MX2017013496A - Tratamiento de enfermedad cronica de injerto contra hospedero con inhibidores de tirosina cinasa de bazo (syk). - Google Patents
Tratamiento de enfermedad cronica de injerto contra hospedero con inhibidores de tirosina cinasa de bazo (syk).Info
- Publication number
- MX2017013496A MX2017013496A MX2017013496A MX2017013496A MX2017013496A MX 2017013496 A MX2017013496 A MX 2017013496A MX 2017013496 A MX2017013496 A MX 2017013496A MX 2017013496 A MX2017013496 A MX 2017013496A MX 2017013496 A MX2017013496 A MX 2017013496A
- Authority
- MX
- Mexico
- Prior art keywords
- host disease
- versus host
- graft versus
- treatment
- chronic graft
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente descripción provee métodos para utilizar compuestos inhibidores de Syk en el tratamiento de enfermedad de injerto contra hospedero (GVHD) en un humano, incluyendo enfermedad aguda de injerto contra hospedero (aGVHD) y enfermedad crónica de injerto contra hospedero (cGVHD), incluyendo el uso de compuestos que se seleccionan a partir del grupo que consiste de las siguientes fórmulas: (I) y (II).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562150691P | 2015-04-21 | 2015-04-21 | |
PCT/US2016/028303 WO2016172117A1 (en) | 2015-04-21 | 2016-04-19 | Treatment of chronic graft versus host disease with syk inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2017013496A true MX2017013496A (es) | 2018-02-09 |
Family
ID=55854820
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2017013496A MX2017013496A (es) | 2015-04-21 | 2016-04-19 | Tratamiento de enfermedad cronica de injerto contra hospedero con inhibidores de tirosina cinasa de bazo (syk). |
Country Status (14)
Country | Link |
---|---|
US (1) | US20160375019A1 (es) |
EP (1) | EP3285808A1 (es) |
JP (1) | JP2018513173A (es) |
KR (1) | KR20170137200A (es) |
CN (1) | CN107530354A (es) |
AU (1) | AU2016252387A1 (es) |
BR (1) | BR112017022323A2 (es) |
CA (1) | CA2983611A1 (es) |
EA (1) | EA201791946A1 (es) |
HK (2) | HK1244453A1 (es) |
MX (1) | MX2017013496A (es) |
SG (1) | SG11201708075RA (es) |
TW (1) | TW201711685A (es) |
WO (1) | WO2016172117A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2744541T3 (es) | 2008-12-08 | 2020-02-25 | Gilead Connecticut Inc | Inhibidores de imidazopirazina Syk |
JP5938352B2 (ja) | 2010-03-11 | 2016-06-22 | ギリアード コネチカット, インコーポレイテッド | イミダゾピリジンsyk阻害剤 |
MD4659B1 (ro) | 2013-07-30 | 2019-11-30 | Gilead Connecticut Inc | Polimorf al inhibitorilor SYK |
MX2016001427A (es) | 2013-07-31 | 2016-08-03 | Gilead Sciences Inc | Inhibidores de syk. |
CN105764516A (zh) | 2013-12-04 | 2016-07-13 | 吉利德科学公司 | 治疗癌症的方法 |
TWI735853B (zh) | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
MA40075A (fr) | 2014-07-14 | 2016-01-21 | Gilead Sciences Inc | Combinaisons pour traiter des cancers |
WO2017106564A1 (en) * | 2015-12-17 | 2017-06-22 | Gilead Sciences, Inc. | Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders |
US10111882B2 (en) | 2016-09-14 | 2018-10-30 | Gilead Sciences, Inc. | SYK inhibitors |
JP7179743B2 (ja) * | 2017-02-17 | 2022-11-29 | オーエスイー・イミュノセラピューティクス | 抗SIRPg抗体の新規の使用 |
