DE60317529D1 - Imidazopyridine als hemmstoffe cyclin abhängiger kinasen - Google Patents

Imidazopyridine als hemmstoffe cyclin abhängiger kinasen

Info

Publication number
DE60317529D1
DE60317529D1 DE60317529T DE60317529T DE60317529D1 DE 60317529 D1 DE60317529 D1 DE 60317529D1 DE 60317529 T DE60317529 T DE 60317529T DE 60317529 T DE60317529 T DE 60317529T DE 60317529 D1 DE60317529 D1 DE 60317529D1
Authority
DE
Germany
Prior art keywords
imidazopyridines
cyclin dependent
dependent kinases
inhibitors
inhibitors cyclin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60317529T
Other languages
English (en)
Other versions
DE60317529T2 (de
Inventor
Michael P Dwyer
Timothy J Guzi
Kamil Paruch
Ronald J Doll
Kartik M Keertikar
Viyyoor M Girijavallabhan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of DE60317529D1 publication Critical patent/DE60317529D1/de
Application granted granted Critical
Publication of DE60317529T2 publication Critical patent/DE60317529T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
DE60317529T 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen Expired - Lifetime DE60317529T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41206302P 2002-09-19 2002-09-19
US412063P 2002-09-19
PCT/US2003/029498 WO2004026867A2 (en) 2002-09-19 2003-09-17 Imidazopyridines as cyclin dependent kinase inhibitors

Publications (2)

Publication Number Publication Date
DE60317529D1 true DE60317529D1 (de) 2007-12-27
DE60317529T2 DE60317529T2 (de) 2008-09-25

Family

ID=32030794

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60317529T Expired - Lifetime DE60317529T2 (de) 2002-09-19 2003-09-17 Imidazopyridine als hemmstoffe cyclin abhängiger kinasen

Country Status (19)

Country Link
US (2) US6992080B2 (de)
EP (1) EP1539756B1 (de)
JP (1) JP4845379B2 (de)
KR (1) KR20050052500A (de)
CN (1) CN100549011C (de)
AR (1) AR041291A1 (de)
AT (1) ATE378336T1 (de)
AU (1) AU2003295332B2 (de)
CA (1) CA2499639C (de)
DE (1) DE60317529T2 (de)
ES (1) ES2293068T3 (de)
HK (1) HK1071757A1 (de)
IL (1) IL167433A (de)
MX (1) MXPA05003058A (de)
MY (1) MY133311A (de)
NZ (1) NZ538566A (de)
TW (1) TWI351405B (de)
WO (1) WO2004026867A2 (de)
ZA (1) ZA200502278B (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU756699B2 (en) * 1996-12-03 2003-01-23 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US20040037818A1 (en) * 1998-07-30 2004-02-26 Brand Stephen J. Treatment for diabetes
GB9819530D0 (en) 1998-09-09 1998-10-28 Smithkline Beecham Plc Novel compositions and use
US20020058286A1 (en) * 1999-02-24 2002-05-16 Danishefsky Samuel J. Synthesis of epothilones, intermediates thereto and analogues thereof
ES2204295B1 (es) * 2002-07-02 2005-08-01 Almirall Prodesfarma, S.A. Nuevos derivados de quinuclidina-amida.
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
NZ538522A (en) 2002-08-23 2008-03-28 Sloan Kettering Inst Cancer Synthesis of epothilones, intermediates thereto, analogues and uses thereof
KR101204247B1 (ko) 2003-07-22 2012-11-22 아스텍스 테라퓨틱스 리미티드 3,4-이치환된 1ｈ-피라졸 화합물 및 그의 시클린 의존성키나제 (ｃｄｋ) 및 글리코겐 합성효소 키나제-3(ｇｓｋ-3) 조정제로서 용도
GB0418328D0 (en) * 2004-08-17 2004-09-22 Imp College Innovations Ltd Cancer methods and medicaments
US20080161251A1 (en) * 2005-01-21 2008-07-03 Astex Therapeutics Limited Pharmaceutical Compounds
JP2008528469A (ja) * 2005-01-21 2008-07-31 アステックス・セラピューティクス・リミテッド ピラゾールキナーゼ阻害剤およびさらなる抗癌剤の組合せ剤
MX2007008781A (es) * 2005-01-21 2007-09-11 Astex Therapeutics Ltd Compuestos farmaceuticos.
US8404718B2 (en) 2005-01-21 2013-03-26 Astex Therapeutics Limited Combinations of pyrazole kinase inhibitors
AR054425A1 (es) 2005-01-21 2007-06-27 Astex Therapeutics Ltd Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico.
JP2008536817A (ja) * 2005-03-24 2008-09-11 グラクソ グループ リミテッド 胃腸疾患の処置用医薬として有用なイミダゾ（１，２−ａ）ピリジン誘導体
DE602006016455D1 (de) * 2005-09-09 2010-10-07 Schering Corp Neue 4-cyano-, 4-amino-, und 4-aminomethylderivative von pyrazoloä1,5-aüpyridinen, pyrazoloä1,5-cüpyrimidinen und 2h-indazolverbindungen und 5-cyano-, 5-amino- und 5-aminomethylderivative von imidazoä1,2-aüpyridinen, und imidazoä1,5-aüpyrazinverbindungen als inhibitoren der cyclinabhänggen kinase
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
WO2007097937A1 (en) 2006-02-16 2007-08-30 Schering Corporation Pyrrolidine derivatives as erk inhibitors
JP2009536186A (ja) * 2006-05-08 2009-10-08 アステックス・セラピューティクス・リミテッド 癌処置のためのジアゾール誘導体の医薬組合せ
FR2906250B1 (fr) * 2006-09-22 2008-10-31 Sanofi Aventis Sa Derives de 2-aryl-6phenyl-imidazo(1,2-a) pyridines, leur preparation et leur application en therapeutique
EP2099798A1 (de) * 2006-12-01 2009-09-16 Galapagos N.V. Für die behandlung von degenerativen und entzündlichen krankheiten geeignete imidazolopyridinverbindungen
US8895745B2 (en) 2006-12-22 2014-11-25 Astex Therapeutics Limited Bicyclic heterocyclic compounds as FGFR inhibitors
AU2007337895C1 (en) 2006-12-22 2014-07-31 Astex Therapeutics Limited Tricyclic amine derivatives as protein tyrosine kinase inhibitors
TWI428132B (zh) 2007-07-02 2014-03-01 Lilly Co Eli 癌症化療效果之強化
GB0720038D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New compounds
GB0720041D0 (en) 2007-10-12 2007-11-21 Astex Therapeutics Ltd New Compounds
US8426441B2 (en) 2007-12-14 2013-04-23 Roche Palo Alto Llc Inhibitors of bruton's tyrosine kinase
WO2009077334A1 (en) * 2007-12-14 2009-06-25 F. Hoffmann-La Roche Ag Novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives
PE20091158A1 (es) * 2007-12-19 2009-08-28 Genentech Inc 5-anilinoimidazopiridinas y metodos de uso
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
CN102015693B (zh) 2008-02-21 2014-10-29 默沙东公司 作为erk抑制剂的化合物
GB0810902D0 (en) 2008-06-13 2008-07-23 Astex Therapeutics Ltd New compounds
CN102131805A (zh) * 2008-06-20 2011-07-20 百时美施贵宝公司 用作激酶抑制剂的咪唑并吡啶和咪唑并吡嗪化合物
CN102066370B (zh) * 2008-07-15 2014-05-14 霍夫曼-拉罗奇有限公司 苯基-咪唑并吡啶类和哒嗪类
JPWO2010035745A1 (ja) * 2008-09-25 2012-02-23 杏林製薬株式会社 ヘテロ環ビアリール誘導体及びそれらを有効成分とするｐｄｅ阻害剤
ES2545610T3 (es) 2008-12-08 2015-09-14 Gilead Connecticut, Inc. Inhibidores de Syk de imidazopirazina
CN102307581B (zh) 2008-12-08 2016-08-17 吉利德康涅狄格股份有限公司 咪唑并哌嗪syk抑制剂
GB0906472D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
GB0906470D0 (en) 2009-04-15 2009-05-20 Astex Therapeutics Ltd New compounds
MX2012004990A (es) 2009-10-30 2012-06-12 Janssen Pharmaceutica Nv Deribados de imidazo [1,2-b] pirimideazina y su uso como inhibidores de la enzima fosfodiesterasa 10.
AR080754A1 (es) 2010-03-09 2012-05-09 Janssen Pharmaceutica Nv Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
NZ602362A (en) 2010-03-11 2014-11-28 Gilead Connecticut Inc Imidazopyridines syk inhibitors
CA2832310A1 (en) * 2011-04-06 2012-10-11 Bayer Intellectual Property Gmbh Substituted imidazopyridines and intermediates thereof
JP6115962B2 (ja) 2011-06-27 2017-04-19 ヤンセン ファーマシューティカ エヌ．ベー． １−アリール−４−メチル−［１，２，４］トリアゾロ［４，３−ａ］キノキサリン誘導体
US8883819B2 (en) 2011-09-01 2014-11-11 Irm Llc Bicyclic heterocycle derivatives for the treatment of pulmonary arterial hypertension
CA2872216C (en) 2012-06-26 2021-07-20 Janssen Pharmaceutica Nv Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl-[1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
BR112015000459B1 (pt) 2012-07-09 2022-02-08 Janssen Pharmaceutica N.V. Inibidores da enzima fosfodiesterase 10, seu uso, composição farmacêutica que os compreende, seus processo de preparação e produto
US9073921B2 (en) 2013-03-01 2015-07-07 Novartis Ag Salt forms of bicyclic heterocyclic derivatives
MX2016001480A (es) 2013-07-30 2017-01-05 Gilead Connecticut Inc Formulacion de inhibidores de syk.
MY176803A (en) 2013-07-30 2020-08-21 Gilead Connecticut Inc Polymorph of syk inhibitors
EA201690608A1 (ru) 2013-12-04 2016-12-30 Джилид Сайэнс, Инк. Способы лечения раковых заболеваний
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
CN106687139A (zh) 2014-07-14 2017-05-17 吉利德科学公司 用于治疗癌症的组合
AU2016357720A1 (en) 2015-11-18 2018-07-05 Genzyme Corporation Biomarker of polycystic kidney disease and uses thereof
CA3011442A1 (en) 2016-01-14 2017-07-20 Handok Inc. Compounds antagonizing a3 adenosine receptor, method for preparing them, and medical-use thereof
WO2018139436A1 (ja) 2017-01-24 2018-08-02 住友化学株式会社 縮合複素環化合物及びそれを含有する組成物
CN110785419B (zh) * 2017-04-12 2024-03-01 博雅缉因（北京）生物科技有限公司 芳烃受体拮抗剂及其用途
AU2018256459B2 (en) * 2017-04-21 2023-12-07 Ikena Oncology, Inc. Indole AHR inhibitors and uses thereof
AU2018321264A1 (en) 2017-08-25 2020-02-27 Kronos Bio, Inc. Polymorphs of Syk inhibitors
MX2021010131A (es) 2019-02-22 2021-11-18 Kronos Bio Inc Formas sólidas de pirazinas condensadas a manera de inhibidores de syk.
EP4065582A1 (de) 2019-11-26 2022-10-05 Ikena Oncology, Inc. Polymorphe carbazolderivate und ihre verwendungen
WO2024068740A1 (en) * 2022-09-28 2024-04-04 Origenis Gmbh Novel cdk9 inhibitors

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5574042A (en) * 1992-11-02 1996-11-12 Fujisawa Pharmaceutical Co., Ltd Imidazo [1,2-a] pyridines and their pharmaceutical use
KR0174752B1 (ko) * 1993-09-10 1999-02-01 나이토 하루오 이환식 헤테로환 함유 술폰아미드 유도체 및 그 제조방법
AU5348396A (en) 1995-05-01 1996-11-21 Fujisawa Pharmaceutical Co., Ltd. Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors
SE9700661D0 (sv) 1997-02-25 1997-02-25 Astra Ab New compounds
SE9801526D0 (sv) 1998-04-29 1998-04-29 Astra Ab New compounds
SE9802794D0 (sv) * 1998-08-21 1998-08-21 Astra Ab New compounds
JP4007743B2 (ja) * 1999-02-26 2007-11-14 エーザイ・アール・アンド・ディー・マネジメント株式会社 血管新生阻害剤
CN100356979C (zh) * 2000-02-03 2007-12-26 卫材R&D管理有限公司 整联蛋白表达抑制剂
SE0003186D0 (sv) 2000-09-07 2000-09-07 Astrazeneca Ab New process
US20040082605A1 (en) * 2001-03-08 2004-04-29 Arne Eek Use

Also Published As

Publication number Publication date
CA2499639A1 (en) 2004-04-01
US6992080B2 (en) 2006-01-31
AU2003295332A1 (en) 2004-04-08
CA2499639C (en) 2011-11-08
MY133311A (en) 2007-11-30
US20060030555A1 (en) 2006-02-09
KR20050052500A (ko) 2005-06-02
EP1539756B1 (de) 2007-11-14
US20040097517A1 (en) 2004-05-20
ATE378336T1 (de) 2007-11-15
JP4845379B2 (ja) 2011-12-28
EP1539756A2 (de) 2005-06-15
ES2293068T3 (es) 2008-03-16
TW200407322A (en) 2004-05-16
US7452902B2 (en) 2008-11-18
CN100549011C (zh) 2009-10-14
ZA200502278B (en) 2006-05-31
WO2004026867A2 (en) 2004-04-01
DE60317529T2 (de) 2008-09-25
MXPA05003058A (es) 2005-05-27
AU2003295332B2 (en) 2007-01-18
JP2006507254A (ja) 2006-03-02
AR041291A1 (es) 2005-05-11
NZ538566A (en) 2008-02-29
WO2004026867A3 (en) 2004-08-05
IL167433A (en) 2011-03-31
CN1703414A (zh) 2005-11-30
TWI351405B (en) 2011-11-01
HK1071757A1 (en) 2005-07-29

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