ECSP055642A - Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas - Google Patents

Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas

Info

Publication number
ECSP055642A
ECSP055642A EC2005005642A ECSP055642A ECSP055642A EC SP055642 A ECSP055642 A EC SP055642A EC 2005005642 A EC2005005642 A EC 2005005642A EC SP055642 A ECSP055642 A EC SP055642A EC SP055642 A ECSP055642 A EC SP055642A
Authority
EC
Ecuador
Prior art keywords
compounds
pirazolopirimidinas
new
inhibitors
methods
Prior art date
Application number
EC2005005642A
Other languages
English (en)
Inventor
Douglas W Hobbs
Timothy J Guzi
Ronald J Doll
Viyyor Moopil Girijavallabhan
Kartik M Keertikar
Ray A James
Michael Dwyer
Kamil Paruch
Alan Mallams
Carmen S Alvarez
Jocelyn Rivera
Tin-Yau Chan
Vincent Madison
Thierry O Fischmann
Original Assignee
Schering Corp
Pharmacopeia Drug Discovery
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp, Pharmacopeia Drug Discovery filed Critical Schering Corp
Publication of ECSP055642A publication Critical patent/ECSP055642A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

En sus muchas realizaciones, la presente invención provee una nueva clase de compuestos de pirazolo[1,5-a]pirimidina como inhibidores de las quinasas dependientes de ciclina, métodos para preparar dichos compuestos, composiciones farmacéuticas que contienen uno o más de dichos compuestos, métodos para la preparación de formulaciones farmacéuticas que comprenden uno o más de dichos compuestos, y métodos para el tratamiento, prevención, inhibición, o mejoría de una o más enfermedades asociadas con las CDK usando dichos compuestos o composiciones farmacéuticas.
EC2005005642A 2002-09-04 2005-03-03 Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas ECSP055642A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40802702P 2002-09-04 2002-09-04
US42195902P 2002-10-29 2002-10-29

Publications (1)

Publication Number Publication Date
ECSP055642A true ECSP055642A (es) 2005-05-30

Family

ID=31981560

Family Applications (2)

Application Number Title Priority Date Filing Date
EC2005005642A ECSP055642A (es) 2002-09-04 2005-03-03 Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas
EC2011005642A ECSP11005642A (es) 2002-09-04 2011-09-01 Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas

Family Applications After (1)

Application Number Title Priority Date Filing Date
EC2011005642A ECSP11005642A (es) 2002-09-04 2011-09-01 Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas

Country Status (12)

Country Link
EP (1) EP2194058B1 (es)
JP (1) JP2010180234A (es)
AR (1) AR041137A1 (es)
CY (1) CY1110666T1 (es)
DE (1) DE60332846D1 (es)
EC (2) ECSP055642A (es)
ES (1) ES2346204T3 (es)
MY (1) MY138201A (es)
PL (1) PL224879B1 (es)
PT (1) PT1537116E (es)
RU (1) RU2380369C9 (es)
TW (1) TWI344468B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6007417B2 (ja) * 2011-05-31 2016-10-12 レセプトス エルエルシー 新規ｇｌｐ−１受容体安定剤および調節剤
EP3008056B8 (en) 2013-06-11 2021-03-03 Receptos Llc Novel glp-1 receptor modulators
JP2017538711A (ja) 2014-12-10 2017-12-28 セルジーン インターナショナル ツー エスエーアールエル Ｇｌｐ−１レセプターモジュレーター
WO2017035354A1 (en) 2015-08-26 2017-03-02 Blueprint Medicines Corporation Compounds and compositions useful for treating disorders related to ntrk
TWI733713B (zh) 2015-11-19 2021-07-21 美商纜圖藥品公司 用於治療神經促進性酪氨酸受體激酶相關之異常的化合物與組成物
CN116570594A (zh) 2016-06-23 2023-08-11 马里兰大学巴尔的摩分校 选择性p38α特异性MAPK抑制剂
CA3122371A1 (en) * 2018-12-07 2020-06-11 University Of Maryland, Baltimore Non-atp/catalytic site p38 mitogen activated protein kinase inhibitors
WO2021236449A1 (en) 2020-05-18 2021-11-25 Gen1E Lifesciences Inc. P38alpha mitogen-activated protein kinase inhibitors
CA3213095A1 (en) 2021-03-23 2022-09-29 Adam Galan Substituted naphthyl p38alpha mitogen-activated protein kinase inhibitors

