BRPI0411126A - derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno - Google Patents

derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno

Info

Publication number
BRPI0411126A
BRPI0411126A BRPI0411126-5A BRPI0411126A BRPI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A BR PI0411126 A BRPI0411126 A BR PI0411126A
Authority
BR
Brazil
Prior art keywords
compounds
phenalene
triaza
treatment
control
Prior art date
Application number
BRPI0411126-5A
Other languages
English (en)
Inventor
Kin-Chun Luk
Zhuming Zhang
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of BRPI0411126A publication Critical patent/BRPI0411126A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/06—Peri-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

"DERIVADOS DE 1,3,4-TRIAZA-FENALENO E 1,3,4,6-TETRAAZAFENALENO". A presente invenção refere-se a novos derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno da fórmula (I). Estes compostos inibem a tirosina cinase de receptor de fator de crescimento epidérmico ('EGFR'). Estes compostos e seus ésteres e sais farmaceuticamente aceitáveis têm atividade antiproliferativa e são úteis, entre outros, no tratamento ou controle de câncer, em particular tumores sólidos. Esta invenção da mesma forma se refere a composições farmacêuticas que contêm tais compostos e aos métodos de tratar ou controlar câncer, mais particularmente o tratamento ou controle de tumores de mama, pulmão, cólon e próstata.
BRPI0411126-5A 2003-06-10 2004-04-26 derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno BRPI0411126A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US47731803P 2003-06-10 2003-06-10
PCT/EP2004/050608 WO2004111055A1 (en) 2003-06-10 2004-04-26 1.3.4-triaza-phenalene and 1,3,4,6-tetraazaphenalene derivatives

Publications (1)

Publication Number Publication Date
BRPI0411126A true BRPI0411126A (pt) 2006-07-18

Family

ID=33551702

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0411126-5A BRPI0411126A (pt) 2003-06-10 2004-04-26 derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno

Country Status (15)

Country Link
US (1) US7217717B2 (pt)
EP (1) EP1680426B1 (pt)
JP (1) JP2006527235A (pt)
KR (1) KR100753385B1 (pt)
CN (1) CN100378101C (pt)
AT (1) ATE373661T1 (pt)
AU (1) AU2004247418B2 (pt)
BR (1) BRPI0411126A (pt)
CA (1) CA2527832A1 (pt)
DE (1) DE602004009097T2 (pt)
ES (1) ES2293251T3 (pt)
MX (1) MXPA05013145A (pt)
PL (1) PL1680426T3 (pt)
RU (1) RU2346946C2 (pt)
WO (1) WO2004111055A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101596526B1 (ko) * 2007-10-03 2016-02-22 에이자이 아이엔씨. Ｐａｒｐ 억제제 화합물, 조성물 및 사용 방법
RU2498986C2 (ru) * 2011-07-20 2013-11-20 Учреждение Российской Академии Наук Институт Проблем Химической Физики Ран (Ипхф Ран) ТЕТРАЦИАНОЗАМЕЩЕННЫЕ 1,4,9b-ТРИАЗАФЕНАЛЕНЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
CN104945406B (zh) * 2015-05-25 2017-10-10 苏州康润医药有限公司 氮杂非那烯‑3‑酮的衍生物、其制备方法及其作为parp抑制剂的应用
CN115894486B (zh) * 2021-09-30 2024-02-09 北京赛特明强医药科技有限公司 一种氢化吡啶并喹唑啉类化合物、组合物及其应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
ATE229331T1 (de) * 1992-09-11 2002-12-15 Univ California Inhibitoren von metazoan-parasit-proteasen
US5739170A (en) * 1992-09-11 1998-04-14 The Regents Of The University Of California Inhibitors of metazoan parasite proteases
WO1996030347A1 (en) 1995-03-30 1996-10-03 Pfizer Inc. Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
TW436485B (en) * 1997-08-01 2001-05-28 American Cyanamid Co Substituted quinazoline derivatives
OA11769A (en) 1998-04-29 2005-07-25 Pfizer Prod Inc N-(3-ethynylphenylamino)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine mesylate anhydrate and monohydrate.
UA74803C2 (uk) 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
MXPA03003714A (es) * 2000-11-03 2004-05-04 Neurocrine Biosciences Inc Antagonistas del receptor crf y metodos relacionados con los mismos.
JP2010532758A (ja) * 2007-07-06 2010-10-14 オーエスアイ・ファーマスーティカルズ・インコーポレーテッド 組み合わせ抗癌療法

