BR0314001A - Pirazolopirimidinas como inibidores de cinase dependente de ciclina - Google Patents

Pirazolopirimidinas como inibidores de cinase dependente de ciclina

Info

Publication number
BR0314001A
BR0314001A BR0314001-6A BR0314001A BR0314001A BR 0314001 A BR0314001 A BR 0314001A BR 0314001 A BR0314001 A BR 0314001A BR 0314001 A BR0314001 A BR 0314001A
Authority
BR
Brazil
Prior art keywords
compounds
cyclin
pyrazolopyrimidines
kinase inhibitors
dependent kinase
Prior art date
Application number
BR0314001-6A
Other languages
English (en)
Other versions
BRPI0314001B1 (pt
BRPI0314001B8 (pt
Inventor
Timothy Guzi
Kamil Paruch
Michael P Dwyer
Ronald J Doll
Viyyoor Moopil Girijavallabhan
Alan Mallams
Carmen S Alvarez
Kartik M Keertikar
Jocelyn Rivera
Tin-Yau Chan
Vincent Madison
Thierry O Fischmann
Lawrence W Dillard
Vinh D Tran
Zhen Min He
Ray Anthony James
Haengsoon Park
Vidyadhar M Paradkar
Douglas Walsh Hobbs
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of BR0314001A publication Critical patent/BR0314001A/pt
Publication of BRPI0314001B1 publication Critical patent/BRPI0314001B1/pt
Publication of BRPI0314001B8 publication Critical patent/BRPI0314001B8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Neurology (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

"PIRAZOLOPIRIMIDINAS COMO INIBIDORES DE CINASE DEPENDENTE DE CICLINA". Em suas muitas modalidades, a presente invenção fornece uma nova classe de compostos pirazolo[1,5-a]pirimidina como inibidores de cinases dependentes de ciclina, métodos de preparar tais compostos, composições farmacêuticas contendo um ou mais compostos, métodos de preparar formulações farmacêuticas compreendendo um ou mais tais compostos e métodos de tratamento, prevenção, inibição ou melhora de uma ou mais doenças associadas às CDKs usando tais compostos ou composições farmacêuticas.
BRPI0314001A 2002-09-04 2003-09-03 pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas BRPI0314001B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US40802702P 2002-09-04 2002-09-04
US42195902P 2002-10-29 2002-10-29
PCT/US2003/027555 WO2004022561A1 (en) 2002-09-04 2003-09-03 Pyrazolopyrimidines as cyclin-dependent kinase inhibitors

Publications (3)

Publication Number Publication Date
BR0314001A true BR0314001A (pt) 2005-07-05
BRPI0314001B1 BRPI0314001B1 (pt) 2018-10-23
BRPI0314001B8 BRPI0314001B8 (pt) 2021-05-25

Family

ID=42828922

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0314001A BRPI0314001B8 (pt) 2002-09-04 2003-09-03 pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas

Country Status (14)

Country Link
EP (1) EP1537116B1 (pt)
JP (1) JP4881558B2 (pt)
KR (1) KR101088922B1 (pt)
AT (1) ATE469903T1 (pt)
AU (1) AU2003263071B2 (pt)
BR (1) BRPI0314001B8 (pt)
CA (1) CA2497440C (pt)
DK (1) DK1537116T3 (pt)
HK (1) HK1071756A1 (pt)
IL (1) IL167086A (pt)
MX (1) MXPA05002571A (pt)
NO (1) NO20051647L (pt)
NZ (1) NZ539165A (pt)
WO (1) WO2004022561A1 (pt)

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CA2497440C (en) 2011-03-22
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MXPA05002571A (es) 2005-09-08
NZ539165A (en) 2008-03-28
ATE469903T1 (de) 2010-06-15
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EP1537116B1 (en) 2010-06-02
AU2003263071A1 (en) 2004-03-29
IL167086A (en) 2015-01-29
AU2003263071B2 (en) 2007-03-15
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