FR2607813B1 - Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique - Google Patents

Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique

Info

Publication number
FR2607813B1
FR2607813B1 FR8617164A FR8617164A FR2607813B1 FR 2607813 B1 FR2607813 B1 FR 2607813B1 FR 8617164 A FR8617164 A FR 8617164A FR 8617164 A FR8617164 A FR 8617164A FR 2607813 B1 FR2607813 B1 FR 2607813B1
Authority
FR
France
Prior art keywords
pyrazines
imidazo
alkylamino
derivatives
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8617164A
Other languages
English (en)
Other versions
FR2607813A1 (fr
Inventor
Claire Sablayrolles
Pierre-Antoine Bonnet
Gerard Cros
Jean-Pierre Chapat
Maurice Boucard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Universite de Montpellier I
Original Assignee
Universite de Montpellier I
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universite de Montpellier I filed Critical Universite de Montpellier I
Priority to FR8617164A priority Critical patent/FR2607813B1/fr
Priority to JP88500907A priority patent/JPH02501575A/ja
Priority to PCT/EP1987/000756 priority patent/WO1988004298A1/fr
Priority to EP88900690A priority patent/EP0348392A1/fr
Priority to US07/364,428 priority patent/US5028605A/en
Publication of FR2607813A1 publication Critical patent/FR2607813A1/fr
Application granted granted Critical
Publication of FR2607813B1 publication Critical patent/FR2607813B1/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
FR8617164A 1986-05-12 1986-12-05 Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique Expired FR2607813B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR8617164A FR2607813B1 (fr) 1986-12-05 1986-12-05 Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique
JP88500907A JPH02501575A (ja) 1986-12-05 1987-12-04 ８‐アルキルアミノ‐イミダゾ〔１，２‐ａ〕ピラジン及びその誘導体、その製法及び治療上の適用
PCT/EP1987/000756 WO1988004298A1 (fr) 1986-12-05 1987-12-04 8-alkylaminoimidazo[1,2-a]pyrazines et leurs derives, leur preparation et leur application en therapeutique
EP88900690A EP0348392A1 (fr) 1986-12-05 1987-12-04 8-alkylaminoimidazo[1,2-a]pyrazines et leurs derives, leur preparation et leur application en therapeutique
US07/364,428 US5028605A (en) 1986-05-12 1987-12-04 8-alkylaminoimidazo(1,2-a)pyrazines and derivatives, their preparation and their application in therapy

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8617164A FR2607813B1 (fr) 1986-12-05 1986-12-05 Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique

Publications (2)

Publication Number Publication Date
FR2607813A1 FR2607813A1 (fr) 1988-06-10
FR2607813B1 true FR2607813B1 (fr) 1989-03-31

Family

ID=9341680

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8617164A Expired FR2607813B1 (fr) 1986-05-12 1986-12-05 Alkylamino-8 imidazo (1,2-a) pyrazines et derives, leur preparation et leur application en therapeutique

Country Status (5)

Country Link
US (1) US5028605A (fr)
EP (1) EP0348392A1 (fr)
JP (1) JPH02501575A (fr)
FR (1) FR2607813B1 (fr)
WO (1) WO1988004298A1 (fr)

Families Citing this family (46)

