EA201791946A1 - Лечение хронической реакции "трансплантат против хозяина" с применением ингибиторов syk - Google Patents
Лечение хронической реакции "трансплантат против хозяина" с применением ингибиторов sykInfo
- Publication number
- EA201791946A1 EA201791946A1 EA201791946A EA201791946A EA201791946A1 EA 201791946 A1 EA201791946 A1 EA 201791946A1 EA 201791946 A EA201791946 A EA 201791946A EA 201791946 A EA201791946 A EA 201791946A EA 201791946 A1 EA201791946 A1 EA 201791946A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- transplantate
- owner
- treatment
- syk inhibitors
- versus host
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
В настоящем описании предложены способы применения соединений, ингибирующих тирозинкиназу селезенки (Syk), для лечения реакции "трансплантат против хозяина" (РТПХ) у человека, включая острую реакцию "трансплантат против хозяина" (оРТПХ) и хроническую реакцию "трансплантат против хозяина" (хРТПХ), включающие применение соединений, выбранных из группы, состоящих из соединений формул, приведенных ниже:
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150691P | 2015-04-21 | 2015-04-21 | |
PCT/US2016/028303 WO2016172117A1 (en) | 2015-04-21 | 2016-04-19 | Treatment of chronic graft versus host disease with syk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791946A1 true EA201791946A1 (ru) | 2018-03-30 |
Family
ID=55854820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791946A EA201791946A1 (ru) | 2015-04-21 | 2016-04-19 | Лечение хронической реакции "трансплантат против хозяина" с применением ингибиторов syk |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160375019A1 (ru) |
EP (1) | EP3285808A1 (ru) |
JP (1) | JP2018513173A (ru) |
KR (1) | KR20170137200A (ru) |
CN (1) | CN107530354A (ru) |
AU (1) | AU2016252387A1 (ru) |
BR (1) | BR112017022323A2 (ru) |
CA (1) | CA2983611A1 (ru) |
EA (1) | EA201791946A1 (ru) |
HK (2) | HK1244453A1 (ru) |
MX (1) | MX2017013496A (ru) |
SG (1) | SG11201708075RA (ru) |
TW (1) | TW201711685A (ru) |
WO (1) | WO2016172117A1 (ru) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102307581B (zh) | 2008-12-08 | 2016-08-17 | 吉利德康涅狄格股份有限公司 | 咪唑并哌嗪syk抑制剂 |
NZ602362A (en) | 2010-03-11 | 2014-11-28 | Gilead Connecticut Inc | Imidazopyridines syk inhibitors |
PL3027618T3 (pl) | 2013-07-30 | 2021-04-19 | Kronos Bio, Inc. | Polimorf inhibitorów syk |
CA2919479C (en) | 2013-07-31 | 2017-08-22 | Gilead Sciences, Inc. | Syk inhibitors |
US9687492B2 (en) | 2013-12-04 | 2017-06-27 | Gilead Sciences, Inc. | Methods for treating cancers |
TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
EA201790086A1 (ru) | 2014-07-14 | 2017-07-31 | Джилид Сайэнс, Инк. | Комбинации для лечения раковых заболеваний |
WO2017106564A1 (en) * | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
EP3512519A1 (en) | 2016-09-14 | 2019-07-24 | Gilead Sciences, Inc. | Syk inhibitors |
EP3583128A1 (en) * | 2017-02-17 | 2019-12-25 | OSE Immunotherapeutics | New uses of anti-sirpg antibodies |
US11384082B2 (en) | 2017-08-25 | 2022-07-12 | Kronos Bio, Inc. | Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors |
WO2020015615A1 (zh) | 2018-07-17 | 2020-01-23 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制蛋白激酶活性的炔基(杂)芳环类化合物 |
KR20210131372A (ko) | 2019-02-22 | 2021-11-02 | 크로노스 바이오, 인코포레이티드 | Syk 억제제로서의 축합된 피라진의 고체 형태 |
CN112939983A (zh) * | 2021-02-01 | 2021-06-11 | 暨明医药科技(苏州)有限公司 | 一种SYK激酶抑制剂Lanraplenib的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7037900B2 (en) * | 2001-10-12 | 2006-05-02 | Supergen, Inc. | Composition and method for treating graft-versus-host disease |
US8450321B2 (en) * | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
MX2011006091A (es) | 2008-12-08 | 2011-11-29 | Gilead Connecticut Inc | Inhibidores de imidazopirazina syk. |
KR20160036590A (ko) | 2013-07-30 | 2016-04-04 | 질레드 코네티컷 인코포레이티드 | Syk 억제제의 제제 |
PL3027618T3 (pl) | 2013-07-30 | 2021-04-19 | Kronos Bio, Inc. | Polimorf inhibitorów syk |
US9687492B2 (en) * | 2013-12-04 | 2017-06-27 | Gilead Sciences, Inc. | Methods for treating cancers |
TWI735853B (zh) * | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
-
2016
- 2016-04-19 MX MX2017013496A patent/MX2017013496A/es unknown
- 2016-04-19 AU AU2016252387A patent/AU2016252387A1/en not_active Abandoned
- 2016-04-19 CA CA2983611A patent/CA2983611A1/en not_active Abandoned
- 2016-04-19 SG SG11201708075RA patent/SG11201708075RA/en unknown
- 2016-04-19 KR KR1020177033177A patent/KR20170137200A/ko not_active Application Discontinuation
- 2016-04-19 EA EA201791946A patent/EA201791946A1/ru unknown
- 2016-04-19 US US15/133,041 patent/US20160375019A1/en not_active Abandoned
- 2016-04-19 BR BR112017022323-6A patent/BR112017022323A2/pt not_active Application Discontinuation
- 2016-04-19 EP EP16718974.5A patent/EP3285808A1/en not_active Withdrawn
- 2016-04-19 JP JP2017554862A patent/JP2018513173A/ja active Pending
- 2016-04-19 WO PCT/US2016/028303 patent/WO2016172117A1/en active Application Filing
- 2016-04-19 CN CN201680023400.1A patent/CN107530354A/zh active Pending
- 2016-04-20 TW TW105112327A patent/TW201711685A/zh unknown
-
2018
- 2018-03-23 HK HK18104045.7A patent/HK1244453A1/zh unknown
- 2018-07-10 HK HK18108940.4A patent/HK1249054A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
HK1249054A1 (zh) | 2018-10-26 |
WO2016172117A1 (en) | 2016-10-27 |
CA2983611A1 (en) | 2016-10-27 |
US20160375019A1 (en) | 2016-12-29 |
KR20170137200A (ko) | 2017-12-12 |
CN107530354A (zh) | 2018-01-02 |
HK1244453A1 (zh) | 2018-08-10 |
SG11201708075RA (en) | 2017-11-29 |
AU2016252387A1 (en) | 2017-10-19 |
TW201711685A (zh) | 2017-04-01 |
EP3285808A1 (en) | 2018-02-28 |
MX2017013496A (es) | 2018-02-09 |
BR112017022323A2 (pt) | 2018-07-03 |
JP2018513173A (ja) | 2018-05-24 |
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