CY1110666T1 - Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων - Google Patents
Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσωνInfo
- Publication number
- CY1110666T1 CY1110666T1 CY20101100638T CY101100638T CY1110666T1 CY 1110666 T1 CY1110666 T1 CY 1110666T1 CY 20101100638 T CY20101100638 T CY 20101100638T CY 101100638 T CY101100638 T CY 101100638T CY 1110666 T1 CY1110666 T1 CY 1110666T1
- Authority
- CY
- Cyprus
- Prior art keywords
- compounds
- pyrazolopyrimidines
- disease treatment
- cancer disease
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Στις πολλές πραγματοποιήσεις της, η παρούσα εφεύρεση παρέχει μια νέα τάξη ενώσεων pyrazolo[1,5-a]pyrimidine ως αναστολείς κυκλινο-εξαρτώμενων κινασών, μεθόδους παρασκευής τέτοιων ενώσεων, φαρμακευτικές συνθέσεις που περιλαμβάνουν μια ή περισσότερες τέτοιες ενώσεις, μεθόδους παρασκευής φαρμακευτικών συνθέσεων που περιλαμβάνουν μια ή περισσότερες τέτοιες ενώσεις, και μεθόδους θεραπείας, πρόληψης, καταστολής ή βελτίωσης μιας ή περισσοτέρων νόσων που σχετίζονται με τις CDKs χρησιμοποιώντας τέτοιες ενώσεις ή φαρμακευτικές συνθέσεις.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40802702P | 2002-09-04 | 2002-09-04 | |
| US42195902P | 2002-10-29 | 2002-10-29 | |
| EP03794592A EP1537116B1 (en) | 2002-09-04 | 2003-09-03 | Pyrazolopyrimidines suitable for the treatment of cancer diseases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1110666T1 true CY1110666T1 (el) | 2015-06-11 |
Family
ID=31981560
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20101100638T CY1110666T1 (el) | 2002-09-04 | 2010-07-08 | Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2194058B1 (el) |
| JP (1) | JP2010180234A (el) |
| AR (1) | AR041137A1 (el) |
| CY (1) | CY1110666T1 (el) |
| DE (1) | DE60332846D1 (el) |
| EC (2) | ECSP055642A (el) |
| ES (1) | ES2346204T3 (el) |
| MY (1) | MY138201A (el) |
| PL (1) | PL224879B1 (el) |
| PT (1) | PT1537116E (el) |
| RU (1) | RU2380369C9 (el) |
| TW (1) | TWI344468B (el) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9278910B2 (en) | 2011-05-31 | 2016-03-08 | Receptos, Inc. | GLP-1 receptor stabilizers and modulators |
| EA030857B1 (ru) | 2013-06-11 | 2018-10-31 | Селджин Интернэшнл Ii Сарл | Новые модуляторы рецептора glp-1 |
| EP3230276B1 (en) | 2014-12-10 | 2020-09-02 | Celgene International II Sarl | Glp-1 receptor modulators |
| RU2744974C2 (ru) | 2015-08-26 | 2021-03-17 | Блюпринт Медсинс Корпорейшн | Соединения и композиции, применяемые для лечения расстройств, связанных с ntrk |
| AU2016355196A1 (en) * | 2015-11-19 | 2018-06-21 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to NTRK |
| EP3474835B1 (en) | 2016-06-23 | 2023-07-05 | University of Maryland, Baltimore | Non-catalytic substrate-selective p38 -specific mapk inhibitors with endothelial-stabilizing and anti-inflammatory activity, and methods of use thereof |
| MX2021006731A (es) | 2018-12-07 | 2021-09-23 | Univ Maryland | Inhibidores de proteínas quinasas activadas por mitógeno p38 en sitio no atp/catalítico. |
| AU2021274475B2 (en) | 2020-05-18 | 2024-03-21 | Gen1E Lifesciences Inc. | P38alpha mitogen-activated protein kinase inhibitors |