Also Published As

Publication number Publication date
AU2004247418A1 (en) 2004-12-23
EP1680426A1 (en) 2006-07-19
AU2004247418B2 (en) 2009-11-05
WO2004111055A1 (en) 2004-12-23
RU2006100034A (ru) 2006-08-27
DE602004009097T2 (de) 2008-06-19
US20040254205A1 (en) 2004-12-16
PL1680426T3 (pl) 2008-02-29
DE602004009097D1 (de) 2007-10-31
ES2293251T3 (es) 2008-03-16
CN1805964A (zh) 2006-07-19
KR100753385B1 (ko) 2007-08-30
ATE373661T1 (de) 2007-10-15
KR20060017854A (ko) 2006-02-27
JP2006527235A (ja) 2006-11-30
EP1680426B1 (en) 2007-09-19
CA2527832A1 (en) 2004-12-23
CN100378101C (zh) 2008-04-02
MXPA05013145A (es) 2006-03-17
RU2346946C2 (ru) 2009-02-20
US7217717B2 (en) 2007-05-15

Similar Documents

Publication Publication Date Title
TW200407326A (en) Pyrimido compounds having antiproliferative activity
MXPA04004492A (es) Indazolilpirrolotriazinas c-5 modificadas.
TR200200717T2 (tr) Terapötik kinazolin türevleri.
DE60028970D1 (de) An her2 bindende peptidverbindungen
TW200420565A (en) C-6 modified indazolylpyrrolotriazines
BRPI0511975A (pt) pirazolopirimidinas
DE602004004811D1 (de) Chinazolinderivate
GEP20074213B (en) Novel inhibitors of kinases
MY134783A (en) Rho-kinase inhibitors
BRPI0409366A (pt) compostos de pirimido
MY145634A (en) Pyrrolotriazine compounds as kinase inhibitors
DE60215682D1 (de) AZAOXOINDOL DERIVATE ALS Trk PROTEIN KINASE HEMMSTOFFE ZUR BEHANDLUNG VON KREBS UND CHRONISCHEM SCHMERZ
TNSN05188A1 (en) 4-aminopyrimidine-5-one
BR0215360A (pt) Derivados de indolina úteis como inibidores de proteìna quinase
GB0309850D0 (en) Quinazoline derivatives
IS2387B (is) Æxliseyðandi efni
EP1427418A4 (en) PIPERAZINONE COMPOUNDS AS ANTITUMOR AND ANTICANCER AGENTS AND METHODS OF TREATMENT
TW200612929A (en) Novel 2,6-diaminopyridine-3-one derivatives
MX2008002060A (es) Nuevas amidas de acido 4-amino-tieno[3,2-c]piridin-7-carboxilico.
WO2005103034A8 (en) Novel piperidine substituted diaminothiazoles
BRPI0411126A (pt) derivados de 1,3,4-triaza-fenaleno e 1,3,4,6-tetraazafenaleno
DE60224299D1 (de) Kombinationsmedikationen mit einem selektiven cyclooxygenase-2-inhibitor
BRPI0511826A (pt) derivados de 2,4-diaminotiazol-5-ona
WO2003080624A3 (en) Dithiolopyrrolone derivatives useful in the treatment of proliferative diseases
HK1082727A1 (en) 2" oxo-voruscharin and derivatives thereof

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 7A E 8A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2159 DE 22/05/2012.