MX2008002060A - Nuevas amidas de acido 4-amino-tieno[3,2-c]piridin-7-carboxilico. - Google Patents

Nuevas amidas de acido 4-amino-tieno[3,2-c]piridin-7-carboxilico.

Info

Publication number
MX2008002060A
MX2008002060A MX2008002060A MX2008002060A MX2008002060A MX 2008002060 A MX2008002060 A MX 2008002060A MX 2008002060 A MX2008002060 A MX 2008002060A MX 2008002060 A MX2008002060 A MX 2008002060A MX 2008002060 A MX2008002060 A MX 2008002060A
Authority
MX
Mexico
Prior art keywords
compounds
thieno
pyridine
amino
novel
Prior art date
Application number
MX2008002060A
Other languages
English (en)
Inventor
Kin-Chun Luk
Peter Michael Wovkulich
Pamela Loreen Rossman
Zhuming Zhang
Lee Apostle Mcdermott
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2008002060A publication Critical patent/MX2008002060A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invencion se refiere a nuevas amidas del acido 4-amino-tieno[3,2-c[piridin-7-carboxilico de la formula (I), y sus sales y esteres farmaceuticamente aceptables (ver formula (I)); cuyos compuestos de la formula (I) son inhibidores selectivos de las cinasas de KDR y/o FGFR. Estos compuestos y sus sales farmaceuticamente aceptables son agentes antiproliferantes utiles para el tratamiento o control de tumores solidos, en particular de tumores solidos de mama, de colon, pulmon y prostata. Se describen tambien composiciones farmaceuticas o medicamentos que contienen estos compuestos, procesos para su fabricacion y metodos para el tratamiento del cancer empleando estos compuestos.
MX2008002060A 2005-08-16 2005-08-16 Nuevas amidas de acido 4-amino-tieno[3,2-c]piridin-7-carboxilico. MX2008002060A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/054022 WO2007019884A1 (en) 2005-08-16 2005-08-16 Novel 4-amino-thieno[3,2-c]pyridine-7-carboxylic acid amides

Publications (1)

Publication Number Publication Date
MX2008002060A true MX2008002060A (es) 2008-04-16

Family

ID=35159670

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008002060A MX2008002060A (es) 2005-08-16 2005-08-16 Nuevas amidas de acido 4-amino-tieno[3,2-c]piridin-7-carboxilico.

Country Status (9)

Country Link
EP (1) EP1917015A1 (es)
JP (1) JP2009504692A (es)
KR (1) KR100995790B1 (es)
AU (1) AU2005335661A1 (es)
BR (1) BRPI0520482A2 (es)
CA (1) CA2619459A1 (es)
IL (1) IL189181A0 (es)
MX (1) MX2008002060A (es)
WO (1) WO2007019884A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0616239A2 (pt) * 2005-09-15 2011-06-14 Hoffmann La Roche derivados de Ácido 4-amino-tieno[3,2-c]piridina-7-carboxÍlico, formulaÇço farmacÊutica contendo os mesmos bem como seus usos
AR070317A1 (es) * 2008-02-06 2010-03-31 Osi Pharm Inc Furo (3,2-c) piridina y tieno (3,2-c) piridinas
US20120189641A1 (en) 2009-02-25 2012-07-26 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
EP2401614A1 (en) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (en) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2012149014A1 (en) 2011-04-25 2012-11-01 OSI Pharmaceuticals, LLC Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (en) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Combination anti-cancer therapy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6232320B1 (en) * 1998-06-04 2001-05-15 Abbott Laboratories Cell adhesion-inhibiting antiinflammatory compounds
US7199119B2 (en) * 2002-10-31 2007-04-03 Amgen Inc. Antiinflammation agents
JP2006528685A (ja) * 2003-05-06 2006-12-21 スミスクライン ビーチャム コーポレーション 新規化合物
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
US20050020619A1 (en) * 2003-07-24 2005-01-27 Patrick Betschmann Thienopyridine kinase inhibitors

Also Published As

Publication number Publication date
BRPI0520482A2 (pt) 2009-05-12
CA2619459A1 (en) 2007-02-22
IL189181A0 (en) 2008-06-05
WO2007019884A1 (en) 2007-02-22
JP2009504692A (ja) 2009-02-05
KR100995790B1 (ko) 2010-11-22
AU2005335661A1 (en) 2007-02-22
KR20080027945A (ko) 2008-03-28
EP1917015A1 (en) 2008-05-07

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Legal Events

Date Code Title Description
FA Abandonment or withdrawal