| CA3213095A1 (en) | 2021-03-23 | 2022-09-29 | Adam Galan | Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3907799A (en) | 1971-08-16 | 1975-09-23 | Icn Pharmaceuticals | Xanthine oxidase inhibitors |
| AU7997091A (en) | 1990-05-30 | 1991-12-31 | American Home Products Corporation | Substituted arylsulfonamides and benzamides |
| KR100191774B1 (ko) | 1991-04-22 | 1999-06-15 | 오스카 아끼히꼬 | 피라졸로[1,5-알파] 피리미딘 유도체 및 이것을 함유하는 항염증제 |
| EP0628559B1 (en) * | 1993-06-10 | 2002-04-03 | Beiersdorf-Lilly GmbH | Pyrimidine compounds and their use as pharmaceuticals |
| US5571813A (en) | 1993-06-10 | 1996-11-05 | Beiersdorf-Lilly Gmbh | Fused pyrimidine compounds and their use as pharmaceuticals |
| CN1046730C (zh) | 1994-06-21 | 1999-11-24 | 株式会社大塚制药工场 | 吡唑并[1,5-a]嘧啶衍生物 |
| GB9716557D0 (en) | 1997-08-06 | 1997-10-08 | Glaxo Group Ltd | Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity |
| ATE355841T1 (de) | 1997-12-13 | 2007-03-15 | Bristol Myers Squibb Co | Verwendung von pyrazolo ( 3,4-b) pyridin als cyclin-abhängige kinase hemmer |
| US6413974B1 (en) * | 1998-02-26 | 2002-07-02 | Aventis Pharmaceuticals Inc. | 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| EP0997474B1 (en) | 1998-08-14 | 2003-10-29 | Pfizer Inc. | Antithrombotic agents |
| EP1124823A1 (en) | 1998-10-30 | 2001-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
| ATE248175T1 (de) | 1998-12-22 | 2003-09-15 | Novartis Pharma Gmbh | Epothilonderivate und ihre verwendung als antitumormittel |
| JP4876239B2 (ja) | 1999-01-11 | 2012-02-15 | プリンストン ユニバーシティー | 標的確認のための高親和性阻害剤およびその使用 |
| CA2379064A1 (en) | 1999-07-15 | 2001-01-25 | Pharmacopeia, Inc. | Bradykinin b1 receptor antagonists |
| CN100457753C (zh) | 2000-07-26 | 2009-02-04 | 布里斯托尔-迈尔斯斯奎布公司 | 依赖细胞周期蛋白的激酶的n－[5－[[[5－烷基－2－唑基]甲基]硫代]－2－噻唑基]甲酰胺抑制剂 |
| ZA200301696B (en) | 2000-09-15 | 2004-04-28 | Vertex Pharma | Isoxazoles and their use as inhibitors of erk. |
| PE20020507A1 (es) | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7067520B2 (en) | 2000-11-17 | 2006-06-27 | Ishihara Sangyo Kaisha, Ltd. | Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts |
| AU2509602A (en) * | 2000-12-20 | 2002-07-01 | Sod Conseils Rech Applic | Cyclin-dependent kinase (CDK) and glycolene synthase kinase-3 (GSK-3) inhibitors |
| WO2002064211A1 (en) | 2001-02-09 | 2002-08-22 | Merck & Co., Inc. | Thrombin inhibitors |
-
2003
- 2003-09-03 ES ES03794592T patent/ES2346204T3/es not_active Expired - Lifetime
- 2003-09-03 TW TW092124347A patent/TWI344468B/zh not_active IP Right Cessation
- 2003-09-03 RU RU2005109543/04A patent/RU2380369C9/ru active
- 2003-09-03 PT PT03794592T patent/PT1537116E/pt unknown
- 2003-09-03 DE DE60332846T patent/DE60332846D1/de not_active Expired - Lifetime
- 2003-09-03 MY MYPI20033337A patent/MY138201A/en unknown
- 2003-09-03 EP EP10152446.0A patent/EP2194058B1/en not_active Expired - Lifetime
- 2003-09-03 AR ARP030103192A patent/AR041137A1/es active IP Right Grant
- 2003-09-03 PL PL375697A patent/PL224879B1/pl unknown
-
2005
- 2005-03-03 EC EC2005005642A patent/ECSP055642A/es unknown
-
2010
- 2010-04-06 JP JP2010088210A patent/JP2010180234A/ja not_active Withdrawn
- 2010-07-08 CY CY20101100638T patent/CY1110666T1/el unknown
