MX2015011097A - Inhibidores de histona desmetilasas. - Google Patents

Inhibidores de histona desmetilasas.

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Publication number
MX2015011097A
MX2015011097A MX2015011097A MX2015011097A MX2015011097A MX 2015011097 A MX2015011097 A MX 2015011097A MX 2015011097 A MX2015011097 A MX 2015011097A MX 2015011097 A MX2015011097 A MX 2015011097A MX 2015011097 A MX2015011097 A MX 2015011097A
Authority
MX
Mexico
Prior art keywords
inhibitors
histone demethylases
compounds
demethylases
histone
Prior art date
Application number
MX2015011097A
Other languages
English (en)
Inventor
Thomas Boesen
Marc Labelle
Qasim Khan
Ying Yang
Mukund Mehrotra
Neerja Saraswat
Farman Ullah
Ramkrishna Reddy Vakiti
Utpal Sharma
Original Assignee
Epitherapeutics Aps
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epitherapeutics Aps filed Critical Epitherapeutics Aps
Publication of MX2015011097A publication Critical patent/MX2015011097A/es

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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
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    • C07D213/40Acylated substituent nitrogen atom
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    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
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Abstract

Compuestos de la forma (ver Fórmula) en la cual Q se selecciona entre -CH=NR12,-W, -CH2NHR13, -CH=O y -CH(OR17)2 capaces de modular la actividad de histona desmetilasas (HDME), las cuales son útiles para la prevención y/o el tratamiento de enfermedades en donde la desregulación genómica está involucrada en la patogénesis, tal como por ej. cáncer y formulaciones y métodos de uso de dichos compuestos.
MX2015011097A 2013-02-27 2014-02-26 Inhibidores de histona desmetilasas. MX2015011097A (es)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361770067P 2013-02-27 2013-02-27
US201361770058P 2013-02-27 2013-02-27
US201361770065P 2013-02-27 2013-02-27
DKPA201370113 2013-02-27
DKPA201370115 2013-02-27
DKPA201370114 2013-02-27
US201461931126P 2014-01-24 2014-01-24
PCT/EP2014/053674 WO2014131777A1 (en) 2013-02-27 2014-02-26 Inhibitors of histone demethylases

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KR (1) KR102229992B1 (es)
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AP (1) AP2015008676A0 (es)
AU (2) AU2014222756B2 (es)
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CA (1) CA2901022C (es)
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Publication number Priority date Publication date Assignee Title
AP2015008389A0 (en) 2012-10-02 2015-04-30 Epitherapeutics Aps Inhibitors of histone demethylases
AP2015008676A0 (en) 2013-02-27 2015-08-31 Epitherapeutics Aps Inhibitors of histone demethylases
CA2943824A1 (en) * 2014-03-31 2015-10-08 Gilead Sciences, Inc. Inhibitors of histone demethylases
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