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3907799A (en) 1971-08-16 1975-09-23 Icn Pharmaceuticals Xanthine oxidase inhibitors
WO1991018904A1 (en) 1990-05-30 1991-12-12 American Home Products Corporation Substituted arylsulfonamides and benzamides
WO1992018504A1 (fr) 1991-04-22 1992-10-29 Otsuka Pharmaceutical Factory, Inc. DERIVE DE PYRAZOLO[1,5-a]PYRIMIDINE ET AGENT ANTI-INFLAMMATOIRECONTENANT CE DERIVE
EP0628559B1 (en) * 1993-06-10 2002-04-03 Beiersdorf-Lilly GmbH Pyrimidine compounds and their use as pharmaceuticals
US5571813A (en) 1993-06-10 1996-11-05 Beiersdorf-Lilly Gmbh Fused pyrimidine compounds and their use as pharmaceuticals
PT714898E (pt) 1994-06-21 2002-04-29 Otsuka Pharma Co Ltd Derivado de pirazolo¬1,5-a|pirimidina
GB9716557D0 (en) 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
ZA9811178B (en) 1997-12-13 2000-06-07 Bristol Myers Squibb Co Use of pyrazolo (3,4-b) pyridine as cyclin dependent kinase inhibitors.
US6413974B1 (en) 1998-02-26 2002-07-02 Aventis Pharmaceuticals Inc. 6,9,-disubstituted 2-[trans-(4-aminocyclohexyl) amino] purines
DE19834047A1 (de) 1998-07-29 2000-02-03 Bayer Ag Substituierte Pyrazolderivate
DE69912379T2 (de) 1998-08-14 2004-05-06 Pfizer Inc. Antithrombosemittel
JP2002528542A (ja) 1998-10-30 2002-09-03 メルク エンド カムパニー インコーポレーテッド トロンビン阻害剤
EP1140944B1 (en) 1998-12-22 2003-08-27 Novartis AG Epothilone derivatives and their use as antitumor agents
DE60004781T2 (de) 1999-01-11 2004-07-08 Princeton University Kinase-inhibitoren mit hoher affinität zur ziel detektion und ihre verwendung
ATE250053T1 (de) 1999-07-15 2003-10-15 Pharmacopeia Inc Bradikinin b1 rezeptor antagonisten
KR20030016429A (ko) 2000-07-26 2003-02-26 브리스톨-마이어스스퀴브컴파니 시클린 의존성 키나제의ｎ-[5-[[[5-알킬-2-옥사졸릴]메틸]티오]-2-티아졸릴]카르복스아미드 저해제
DE60122176T2 (de) 2000-09-15 2007-07-05 Vertex Pharmaceuticals Inc., Cambridge Isoxazole und ihre verwendung als erk-inhibitoren
PE20020507A1 (es) 2000-10-17 2002-06-25 Schering Corp Compuestos no-imidazoles como antagonistas del receptor histamina h3
US7067520B2 (en) 2000-11-17 2006-06-27 Ishihara Sangyo Kaisha, Ltd. Preventive or therapeutic medicines for diabetes containing fused-heterocyclic compounds or their salts
AU2509602A (en) 2000-12-20 2002-07-01 Sod Conseils Rech Applic Cyclin-dependent kinase (CDK) and glycolene synthase kinase-3 (GSK-3) inhibitors
WO2002064211A1 (en) 2001-02-09 2002-08-22 Merck & Co., Inc. Thrombin inhibitors

Also Published As

Publication number Publication date
CY1110666T1 (el) 2015-06-11
TW200410973A (en) 2004-07-01
MY138201A (en) 2009-05-29
PL224879B1 (pl) 2017-02-28
TWI344468B (en) 2011-07-01
EP2194058B1 (en) 2013-11-27
RU2005109543A (ru) 2006-05-10
JP2010180234A (ja) 2010-08-19
PT1537116E (pt) 2010-09-03
PL375697A1 (en) 2005-12-12
EP2194058A1 (en) 2010-06-09
ECSP11005642A (es) 2011-10-31
RU2380369C9 (ru) 2011-07-10
RU2380369C2 (ru) 2010-01-27
DE60332846D1 (de) 2010-07-15
AR041137A1 (es) 2005-05-04
ES2346204T3 (es) 2010-10-13

Similar Documents

Publication Publication Date Title
ECSP088345A (es) Nuevas pirazolopirimidinas como inhibidores de quinasa dependientes de ciclina
ECSP066763A (es) Pirazolopirimidinas novedosas como inhibidores de quinasa ciclina-dependientes
ECSP11005642A (es) Nuevos pirazolopirimidinas como inhibidores de quinasa dependientes de ciclinas
ECSP088350A (es) Pirazolopirimidinas como inhibidores de protein quinasas
BRPI0314001B8 (pt) pirazolopirimidinas como inibidores de cinase dependente de ciclina e composição farmacêutica compreendendo as mesmas
MY149044A (en) Pyrazolopyrimidines - derivatives as cyclin dependent kinase inhibitors
MY137843A (en) Pyrazolopyrimidines as cyclin dependent kinase inhibitors
HK1112233A1 (en) Pyrazolopyrimidines as cyclin dependent kinase inhibitors for the treatment of cancer
MX2009011355A (es) Nuevas pirazolopirimidinas como inhibidores de quinasas dependientes de ciclinas.
MY139336A (en) N-heteroaryl pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY137888A (en) Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MX2009003733A (es) Pirazolopirimidinas como inhibidores de quinasas dependientes de ciclina.
MY134589A (en) Imidazopyrazines as cyclin dependent kinase inhibitors
ECSP088906A (es) PIRAZOLO 1,5-a PIRIMIDINAS
MX2009003734A (es) Pirazolopirimidinas como inhibidor de cinasas dependientes de ciclina.
ECSP088440A (es) Imidazopirazinas como inhibidores de proteinquinasa
TW200745128A (en) Pyrazolopyrimidines as protein kinase inhibitors
MY133311A (en) Novel imidazopyridines as cyclin dependent kinase inhibitors
TW200745127A (en) Pyrazolopyrimidines as protein kinase inhibitors
WO2007044401A3 (en) Novel pyrazolopyrimidines as cyclin dependent kinase inhibitors
UY27714A1 (es) 2 - heteroaril - pirimidinas inhibidoras de cdk, su preparación y su uso como medicamentos.
IL184898A0 (en) Pyrrolopyrimidine derivatives and pharmaceutical compositions containing the same
WO2004078682A3 (en) Cyclic compounds and compositions as protein kinase inhibitors
WO2008045267A3 (en) Pyrazolopyrimidines as cyclin dependent kinase inhibitors
MY136840A (en) Pyrazolopyridines as cyclin dependent kinase inhibitors