HK1249054A1 - 使用syk抑制劑對慢性移植物抗宿主病的治療 - Google Patents

使用syk抑制劑對慢性移植物抗宿主病的治療

Info

Publication number
HK1249054A1
HK1249054A1 HK18108940.4A HK18108940A HK1249054A1 HK 1249054 A1 HK1249054 A1 HK 1249054A1 HK 18108940 A HK18108940 A HK 18108940A HK 1249054 A1 HK1249054 A1 HK 1249054A1
Authority
HK
Hong Kong
Prior art keywords
treatment
host disease
versus host
graft versus
chronic graft
Prior art date
Application number
HK18108940.4A
Other languages
English (en)
Inventor
A Di Paolo Julie
Haw-Ling Lin Joseph
Lin Shao-Lee
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of HK1249054A1 publication Critical patent/HK1249054A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK18108940.4A 2015-04-21 2018-07-10 使用syk抑制劑對慢性移植物抗宿主病的治療 HK1249054A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562150691P 2015-04-21 2015-04-21
PCT/US2016/028303 WO2016172117A1 (en) 2015-04-21 2016-04-19 Treatment of chronic graft versus host disease with syk inhibitors

Publications (1)

Publication Number Publication Date
HK1249054A1 true HK1249054A1 (zh) 2018-10-26

Family

ID=55854820

Family Applications (2)

Application Number Title Priority Date Filing Date
HK18104045.7A HK1244453A1 (zh) 2015-04-21 2018-03-23 使用syk抑制劑對慢性移植物抗宿主病的治療
HK18108940.4A HK1249054A1 (zh) 2015-04-21 2018-07-10 使用syk抑制劑對慢性移植物抗宿主病的治療

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK18104045.7A HK1244453A1 (zh) 2015-04-21 2018-03-23 使用syk抑制劑對慢性移植物抗宿主病的治療

Country Status (14)

Country Link
US (1) US20160375019A1 (zh)
EP (1) EP3285808A1 (zh)
JP (1) JP2018513173A (zh)
KR (1) KR20170137200A (zh)
CN (1) CN107530354A (zh)
AU (1) AU2016252387A1 (zh)
BR (1) BR112017022323A2 (zh)
CA (1) CA2983611A1 (zh)
EA (1) EA201791946A1 (zh)
HK (2) HK1244453A1 (zh)
MX (1) MX2017013496A (zh)
SG (1) SG11201708075RA (zh)
TW (1) TW201711685A (zh)
WO (1) WO2016172117A1 (zh)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101743784B1 (ko) 2008-12-08 2017-06-05 질레드 코네티컷 인코포레이티드 이미다조피라진 ｓｙｋ 억제제
MX350010B (es) 2010-03-11 2017-08-23 Gilead Connecticut Inc Inhibidores syk de imidazopiridinas.
NZ715776A (en) 2013-07-30 2017-04-28 Gilead Connecticut Inc Polymorph of syk inhibitors
AU2014296184B2 (en) 2013-07-31 2017-04-27 Gilead Sciences, Inc. Syk inhibitors
WO2015084992A1 (en) 2013-12-04 2015-06-11 Gilead Sciences, Inc. Methods for treating cancers
TWI735853B (zh) 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
NZ726365A (en) 2014-07-14 2018-06-29 Gilead Sciences Inc Combinations for treating cancers
US20170173034A1 (en) * 2015-12-17 2017-06-22 Gilead Sciences, Inc. Combination of a jak inhibitor and a syk inhibitor for treating cancers and inflammatory disorders
EP3512519A1 (en) 2016-09-14 2019-07-24 Gilead Sciences, Inc. Syk inhibitors
JP7179743B2 (ja) * 2017-02-17 2022-11-29 オーエスイー・イミュノセラピューティクス 抗ＳＩＲＰｇ抗体の新規の使用
CA3073871A1 (en) 2017-08-25 2019-02-28 Gilead Sciences, Inc. Polymorphs of syk inhibitors
US11746110B2 (en) 2018-07-17 2023-09-05 Shenzhen Targetrx, Inc. Alkynyl (hetero) aromatic ring compounds used for inhibiting protein kinase activity
WO2020172431A1 (en) 2019-02-22 2020-08-27 Gilead Sciences, Inc. Solid forms of condensed pyrazines as syk inhibitors
CN112939983A (zh) * 2021-02-01 2021-06-11 暨明医药科技（苏州）有限公司 一种SYK激酶抑制剂Lanraplenib的合成方法
WO2024124063A1 (en) * 2022-12-09 2024-06-13 Kronos Bio, Inc. Crystalline forms of lanraplenib and methods of making and using the same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7037900B2 (en) * 2001-10-12 2006-05-02 Supergen, Inc. Composition and method for treating graft-versus-host disease
WO2010068257A1 (en) * 2008-12-08 2010-06-17 Cgi Pharmaceuticals, Inc. Imidazopyrazine syk inhibitors
US8450321B2 (en) * 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
NZ715776A (en) 2013-07-30 2017-04-28 Gilead Connecticut Inc Polymorph of syk inhibitors
EA201690127A1 (ru) 2013-07-30 2016-07-29 Джилид Коннектикут, Инк. Состав на основе ингибиторов syk
WO2015084992A1 (en) * 2013-12-04 2015-06-11 Gilead Sciences, Inc. Methods for treating cancers
TWI735853B (zh) * 2013-12-23 2021-08-11 美商克洛諾斯生技有限公司 脾酪胺酸激酶抑制劑
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors

Also Published As

Publication number Publication date
HK1244453A1 (zh) 2018-08-10
CN107530354A (zh) 2018-01-02
TW201711685A (zh) 2017-04-01
JP2018513173A (ja) 2018-05-24
SG11201708075RA (en) 2017-11-29
CA2983611A1 (en) 2016-10-27
BR112017022323A2 (pt) 2018-07-03
US20160375019A1 (en) 2016-12-29
EP3285808A1 (en) 2018-02-28
WO2016172117A1 (en) 2016-10-27
EA201791946A1 (ru) 2018-03-30
MX2017013496A (es) 2018-02-09
AU2016252387A1 (en) 2017-10-19
KR20170137200A (ko) 2017-12-12

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