ATE435224T1 - Neue piperidinsubstituierte diaminothiazole - Google Patents
Neue piperidinsubstituierte diaminothiazoleInfo
- Publication number
- ATE435224T1 ATE435224T1 AT05730856T AT05730856T ATE435224T1 AT E435224 T1 ATE435224 T1 AT E435224T1 AT 05730856 T AT05730856 T AT 05730856T AT 05730856 T AT05730856 T AT 05730856T AT E435224 T1 ATE435224 T1 AT E435224T1
- Authority
- AT
- Austria
- Prior art keywords
- diaminothiazoles
- substituted
- treatment
- control
- new piperidine
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 abstract 3
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WKXCZMFWXZRMEZ-UHFFFAOYSA-N 1,3-thiazole-2,4-diamine Chemical class NC1=CSC(N)=N1 WKXCZMFWXZRMEZ-UHFFFAOYSA-N 0.000 abstract 1
- 208000026310 Breast neoplasm Diseases 0.000 abstract 1
- 102000013701 Cyclin-Dependent Kinase 4 Human genes 0.000 abstract 1
- 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 abstract 1
- 210000000481 breast Anatomy 0.000 abstract 1
- 210000001072 colon Anatomy 0.000 abstract 1
- 208000029742 colonic neoplasm Diseases 0.000 abstract 1
- 210000004072 lung Anatomy 0.000 abstract 1
- 208000037841 lung tumor Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 208000023958 prostate neoplasm Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US56371204P | 2004-04-20 | 2004-04-20 | |
| PCT/EP2005/003734 WO2005103034A1 (en) | 2004-04-20 | 2005-04-08 | Novel piperidine substituted diaminothiazoles |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE435224T1 true ATE435224T1 (de) | 2009-07-15 |
Family
ID=34964131
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05730856T ATE435224T1 (de) | 2004-04-20 | 2005-04-08 | Neue piperidinsubstituierte diaminothiazole |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7211576B2 (de) |
| EP (1) | EP1740576B1 (de) |
| JP (1) | JP2007533674A (de) |
| KR (1) | KR100832280B1 (de) |
| CN (1) | CN1942464A (de) |
| AT (1) | ATE435224T1 (de) |
| AU (1) | AU2005235679A1 (de) |
| BR (1) | BRPI0510001A (de) |
| CA (1) | CA2562377A1 (de) |
| DE (1) | DE602005015203D1 (de) |
| ES (1) | ES2327248T3 (de) |
| MX (1) | MXPA06011996A (de) |
| RU (1) | RU2382784C2 (de) |
| WO (1) | WO2005103034A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7423053B2 (en) * | 2004-07-15 | 2008-09-09 | Hoffmann-La Roche Inc. | 4-Aminothiazole derivatives |
| US7705009B2 (en) * | 2005-11-22 | 2010-04-27 | Hoffman-La Roche Inc. | 4-aminopyrimidine-5-thione derivatives |
| US10787410B2 (en) * | 2013-12-16 | 2020-09-29 | The Johns Hopkins University | Treating and preventing diseases by modulating cell mechanics |
| WO2017015484A1 (en) * | 2015-07-23 | 2017-01-26 | Temple University-Of The Commonwealth System Of Higher Education | Novel aminothiazole compounds and methods using same |
| US10941126B2 (en) | 2017-01-19 | 2021-03-09 | Temple University-Of The Commonwealth System Of Higher Education | Bridged bicycloalkyl-substituted aminothiazoles and their methods of use |
| CN110950848B (zh) * | 2018-09-27 | 2024-03-26 | 徐诺药业 | 新型氨基吡唑类衍生物的合成与应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5733920A (en) | 1995-10-31 | 1998-03-31 | Mitotix, Inc. | Inhibitors of cyclin dependent kinases |
| JP2001509805A (ja) | 1997-02-05 | 2001-07-24 | ワーナー−ランバート・コンパニー | 細胞増殖阻害剤としてのピリド〔２，３−ｄ〕ピリミジンおよび４−アミノピリミジン |
| WO1999009030A1 (en) | 1997-08-20 | 1999-02-25 | Warner-Lambert Company | Naphthyridinones for inhibiting protein tyrosine kinase and cell cycle kinase mediated cellular proliferation |
| CN1158269C (zh) * | 1997-10-27 | 2004-07-21 | 阿古龙制药公司 | 作为cdk抑制剂的取代的4-氨基-噻唑-2-基化合物 |
| US6040321A (en) | 1997-11-12 | 2000-03-21 | Bristol-Myers Squibb Company | Aminothiazole inhibitors of cyclin dependent kinases |
| US6479487B1 (en) | 1998-02-26 | 2002-11-12 | Aventis Pharmaceuticals Inc. | 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines |
| PL344021A1 (en) | 1998-02-26 | 2001-09-24 | Aventis Pharma Inc | 6,9-disubstituted 2-[trans-(4- aminocyclohexyl) amino]purines |
| WO2000012485A1 (en) | 1998-08-29 | 2000-03-09 | Astrazeneca Ab | Pyrimidine compounds |
| GB9823871D0 (en) | 1998-10-30 | 1998-12-23 | Pharmacia & Upjohn Spa | 2-Amino-thiazole derivatives, process for their preparation, and their use as antitumour agents |
| GB9828511D0 (en) | 1998-12-24 | 1999-02-17 | Zeneca Ltd | Chemical compounds |
| UA71971C2 (en) | 1999-06-04 | 2005-01-17 | Agoron Pharmaceuticals Inc | Diaminothiazoles, composition based thereon, a method for modulation of protein kinases activity, a method for the treatment of diseases mediated by protein kinases |
| AU2001230026A1 (en) | 2000-02-04 | 2001-08-14 | Novo-Nordisk A/S | 2,4-diaminothiazole derivatives |
| AU3704101A (en) | 2000-02-17 | 2001-08-27 | Amgen Inc | Kinase inhibitors |
| BR0110302A (pt) | 2000-04-18 | 2003-01-14 | Agouron Pharma | Compostos de pirazol para inibição de proteìnas cinase, sal e pró-droga farmaceuticamente aceitável, metabólito farmaceuticamente ativo ou sal farmaceuticamente aceitável de metabólito, composição farmacêutica, método de tratamento de condição doentia em mamìferos mediada pela atividade de proteìna cinase, método de modulação ou inibição da atividade de um receptor de proteìna cinase |
| JP2004505983A (ja) | 2000-08-09 | 2004-02-26 | アグーロン ファーマシューティカルズ，インコーポレイテッド | ピラゾール−チアゾール化合物、これらを含む医薬組成物、およびサイクリン依存性キナーゼの阻害のためのこれらの使用方法 |
| US6756374B2 (en) * | 2001-01-22 | 2004-06-29 | Hoffmann-La Roche Inc. | Diaminothiazoles having antiproliferative activity |
| US6818663B2 (en) * | 2002-05-17 | 2004-11-16 | Hoffmann-La Roches | Diaminothiazoles |
| AU2003282231A1 (en) | 2002-08-09 | 2004-02-25 | Pfizer Inc. | Antiproliferative 2-(heteroaryl)-aminothiazole compounds, pharmaceutical compositions and methods for their use |
| US7157455B2 (en) * | 2003-02-10 | 2007-01-02 | Hoffmann-La Roche Inc. | 4-Aminopyrimidine-5-one derivatives |
-
2005
- 2005-04-04 US US11/098,563 patent/US7211576B2/en not_active Expired - Fee Related
- 2005-04-08 EP EP05730856A patent/EP1740576B1/de not_active Not-in-force
- 2005-04-08 AT AT05730856T patent/ATE435224T1/de not_active IP Right Cessation
- 2005-04-08 MX MXPA06011996A patent/MXPA06011996A/es active IP Right Grant
- 2005-04-08 KR KR1020067021898A patent/KR100832280B1/ko not_active IP Right Cessation
- 2005-04-08 BR BRPI0510001-1A patent/BRPI0510001A/pt not_active IP Right Cessation
- 2005-04-08 DE DE602005015203T patent/DE602005015203D1/de active Active
- 2005-04-08 RU RU2006140862/04A patent/RU2382784C2/ru not_active IP Right Cessation
- 2005-04-08 AU AU2005235679A patent/AU2005235679A1/en not_active Abandoned
- 2005-04-08 CA CA002562377A patent/CA2562377A1/en not_active Abandoned
- 2005-04-08 ES ES05730856T patent/ES2327248T3/es active Active
- 2005-04-08 JP JP2007508763A patent/JP2007533674A/ja active Pending
- 2005-04-08 WO PCT/EP2005/003734 patent/WO2005103034A1/en active Application Filing
- 2005-04-08 CN CNA2005800117620A patent/CN1942464A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1942464A (zh) | 2007-04-04 |
| WO2005103034A1 (en) | 2005-11-03 |
| EP1740576A1 (de) | 2007-01-10 |
| CA2562377A1 (en) | 2005-11-03 |
| DE602005015203D1 (de) | 2009-08-13 |
| WO2005103034A8 (en) | 2006-11-02 |
| US7211576B2 (en) | 2007-05-01 |
| US20050239843A1 (en) | 2005-10-27 |
| RU2382784C2 (ru) | 2010-02-27 |
| EP1740576B1 (de) | 2009-07-01 |
| BRPI0510001A (pt) | 2007-09-18 |
| RU2006140862A (ru) | 2008-05-27 |
| KR100832280B1 (ko) | 2008-05-26 |
| AU2005235679A1 (en) | 2005-11-03 |
| JP2007533674A (ja) | 2007-11-22 |
| KR20060135905A (ko) | 2006-12-29 |
| MXPA06011996A (es) | 2007-04-24 |
| ES2327248T3 (es) | 2009-10-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |