TW200407322A - Novel imidazopyridines as cyclin dependent kinase inhibitors - Google Patents

Novel imidazopyridines as cyclin dependent kinase inhibitors

Info

Publication number
TW200407322A
TW200407322A TW092125636A TW92125636A TW200407322A TW 200407322 A TW200407322 A TW 200407322A TW 092125636 A TW092125636 A TW 092125636A TW 92125636 A TW92125636 A TW 92125636A TW 200407322 A TW200407322 A TW 200407322A
Authority
TW
Taiwan
Prior art keywords
compounds
cyclin dependent
kinase inhibitors
dependent kinase
methods
Prior art date
Application number
TW092125636A
Other languages
Chinese (zh)
Other versions
TWI351405B (en
Inventor
Michael P Dwyer
Timothy J Guzi
Kamil Paruch
Ronald J Doll
Kartik M Keertikar
M Girijavallabhan Viyyoor
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of TW200407322A publication Critical patent/TW200407322A/en
Application granted granted Critical
Publication of TWI351405B publication Critical patent/TWI351405B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

In its many embodiments, the present invention provides a novel class of imidazo[1,2-a]pyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
TW092125636A 2002-09-19 2003-09-17 Novel imidazopyridines as cyclin dependent kinase TWI351405B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41206302P 2002-09-19 2002-09-19

Publications (2)

Publication Number Publication Date
TW200407322A true TW200407322A (en) 2004-05-16
TWI351405B TWI351405B (en) 2011-11-01

Family

ID=32030794

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092125636A TWI351405B (en) 2002-09-19 2003-09-17 Novel imidazopyridines as cyclin dependent kinase

Country Status (19)

Country Link
US (2) US6992080B2 (en)
EP (1) EP1539756B1 (en)
JP (1) JP4845379B2 (en)
KR (1) KR20050052500A (en)
CN (1) CN100549011C (en)
AR (1) AR041291A1 (en)
AT (1) ATE378336T1 (en)
AU (1) AU2003295332B2 (en)
CA (1) CA2499639C (en)
DE (1) DE60317529T2 (en)
ES (1) ES2293068T3 (en)
HK (1) HK1071757A1 (en)
IL (1) IL167433A (en)
MX (1) MXPA05003058A (en)
MY (1) MY133311A (en)
NZ (1) NZ538566A (en)
TW (1) TWI351405B (en)
WO (1) WO2004026867A2 (en)
ZA (1) ZA200502278B (en)

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Also Published As

Publication number Publication date
WO2004026867A3 (en) 2004-08-05
WO2004026867A2 (en) 2004-04-01
ES2293068T3 (en) 2008-03-16
MY133311A (en) 2007-11-30
CA2499639C (en) 2011-11-08
ATE378336T1 (en) 2007-11-15
EP1539756A2 (en) 2005-06-15
CN1703414A (en) 2005-11-30
US20040097517A1 (en) 2004-05-20
AU2003295332B2 (en) 2007-01-18
IL167433A (en) 2011-03-31
EP1539756B1 (en) 2007-11-14
ZA200502278B (en) 2006-05-31
AR041291A1 (en) 2005-05-11
US20060030555A1 (en) 2006-02-09
CA2499639A1 (en) 2004-04-01
MXPA05003058A (en) 2005-05-27
AU2003295332A1 (en) 2004-04-08
DE60317529D1 (en) 2007-12-27
DE60317529T2 (en) 2008-09-25
JP4845379B2 (en) 2011-12-28
JP2006507254A (en) 2006-03-02
TWI351405B (en) 2011-11-01
US6992080B2 (en) 2006-01-31
HK1071757A1 (en) 2005-07-29
CN100549011C (en) 2009-10-14
KR20050052500A (en) 2005-06-02
US7452902B2 (en) 2008-11-18
NZ538566A (en) 2008-02-29

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