US11384082B2 (en) | 2017-08-25 | 2022-07-12 | Kronos Bio, Inc. | Hydrates of polymorphs of 6-(1H-indazol-6-YL)-N-(4-morpholinophenyl)-2,3-dihydroimidazo[1,2-A]pyrazin-8-amine bisemsylate as Syk inhibitors |
US11746110B2 (en) | 2018-07-17 | 2023-09-05 | Shenzhen Targetrx, Inc. | Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity |
US11339168B2 (en) | 2019-02-22 | 2022-05-24 | Kronos Bio, Inc. | Crystalline forms of 6-(6-aminopyrazin-2-yl)-N-(4-(4-(oxetan-3-yl)piperazin-1-yl)phenyl)imidazo[1,2-a]pyrazin-8-amine as Syk inhibitors |
CN112939983A (zh) * | 2021-02-01 | 2021-06-11 | 暨明医药科技(苏州)有限公司 | 一种SYK激酶抑制剂Lanraplenib的合成方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7037900B2 (en) * | 2001-10-12 | 2006-05-02 | Supergen, Inc. | Composition and method for treating graft-versus-host disease |
US8450321B2 (en) * | 2008-12-08 | 2013-05-28 | Gilead Connecticut, Inc. | 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor |
DK2716157T3 (en) * | 2008-12-08 | 2016-08-15 | Gilead Connecticut Inc | Imidazopyrazin-Syk inhibitors |
JP6153667B2 (ja) | 2013-07-30 | 2017-06-28 | ギリアード コネチカット, インコーポレイテッド | Sky阻害剤の製剤 |
MD4659B1 (ro) | 2013-07-30 | 2019-11-30 | Gilead Connecticut Inc | Polimorf al inhibitorilor SYK |
CN105764516A (zh) * | 2013-12-04 | 2016-07-13 | 吉利德科学公司 | 治疗癌症的方法 |
TWI735853B (zh) * | 2013-12-23 | 2021-08-11 | 美商克洛諾斯生技有限公司 | 脾酪胺酸激酶抑制劑 |
US9290505B2 (en) | 2013-12-23 | 2016-03-22 | Gilead Sciences, Inc. | Substituted imidazo[1,2-a]pyrazines as Syk inhibitors |
-
2016
- 2016-04-19 JP JP2017554862A patent/JP2018513173A/ja active Pending
- 2016-04-19 CN CN201680023400.1A patent/CN107530354A/zh active Pending
- 2016-04-19 WO PCT/US2016/028303 patent/WO2016172117A1/en active Application Filing
- 2016-04-19 BR BR112017022323-6A patent/BR112017022323A2/pt not_active Application Discontinuation
- 2016-04-19 EA EA201791946A patent/EA201791946A1/ru unknown
- 2016-04-19 US US15/133,041 patent/US20160375019A1/en not_active Abandoned
- 2016-04-19 SG SG11201708075RA patent/SG11201708075RA/en unknown
- 2016-04-19 MX MX2017013496A patent/MX2017013496A/es unknown
- 2016-04-19 AU AU2016252387A patent/AU2016252387A1/en not_active Abandoned
- 2016-04-19 KR KR1020177033177A patent/KR20170137200A/ko not_active Application Discontinuation
- 2016-04-19 EP EP16718974.5A patent/EP3285808A1/en not_active Withdrawn
- 2016-04-19 CA CA2983611A patent/CA2983611A1/en not_active Abandoned
- 2016-04-20 TW TW105112327A patent/TW201711685A/zh unknown
-
2018
- 2018-03-23 HK HK18104045.7A patent/HK1244453A1/zh unknown
- 2018-07-10 HK HK18108940.4A patent/HK1249054A1/zh unknown
Also Published As
Publication number | Publication date |
---|---|
AU2016252387A1 (en) | 2017-10-19 |
CN107530354A (zh) | 2018-01-02 |
SG11201708075RA (en) | 2017-11-29 |
EP3285808A1 (en) | 2018-02-28 |
WO2016172117A1 (en) | 2016-10-27 |
CA2983611A1 (en) | 2016-10-27 |
HK1249054A1 (zh) | 2018-10-26 |
US20160375019A1 (en) | 2016-12-29 |
JP2018513173A (ja) | 2018-05-24 |
BR112017022323A2 (pt) | 2018-07-03 |
HK1244453A1 (zh) | 2018-08-10 |
EA201791946A1 (ru) | 2018-03-30 |
KR20170137200A (ko) | 2017-12-12 |
TW201711685A (zh) | 2017-04-01 |
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