-
2011
- 2011-09-01 EC EC2011005642A patent/ECSP11005642A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010180234A (ja) | 2010-08-19 |
| TW200410973A (en) | 2004-07-01 |
| AR041137A1 (es) | 2005-05-04 |
| MY138201A (en) | 2009-05-29 |
| ES2346204T3 (es) | 2010-10-13 |
| EP2194058B1 (en) | 2013-11-27 |
| TWI344468B (en) | 2011-07-01 |
| ECSP11005642A (es) | 2011-10-31 |
| PL375697A1 (en) | 2005-12-12 |
| ECSP055642A (es) | 2005-05-30 |
| PL224879B1 (pl) | 2017-02-28 |
| RU2005109543A (ru) | 2006-05-10 |
| RU2380369C9 (ru) | 2011-07-10 |
| PT1537116E (pt) | 2010-09-03 |
| RU2380369C2 (ru) | 2010-01-27 |
| EP2194058A1 (en) | 2010-06-09 |
| DE60332846D1 (de) | 2010-07-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CY1110666T1 (el) | Πυραζολοπυριμιδινες καταλληλες για θεραπεια καρκινικων νοσων | |
| CY1112400T1 (el) | Παραγωγα πυραζολοπυριμιδινης ως αναστολεις της εξαρτωμενης απο κυκλινη κινασης | |
| DK1537116T3 (da) | Pyrazolopyrimidiner egnede til behandling af cancersygdomme | |
| CY1122336T1 (el) | Eνωσεις πυρρολιου ως αναστολεις πρωτεϊνικων κινασων εrκ και φαρμακευτικες συνθεσεις που περιεχουν αυτες τις ενωσεις | |
| TW200745123A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| HK1112233A1 (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors for the treatment of cancer | |
| MY139336A (en) | N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| TW200745128A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| TW200745127A (en) | Pyrazolopyrimidines as protein kinase inhibitors | |
| MY137888A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| MY137843A (en) | Pyrazolopyrimidines as cyclin dependent kinase inhibitors | |
| BRPI0616987A2 (pt) | pirazolopirimidinas como inibidores de cinase dependente de ciclina | |
| MY134589A (en) | Imidazopyrazines as cyclin dependent kinase inhibitors | |
| ATE420883T1 (de) | Pyrrolopyrimidine verwendbar als protein kinase inhibitoren | |
| CY1106816T1 (el) | 1,5-δισυποκαταστημενες ενωσεις 3,4-διυδρο-1h-πυριμιδο [4,5-d] πυριμιδιν-2-ονης και η χρησιμοποιηση αυτων δια τη θεραπευτικη αγωγη ασθενειων εις τις οποιες μεσολαβει η csbp/p38 κιναση | |
| ECSP066763A (es) | Pirazolopirimidinas novedosas como inhibidores de quinasa ciclina-dependientes | |
| ECSP056246A (es) | DERIVADOS DE PIRROLO [3,4-c]PIRAZOL ACTIVOS COMO INHIBIDORES DE QUINASA | |
| WO2006004833A3 (en) | Pyrrolotriazine kinase inhibitors | |
| DE602005025655D1 (de) | Als proteinkinaseinhibitoren geeignete diaminotriazolverbindungen | |
| MX2009005011A (es) | Imidazopirazinas como inhibidores de proteina quinasa. | |
| MX2009003733A (es) | Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina. | |
| MY136840A (en) | Pyrazolopyridines as cyclin dependent kinase inhibitors | |
| AU2972701A (en) | 3-aminopyrazole inhibitors of cyclin dependent kinases | |
| MY136822A (en) | Derivatives of [6, 7-dihydro-5h-imidazo[1,2-a]imidazole-3-sulfonylamino]-propionamide and their use as inhibitors upon the interaction of cams and leukointegrins | |
| TH148526B (th) | ไพราโซโลไพริมิดีนชนิดใหม่ (Novel pyrazolopyrimidines) ล่าสุดในฐานะตัวยับยั้งไซคลินดีเพนเดนท์คิเนส (Cyclin dependent kinase inhibitors) |