EA201690608A1 - Способы лечения раковых заболеваний - Google Patents
Способы лечения раковых заболеванийInfo
- Publication number
- EA201690608A1 EA201690608A1 EA201690608A EA201690608A EA201690608A1 EA 201690608 A1 EA201690608 A1 EA 201690608A1 EA 201690608 A EA201690608 A EA 201690608A EA 201690608 A EA201690608 A EA 201690608A EA 201690608 A1 EA201690608 A1 EA 201690608A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- subject
- cancer
- methods
- treatment
- cancer diseases
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
Abstract
Предложены способы лечения ракового заболевания у нуждающегося в этом субъекта (например, человека), включающие введение указанному субъекту терапевтически эффективного количества соединения формулы Iили его фармацевтически приемлемой соли. У указанного субъекта может иметься очень значительный или значительный риск развития ракового заболевания. У страдающего раковым заболеванием субъекта может также наблюдаться резистентность по меньшей мере к одному варианту химиотерапевтического лечения или рецидив после химиотерапевтического лечения, или и первое, и второе. Указанное раковое заболевание может представлять собой гематологическое злокачественное новообразование, такое как лейкоз или лимфома.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361911978P | 2013-12-04 | 2013-12-04 | |
PCT/US2014/068423 WO2015084992A1 (en) | 2013-12-04 | 2014-12-03 | Methods for treating cancers |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201690608A1 true EA201690608A1 (ru) | 2016-12-30 |
Family
ID=52232435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201690608A EA201690608A1 (ru) | 2013-12-04 | 2014-12-03 | Способы лечения раковых заболеваний |
Country Status (15)
Country | Link |
---|---|
US (2) | US9687492B2 (ru) |
EP (1) | EP3076976B1 (ru) |
JP (1) | JP6298539B2 (ru) |
KR (2) | KR20160090903A (ru) |
CN (1) | CN105764516A (ru) |
AU (1) | AU2014360537B2 (ru) |
CA (1) | CA2932726C (ru) |
DK (1) | DK3076976T3 (ru) |
EA (1) | EA201690608A1 (ru) |
ES (1) | ES2835549T3 (ru) |
MX (1) | MX2016007311A (ru) |
NZ (1) | NZ718825A (ru) |
PT (1) | PT3076976T (ru) |
SG (1) | SG11201603050TA (ru) |
WO (1) | WO2015084992A1 (ru) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102307581B (zh) | 2008-12-08 | 2016-08-17 | 吉利德康涅狄格股份有限公司 | 咪唑并哌嗪syk抑制剂 |
NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
MX2016001480A (es) | 2013-07-30 | 2017-01-05 | Gilead Connecticut Inc | Formulacion de inhibidores de syk. |
MY176803A (en) | 2013-07-30 | 2020-08-21 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
WO2015017610A1 (en) | 2013-07-31 | 2015-02-05 | Gilead Sciences, Inc. | Syk inhibitors |
EA201690608A1 (ru) | 2013-12-04 | 2016-12-30 | Джилид Сайэнс, Инк. | Способы лечения раковых заболеваний |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
CN106687139A (zh) * | 2014-07-14 | 2017-05-17 | 吉利德科学公司 | 用于治疗癌症的组合 |
EA201791946A1 (ru) * | 2015-04-21 | 2018-03-30 | Джилид Сайэнс, Инк. | Лечение хронической реакции "трансплантат против хозяина" с применением ингибиторов syk |
TW201822764A (zh) * | 2016-09-14 | 2018-07-01 | 美商基利科學股份有限公司 | Syk抑制劑 |
EP3512519A1 (en) | 2016-09-14 | 2019-07-24 | Gilead Sciences, Inc. | Syk inhibitors |
MA46759A (fr) * | 2016-11-14 | 2019-09-18 | Millennium Pharm Inc | Dosage de conjugués anticorps-médicament anti-cd30 pour humain non adulte |
WO2018195471A1 (en) | 2017-04-21 | 2018-10-25 | Gilead Sciences, Inc. | Syk inhibitors in combination with hypomethylating agents |
AU2018321264A1 (en) | 2017-08-25 | 2020-02-27 | Kronos Bio, Inc. | Polymorphs of Syk inhibitors |
TW202016316A (zh) * | 2018-06-19 | 2020-05-01 | 日商武田藥品工業股份有限公司 | 癌症治療方法 |
MX2021010131A (es) | 2019-02-22 | 2021-11-18 | Kronos Bio Inc | Formas sólidas de pirazinas condensadas a manera de inhibidores de syk. |
WO2023174948A2 (en) * | 2022-03-14 | 2023-09-21 | TRx Biosciences Limited | Compositions having improved bioavailability of therapeutics and uses thereof |
Family Cites Families (67)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
US4326525A (en) | 1980-10-14 | 1982-04-27 | Alza Corporation | Osmotic device that improves delivery properties of agent in situ |
US5364620A (en) | 1983-12-22 | 1994-11-15 | Elan Corporation, Plc | Controlled absorption diltiazem formulation for once daily administration |
US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
FR2607813B1 (fr) | 1986-12-05 | 1989-03-31 | Montpellier I Universite | Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique |
US4992445A (en) | 1987-06-12 | 1991-02-12 | American Cyanamid Co. | Transdermal delivery of pharmaceuticals |
US5001139A (en) | 1987-06-12 | 1991-03-19 | American Cyanamid Company | Enchancers for the transdermal flux of nivadipine |
US4902514A (en) | 1988-07-21 | 1990-02-20 | Alza Corporation | Dosage form for administering nilvadipine for treating cardiovascular symptoms |
US5137876A (en) | 1990-10-12 | 1992-08-11 | Merck & Co., Inc. | Nucleoside antiviral and anti-inflammatory compounds and compositions and methods for using same |
DE4327027A1 (de) | 1993-02-15 | 1994-08-18 | Bayer Ag | Imidazoazine |
DE4337611A1 (de) | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Benzoylguanidine, ihre Herstellung und ihre Verwendung in Arzneimitteln |
DE4337609A1 (de) | 1993-11-04 | 1995-05-11 | Boehringer Ingelheim Kg | Neue Pyrazincarboxamidderivate, ihre Herstellung und ihre Verwendung in Arzneimitteln |
FR2711993B1 (fr) | 1993-11-05 | 1995-12-01 | Rhone Poulenc Rorer Sa | Médicaments contenant des dérivés de 7H-imidazol[1,2-a]pyrazine-8-one, les nouveaux composés et leur préparation. |
US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
KR20040068613A (ko) | 1994-03-25 | 2004-07-31 | 이소테크니카 인코포레이티드 | 중수소화된 화합물 이를 포함하는 고혈압 치료용 조성물 |
FR2723373B1 (fr) | 1994-08-02 | 1996-09-13 | Rhone Poulenc Rorer Sa | Forme purifiee de streptogramines, sa preparation et les compositions pharmaceutiques qui la contiennent |
AU5348396A (en) | 1995-05-01 | 1996-11-21 | Fujisawa Pharmaceutical Co., Ltd. | Imidazo 1,2-a pyridine and imidazo 1,2-a pyridezine derivati ves and their use as bone resorption inhibitors |
US5593997A (en) | 1995-05-23 | 1997-01-14 | Pfizer Inc. | 4-aminopyrazolo(3-,4-D)pyrimidine and 4-aminopyrazolo-(3,4-D)pyridine tyrosine kinase inhibitors |
SE9704404D0 (sv) | 1997-11-28 | 1997-11-28 | Astra Ab | New compounds |
DE19948434A1 (de) | 1999-10-08 | 2001-06-07 | Gruenenthal Gmbh | Substanzbibliothek enthaltend bicyclische Imidazo-5-amine und/oder bicyclische Imidazo-3-amine |
JP2001302667A (ja) | 2000-04-28 | 2001-10-31 | Bayer Ag | イミダゾピリミジン誘導体およびトリアゾロピリミジン誘導体 |
GB0018473D0 (en) | 2000-07-27 | 2000-09-13 | Merck Sharp & Dohme | Therapeutic agents |
DE10050663A1 (de) | 2000-10-13 | 2002-04-18 | Gruenenthal Gmbh | Verwendung von substituierten Imidazo[1,2-a]pyridin-, -pyrimidin- und pyrazin-3-yl-amin-Derivaten zur Herstellung von Medikamenten zur NOS-Inhibierung |
WO2002060492A1 (en) | 2001-01-30 | 2002-08-08 | Cytopia Pty Ltd | Methods of inhibiting kinases |
GB0103926D0 (en) | 2001-02-17 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
WO2002076985A1 (en) | 2001-03-23 | 2002-10-03 | Smithkline Beecham Corporation | Compounds useful as kinase inhibitors for the treatment of hyperproliferative diseases |
JP2005523288A (ja) | 2002-02-19 | 2005-08-04 | ファルマシア・アンド・アップジョン・カンパニー・エルエルシー | 疾病治療用の縮合した二環式−n−架橋−複素環式芳香族カルボキサミド |
AU2003221731B2 (en) | 2002-04-19 | 2010-04-15 | Cgi Pharmaceuticals, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines method of making and method of use thereof |
US7312341B2 (en) | 2002-09-09 | 2007-12-25 | Cgi Pharmaceuticals, Inc. | 6-aryl-imidazo[1,2-a] pyrazin-8-ylamines, method of making, and method of use thereof |
TWI351405B (en) | 2002-09-19 | 2011-11-01 | Schering Corp | Novel imidazopyridines as cyclin dependent kinase |
AU2003275031B2 (en) | 2002-09-23 | 2006-08-17 | Schering Corporation | Novel imidazopyrazines as cyclin dependent kinase inhibitors |
MXPA05003120A (es) | 2002-09-23 | 2005-06-22 | Schering Corp | Imidazopirazinas como inhibidores de cinasa dependientes de ciclinas. |
US7189723B2 (en) | 2003-02-10 | 2007-03-13 | Cgi Pharmaceuticals, Inc. | Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity |
US7157460B2 (en) | 2003-02-20 | 2007-01-02 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US7186832B2 (en) | 2003-02-20 | 2007-03-06 | Sugen Inc. | Use of 8-amino-aryl-substituted imidazopyrazines as kinase inhibitors |
US7405295B2 (en) | 2003-06-04 | 2008-07-29 | Cgi Pharmaceuticals, Inc. | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
US20060183746A1 (en) | 2003-06-04 | 2006-08-17 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds |
WO2005005429A1 (en) | 2003-06-30 | 2005-01-20 | Cellular Genomics, Inc. | Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds |
US7259164B2 (en) | 2003-08-11 | 2007-08-21 | Cgi Pharmaceuticals, Inc. | Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity |
US20050288295A1 (en) | 2003-11-11 | 2005-12-29 | Currie Kevin S | Certain imidazo[1,2-a]pyrazin-8-ylamines, method of making, and method of use thereof |
WO2005085252A1 (en) | 2004-03-04 | 2005-09-15 | Biofocus Discovery Limited | Imidazo ‘1,2-a’ pyrazine compounds which interact with protein kinases |
ATE479687T1 (de) | 2004-10-15 | 2010-09-15 | Takeda Pharmaceutical | Kinaseinhibitoren |
MX2007005643A (es) | 2004-11-10 | 2008-03-13 | Cgi Pharmaceuticals Inc | Ciertas imidazo [1,2-a] pirazin-8-ilaminas, metodo para su elaboracion y metodo de uso de las mismas. |
BRPI0618520A2 (pt) | 2005-11-10 | 2011-09-06 | Schering Corp | imidazopirazinas como inibidores de proteìna cinase |
JP5336375B2 (ja) | 2006-08-30 | 2013-11-06 | セルゾーム リミテッド | キナーゼ阻害剤としてのトリアゾール誘導体 |
WO2009077334A1 (en) | 2007-12-14 | 2009-06-25 | F. Hoffmann-La Roche Ag | Novel imidazo[1,2-a]pyridine and imidazo[1,2-b]pyridazine derivatives |
US20090221612A1 (en) | 2008-02-13 | 2009-09-03 | Mitchell Scott A | Certain substituted amides, method of making, and method of use thereof |
CN102066370B (zh) | 2008-07-15 | 2014-05-14 | 霍夫曼-拉罗奇有限公司 | 苯基-咪唑并吡啶类和哒嗪类 |
TWI453207B (zh) | 2008-09-08 | 2014-09-21 | Signal Pharm Llc | 胺基三唑并吡啶,其組合物及使用其之治療方法 |
US8450321B2 (en) * | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
CN102307581B (zh) | 2008-12-08 | 2016-08-17 | 吉利德康涅狄格股份有限公司 | 咪唑并哌嗪syk抑制剂 |
ES2545610T3 (es) | 2008-12-08 | 2015-09-14 | Gilead Connecticut, Inc. | Inhibidores de Syk de imidazopirazina |
NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
ES2602072T3 (es) * | 2011-09-29 | 2017-02-17 | Trovagene, Inc. | Mutaciones en SF3B1 y leucemia linfocítica crónica |
US20130338142A1 (en) | 2012-06-14 | 2013-12-19 | Gilead Connecticut, Inc. | Imidazopyrazine syk inhibitors |
AU2013302617A1 (en) | 2012-08-14 | 2015-02-05 | Gilead Calistoga Llc | Combination therapies for treating cancer |
US20140148430A1 (en) | 2012-11-26 | 2014-05-29 | Gilead Connecticut, Inc. | Imidazopyridines syk inhibitors |
MY176803A (en) | 2013-07-30 | 2020-08-21 | Gilead Connecticut Inc | Polymorph of syk inhibitors |
MX2016001480A (es) | 2013-07-30 | 2017-01-05 | Gilead Connecticut Inc | Formulacion de inhibidores de syk. |
WO2015017610A1 (en) | 2013-07-31 | 2015-02-05 | Gilead Sciences, Inc. | Syk inhibitors |
EA201690608A1 (ru) | 2013-12-04 | 2016-12-30 | Джилид Сайэнс, Инк. | Способы лечения раковых заболеваний |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
TWI662037B (zh) | 2013-12-23 | 2019-06-11 | 美商基利科學股份有限公司 | 脾酪胺酸激酶抑制劑 |
CN106687139A (zh) | 2014-07-14 | 2017-05-17 | 吉利德科学公司 | 用于治疗癌症的组合 |
TW201617074A (zh) | 2014-07-14 | 2016-05-16 | 吉李德科學股份有限公司 | Syk(脾酪胺酸激酶)抑制劑 |
TW201639573A (zh) | 2015-02-03 | 2016-11-16 | 吉李德科學股份有限公司 | 有關治療癌症之合併治療 |
EA201791946A1 (ru) | 2015-04-21 | 2018-03-30 | Джилид Сайэнс, Инк. | Лечение хронической реакции "трансплантат против хозяина" с применением ингибиторов syk |
-
2014
- 2014-12-03 EA EA201690608A patent/EA201690608A1/ru unknown
- 2014-12-03 CN CN201480064630.3A patent/CN105764516A/zh active Pending
- 2014-12-03 DK DK14821005.7T patent/DK3076976T3/da active
- 2014-12-03 MX MX2016007311A patent/MX2016007311A/es unknown
- 2014-12-03 WO PCT/US2014/068423 patent/WO2015084992A1/en active Application Filing
- 2014-12-03 ES ES14821005T patent/ES2835549T3/es active Active
- 2014-12-03 NZ NZ718825A patent/NZ718825A/en not_active IP Right Cessation
- 2014-12-03 AU AU2014360537A patent/AU2014360537B2/en not_active Ceased
- 2014-12-03 JP JP2016556694A patent/JP6298539B2/ja active Active
- 2014-12-03 SG SG11201603050TA patent/SG11201603050TA/en unknown
- 2014-12-03 PT PT148210057T patent/PT3076976T/pt unknown
- 2014-12-03 US US14/559,707 patent/US9687492B2/en active Active
- 2014-12-03 KR KR1020167017388A patent/KR20160090903A/ko active Search and Examination
- 2014-12-03 CA CA2932726A patent/CA2932726C/en not_active Expired - Fee Related
- 2014-12-03 KR KR1020177036826A patent/KR20180002888A/ko not_active Application Discontinuation
- 2014-12-03 EP EP14821005.7A patent/EP3076976B1/en active Active
-
2017
- 2017-05-24 US US15/603,663 patent/US9974792B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3076976B1 (en) | 2020-09-02 |
AU2014360537B2 (en) | 2017-09-07 |
US20150150881A1 (en) | 2015-06-04 |
JP6298539B2 (ja) | 2018-03-20 |
US20170258804A1 (en) | 2017-09-14 |
CA2932726A1 (en) | 2015-06-11 |
US9687492B2 (en) | 2017-06-27 |
NZ718825A (en) | 2017-10-27 |
KR20160090903A (ko) | 2016-08-01 |
JP2016538347A (ja) | 2016-12-08 |
AU2014360537A1 (en) | 2016-05-05 |
EP3076976A1 (en) | 2016-10-12 |
CA2932726C (en) | 2019-06-04 |
US9974792B2 (en) | 2018-05-22 |
CN105764516A (zh) | 2016-07-13 |
SG11201603050TA (en) | 2016-05-30 |
KR20180002888A (ko) | 2018-01-08 |
MX2016007311A (es) | 2016-09-07 |
PT3076976T (pt) | 2020-12-07 |
DK3076976T3 (da) | 2020-12-07 |
WO2015084992A1 (en) | 2015-06-11 |
ES2835549T3 (es) | 2021-06-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
EA201690608A1 (ru) | Способы лечения раковых заболеваний | |
EA201790086A1 (ru) | Комбинации для лечения раковых заболеваний | |
MX2019008208A (es) | Métodos para tratar el cáncer con anticuerpos anti-tim-3. | |
EA201890159A1 (ru) | СПОСОБЫ ЛЕЧЕНИЯ ГЕМАТОЛОГИЧЕСКОГО ЗЛОКАЧЕСТВЕННОГО НОВООБРАЗОВАНИЯ С ПОМОЩЬЮ КОМБИНИРОВАННОЙ ТЕРАПИИ ИНГИБИТОРОМ mTOR В ВИДЕ НАНОЧАСТИЦ | |
EA201891268A1 (ru) | Соединения, которые можно применять в качестве ингибиторов киназы | |
EA201591327A1 (ru) | Замещенные пирролопиримидиновые соединения, их композиции и способы лечения с использованием таких соединений | |
EA201600204A1 (ru) | Производные хиназолина, фармацевтическая композиция на их основе и их применение для профилактики или лечения опухоли | |
PH12016502354A1 (en) | Pharmaceutical composition | |
EA201890730A1 (ru) | Производные пиразолопиримидина в качестве ингибиторов btk для лечения злокачественного новообразования | |
EA201591745A1 (ru) | 3-пиримидин-4-ил-оксазолидин-2-оны в качестве ингибиторов мутантого idh | |
EA201591753A1 (ru) | 3-пиримидин-4-илоксазолидин-2-оны в качестве ингибиторов мутантного idh | |
EA201491330A1 (ru) | Терапевтически активные соединения и способы их использования | |
NZ629456A (en) | Methods for treating cancer using tor kinase inhibitor combination therapy | |
EA201591924A1 (ru) | Способы лечения злокачественной опухоли с использованием комбинированной терапии с коферментом q10 | |
EA201491447A1 (ru) | Ендиины, их конъюгаты и способы их получения и применения | |
EA201590866A1 (ru) | Комбинация анти-cd20 антитела и селективного ингибитора киназы pi3 | |
EA201690020A1 (ru) | Применение производных пиразолопиридина для лечения рака мочевого пузыря | |
MX2015014590A (es) | Tratamiento de cancer con dihidropirazino-pirazinas. | |
MD4643C1 (ru) | Новые индолизиновые соединения, способ их получения ифармацевтические композиции их содержащие | |
EA201491694A1 (ru) | Лечение рака ингибиторами tor киназы | |
EA201591987A1 (ru) | Лечение злокачественной опухоли дигидропиразинопиразинами | |
EA201592108A1 (ru) | Гетероциклические соединения в качестве ингибиторов сигнального пути hedgehog | |
EA201692481A1 (ru) | Комбинация, содержащая глюкокортикоид и edo-s101 | |
EA201691342A1 (ru) | Пиразолоновые соединения и их применение | |
EA201690763A1 (ru) | Лечение рака поджелудочной железы |