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Publication number Priority date Publication date Assignee Title
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
FR2662163A1 (fr) * 1990-05-16 1991-11-22 Lipha Nouvelles 8-amino-1,2,4-triazolo(4,3-a) pyrazines, procedes de preparation et medicaments les contenant.
US6992188B1 (en) 1995-12-08 2006-01-31 Pfizer, Inc. Substituted heterocyclic derivatives
ES2200039T3 (es) * 1995-12-08 2004-03-01 Pfizer Inc. Derivados heterociclicos sustituidos como antagonistas de crf.
US6650607B1 (en) * 1998-10-12 2003-11-18 Hitachi, Ltd. Information recording method, information recording medium, and information recording apparatus
IL164703A0 (en) * 2002-04-19 2005-12-18 Cellular Genomics Inc ImidazoÄ1,2-AÜpyrazin-8-ylamines method of making and method of use thereof
AU2003270489A1 (en) * 2002-09-09 2004-03-29 Cellular Genomics, Inc. 6-ARYL-IMIDAZO(1,2-a)PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
CA2499874A1 (fr) 2002-09-23 2004-04-01 Schering Corporation Nouvelles imidazopyrazines comme inhibiteurs de kinases dependant des cyclines
WO2004026877A1 (fr) * 2002-09-23 2004-04-01 Schering Corporation Imidazopyrazines utilises en tant qu'inhibiteurs de kinase dependant de la cycline
US7189723B2 (en) 2003-02-10 2007-03-13 Cgi Pharmaceuticals, Inc. Certain 8-heteroaryl-6-phenyl-imidazo[1,2-a]pyrazines as modulators of kinase activity
WO2005014599A1 (fr) 2003-06-04 2005-02-17 Cellular Genomics, Inc. Imidazo[1,2-a]pyrazin-8-ylamines et methodes d'inhibition de la tyrosine kinase de bruton par de tels composes
US7393848B2 (en) 2003-06-30 2008-07-01 Cgi Pharmaceuticals, Inc. Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
WO2007024294A2 (fr) * 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certains urees substitues, modulateurs de l'activite des kinases
WO2007145921A1 (fr) * 2006-06-06 2007-12-21 Schering Corporation Imidazopyrazines utilisées en tant qu'inhibiteur de protéine kinase
GB0716292D0 (en) * 2007-08-21 2007-09-26 Biofocus Dpi Ltd Imidazopyrazine compounds
NZ587039A (en) 2008-02-13 2013-01-25 Gilead Connecticut Inc 6-aryl-imidazo[1, 2-a]pyrazine derivatives, method of making, and method of use thereof
CA2745871C (fr) 2008-12-08 2018-02-20 Gilead Connecticut, Inc. Inhibiteurs d'imidazopyrazine syk
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
JP5567587B2 (ja) 2008-12-08 2014-08-06 ギリアード コネチカット， インコーポレイテッド イミダゾピラジンＳｙｋ阻害剤
AU2010238361B2 (en) 2009-04-16 2015-08-06 Fundacion Centro Nacional De Investigaciones Oncologicas Carlos Iii Imidazopyrazines for use as kinase inhibitors
WO2011112995A1 (fr) 2010-03-11 2011-09-15 Gilead Sciences, Inc. Inhibiteurs de syk à base d'imidazopyridines
WO2012052745A1 (fr) 2010-10-21 2012-04-26 Centro Nacional De Investigaciones Oncológicas (Cnio) Combinaisons d'inhibiteurs de pi3k avec un second agent antitumoral
EP2444084A1 (fr) 2010-10-21 2012-04-25 Centro Nacional de Investigaciones Oncológicas (CNIO) Utilisation d'inhibiteurs de PI3K pour le traitement de l'obésité
CA2821817A1 (fr) * 2010-12-17 2012-06-21 Bayer Intellectual Property Gmbh 6-imidazopyrazines substituees pour l'utilisation en tant qu'inhibiteurs de mps-1 et de tkk dans le traitement de troubles d'hyperproliferation
CA2919661C (fr) 2013-07-30 2020-08-18 Gilead Connecticut, Inc. Polymorphes d'inhibiteurs de syk
AU2014296314B2 (en) 2013-07-30 2017-07-27 Gilead Connecticut, Inc. Formulation of Syk inhibitors
EP3076976B1 (fr) 2013-12-04 2020-09-02 Gilead Sciences, Inc. Méthode de traitement du cancer
TWI662037B (zh) 2013-12-23 2019-06-11 美商基利科學股份有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
US9670210B2 (en) 2014-02-13 2017-06-06 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
ME03580B (fr) 2014-02-13 2020-07-20 Incyte Corp Cyclopropylamines en tant qu'inhibiteurs de lsd1
US9493442B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
US9695168B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,5-α]pyridines and imidazo[1,5-α]pyrazines as LSD1 inhibitors
WO2016007736A1 (fr) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines en tant qu'inhibiteurs de lsd1
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
EA201790086A1 (ru) 2014-07-14 2017-07-31 Джилид Сайэнс, Инк. Комбинации для лечения раковых заболеваний
US9944647B2 (en) 2015-04-03 2018-04-17 Incyte Corporation Heterocyclic compounds as LSD1 inhibitors
US10329255B2 (en) 2015-08-12 2019-06-25 Incyte Corporation Salts of an LSD1 inhibitor
MA44725A (fr) 2016-04-22 2019-02-27 Incyte Corp Formulations d'un inhibiteur de lsd1
CN111051311A (zh) 2017-08-25 2020-04-21 吉利德科学公司 Syk抑制剂的多晶型物
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
WO2020172431A1 (fr) 2019-02-22 2020-08-27 Gilead Sciences, Inc. Formes solides de pyrazines condensées en tant qu'inhibiteur de syk
EP4049726A1 (fr) * 2021-02-25 2022-08-31 Fundación del Sector Público Estatal Centro Nacional de Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Imidazo[1,2-a]pyrazines en tant qu'inhibiteurs de haspine et leurs utilisations thérapeutiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3061283D1 (en) * 1979-01-22 1983-01-20 Merck & Co Inc Piperazinyl-imidazo(1,2-a)pyrazine derivatives, process for their preparation and pharmaceutical compositions containing them
US4537889A (en) * 1982-12-27 1985-08-27 Eli Lilly And Company Inotropic agents
MC1673A1 (fr) * 1984-06-27 1986-06-03 Wellcome Found Derives aryliques de composes imidazoliques,leur preparation et leur emploi pour la preparation des medicaments

Also Published As

Publication number Publication date
WO1988004298A1 (fr) 1988-06-16
FR2607813A1 (fr) 1988-06-10
US5028605A (en) 1991-07-02
EP0348392A1 (fr) 1990-01-03
JPH02501575A (ja) 1990-05-31

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Legal Events

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ST Notification of lapse