP1560582A4 (de) AZAINDOL-DERIVATE ALS HEMMER DER p38 KINASE
ATE374201T1 (de) 6-alkoxypyridopyrimidine als inhibitoren der p-38-map-kinase
SI1562589T1 (sl) Diaminotriazoli, koristni kot inhibitorji proteinkinaz
ATE370142T1 (de) Triazolopyrimidinderivate als inhibitoren von glycogensynthasekinase-3
DE602005025733D1 (de) Pyrazolopyrimidinderivate als inhibitoren der cyclinabhängigen kinase
ATE382048T1 (de) Pyrazolopyrimdine als hemmstoffe cyclin abhängiger kinasen
EP1534290A4 (de) Neue kinase-hemmer
ATE362474T1 (de) Pyrazolo(1,5-a)pyrimidine als hemmstoffe cyclin- abhängiger kinasen
ATE505460T1 (de) Indazolderivate als inhibitoren der hormon- sensitiven lipase
DK1888582T3 (da) Imidazo- og triazolopyridiner som hæmmere af 11-beta-hydroxysteroid dehydrigenase
ATE443706T1 (de) Pyrrolotriazinverbindungen als kinaseinhibitoren
DE602004028827D1 (de) Pyrrolodihydroisochinoline als pde10- inhibitoren
IL173615A0 (en) N3-substituted imidazopyridine c-kit inhibitor
ATE393159T1 (de) Heterobicyclische pyrazolderivate als kinaseinhibitoren
DK1811998T3 (da) Triazoler anvendelige som inhibitorer af proteinkinaser
DE602004011548D1 (de) 4-aminochinolin-3-carbonsäureamid-derivate als pde4-hemmer
ATE353893T1 (de) Nicotinamid-derivate verwendbar als pde4 inhibitoren
ATE520683T1 (de) Als inhibitoren von chemokinrezeptoren geeignete bipiperidinylderivate

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties